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Showing 1 to 12 of 213 entries
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A new method for analyzing auditory brain-stem response waveforms using a moving-minimum subtraction procedure of digitized analog recordings.

Neuropsychiatric disease and treatment

Källstrand J, Lewander T, Baghdassarian E, Nielzén S.
PMID: 24944514
Neuropsychiatr Dis Treat. 2014 Jun 06;10:1011-6. doi: 10.2147/NDT.S59178. eCollection 2014.

The auditory brain-stem response (ABR) waveform comprises a set of waves (labeled I-VII) recorded with scalp electrodes over 10 ms after an auditory stimulation with a brief click sound. Quite often, the waves are fused (confluent) and baseline-irregular and...

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives.

Tetrahedron letters

Richardson MA, Furlani RE, Podell BK, Ackart DF, Haugen JD, Melander RJ, Melander C, Basaraba RJ.
PMID: 26146419
Tetrahedron Lett. 2015;56(23):3406-3409. doi: 10.1016/j.tetlet.2015.01.122.

Advanced glycation end-products (AGEs), unregulated modifications to host macromolecules that occur as a result of metabolic dysregulation, play a role in many diabetes related complications, inflammation and aging, and may lead to increased cardiovascular risk. Small molecules that have...

Truncated HSPB1 causes axonal neuropathy and impairs tolerance to unfolded protein stress.

BBA clinical

Ylikallio E, Konovalova S, Dhungana Y, Hilander T, Junna N, Partanen JV, Toppila JP, Auranen M, Tyynismaa H.
PMID: 26675522
BBA Clin. 2015 Mar 11;3:233-42. doi: 10.1016/j.bbacli.2015.03.002. eCollection 2015 Jun.

BACKGROUND: HSPB1 belongs to the family of small heat shock proteins (sHSP) that have importance in protection against unfolded protein stress, in cancer cells for escaping drug toxicity stress and in neurons for suppression of protein aggregates. sHSPs have...

Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium.

The Journal of organic chemistry

Melander C, Horne DA.
PMID: 11667834
J Org Chem. 1996 Nov 15;61(23):8344-8346. doi: 10.1021/jo961331q.

No abstract available.

Compact, open and general purpose cell of variable effective pathlength: direct absorption measurement of SO(4)(2-) in water.

Analytical and bioanalytical chemistry

Favier JP, Bicanic D, Chirtoc M, Helander P.
PMID: 15045411
Anal Bioanal Chem. 1996 Jun;355(3):357-8. doi: 10.1007/s0021663550357.

The use of an optothermal window (OW) was proposed for the direct (no need for sample preparation) spectroscopic, non-destructive measurement of SO(4)(2-) in water at 1078 cm(-1). The presently determined limit of detection (LOD) of 1 mmol/L is comparable...

Misleading results of ethanol analysis in urine specimens from rape victims suffering from diabetes.

Journal of clinical forensic medicine

Jones AW, Eklund A, Helander A.
PMID: 16083664
J Clin Forensic Med. 2000 Sep;7(3):144-6. doi: 10.1054/jcfm.2000.0432.

We report appreciably high concentrations of ethanol (82 and 102 mg/dL) in specimens of urine collected from two victims of date rape. Both girls (aged 15 and 18 years) suffered from diabetes mellitus, but adamantly denied drinking any alcohol...

Intrinsic ambipolarity and rotation in stellarators.

Physical review letters

Helander P, Simakov AN.
PMID: 18851538
Phys Rev Lett. 2008 Oct 03;101(14):145003. doi: 10.1103/PhysRevLett.101.145003. Epub 2008 Sep 29.

It is shown that collisional plasma transport is intrinsically ambipolar only in quasiaxisymmetric or quasihelically symmetric magnetic configurations. Only in such fields can the plasma rotate freely, and then only in the direction of quasisymmetry. In a non-quasi-symmetric magnetic...

Model for current-driven edge-localized modes.

Physical review letters

Gimblett CG, Hastie RJ, Helander P.
PMID: 16486720
Phys Rev Lett. 2006 Jan 27;96(3):035006. doi: 10.1103/PhysRevLett.96.035006. Epub 2006 Jan 27.

Edge-localized modes (ELMs) are cyclic disturbances in the outer region of tokamak plasmas that are influential in determining present and future tokamak performance. In this Letter, we outline an approach to modeling ELMs in which we envisage toroidal peeling...

CO dissociation on iron nanoparticles: size and geometry effects.

The Journal of chemical physics

Melander M, Latsa V, Laasonen K.
PMID: 24182042
J Chem Phys. 2013 Oct 28;139(16):164320. doi: 10.1063/1.4827078.

The reactivity of 0.5-1.4 nm iron nanoparticles and corresponding bulk surfaces has been systematically studied using density functional theory. The study includes both ideally symmetric and more realistic rugged nanoparticles. The activation energies for CO dissociation vary between 1.1...

The histone deacetylase inhibitor valproic acid sensitizes diffuse large B-cell lymphoma cell lines to CHOP-induced cell death.

American journal of translational research

Ageberg M, Rydström K, Relander T, Drott K.
PMID: 23573362
Am J Transl Res. 2013;5(2):170-83. Epub 2013 Mar 28.

Epigenetic code modifications by histone deacetylase inhibitors (HDACis) have recently been proposed as potential new therapies for hematological malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common form of aggressive lymphoma. At present, standard first line treatment for...

Generalized adiabatic invariants in one-dimensional Hamiltonian systems.

Physical review letters

Helander P, Lisak M, Semenov VE.
PMID: 10045764
Phys Rev Lett. 1992 Jun 22;68(25):3659-3662. doi: 10.1103/PhysRevLett.68.3659.

No abstract available.

Analysis of Mitochondrial Protein Synthesis: De Novo Translation, Steady-State Levels, and Assembled OXPHOS Complexes.

Current protocols in toxicology

Hilander T, Konovalova S, Terzioglu M, Tyynismaa H.
PMID: 30063298
Curr Protoc Toxicol. 2018 Aug;77(1):e56. doi: 10.1002/cptx.56. Epub 2018 Jul 31.

Mitochondria are multifunctional organelles with their own genome and protein synthesis machinery. The 13 proteins encoded by mitochondrial DNA (mtDNA) are core subunits of the oxidative phosphorylation (OXPHOS) system producing the majority of cellular ATP. Yet most mitochondrial proteins...

Showing 1 to 12 of 213 entries