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Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.

ACS medicinal chemistry letters

Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M.
PMID: 28947941
ACS Med Chem Lett. 2017 Jul 31;8(9):941-946. doi: 10.1021/acsmedchemlett.7b00229. eCollection 2017 Sep 14.

We report the synthesis, biological evaluation, and structural study of a series of substituted heteroaryl-pyrazole carboxylic acid derivatives. These compounds have been developed as inhibitors of specific isoforms of carbonic anhydrase (CA), with potential as prototypes of a new...

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Cadoni R, Pala N, Lomelino C, et al. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett. 2017;8(9):941-946doi: 10.1021/acsmedchemlett.7b00229.
Cadoni, R., Pala, N., Lomelino, C., Mahon, B. P., McKenna, R., Dallocchio, R., Dessì, A., Carcelli, M., Rogolino, D., Sanna, V., Rassu, M., Iaccarino, C., Vullo, D., Supuran, C. T., & Sechi, M. (2017). Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS medicinal chemistry letters, 8(9), 941-946. https://doi.org/10.1021/acsmedchemlett.7b00229
Cadoni, Roberta, et al. "Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors." ACS medicinal chemistry letters vol. 8,9 (2017): 941-946. doi: https://doi.org/10.1021/acsmedchemlett.7b00229
Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett. 2017 Jul 31;8(9):941-946. doi: 10.1021/acsmedchemlett.7b00229. eCollection 2017 Sep 14. PMID: 28947941; PMCID: PMC5601383.
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Unmasking of primary hyperparathyroidism by Vitamin D therapy.

Indian journal of nephrology

Bala S, Shah B, Rajput P, Rao P.
PMID: 26664216
Indian J Nephrol. 2015 Nov-Dec;25(6):377-9. doi: 10.4103/0971-4065.157427.

A 38-year-old female on Vitamin D therapy presented with hypercalcemia induced acute kidney injury. Evaluation revealed primary hyperparathyroidism (PHPT) and iatrogenic hypervitaminosis D. After medical stabilization, she underwent surgical removal of the parathyroid adenoma, and made a full recovery....

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Bala S, Shah B, Rajput P, et al. Unmasking of primary hyperparathyroidism by Vitamin D therapy. Indian J Nephrol. 2015;25(6):377-9doi: 10.4103/0971-4065.157427.
Bala, S., Shah, B., Rajput, P., & Rao, P. (2015). Unmasking of primary hyperparathyroidism by Vitamin D therapy. Indian journal of nephrology, 25(6), 377-9. https://doi.org/10.4103/0971-4065.157427
Bala, S, et al. "Unmasking of primary hyperparathyroidism by Vitamin D therapy." Indian journal of nephrology vol. 25,6 (2015): 377-9. doi: https://doi.org/10.4103/0971-4065.157427
Bala S, Shah B, Rajput P, Rao P. Unmasking of primary hyperparathyroidism by Vitamin D therapy. Indian J Nephrol. 2015 Nov-Dec;25(6):377-9. doi: 10.4103/0971-4065.157427. PMID: 26664216; PMCID: PMC4663778.
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The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease.

Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

Alizade E, Avcı A, Açar G, Fidan S, Öcal L, Bulut M, Tellice M, Akçakoyun M, Pala S, Esen AM.
PMID: 25848367
Postepy Kardiol Interwencyjnej. 2015;11(1):26-31. doi: 10.5114/pwki.2015.49181. Epub 2015 Mar 06.

INTRODUCTION: The relation between serum rheumatoid factor levels and the extent, severity, and complexity of coronary artery disease has not been adequately studied.AIM: Therefore, we assessed the relationship between the severity of coronary artery disease assessed by SYNTAX score...

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Alizade E, Avcı A, Açar G, et al. The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease. Postepy Kardiol Interwencyjnej. 2015;11(1):26-31doi: 10.5114/pwki.2015.49181.
Alizade, E., Avcı, A., Açar, G., Fidan, S., Öcal, L., Bulut, M., Tellice, M., Akçakoyun, M., Pala, S., & Esen, A. M. (2015). The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease. Postepy w kardiologii interwencyjnej = Advances in interventional cardiology, 11(1), 26-31. https://doi.org/10.5114/pwki.2015.49181
Alizade, Elnur, et al. "The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease." Postepy w kardiologii interwencyjnej = Advances in interventional cardiology vol. 11,1 (2015): 26-31. doi: https://doi.org/10.5114/pwki.2015.49181
Alizade E, Avcı A, Açar G, Fidan S, Öcal L, Bulut M, Tellice M, Akçakoyun M, Pala S, Esen AM. The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease. Postepy Kardiol Interwencyjnej. 2015;11(1):26-31. doi: 10.5114/pwki.2015.49181. Epub 2015 Mar 06. PMID: 25848367; PMCID: PMC4372628.
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Measurement of pH micro-heterogeneity in natural cheese matrices by fluorescence lifetime imaging.

Frontiers in microbiology

Burdikova Z, Svindrych Z, Pala J, Hickey CD, Wilkinson MG, Panek J, Auty MA, Periasamy A, Sheehan JJ.
PMID: 25798136
Front Microbiol. 2015 Mar 06;6:183. doi: 10.3389/fmicb.2015.00183. eCollection 2015.

Cheese, a product of microbial fermentation may be defined as a protein matrix entrapping fat, moisture, minerals and solutes as well as dispersed bacterial colonies. The growth and physiology of bacterial cells in these colonies may be influenced by...

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Burdikova Z, Svindrych Z, Pala J, et al. Measurement of pH micro-heterogeneity in natural cheese matrices by fluorescence lifetime imaging. Front Microbiol. 2015;6:183doi: 10.3389/fmicb.2015.00183.
Burdikova, Z., Svindrych, Z., Pala, J., Hickey, C. D., Wilkinson, M. G., Panek, J., Auty, M. A., Periasamy, A., & Sheehan, J. J. (2015). Measurement of pH micro-heterogeneity in natural cheese matrices by fluorescence lifetime imaging. Frontiers in microbiology, 6183. https://doi.org/10.3389/fmicb.2015.00183
Burdikova, Zuzana, et al. "Measurement of pH micro-heterogeneity in natural cheese matrices by fluorescence lifetime imaging." Frontiers in microbiology vol. 6 (2015): 183. doi: https://doi.org/10.3389/fmicb.2015.00183
Burdikova Z, Svindrych Z, Pala J, Hickey CD, Wilkinson MG, Panek J, Auty MA, Periasamy A, Sheehan JJ. Measurement of pH micro-heterogeneity in natural cheese matrices by fluorescence lifetime imaging. Front Microbiol. 2015 Mar 06;6:183. doi: 10.3389/fmicb.2015.00183. eCollection 2015. PMID: 25798136; PMCID: PMC4351631.
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Proliferating Cell Nuclear Antigen in Premalignancy and Oral Squamous Cell Carcinoma.

Journal of clinical and diagnostic research : JCDR

Poosarla C, Ramesh M, Ramesh K, Gudiseva S, Bala S, Sundar M.
PMID: 26266215
J Clin Diagn Res. 2015 Jun;9(6):ZC39-41. doi: 10.7860/JCDR/2015/12645.6094. Epub 2015 Jun 01.

INTRODUCTION: Cancer has multifactorial aetiology and is a multistep process involving initiation, promotion and tumour progression. Cellular proliferation is one of the important indicators for the biologic aggressiveness of a malignant lesion. The dysregulated proliferation may be a significant...

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Poosarla C, Ramesh M, Ramesh K, et al. Proliferating Cell Nuclear Antigen in Premalignancy and Oral Squamous Cell Carcinoma. J Clin Diagn Res. 2015;9(6):ZC39-41doi: 10.7860/JCDR/2015/12645.6094.
Poosarla, C., Ramesh, M., Ramesh, K., Gudiseva, S., Bala, S., & Sundar, M. (2015). Proliferating Cell Nuclear Antigen in Premalignancy and Oral Squamous Cell Carcinoma. Journal of clinical and diagnostic research : JCDR, 9(6), ZC39-41. https://doi.org/10.7860/JCDR/2015/12645.6094
Poosarla, Chandrashekar, et al. "Proliferating Cell Nuclear Antigen in Premalignancy and Oral Squamous Cell Carcinoma." Journal of clinical and diagnostic research : JCDR vol. 9,6 (2015): ZC39-41. doi: https://doi.org/10.7860/JCDR/2015/12645.6094
Poosarla C, Ramesh M, Ramesh K, Gudiseva S, Bala S, Sundar M. Proliferating Cell Nuclear Antigen in Premalignancy and Oral Squamous Cell Carcinoma. J Clin Diagn Res. 2015 Jun;9(6):ZC39-41. doi: 10.7860/JCDR/2015/12645.6094. Epub 2015 Jun 01. PMID: 26266215; PMCID: PMC4525605.
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Pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of family: A forensic approach to identify family hierarchy.

Journal of forensic dental sciences

Mala S, Rathod V, Pundir S, Dixit S.
PMID: 28584469
J Forensic Dent Sci. 2017 Jan-Apr;9(1):15-19. doi: 10.4103/jfo.jfds_115_15.

CONTEXT: The unique pattern and structural diversity of fingerprints, lip prints, palatal rugae, and their occurrence in different patterns among individuals make it questionable whether they are completely unique even in a family hierarchy? Do they have any repetition...

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Mala S, Rathod V, Pundir S, et al. Pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of family: A forensic approach to identify family hierarchy. J Forensic Dent Sci. 2017;9(1):15-19doi: 10.4103/jfo.jfds_115_15.
Mala, S., Rathod, V., Pundir, S., & Dixit, S. (2017). Pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of family: A forensic approach to identify family hierarchy. Journal of forensic dental sciences, 9(1), 15-19. https://doi.org/10.4103/jfo.jfds_115_15
Mala, Sankeerti, et al. "Pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of family: A forensic approach to identify family hierarchy." Journal of forensic dental sciences vol. 9,1 (2017): 15-19. doi: https://doi.org/10.4103/jfo.jfds_115_15
Mala S, Rathod V, Pundir S, Dixit S. Pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of family: A forensic approach to identify family hierarchy. J Forensic Dent Sci. 2017 Jan-Apr;9(1):15-19. doi: 10.4103/jfo.jfds_115_15. PMID: 28584469; PMCID: PMC5450477.
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GIMS-Software for asset market experiments.

Journal of behavioral and experimental finance

Palan S.
PMID: 26525085
J Behav Exp Finance. 2015 Mar;5:1-14. doi: 10.1016/j.jbef.2015.02.001.

In this article we lay out requirements for an experimental market software for financial and economic research. We then discuss existing solutions. Finally, we introduce GIMS, an open source market software which is characterized by extensibility and ease of...

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Palan S. GIMS-Software for asset market experiments. J Behav Exp Finance. 2015;5:1-14doi: 10.1016/j.jbef.2015.02.001.
Palan, S. (2015). GIMS-Software for asset market experiments. Journal of behavioral and experimental finance, 51-14. https://doi.org/10.1016/j.jbef.2015.02.001
Palan, Stefan. "GIMS-Software for asset market experiments." Journal of behavioral and experimental finance vol. 5 (2015): 1-14. doi: https://doi.org/10.1016/j.jbef.2015.02.001
Palan S. GIMS-Software for asset market experiments. J Behav Exp Finance. 2015 Mar;5:1-14. doi: 10.1016/j.jbef.2015.02.001. PMID: 26525085; PMCID: PMC4599443.
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Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I.

FEBS open bio

Kern S, Feng HZ, Wei H, Cala S, Jin JP.
PMID: 24319652
FEBS Open Bio. 2013 Nov 23;4:11-7. doi: 10.1016/j.fob.2013.11.002. eCollection 2013.

We previously reported that a restrictive N-terminal truncation of cardiac troponin I (cTnI-ND) is up-regulated in the heart in adaptation to hemodynamic stresses. Over-expression of cTnI-ND in the hearts of transgenic mice revealed functional benefits such as increased relaxation...

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Kern S, Feng HZ, Wei H, et al. Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I. FEBS Open Bio. 2013;4:11-7doi: 10.1016/j.fob.2013.11.002.
Kern, S., Feng, H. Z., Wei, H., Cala, S., & Jin, J. P. (2013). Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I. FEBS open bio, 411-7. https://doi.org/10.1016/j.fob.2013.11.002
Kern, Stephanie, et al. "Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I." FEBS open bio vol. 4 (2013): 11-7. doi: https://doi.org/10.1016/j.fob.2013.11.002
Kern S, Feng HZ, Wei H, Cala S, Jin JP. Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I. FEBS Open Bio. 2013 Nov 23;4:11-7. doi: 10.1016/j.fob.2013.11.002. eCollection 2013. PMID: 24319652; PMCID: PMC3851183.
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Coping strategies in egyptian ladies with breast cancer.

Breast cancer : basic and clinical research

Elsheshtawy EA, Abo-Elez WF, Ashour HS, Farouk O, El Zaafarany MI.
PMID: 24940070
Breast Cancer (Auckl). 2014 Jun 05;8:97-102. doi: 10.4137/BCBCR.S14755. eCollection 2014.

INTRODUCTION: A diagnosis of breast cancer regardless of the stage can be stressful, impact multiple spheres of life, and disrupt physical status, emotional and spiritual well-being, and personal relationships for the patient and family. In order to adapt, the...

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Elsheshtawy EA, Abo-Elez WF, Ashour HS, et al. Coping strategies in egyptian ladies with breast cancer. Breast Cancer (Auckl). 2014;8:97-102doi: 10.4137/BCBCR.S14755.
Elsheshtawy, E. A., Abo-Elez, W. F., Ashour, H. S., Farouk, O., & El Zaafarany, M. I. (2014). Coping strategies in egyptian ladies with breast cancer. Breast cancer : basic and clinical research, 897-102. https://doi.org/10.4137/BCBCR.S14755
Elsheshtawy, Eman A, et al. "Coping strategies in egyptian ladies with breast cancer." Breast cancer : basic and clinical research vol. 8 (2014): 97-102. doi: https://doi.org/10.4137/BCBCR.S14755
Elsheshtawy EA, Abo-Elez WF, Ashour HS, Farouk O, El Zaafarany MI. Coping strategies in egyptian ladies with breast cancer. Breast Cancer (Auckl). 2014 Jun 05;8:97-102. doi: 10.4137/BCBCR.S14755. eCollection 2014. PMID: 24940070; PMCID: PMC4055407.
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Role of insulin in the type 2 diabetes therapy: past, present and future.

International journal of endocrinology and metabolism

Maria Rotella C, Pala L, Mannucci E.
PMID: 24348585
Int J Endocrinol Metab. 2013;11(3):137-44. doi: 10.5812/ijem.7551. Epub 2013 Jul 01.

CONTEXT: Since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on...

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Maria Rotella C, Pala L, Mannucci E. Role of insulin in the type 2 diabetes therapy: past, present and future. Int J Endocrinol Metab. 2013;11(3):137-44doi: 10.5812/ijem.7551.
Maria Rotella, C., Pala, L., & Mannucci, E. (2013). Role of insulin in the type 2 diabetes therapy: past, present and future. International journal of endocrinology and metabolism, 11(3), 137-44. https://doi.org/10.5812/ijem.7551
Maria Rotella, Carlo, et al. "Role of insulin in the type 2 diabetes therapy: past, present and future." International journal of endocrinology and metabolism vol. 11,3 (2013): 137-44. doi: https://doi.org/10.5812/ijem.7551
Maria Rotella C, Pala L, Mannucci E. Role of insulin in the type 2 diabetes therapy: past, present and future. Int J Endocrinol Metab. 2013;11(3):137-44. doi: 10.5812/ijem.7551. Epub 2013 Jul 01. PMID: 24348585; PMCID: PMC3860110.
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Correction: The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort.

PloS one

Roura E, Travier N, Waterboer T, de Sanjosé S, Bosch FX, Pawlita M, Pala V, Weiderpass E, Margall N, Dillner J, Gram IT, Tjønneland A, Munk C, Palli D, Khaw KT, Overvad K, Clavel-Chapelon F, Mesrine S, Fournier A, Fortner RT, Ose J, Steffen A, Trichopoulou A, Lagiou P, Orfanos P, Masala G, Tumino R, Sacerdote C, Polidoro S, Mattiello A, Lund E, Peeters PH, Bueno-de-Mesquita HB, Ramón Quirós J, Sánchez MJ, Navarro C, Barricarte A, Larrañaga N, Ekström J, Lindquist D, Idahl A, Travis RC, Merritt MA, Gunter MJ, Rinaldi S, Tommasino M, Franceschi S, Riboli E, Castellsagué X.
PMID: 26954296
PLoS One. 2016 Mar 08;11(3):e0151427. doi: 10.1371/journal.pone.0151427. eCollection 2016.

No abstract available.

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Roura E, Travier N, Waterboer T, et al. Correction: The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. PLoS One. 2016;11(3):e0151427doi: 10.1371/journal.pone.0151427.
Roura, E., Travier, N., Waterboer, T., de Sanjosé, S., Bosch, F. X., Pawlita, M., Pala, V., Weiderpass, E., Margall, N., Dillner, J., Gram, I. T., Tjønneland, A., Munk, C., Palli, D., Khaw, K. T., Overvad, K., Clavel-Chapelon, F., Mesrine, S., Fournier, A., Fortner, R. T., Ose, J., Steffen, A., Trichopoulou, A., Lagiou, P., Orfanos, P., Masala, G., Tumino, R., Sacerdote, C., Polidoro, S., Mattiello, A., Lund, E., Peeters, P. H., Bueno-de-Mesquita, H. B., Ramón Quirós, J., Sánchez, M. J., Navarro, C., Barricarte, A., Larrañaga, N., Ekström, J., Lindquist, D., Idahl, A., Travis, R. C., Merritt, M. A., Gunter, M. J., Rinaldi, S., Tommasino, M., Franceschi, S., Riboli, E., & Castellsagué, X. (2016). Correction: The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. PloS one, 11(3), e0151427. https://doi.org/10.1371/journal.pone.0151427
Roura, Esther, et al. "Correction: The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort." PloS one vol. 11,3 (2016): e0151427. doi: https://doi.org/10.1371/journal.pone.0151427
Roura E, Travier N, Waterboer T, de Sanjosé S, Bosch FX, Pawlita M, Pala V, Weiderpass E, Margall N, Dillner J, Gram IT, Tjønneland A, Munk C, Palli D, Khaw KT, Overvad K, Clavel-Chapelon F, Mesrine S, Fournier A, Fortner RT, Ose J, Steffen A, Trichopoulou A, Lagiou P, Orfanos P, Masala G, Tumino R, Sacerdote C, Polidoro S, Mattiello A, Lund E, Peeters PH, Bueno-de-Mesquita HB, Ramón Quirós J, Sánchez MJ, Navarro C, Barricarte A, Larrañaga N, Ekström J, Lindquist D, Idahl A, Travis RC, Merritt MA, Gunter MJ, Rinaldi S, Tommasino M, Franceschi S, Riboli E, Castellsagué X. Correction: The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. PLoS One. 2016 Mar 08;11(3):e0151427. doi: 10.1371/journal.pone.0151427. eCollection 2016. PMID: 26954296; PMCID: PMC4783099.
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Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training.

Journal of sports science & medicine

Pala R, Orhan C, Tuzcu M, Sahin N, Ali S, Cinar V, Atalay M, Sahin K.
PMID: 26957943
J Sports Sci Med. 2016 Feb 23;15(1):196-203. eCollection 2016 Mar.

This study reports the effects of Q10, coenzyme Q10 or ubiquinone, a component of the electron transport chain in mitochondria, on nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), inhibitors of kappa B (IκB), nuclear factor (erythroid-derived 2)-like 2...

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Pala R, Orhan C, Tuzcu M, et al. Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training. J Sports Sci Med. 2016;15(1):196-203
Pala, R., Orhan, C., Tuzcu, M., Sahin, N., Ali, S., Cinar, V., Atalay, M., & Sahin, K. (2016). Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training. Journal of sports science & medicine, 15(1), 196-203.
Pala, Ragip, et al. "Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training." Journal of sports science & medicine vol. 15,1 (2016): 196-203.
Pala R, Orhan C, Tuzcu M, Sahin N, Ali S, Cinar V, Atalay M, Sahin K. Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training. J Sports Sci Med. 2016 Feb 23;15(1):196-203. eCollection 2016 Mar. PMID: 26957943; PMCID: PMC4763840.
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