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Showing 1 to 12 of 151 entries
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Influence of site on course of intracerebral hemorrhage.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Hier DB, Babcock DJ, Foulkes MA, Mohr JP, Price TR, Wolf PA.
PMID: 26487080
J Stroke Cerebrovasc Dis. 1993;3(1):65-74. doi: 10.1016/S1052-3057(10)80134-X. Epub 2010 Jun 10.

The influence of site of hemorrhage on presentation, clinical profile, hospital course, and outcome was examined in 225 patients with intracerebral hemorrhage in the NINDS Stroke Data Bank. Mode of presentation differed by hemorrhage site (coma at onset was...

Potential causes of subfertility in patients with intramural fibroids.

Fertility research and practice

Pier BD, Bates GW.
PMID: 28620517
Fertil Res Pract. 2015 Aug 25;1:12. doi: 10.1186/s40738-015-0005-2. eCollection 2015.

BACKGROUND: Intramural leiomyomas have been long debated as a potential cause of infertility and pregnancy loss.FINDINGS: Previous research has linked intramural fibroids to defective implantation, as well as to abnormal peristaltic events of the uterine smooth muscle. Previous reports...

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes.

Molecular therapy. Methods & clinical development

Hui DJ, Edmonson SC, Podsakoff GM, Pien GC, Ivanciu L, Camire RM, Ertl H, Mingozzi F, High KA, Basner-Tschakarjan E.
PMID: 26445723
Mol Ther Methods Clin Dev. 2015 Sep 30;2:15029. doi: 10.1038/mtm.2015.29. eCollection 2015.

Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe....

Syntheses of Theaspirone and Vitispirane via Palladium(II)-Catalyzed Oxaspirocyclization.

The Journal of organic chemistry

Nilsson YI, Aranyos A, Andersson PG, Bäckvall JE, Parrain JL, Ploteau C, Quintard JP.
PMID: 11667056
J Org Chem. 1996 Mar 08;61(5):1825-1829. doi: 10.1021/jo9505031.

Total syntheses of theaspirone (A and B) and vitispirane (A and B) are described. The key step in the syntheses is the palladium(II)-catalyzed intramolecular oxaspirocyclization of diene alcohol 4 to either vitispirane or the allylic alcohol 9. The outcome...

Intermolecular accessibility: the meaning of molecular connectivity.

Journal of chemical information and computer sciences

Kier LB, Hall LH.
PMID: 10850784
J Chem Inf Comput Sci. 2000 May;40(3):792-5. doi: 10.1021/ci990135s.

The molecular connectivity indices are shown to be the numerical possibilities of a molecule encountering another identical molecule, derived from the bond accessibilites of each. The meaning of the delta values and the significance of all suppressed X-H bonds...

Oral Mucosa Bleeding Times of Normal Cats and Cats with Chediak-Higashi Syndrome or Hageman Trait (Factor XII Deficiency).

Veterinary clinical pathology

Parker MT, Collier LL, Kier AB, Johnson GS.
PMID: 15162339
Vet Clin Pathol. 1988;17(1):9-12. doi: 10.1111/j.1939-165x.1988.tb00479.x.

A commercially available, disposable blade in a spring-loaded cassette was used to measure oral mucosa bleeding times (OMBT) of ketamine/acepromazine-anesthetized cats. The OMBT were determined in cats homozygous for Chediak-Higashi syndrome (CHS, n = 7), cats heterozygous for CHS...

Lack of correlation between pulmonary disease and cystic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis: a case report.

Journal of medical case reports

Levy H, Cannon CL, Asher D, García C, Cleveland RH, Pier GB, Knowles MR, Colin AA.
PMID: 20420703
J Med Case Rep. 2010 Apr 26;4:117. doi: 10.1186/1752-1947-4-117.

INTRODUCTION: Mutations in both alleles of the cystic fibrosis transmembrane conductance regulator gene result in the disease cystic fibrosis, which usually manifests as chronic sinopulmonary disease, pancreatic insufficiency, elevated sodium chloride loss in sweat, infertility among men due to...

A systems biology approach to invasive behavior: comparing cancer metastasis and suburban sprawl development.

BMC research notes

Ryan JJ, Dows BL, Kirk MV, Chen X, Eastman JR, Dyer RJ, Kier LB.
PMID: 20181145
BMC Res Notes. 2010 Feb 10;3:36. doi: 10.1186/1756-0500-3-36.

BACKGROUND: Despite constant progress, cancer remains the second leading cause of death in the United States. The ability of tumors to metastasize is central to this dilemma, as many studies demonstrate successful treatment correlating to diagnosis prior to cancer...

Water chreodes and the mechanisms of ligand diffusion, general anesthesia, and sleep.

Biochemistry research international

Kier LB.
PMID: 21804942
Biochem Res Int. 2011;2011:396560. doi: 10.1155/2011/396560. Epub 2011 Jul 26.

The concept of the presence of passageways, chreodes, created by the influence of the hydropathic states of amino acid side chains on the surface water of proteins, has been proposed. These chreodes facilitate and direct the diffusion of neurotransmitters...

Quantification of Epicardial Fat by Cardiac CT Imaging.

The open medical informatics journal

Coppini G, Favilla R, Marraccini P, Moroni D, Pieri G.
PMID: 21589854
Open Med Inform J. 2010 Jul 27;4:126-35. doi: 10.2174/1874431101004010126.

The aim of this work is to introduce and design image processing methods for the quantitative analysis of epicardial fat by using cardiac CT imaging.Indeed, epicardial fat has recently been shown to correlate with cardiovascular disease, cardiovascular risk factors...

Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis.

Nature communications

Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Williams TN, Weatherall DJ, Hay SI.
PMID: 21045822
Nat Commun. 2010 Nov 02;1:104. doi: 10.1038/ncomms1104.

It has been 100 years since the first report of sickle haemoglobin (HbS). More than 50 years ago, it was suggested that the gene responsible for this disorder could reach high frequencies because of resistance conferred against malaria by...

Novel 8-heterocyclyl xanthine derivatives in drug development - an update.

Expert opinion on drug discovery

Baraldi PG, Fruttarolo F, Tabrizi MA, Romagnoli R, Preti D.
PMID: 23496127
Expert Opin Drug Discov. 2007 Sep;2(9):1161-83. doi: 10.1517/17460441.2.9.1161.

Naturally occurring methyl xanthines, especially caffeine and theophylline, have been widely investigated for their pharmacological properties as cognition enhancers, bronchodilator agents and mild diuretics. The xanthine core (3,7-dihydro-1H-purine-2,6-dione) has been largely manipulated in the search for selective ligands for...

Showing 1 to 12 of 151 entries