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Showing 1 to 12 of 18 entries
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Antibody-Hapten Recognition at the Surface of Functionalized Liposomes Studied by SPR: Steric Hindrance of Pegylated Phospholipids in Stealth Liposomes Prepared for Targeted Radionuclide Delivery.

Journal of drug delivery

Botosoa EP, Maillasson M, Mougin-Degraef M, Remaud-Le Saëc P, Gestin JF, Jacques Y, Barbet J, Faivre-Chauvet A.
PMID: 21490749
J Drug Deliv. 2011;2011:368535. doi: 10.1155/2011/368535. Epub 2011 Jan 17.

Targeted PEGylated liposomes could increase the amount of drugs or radionuclides delivered to tumor cells. They show favorable stability and pharmacokinetics, but steric hindrance of the PEG chains can block the binding of the targeting moiety. Here, specific interactions...

Multicomponent flow on curved surfaces: A vielbein lattice Boltzmann approach.

Physical review. E

Ambruş VE, Busuioc S, Wagner AJ, Paillusson F, Kusumaatmaja H.
PMID: 31962535
Phys Rev E. 2019 Dec;100(6):063306. doi: 10.1103/PhysRevE.100.063306.

We develop and implement a finite difference lattice Boltzmann scheme to study multicomponent flows on curved surfaces, coupling the continuity and Navier-Stokes equations with the Cahn-Hilliard equation to track the evolution of the binary fluid interfaces. The standard lattice...

hnRNP-A1 binds to the IRES of MELOE-1 antigen to promote its translation in stressed melanoma cells.

Molecular oncology

Charpentier M, Dupré E, Fortun A, Briand F, Maillasson M, Com E, Pineau C, Labarrière N, Rabu C, Lang F.
PMID: 34418284
Mol Oncol. 2021 Aug 21; doi: 10.1002/1878-0261.13088. Epub 2021 Aug 21.

The major challenge in antigen-specific immunotherapy of cancer is to select the most relevant tumor antigens to target. To this aim, understanding their mode of expression by tumor cells is critical. We previously identified a melanoma-specific antigen, melanoma-overexpressed antigen...

Two-Chains Tissue Plasminogen Activator Unifies Met and NMDA Receptor Signalling to Control Neuronal Survival.

International journal of molecular sciences

Hedou E, Douceau S, Chevilley A, Varangot A, Thiebaut AM, Triniac H, Bardou I, Ali C, Maillasson M, Crepaldi T, Comoglio P, Lemarchand E, Agin V, Roussel BD, Vivien D.
PMID: 34948279
Int J Mol Sci. 2021 Dec 15;22(24). doi: 10.3390/ijms222413483.

Tissue-type plasminogen activator (tPA) plays roles in the development and the plasticity of the nervous system. Here, we demonstrate in neurons, that by opposition to the single chain form (sc-tPA), the two-chains form of tPA (tc-tPA) activates the MET...

Gastrointestinal mucosal biopsies in Parkinson's disease: beyond alpha-synuclein detection.

Journal of neural transmission (Vienna, Austria : 1996)

Derkinderen P, Cossais F, de Guilhem de Lataillade A, Leclair-Visonneau L, Neunlist M, Paillusson S, De Giorgio R.
PMID: 34816335
J Neural Transm (Vienna). 2021 Nov 24; doi: 10.1007/s00702-021-02445-6. Epub 2021 Nov 24.

Alpha-synuclein deposits, the pathological hallmarks of Parkinson's disease, are consistently found in the gastrointestinal tract of parkinsonian subjects. These observations have raised the potential that endoscopically obtainable mucosal biopsies can aid to a molecular diagnosis of the disease. The...

Probing ergodicity in granular matter.

Physical review letters

Paillusson F, Frenkel D.
PMID: 23215524
Phys Rev Lett. 2012 Nov 16;109(20):208001. doi: 10.1103/PhysRevLett.109.208001. Epub 2012 Nov 13.

When a granular system is tapped, its volume changes. Here, using a well-defined macroscopic protocol, we prepare an ensemble of granular systems and track the statistics of volume changes as a function of the number of taps. This is...

Biopsable neural tissues: toward new biomarkers for Parkinson's disease?.

Frontiers in psychiatry

Lebouvier T, Tasselli M, Paillusson S, Pouclet H, Neunlist M, Derkinderen P.
PMID: 21423439
Front Psychiatry. 2010 Sep 03;1:128. doi: 10.3389/fpsyt.2010.00128. eCollection 2010.

Biomarkers for Parkinson's disease (PD) are mainly intended for the early diagnosis of the disease and to monitor its progression, two aspects insufficiently covered by clinical evaluation. In the last 20 years, the search for biomarkers has been supported...

Devising a protocol-related statistical mechanics framework for granular materials.

Physical review. E, Statistical, nonlinear, and soft matter physics

Paillusson F.
PMID: 25679616
Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jan;91(1):012204. doi: 10.1103/PhysRevE.91.012204. Epub 2015 Jan 29.

Devising a statistical mechanics framework for jammed granular materials is a challenging task as those systems do not share some important properties required to characterize them with statistical thermodynamics tools. In a recent paper [Asenjo et al. Phys. Rev....

Numerical calculation of granular entropy.

Physical review letters

Asenjo D, Paillusson F, Frenkel D.
PMID: 24655280
Phys Rev Lett. 2014 Mar 07;112(9):098002. doi: 10.1103/PhysRevLett.112.098002. Epub 2014 Mar 05.

We present numerical simulations that allow us to compute the number of ways in which N particles can pack into a given volume V. Our technique modifies the method of Xu, Frenkel, and Liu [Phys. Rev. Lett. 106, 245502...

Ongoing ecological speciation in Cotesia sesamiae, a biological control agent of cereal stem borers.

Evolutionary applications

Kaiser L, Le Ru BP, Kaoula F, Paillusson C, Capdevielle-Dulac C, Obonyo JO, Herniou EA, Jancek S, Branca A, Calatayud PA, Silvain JF, Dupas S.
PMID: 26366198
Evol Appl. 2015 Sep;8(8):807-20. doi: 10.1111/eva.12260. Epub 2015 Jul 07.

To develop efficient and safe biological control, we need to reliably identify natural enemy species, determine their host range, and understand the mechanisms that drive host range evolution. We investigated these points in Cotesia sesamiae, an African parasitic wasp...

Dielectric response in the vicinity of an ion: A nonlocal and nonlinear model of the dielectric properties of water.

The Journal of chemical physics

Berthoumieux H, Paillusson F.
PMID: 30849905
J Chem Phys. 2019 Mar 07;150(9):094507. doi: 10.1063/1.5080183.

The goal of this work is to propose a simple continuous model that captures the dielectric properties of water at the nanometric scale. We write an electrostatic energy as a functional of the polarisation field containing a term in...

Multivalent Thiosialosides and Their Synergistic Interaction with Pathogenic Sialidases.

Chemistry (Weinheim an der Bergstrasse, Germany)

Brissonnet Y, Assailly C, Saumonneau A, Bouckaert J, Maillasson M, Petitot C, Roubinet B, Didak B, Landemarre L, Bridot C, Blossey R, Deniaud D, Yan X, Bernard J, Tellier C, Grandjean C, Daligault F, Gouin SG.
PMID: 30516296
Chemistry. 2019 Feb 11;25(9):2358-2365. doi: 10.1002/chem.201805790. Epub 2019 Jan 11.

Sialidases (SAs) hydrolyze sialyl residues from glycoconjugates of the eukaryotic cell surface and are virulence factors expressed by pathogenic bacteria, viruses, and parasites. The catalytic domains of SAs are often flanked with carbohydrate-binding module(s) previously shown to bind sialosides...

Showing 1 to 12 of 18 entries