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Controllable genetic manipulation of apoptosis of cells in culture.

Cytotechnology

Littlewood T, McCarthy N, Whyte M, Pelengaris S, James C, Evan G.
PMID: 22358926
Cytotechnology. 1996 Jan;22(1):157-67. doi: 10.1007/BF00353935.

Apoptosis of mammalian cell is under the control of a wide range of intracellular and extracellular factors-amongst them proteases, protein kinases, cytokines and the protein products of oncogenes and tumour suppressor genes. The c-myc proto-oncogene encodes an essential component...

A simple matter of life and death-the trials of postnatal Beta-cell mass regulation.

International journal of endocrinology

Tarabra E, Pelengaris S, Khan M.
PMID: 22577380
Int J Endocrinol. 2012;2012:516718. doi: 10.1155/2012/516718. Epub 2012 Apr 22.

Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. Thus, the identification...

Use of retroviruses to express exogenous genes in vascular smooth muscle cells.

Methods in molecular medicine

Littlewood TD, Pelengaris SA.
PMID: 21341037
Methods Mol Med. 1999;30:323-41. doi: 10.1385/1-59259-247-3:323.

The ability to express cloned genes in mammalian cells has proved invaluable in the study of gene expression and function and in clinical applications for the correction of functional gene loss by gene therapy. Despite the wide use of...

Showing 1 to 3 of 3 entries