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Showing 1 to 12 of 22 entries
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Magnetization transfer ratio relates to cognitive impairment in normal elderly.

Frontiers in aging neuroscience

Seiler S, Pirpamer L, Hofer E, Duering M, Jouvent E, Fazekas F, Mangin JF, Chabriat H, Dichgans M, Ropele S, Schmidt R.
PMID: 25309438
Front Aging Neurosci. 2014 Sep 25;6:263. doi: 10.3389/fnagi.2014.00263. eCollection 2014.

Magnetization transfer imaging (MTI) can detect microstructural brain tissue changes and may be helpful in determining age-related cerebral damage. We investigated the association between the magnetization transfer ratio (MTR) in gray and white matter (WM) and cognitive functioning in...

Genetic architecture of orbital telorism.

Human molecular genetics

Knol MJ, Pawlak MA, Lamballais S, Terzikhan N, Hofer E, Xiong Z, Klaver CCW, Pirpamer L, Vernooij MW, Ikram MA, Schmidt R, Kayser M, Evans TE, Adams HHH.
PMID: 34791242
Hum Mol Genet. 2021 Nov 15; doi: 10.1093/hmg/ddab334. Epub 2021 Nov 15.

The interocular distance, or orbital telorism, is a distinctive craniofacial trait that also serves as a clinically informative measure. While its extremes, hypo- and hypertelorism, have been linked to monogenic disorders and are often syndromic, little is known about...

Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.

Cerebral cortex (New York, N.Y. : 1991)

Shin J, Ma S, Hofer E, Patel Y, Vosberg DE, Tilley S, Roshchupkin GV, Sousa AMM, Jian X, Gottesman R, Mosley TH, Fornage M, Saba Y, Pirpamer L, Schmidt R, Schmidt H, Carrion-Castillo A, Crivello F, Mazoyer B, Bis JC, Li S, Yang Q, Luciano M, Karama S, Lewis L, Bastin ME, Harris MA, Wardlaw JM, Deary IE, Scholz M, Loeffler M, Witte AV, Beyer F, Villringer A, Armstrong NJ, Mather KA, Ames D, Jiang J, Kwok JB, Schofield PR, Thalamuthu A, Trollor JN, Wright MJ, Brodaty H, Wen W, Sachdev PS, Terzikhan N, Evans TE, Adams HHHH, Ikram MA, Frenzel S, Auwera-Palitschka SV, Wittfeld K, Bülow R, Grabe HJ, Tzourio C, Mishra A, Maingault S, Debette S, Gillespie NA, Franz CE, Kremen WS, Ding L, Jahanshad N, Sestan N, Pausova Z, Seshadri S, Paus T.
PMID: 32198502
Cereb Cortex. 2020 Jun 01;30(7):4121-4139. doi: 10.1093/cercor/bhaa035.

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most...

Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration.

Journal of neurology, neurosurgery, and psychiatry

Egle M, Hilal S, Tuladhar AM, Pirpamer L, Hofer E, Duering M, Wason J, Morris RG, Dichgans M, Schmidt R, Tozer D, Chen C, de Leeuw FE, Markus HS.
PMID: 34509999
J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):14-23. doi: 10.1136/jnnp-2021-326571. Epub 2021 Sep 11.

OBJECTIVES: It has been suggested that diffusion tensor imaging (DTI) measures sensitive to white matter (WM) damage may predict future dementia risk not only in cerebral small vessel disease (SVD), but also in mild cognitive impairment. To determine whether...

Decreased Cerebrospinal Fluid Antioxidative Capacity Is Related to Disease Severity and Progression in Early Multiple Sclerosis.

Biomolecules

Voortman MM, Damulina A, Pirpamer L, Pinter D, Pichler A, Enzinger C, Ropele S, Bachmaier G, Archelos JJ, Marsche G, Khalil M.
PMID: 34572477
Biomolecules. 2021 Aug 25;11(9). doi: 10.3390/biom11091264.

No abstract available.

Are morphologic features of recent small subcortical infarcts related to specific etiologic aspects?.

Therapeutic advances in neurological disorders

Eppinger S, Gattringer T, Nachbaur L, Fandler S, Pirpamer L, Ropele S, Wardlaw J, Enzinger C, Fazekas F.
PMID: 31040879
Ther Adv Neurol Disord. 2019 Apr 22;12:1756286419835716. doi: 10.1177/1756286419835716. eCollection 2019.

BACKGROUND: Recent small subcortical infarcts (RSSIs) mostly result from the occlusion of a single, small, brain artery due to intrinsic cerebral small-vessel disease (CSVD). Some RSSIs may be attributable to other causes such as cardiac embolism or large-artery disease,...

Determinants of brain swelling in pediatric and adult cerebral malaria.

JCI insight

Sahu PK, Duffy FJ, Dankwa S, Vishnyakova M, Majhi M, Pirpamer L, Vigdorovich V, Bage J, Maharana S, Mandala W, Rogerson SJ, Seydel KB, Taylor TE, Kim K, Sather DN, Mohanty A, Mohanty RR, Mohanty A, Pattnaik R, Aitchison JD, Hoffman A, Mohanty S, Smith JD, Bernabeu M, Wassmer SC.
PMID: 34549725
JCI Insight. 2021 Sep 22;6(18). doi: 10.1172/jci.insight.145823.

Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in children. To investigate features associated with brain swelling in malaria, we performed blood profiling and brain MRI in a cohort of pediatric and adult patients...

Factors influencing serum neurofilament light chain levels in normal aging.

Aging

Koini M, Pirpamer L, Hofer E, Buchmann A, Pinter D, Ropele S, Enzinger C, Benkert P, Leppert D, Kuhle J, Schmidt R, Khalil M.
PMID: 34923481
Aging (Albany NY). 2021 Dec 18;13. doi: 10.18632/aging.203790. Epub 2021 Dec 18.

OBJECTIVE: Serum neurofilament light (sNfL) is a promising marker for neuro-axonal damage and it is now well known that its levels also increase with higher age. However, the effect of other determinants besides age is still poorly investigated. We...

Factors influencing serum neurofilament light chain levels in normal aging.

Aging

Koini M, Pirpamer L, Hofer E, Buchmann A, Pinter D, Ropele S, Enzinger C, Benkert P, Leppert D, Kuhle J, Schmidt R, Khalil M.
PMID: 34923481
Aging (Albany NY). 2021 Dec 18;13(24):25729-25738. doi: 10.18632/aging.203790. Epub 2021 Dec 18.

OBJECTIVE: Serum neurofilament light (sNfL) is a promising marker for neuro-axonal damage and it is now well known that its levels also increase with higher age. However, the effect of other determinants besides age is still poorly investigated. We...

Kidney function, brain morphology and cognition in the elderly: sex differences in the Austrian Stroke Prevention Study.

Aging

Kolland M, Hofer E, Pirpamer L, Eibl D, Enzinger C, Rosenkranz AR, Schmidt R.
PMID: 35025758
Aging (Albany NY). 2022 Jan 13;14. doi: 10.18632/aging.203829. Epub 2022 Jan 13.

Impaired kidney function is associated with structural brain changes and cognitive dysfunction. In the aging kidney, hemodynamic and structural alterations reduce the glomerular filtration rate (eGFR). Little is known about differences between men and women regarding decline of kidney...

Anatomically Standardized Detection of MRI Atrophy Patterns in Early-Stage Alzheimer's Disease.

Brain sciences

Lenhart L, Seiler S, Pirpamer L, Goebel G, Potrusil T, Wagner M, Dal Bianco P, Ransmayr G, Schmidt R, Benke T, Scherfler C.
PMID: 34827490
Brain Sci. 2021 Nov 11;11(11). doi: 10.3390/brainsci11111491.

MRI studies have consistently identified atrophy patterns in Alzheimer's disease (AD) through a whole-brain voxel-based analysis, but efforts to investigate morphometric profiles using anatomically standardized and automated whole-brain ROI analyses, performed at the individual subject space, are still lacking....

Factors influencing serum neurofilament light chain levels in normal aging.

Aging

Koini M, Pirpamer L, Hofer E, Buchmann A, Pinter D, Ropele S, Enzinger C, Benkert P, Leppert D, Kuhle J, Schmidt R, Khalil M.
PMID: 34923481
Aging (Albany NY). 2021 Dec 18;13(24):25729-25738. doi: 10.18632/aging.203790. Epub 2021 Dec 18.

OBJECTIVE: Serum neurofilament light (sNfL) is a promising marker for neuro-axonal damage and it is now well known that its levels also increase with higher age. However, the effect of other determinants besides age is still poorly investigated. We...

Showing 1 to 12 of 22 entries