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Showing 1 to 12 of 22 entries
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Resolution-limited optical recording in 3D.

Optics express

Orlic S, Dietz E, Frohmann S, Rass J.
PMID: 21934972
Opt Express. 2011 Aug 15;19(17):16096-105. doi: 10.1364/OE.19.016096.

We present an optical write/read system for high density optical data storage in 3-D. The microholographic approach relies on submicron-sized reflection gratings that encode the digital data. As in conventional optical data storage, the physical limitations are imposed by...

Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.

Cell reports

Yucer N, Ahdoot R, Workman MJ, Laperle AH, Recouvreux MS, Kurowski K, Naboulsi DJ, Liang V, Qu Y, Plummer JT, Gayther SA, Orsulic S, Karlan BY, Svendsen CN.
PMID: 34965417
Cell Rep. 2021 Dec 28;37(13):110146. doi: 10.1016/j.celrep.2021.110146.

Germline pathogenic mutations in BReast CAncer (BRCA1) genes are thought to drive normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian cancer. No human models capture the sequence of events for disease initiation and progression. Here, we...

Modeling material saturation effects in microholographic recording.

Optics express

Nagy Z, Koppa P, Ujhelyi F, Dietz E, Frohmann S, Orlic S.
PMID: 19532410
Opt Express. 2007 Feb 19;15(4):1732-7. doi: 10.1364/oe.15.001732.

Microholographic data storage system model is presented that includes non-linear and non-local behavior of the storage material for accurate simulation of the system and optimization of the writing process. For the description of the photopolymer material a diffusion based...

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).

Journal of genetics and genome research

Jim HS, Lin HY, Tyrer JP, Lawrenson K, Dennis J, Chornokur G, Chen Z, Chen AY, Permuth-Wey J, Aben KK, Anton-Culver H, Antonenkova N, Bruinsma F, Bandera EV, Bean YT, Beckmann MW, Bisogna M, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bunker CH, Butzow R, Campbell IG, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, du Bois A, Despierre E, Sieh W, Doherty JA, Dörk T, Dürst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gao YT, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harter P, Hasmad HN, Hein A, Heitz F, Hildebrandt MA, Hillemanns P, Hogdall CK, Hogdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Karlan BY, Kellar M, Kiemeney LA, Krakstad C, Kjaer SK, Kupryjanczyk J, Vierkant RA, Lambrechts D, Lambrechts S, Le ND, Lee AW, Lele S, Leminen A, Lester J, Levine DA, Liang D, Lim BK, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Thomsen L, Moysich KB, Ness RB, Nevanlinna H, Eilber U, Odunsi K, Olson SH, Orlow I, Orsulic S, Palmieri Weber R, Paul J, Pearce CL, Pejovic T, Pelttari LM, Pike MC, Poole EM, Schernhammer E, Risch HA, Rosen B, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Song H, Southey MC, Spiewankiewicz B, Sucheston-Campbell L, Teo SH, Terry KL, Thompson PJ, Tangen IL, Tworoger SS, van Altena AM, Vergote I, Walsh CS, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wicklund KG, Wilkens LR, Wu AH, Wu X, Woo YL, Yang H, Zheng W, Ziogas A, Amankwah E, Berchuck A, Schildkraut JM, Kelemen LE, Ramus SJ, Monteiro AN, Goode EL, Narod SA, Gayther SA, Pharoah PD, Sellers TA, Phelan CM.
PMID: 26807442
J Genet Genome Res. 2015;2(2). doi: 10.23937/2378-3648/1410017. Epub 2015 Sep 15.

Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadian genes are highly expressed in the...

Immunological configuration of ovarian carcinoma: features and impact on disease outcome.

Journal for immunotherapy of cancer

Fucikova J, Coosemans A, Orsulic S, Cibula D, Vergote I, Galluzzi L, Spisek R.
PMID: 34645669
J Immunother Cancer. 2021 Oct;9(10). doi: 10.1136/jitc-2021-002873.

Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive...

Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment.

Nature communications

Dinh HQ, Pan F, Wang G, Huang QF, Olingy CE, Wu ZY, Wang SH, Xu X, Xu XE, He JZ, Yang Q, Orsulic S, Haro M, Li LY, Huang GW, Breunig JJ, Koeffler HP, Hedrick CC, Xu LY, Lin DC, Li EM.
PMID: 34921160
Nat Commun. 2021 Dec 17;12(1):7335. doi: 10.1038/s41467-021-27599-5.

The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze the microenvironment of esophageal squamous cell carcinoma (ESCC) using single-cell transcriptome sequencing in 62,161...

Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment.

Nature communications

Dinh HQ, Pan F, Wang G, Huang QF, Olingy CE, Wu ZY, Wang SH, Xu X, Xu XE, He JZ, Yang Q, Orsulic S, Haro M, Li LY, Huang GW, Breunig JJ, Koeffler HP, Hedrick CC, Xu LY, Lin DC, Li EM.
PMID: 34921160
Nat Commun. 2021 Dec 17;12(1):7335. doi: 10.1038/s41467-021-27599-5.

The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze the microenvironment of esophageal squamous cell carcinoma (ESCC) using single-cell transcriptome sequencing in 62,161...

Editorial: The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches.

Frontiers in cell and developmental biology

Korkaya H, Orsulic S.
PMID: 33043018
Front Cell Dev Biol. 2020 Sep 17;8:586176. doi: 10.3389/fcell.2020.586176. eCollection 2020.

No abstract available.

Identification of Infertility-Associated Topologically Important Genes Using Weighted Co-expression Network Analysis.

Frontiers in genetics

Wu J, Xia X, Hu Y, Fang X, Orsulic S.
PMID: 33613630
Front Genet. 2021 Feb 03;12:580190. doi: 10.3389/fgene.2021.580190. eCollection 2021.

Endometriosis has been associated with a high risk of infertility. However, the underlying molecular mechanism of infertility in endometriosis remains poorly understood. In our study, we aimed to discover topologically important genes related to infertility in endometriosis, based on...

Models of ovarian cancer metastasis: Murine models.

Drug discovery today. Disease models

Sale S, Orsulic S.
PMID: 19337569
Drug Discov Today Dis Models. 2006 Jun 01;3(2):149-154. doi: 10.1016/j.ddmod.2006.05.006.

Mice have mainly been used in ovarian cancer research as immunodeficient hosts for cell lines derived from the primary tumors and ascites of ovarian cancer patients. These xenograft models have provided a valuable system for pre-clinical trials, however, the...

Are Epithelial Ovarian Cancers of the Mesenchymal Subtype Actually Intraperitoneal Metastases to the Ovary?.

Frontiers in cell and developmental biology

Hu Y, Taylor-Harding B, Raz Y, Haro M, Recouvreux MS, Taylan E, Lester J, Millstein J, Walts AE, Karlan BY, Orsulic S.
PMID: 32766252
Front Cell Dev Biol. 2020 Jul 17;8:647. doi: 10.3389/fcell.2020.00647. eCollection 2020.

Primary ovarian high-grade serous carcinoma (HGSC) has been classified into 4 molecular subtypes: Immunoreactive, Proliferative, Differentiated, and Mesenchymal (Mes), of which the Mes subtype (Mes-HGSC) is associated with the worst clinical outcomes. We propose that Mes-HGSC comprise clusters of...

Holographic reflection gratings in azobenzene polymers.

Optics letters

Eichler HJ, Orlic S, Schulz R, Rübner J.
PMID: 18040389
Opt Lett. 2001 May 01;26(9):581-3. doi: 10.1364/ol.26.000581.

Writing and reading of reflection gratings in films of an azo side-group polymer are reported. The gratings were induced holographically by use of an argon-ion laser at 488 nm. The measured diffraction efficiency was in the range 2-10%. To...

Showing 1 to 12 of 22 entries