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The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner.

Journal of cellular and molecular medicine

Mnich K, Koryga I, Pakos-Zebrucka K, Thomas M, Logue SE, Eriksson LA, Gorman AM, Samali A.
PMID: 34363313
J Cell Mol Med. 2021 Sep;25(18):8809-8820. doi: 10.1111/jcmm.16840. Epub 2021 Aug 07.

Stress-induced apoptosis is mediated primarily through the intrinsic pathway that involves caspase-9. We previously reported that in caspase-9-deficient cells, a protein complex containing ATG5 and Fas-associated death domain (FADD) facilitated caspase-8 activation and cell death in response to endoplasmic...

Showing 1 to 1 of 1 entries