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Showing 1 to 11 of 11 entries
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Estimating surface NO.

Journal of atmospheric chemistry

Knepp T, Pippin M, Crawford J, Chen G, Szykman J, Long R, Cowen L, Cede A, Abuhassan N, Herman J, Delgado R, Compton J, Berkoff T, Fishman J, Martins D, Stauffer R, Thompson AM, Weinheimer A, Knapp D, Montzka D, Lenschow D, Neil D.
PMID: 26692593
J Atmos Chem. 2015;72(3):261-286. doi: 10.1007/s10874-013-9257-6. Epub 2013 May 25.

Total-column nitrogen dioxide (NO

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities.

bioRxiv : the preprint server for biology

Swaim CD, Perng YC, Zhao X, Canadeo LA, Harastani HH, Darling TL, Boon ACM, Lenschow DJ, Huibregtse JM.
PMID: 32637945
bioRxiv. 2020 Jul 02; doi: 10.1101/2020.07.01.183020.

A recently emerged betacoronavirus, SARS-CoV-2, has led to a global health crisis that calls for the identification of effective therapeutics for COVID-19 disease. Coronavirus papain-like protease (PLpro) is an attractive drug target as it is essential for viral polyprotein...

Interferon Alpha, but Not Interferon Beta, Acts Early To Control Chronic Chikungunya Virus Pathogenesis.

Journal of virology

Locke MC, Fox LE, Dunlap BF, Young AR, Monte K, Lenschow DJ.
PMID: 34668781
J Virol. 2022 Jan 12;96(1):e0114321. doi: 10.1128/JVI.01143-21. Epub 2021 Oct 20.

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that causes both debilitating acute and chronic disease. Previous work has shown that type I interferons (IFNs) play a critical role in limiting CHIKV pathogenesis and that interferon alpha (IFN-α) and interferon...

En garde! The duel functions of MORC3.

Cell host & microbe

Fox LE, Lenschow DJ.
PMID: 35026136
Cell Host Microbe. 2022 Jan 12;30(1):8-9. doi: 10.1016/j.chom.2021.12.017.

Effector-triggered immunity involves "guarded" host processes that, when perturbed by pathogen factors, prompt a secondary response. A recent study published in Nature by Gaidt et al. demonstrates that MORC3 serves as both the guard and the guarded antiviral host...

Antiviral Properties of ISG15.

Viruses

Lenschow DJ.
PMID: 21994614
Viruses. 2010 Oct;2(10):2154-68. doi: 10.3390/v2102154. Epub 2010 Sep 28.

The type I interferon system plays a critical role in limiting the spread of viral infection. Viruses induce the production of interferon (IFN), which after binding to the IFN-α/β receptor (IFNAR), and triggering of the JAK/STAT signaling cascade, results...

Multi-year ozone concentration and its spectra in Shanghai, China.

The Science of the total environment

Geng F, Mao X, Zhou M, Zhong S, Lenschow D.
PMID: 25829291
Sci Total Environ. 2015 Jul 15;521:135-43. doi: 10.1016/j.scitotenv.2015.03.082. Epub 2015 Mar 30.

The periodic properties of surface ozone variation were studied at five stations with different environmental conditions in Shanghai based on multi-year observations of ozone concentration and UV radiation using spectral decomposition methods. The spectra of surface ozone have distinct...

Particle nucleation in the tropical boundary layer and its coupling to marine sulfur sources .

Science (New York, N.Y.)

Clarke AD, Davis D, Kapustin VN, Eisele F, Chen G, Paluch I, Lenschow D, Bandy AR, Thornton D, Moore K, Mauldin L, Tanner D, Litchy M, Carroll MA, Collins J, Albercook G.
PMID: 9756483
Science. 1998 Oct 02;282(5386):89-92. doi: 10.1126/science.282.5386.89.

New particle formation in a tropical marine boundary layer setting was characterized during NASA's Pacific Exploratory Mission-Tropics A program. It represents the clearest demonstration to date of aerosol nucleation and growth being linked to the natural marine sulfur cycle....

IFNα, but not IFNβ, acts early to control chronic chikungunya virus pathogenesis.

Journal of virology

Locke MC, Fox LE, Dunlap BF, Young AR, Monte K, Lenschow DJ.
PMID: 34668781
J Virol. 2021 Oct 20;JVI0114321. doi: 10.1128/JVI.01143-21. Epub 2021 Oct 20.

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that causes both debilitating acute and chronic disease. Previous work has shown that type I IFNs play a critical role in limiting CHIKV pathogenesis and that IFNα and IFNβ control acute CHIKV...

Interferon Alpha, but Not Interferon Beta, Acts Early To Control Chronic Chikungunya Virus Pathogenesis.

Journal of virology

Locke MC, Fox LE, Dunlap BF, Young AR, Monte K, Lenschow DJ.
PMID: 34668781
J Virol. 2022 Jan 12;96(1):e0114321. doi: 10.1128/JVI.01143-21. Epub 2021 Oct 20.

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that causes both debilitating acute and chronic disease. Previous work has shown that type I interferons (IFNs) play a critical role in limiting CHIKV pathogenesis and that interferon alpha (IFN-α) and interferon...

Sensing glucose concentrations at GHz frequencies with a fully embedded Biomicro-electromechanical system (BioMEMS).

Journal of applied physics

Birkholz M, Ehwald KE, Basmer T, Kulse P, Reich C, Drews J, Genschow D, Haak U, Marschmeyer S, Matthus E, Schulz K, Wolansky D, Winkler W, Guschauski T, Ehwald R.
PMID: 25332510
J Appl Phys. 2013 Jun 28;113(24):244904. doi: 10.1063/1.4811351. Epub 2013 Jun 26.

The progressive scaling in semiconductor technology allows for advanced miniaturization of intelligent systems like implantable biosensors for low-molecular weight analytes. A most relevant application would be the monitoring of glucose in diabetic patients, since no commercial solution is available...

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro.

iScience

Swaim CD, Dwivedi V, Perng YC, Zhao X, Canadeo LA, Harastani HH, Darling TL, Boon ACM, Lenschow DJ, Kulkarni V, Huibregtse JM.
PMID: 34632326
iScience. 2021 Oct 22;24(10):103213. doi: 10.1016/j.isci.2021.103213. Epub 2021 Oct 02.

The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attractive drug target as...

Showing 1 to 11 of 11 entries