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Showing 1 to 6 of 6 entries
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New ordered phases in a class of generalized XY models.

Physical review letters

Poderoso FC, Arenzon JJ, Levin Y.
PMID: 21405491
Phys Rev Lett. 2011 Feb 11;106(6):067202. doi: 10.1103/PhysRevLett.106.067202. Epub 2011 Feb 10.

It is well known that the 2D XY model exhibits an unusual infinite order phase transition belonging to the Kosterlitz-Thouless (KT) universality class. Introduction of a nematic coupling into the XY Hamiltonian leads to an additional phase transition in...

SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.

Oncotarget

Peixoto E, Atorrasagasti C, Malvicini M, Fiore E, Rodriguez M, Garcia M, Finocchieto P, Poderoso JJ, Corrales F, Mazzolini G.
PMID: 31289615
Oncotarget. 2016 May 18;10(41):4169-4179. doi: 10.18632/oncotarget.9456. eCollection 2019 Jun 25.

SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such as concanavalin A and lipopolysacharide (LPS)/D-galactosamine. We...

Pathogenicity and virulence of West Nile virus revisited eight decades after its first isolation.

Virulence

Saiz JC, Martín-Acebes MA, Blázquez AB, Escribano-Romero E, Poderoso T, Jiménez de Oya N.
PMID: 33843445
Virulence. 2021 Dec;12(1):1145-1173. doi: 10.1080/21505594.2021.1908740.

West Nile virus (WNV) is a flavivirus which transmission cycle is maintained between mosquitoes and birds, although it occasionally causes sporadic outbreaks in horses and humans that can result in serious diseases and even death. Since its first isolation...

Neuroprotection in Parkinson's disease; a commentary.

Neurotoxicity research

Gatto EM, Riobó N, Carreras MC, Poderoso JJ, Micheli FE.
PMID: 12829414
Neurotox Res. 2002 Mar;4(2):141-5. doi: 10.1080/10298420290015881.

Parkinson's disease (PD) is a worldwide neurodegenerative disorder. Although the etiology has been linked to genetic and environmental factors, curative treatment remains a challenge. Several hypotheses support different pathophysiological mechanisms related to oxidative stress, glutamate-mediated neurotoxicity, mitochondrial energetic impairment...

Role of Protein Phosphorylation and Tyrosine Phosphatases in the Adrenal Regulation of Steroid Synthesis and Mitochondrial Function.

Frontiers in endocrinology

Paz C, Cornejo Maciel F, Gorostizaga A, Castillo AF, Mori Sequeiros García MM, Maloberti PM, Orlando UD, Mele PG, Poderoso C, Podesta EJ.
PMID: 27375556
Front Endocrinol (Lausanne). 2016 Jun 09;7:60. doi: 10.3389/fendo.2016.00060. eCollection 2016.

In adrenocortical cells, adrenocorticotropin (ACTH) promotes the activation of several protein kinases. The action of these kinases is linked to steroid production, mainly through steroidogenic acute regulatory protein (StAR), whose expression and activity are dependent on protein phosphorylation events...

Inhibition of Mitochondrial Fission by Drp-1 Blockade by Short-Term Leptin and Mdivi-1 Treatment Improves White Adipose Tissue Abnormalities in Obesity and Diabetes.

Pharmacological research

Finocchietto P, Perez H, Blanco G, Miksztowicz, Marotte C, Morales C, Peralta J, Berg G, Poderoso C, Poderoso JJ, Carreras MC.
PMID: 34896541
Pharmacol Res. 2021 Dec 09;106028. doi: 10.1016/j.phrs.2021.106028. Epub 2021 Dec 09.

BACKGROUND: Obesity and type 2 diabetes are chronic diseases characterized by insulin resistance, mitochondrial dysfunction and morphological abnormalities.OBJECTIVE: We have investigated if dysregulation of mitochondrial dynamics and biogenesis is involved in an animal model of obesity and diabetes.METHODS: The...

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