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Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study.

Journal of the Endocrine Society

Jiménez MC, Tucker KL, Rodriguez F, Porneala BC, Meigs JB, López L.
PMID: 30623167
J Endocr Soc. 2018 Dec 03;3(1):291-303. doi: 10.1210/js.2018-00205. eCollection 2019 Jan 01.

Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and...

Cite
Jiménez MC, Tucker KL, Rodriguez F, et al. Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study. J Endocr Soc. 2018;3(1):291-303doi: 10.1210/js.2018-00205.
Jiménez, M. C., Tucker, K. L., Rodriguez, F., Porneala, B. C., Meigs, J. B., & López, L. (2019). Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study. Journal of the Endocrine Society, 3(1), 291-303. https://doi.org/10.1210/js.2018-00205
Jiménez, Monik C, et al. "Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study." Journal of the Endocrine Society vol. 3,1 (2019): 291-303. doi: https://doi.org/10.1210/js.2018-00205
Jiménez MC, Tucker KL, Rodriguez F, Porneala BC, Meigs JB, López L. Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study. J Endocr Soc. 2018 Dec 03;3(1):291-303. doi: 10.1210/js.2018-00205. eCollection 2019 Jan 01. PMID: 30623167; PMCID: PMC6320241.
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Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol.

Diabetes care

Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, Sitlani CM, Raffield LM, Yanek LR, Feitosa MF, Cuadrat RRC, Qi Q, Arfan Ikram M, Ellervik C, Ericson U, Goodarzi MO, Brody JA, Lange L, Mercader JM, Vaidya D, An P, Schulze MB, Masana L, Ghanbari M, Olesen MS, Cai J, Guo X, Floyd JS, Jäger S, Province MA, Kalyani RR, Psaty BM, Orho-Melander M, Ridker PM, Kanters JK, Uitterlinden A, Davey Smith G, Gill D, Kaplan RC, Kavousi M, Raghavan S, Chasman DI, Rotter JI, Meigs JB, Florez JC, Dupuis J, Liu CT, Merino J.
PMID: 34789503
Diabetes Care. 2022 Jan 01;45(1):232-240. doi: 10.2337/dc21-1284.

OBJECTIVE: LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown.RESEARCH DESIGN AND METHODS: We conducted summary-level univariable...

Cite
Wu P, Moon JY, Daghlas I, et al. Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2022;45(1):232-240doi: 10.2337/dc21-1284.
Wu, P., Moon, J. Y., Daghlas, I., Franco, G., Porneala, B. C., Ahmadizar, F., Richardson, T. G., Isaksen, J. L., Hindy, G., Yao, J., Sitlani, C. M., Raffield, L. M., Yanek, L. R., Feitosa, M. F., Cuadrat, R. R. C., Qi, Q., Arfan Ikram, M., Ellervik, C., Ericson, U., Goodarzi, M. O., Brody, J. A., Lange, L., Mercader, J. M., Vaidya, D., An, P., Schulze, M. B., Masana, L., Ghanbari, M., Olesen, M. S., Cai, J., Guo, X., Floyd, J. S., Jäger, S., Province, M. A., Kalyani, R. R., Psaty, B. M., Orho-Melander, M., Ridker, P. M., Kanters, J. K., Uitterlinden, A., Davey Smith, G., Gill, D., Kaplan, R. C., Kavousi, M., Raghavan, S., Chasman, D. I., Rotter, J. I., Meigs, J. B., Florez, J. C., Dupuis, J., Liu, C. T., & Merino, J. (2022). Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes care, 45(1), 232-240. https://doi.org/10.2337/dc21-1284
Wu, Peitao, et al. "Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol." Diabetes care vol. 45,1 (2022): 232-240. doi: https://doi.org/10.2337/dc21-1284
Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, Sitlani CM, Raffield LM, Yanek LR, Feitosa MF, Cuadrat RRC, Qi Q, Arfan Ikram M, Ellervik C, Ericson U, Goodarzi MO, Brody JA, Lange L, Mercader JM, Vaidya D, An P, Schulze MB, Masana L, Ghanbari M, Olesen MS, Cai J, Guo X, Floyd JS, Jäger S, Province MA, Kalyani RR, Psaty BM, Orho-Melander M, Ridker PM, Kanters JK, Uitterlinden A, Davey Smith G, Gill D, Kaplan RC, Kavousi M, Raghavan S, Chasman DI, Rotter JI, Meigs JB, Florez JC, Dupuis J, Liu CT, Merino J. Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2022 Jan 01;45(1):232-240. doi: 10.2337/dc21-1284. PMID: 34789503.
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Effective recruitment for practice-based research: Lessons from the REAL HEALTH-Diabetes Study.

Contemporary clinical trials communications

Goldman V, Dushkin A, Wexler DJ, Chang Y, Porneala B, Bissett L, McCarthy J, Rodriguez A, Chase B, LaRocca R, Wheeler A, Delahanty LM.
PMID: 31193095
Contemp Clin Trials Commun. 2019 May 01;15:100374. doi: 10.1016/j.conctc.2019.100374. eCollection 2019 Sep.

BACKGROUND: Aims: The REAL HEALTH Diabetes Study is a practice-based randomized clinical trial that compares the effectiveness of lifestyle intervention aimed at weight reduction to medical nutrition therapy in primary care patients with type 2 diabetes. This paper describes...

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Goldman V, Dushkin A, Wexler DJ, et al. Effective recruitment for practice-based research: Lessons from the REAL HEALTH-Diabetes Study. Contemp Clin Trials Commun. 2019;15:100374doi: 10.1016/j.conctc.2019.100374.
Goldman, V., Dushkin, A., Wexler, D. J., Chang, Y., Porneala, B., Bissett, L., McCarthy, J., Rodriguez, A., Chase, B., LaRocca, R., Wheeler, A., & Delahanty, L. M. (2019). Effective recruitment for practice-based research: Lessons from the REAL HEALTH-Diabetes Study. Contemporary clinical trials communications, 15100374. https://doi.org/10.1016/j.conctc.2019.100374
Goldman, Valerie, et al. "Effective recruitment for practice-based research: Lessons from the REAL HEALTH-Diabetes Study." Contemporary clinical trials communications vol. 15 (2019): 100374. doi: https://doi.org/10.1016/j.conctc.2019.100374
Goldman V, Dushkin A, Wexler DJ, Chang Y, Porneala B, Bissett L, McCarthy J, Rodriguez A, Chase B, LaRocca R, Wheeler A, Delahanty LM. Effective recruitment for practice-based research: Lessons from the REAL HEALTH-Diabetes Study. Contemp Clin Trials Commun. 2019 May 01;15:100374. doi: 10.1016/j.conctc.2019.100374. eCollection 2019 Sep. PMID: 31193095; PMCID: PMC6517530.
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Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172-2182.

Diabetes

Vassy JL, Hivert MF, Porneala B, Dauriz M, Florez JC, Dupuis J, Siscovick DS, Fornage M, Rasmussen-Torvik LJ, Bouchard C, Meigs JB.
PMID: 29669744
Diabetes. 2018 Jun;67(6):1206. doi: 10.2337/db18-er06a. Epub 2018 Apr 18.

No abstract available.

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Vassy JL, Hivert MF, Porneala B, et al. Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172-2182. Diabetes. 2018;67(6):1206doi: 10.2337/db18-er06a.
Vassy, J. L., Hivert, M. F., Porneala, B., Dauriz, M., Florez, J. C., Dupuis, J., Siscovick, D. S., Fornage, M., Rasmussen-Torvik, L. J., Bouchard, C., & Meigs, J. B. (2018). Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172-2182. Diabetes, 67(6), 1206. https://doi.org/10.2337/db18-er06a
Vassy, Jason L, et al. "Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172-2182." Diabetes vol. 67,6 (2018): 1206. doi: https://doi.org/10.2337/db18-er06a
Vassy JL, Hivert MF, Porneala B, Dauriz M, Florez JC, Dupuis J, Siscovick DS, Fornage M, Rasmussen-Torvik LJ, Bouchard C, Meigs JB. Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172-2182. Diabetes. 2018 Jun;67(6):1206. doi: 10.2337/db18-er06a. Epub 2018 Apr 18. PMID: 29669744; PMCID: PMC5961407.
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Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial.

JAMA network open

Thorndike AN, McCurley JL, Gelsomin ED, Anderson E, Chang Y, Porneala B, Johnson C, Rimm EB, Levy DE.
PMID: 34097048
JAMA Netw Open. 2021 Jun 01;4(6):e2112528. doi: 10.1001/jamanetworkopen.2021.12528.

IMPORTANCE: Personalized interventions that leverage workplace data and environments could improve effectiveness, sustainability, and scalability of employee wellness programs.OBJECTIVE: To test an automated behavioral intervention to prevent weight gain and improve diet using employee cafeteria purchasing data.DESIGN, SETTING, AND...

Cite
Thorndike AN, McCurley JL, Gelsomin ED, et al. Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial. JAMA Netw Open. 2021;4(6):e2112528doi: 10.1001/jamanetworkopen.2021.12528.
Thorndike, A. N., McCurley, J. L., Gelsomin, E. D., Anderson, E., Chang, Y., Porneala, B., Johnson, C., Rimm, E. B., & Levy, D. E. (2021). Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial. JAMA network open, 4(6), e2112528. https://doi.org/10.1001/jamanetworkopen.2021.12528
Thorndike, Anne N, et al. "Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial." JAMA network open vol. 4,6 (2021): e2112528. doi: https://doi.org/10.1001/jamanetworkopen.2021.12528
Thorndike AN, McCurley JL, Gelsomin ED, Anderson E, Chang Y, Porneala B, Johnson C, Rimm EB, Levy DE. Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial. JAMA Netw Open. 2021 Jun 01;4(6):e2112528. doi: 10.1001/jamanetworkopen.2021.12528. PMID: 34097048; PMCID: PMC8185595.
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Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol.

Diabetes care

Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, Sitlani CM, Raffield LM, Yanek LR, Feitosa MF, Cuadrat RRC, Qi Q, Arfan Ikram M, Ellervik C, Ericson U, Goodarzi MO, Brody JA, Lange L, Mercader JM, Vaidya D, An P, Schulze MB, Masana L, Ghanbari M, Olesen MS, Cai J, Guo X, Floyd JS, Jäger S, Province MA, Kalyani RR, Psaty BM, Orho-Melander M, Ridker PM, Kanters JK, Uitterlinden A, Davey Smith G, Gill D, Kaplan RC, Kavousi M, Raghavan S, Chasman DI, Rotter JI, Meigs JB, Florez JC, Dupuis J, Liu CT, Merino J.
PMID: 34789503
Diabetes Care. 2021 Nov 17; doi: 10.2337/dc21-1284. Epub 2021 Nov 17.

OBJECTIVE: LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown.RESEARCH DESIGN AND METHODS: We conducted summary-level univariable...

Cite
Wu P, Moon JY, Daghlas I, et al. Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2021;doi: 10.2337/dc21-1284.
Wu, P., Moon, J. Y., Daghlas, I., Franco, G., Porneala, B. C., Ahmadizar, F., Richardson, T. G., Isaksen, J. L., Hindy, G., Yao, J., Sitlani, C. M., Raffield, L. M., Yanek, L. R., Feitosa, M. F., Cuadrat, R. R. C., Qi, Q., Arfan Ikram, M., Ellervik, C., Ericson, U., Goodarzi, M. O., Brody, J. A., Lange, L., Mercader, J. M., Vaidya, D., An, P., Schulze, M. B., Masana, L., Ghanbari, M., Olesen, M. S., Cai, J., Guo, X., Floyd, J. S., Jäger, S., Province, M. A., Kalyani, R. R., Psaty, B. M., Orho-Melander, M., Ridker, P. M., Kanters, J. K., Uitterlinden, A., Davey Smith, G., Gill, D., Kaplan, R. C., Kavousi, M., Raghavan, S., Chasman, D. I., Rotter, J. I., Meigs, J. B., Florez, J. C., Dupuis, J., Liu, C. T., & Merino, J. (2021). Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes care, . https://doi.org/10.2337/dc21-1284
Wu, Peitao, et al. "Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol." Diabetes care vol. (2021). doi: https://doi.org/10.2337/dc21-1284
Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, Sitlani CM, Raffield LM, Yanek LR, Feitosa MF, Cuadrat RRC, Qi Q, Arfan Ikram M, Ellervik C, Ericson U, Goodarzi MO, Brody JA, Lange L, Mercader JM, Vaidya D, An P, Schulze MB, Masana L, Ghanbari M, Olesen MS, Cai J, Guo X, Floyd JS, Jäger S, Province MA, Kalyani RR, Psaty BM, Orho-Melander M, Ridker PM, Kanters JK, Uitterlinden A, Davey Smith G, Gill D, Kaplan RC, Kavousi M, Raghavan S, Chasman DI, Rotter JI, Meigs JB, Florez JC, Dupuis J, Liu CT, Merino J. Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2021 Nov 17; doi: 10.2337/dc21-1284. Epub 2021 Nov 17. PMID: 34789503.
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Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.

Gut

Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC.
PMID: 34127525
Gut. 2021 Jun 14; doi: 10.1136/gutjnl-2021-324053. Epub 2021 Jun 14.

OBJECTIVE: Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota.METHOD: We...

Cite
Qi Q, Li J, Yu B, et al. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2021;doi: 10.1136/gutjnl-2021-324053.
Qi, Q., Li, J., Yu, B., Moon, J. Y., Chai, J. C., Merino, J., Hu, J., Ruiz-Canela, M., Rebholz, C., Wang, Z., Usyk, M., Chen, G. C., Porneala, B. C., Wang, W., Nguyen, N. Q., Feofanova, E. V., Grove, M. L., Wang, T. J., Gerszten, R. E., Dupuis, J., Salas-Salvadó, J., Bao, W., Perkins, D. L., Daviglus, M. L., Thyagarajan, B., Cai, J., Wang, T., Manson, J. E., Martínez-González, M. A., Selvin, E., Rexrode, K. M., Clish, C. B., Hu, F. B., Meigs, J. B., Knight, R., Burk, R. D., Boerwinkle, E., & Kaplan, R. C. (2021). Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut, . https://doi.org/10.1136/gutjnl-2021-324053
Qi, Qibin, et al. "Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies." Gut vol. (2021). doi: https://doi.org/10.1136/gutjnl-2021-324053
Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2021 Jun 14; doi: 10.1136/gutjnl-2021-324053. Epub 2021 Jun 14. PMID: 34127525; PMCID: PMC8697256.
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Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.

Gut

Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC.
PMID: 34127525
Gut. 2021 Jun 14; doi: 10.1136/gutjnl-2021-324053. Epub 2021 Jun 14.

OBJECTIVE: Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota.METHOD: We...

Cite
Qi Q, Li J, Yu B, et al. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2021;doi: 10.1136/gutjnl-2021-324053.
Qi, Q., Li, J., Yu, B., Moon, J. Y., Chai, J. C., Merino, J., Hu, J., Ruiz-Canela, M., Rebholz, C., Wang, Z., Usyk, M., Chen, G. C., Porneala, B. C., Wang, W., Nguyen, N. Q., Feofanova, E. V., Grove, M. L., Wang, T. J., Gerszten, R. E., Dupuis, J., Salas-Salvadó, J., Bao, W., Perkins, D. L., Daviglus, M. L., Thyagarajan, B., Cai, J., Wang, T., Manson, J. E., Martínez-González, M. A., Selvin, E., Rexrode, K. M., Clish, C. B., Hu, F. B., Meigs, J. B., Knight, R., Burk, R. D., Boerwinkle, E., & Kaplan, R. C. (2021). Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut, . https://doi.org/10.1136/gutjnl-2021-324053
Qi, Qibin, et al. "Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies." Gut vol. (2021). doi: https://doi.org/10.1136/gutjnl-2021-324053
Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2021 Jun 14; doi: 10.1136/gutjnl-2021-324053. Epub 2021 Jun 14. PMID: 34127525.
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Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol.

Diabetes care

Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, Sitlani CM, Raffield LM, Yanek LR, Feitosa MF, Cuadrat RRC, Qi Q, Arfan Ikram M, Ellervik C, Ericson U, Goodarzi MO, Brody JA, Lange L, Mercader JM, Vaidya D, An P, Schulze MB, Masana L, Ghanbari M, Olesen MS, Cai J, Guo X, Floyd JS, Jäger S, Province MA, Kalyani RR, Psaty BM, Orho-Melander M, Ridker PM, Kanters JK, Uitterlinden A, Davey Smith G, Gill D, Kaplan RC, Kavousi M, Raghavan S, Chasman DI, Rotter JI, Meigs JB, Florez JC, Dupuis J, Liu CT, Merino J.
PMID: 34789503
Diabetes Care. 2021 Nov 17; doi: 10.2337/dc21-1284. Epub 2021 Nov 17.

OBJECTIVE: LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown.RESEARCH DESIGN AND METHODS: We conducted summary-level univariable...

Cite
Wu P, Moon JY, Daghlas I, et al. Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2021;doi: 10.2337/dc21-1284.
Wu, P., Moon, J. Y., Daghlas, I., Franco, G., Porneala, B. C., Ahmadizar, F., Richardson, T. G., Isaksen, J. L., Hindy, G., Yao, J., Sitlani, C. M., Raffield, L. M., Yanek, L. R., Feitosa, M. F., Cuadrat, R. R. C., Qi, Q., Arfan Ikram, M., Ellervik, C., Ericson, U., Goodarzi, M. O., Brody, J. A., Lange, L., Mercader, J. M., Vaidya, D., An, P., Schulze, M. B., Masana, L., Ghanbari, M., Olesen, M. S., Cai, J., Guo, X., Floyd, J. S., Jäger, S., Province, M. A., Kalyani, R. R., Psaty, B. M., Orho-Melander, M., Ridker, P. M., Kanters, J. K., Uitterlinden, A., Davey Smith, G., Gill, D., Kaplan, R. C., Kavousi, M., Raghavan, S., Chasman, D. I., Rotter, J. I., Meigs, J. B., Florez, J. C., Dupuis, J., Liu, C. T., & Merino, J. (2021). Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes care, . https://doi.org/10.2337/dc21-1284
Wu, Peitao, et al. "Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol." Diabetes care vol. (2021). doi: https://doi.org/10.2337/dc21-1284
Wu P, Moon JY, Daghlas I, Franco G, Porneala BC, Ahmadizar F, Richardson TG, Isaksen JL, Hindy G, Yao J, Sitlani CM, Raffield LM, Yanek LR, Feitosa MF, Cuadrat RRC, Qi Q, Arfan Ikram M, Ellervik C, Ericson U, Goodarzi MO, Brody JA, Lange L, Mercader JM, Vaidya D, An P, Schulze MB, Masana L, Ghanbari M, Olesen MS, Cai J, Guo X, Floyd JS, Jäger S, Province MA, Kalyani RR, Psaty BM, Orho-Melander M, Ridker PM, Kanters JK, Uitterlinden A, Davey Smith G, Gill D, Kaplan RC, Kavousi M, Raghavan S, Chasman DI, Rotter JI, Meigs JB, Florez JC, Dupuis J, Liu CT, Merino J. Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol. Diabetes Care. 2021 Nov 17; doi: 10.2337/dc21-1284. Epub 2021 Nov 17. PMID: 34789503.
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Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial.

JAMA network open

Thorndike AN, McCurley JL, Gelsomin ED, Anderson E, Chang Y, Porneala B, Johnson C, Rimm EB, Levy DE.
PMID: 34097048
JAMA Netw Open. 2021 Jun 01;4(6):e2112528. doi: 10.1001/jamanetworkopen.2021.12528.

IMPORTANCE: Personalized interventions that leverage workplace data and environments could improve effectiveness, sustainability, and scalability of employee wellness programs.OBJECTIVE: To test an automated behavioral intervention to prevent weight gain and improve diet using employee cafeteria purchasing data.DESIGN, SETTING, AND...

Cite
Thorndike AN, McCurley JL, Gelsomin ED, et al. Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial. JAMA Netw Open. 2021;4(6):e2112528doi: 10.1001/jamanetworkopen.2021.12528.
Thorndike, A. N., McCurley, J. L., Gelsomin, E. D., Anderson, E., Chang, Y., Porneala, B., Johnson, C., Rimm, E. B., & Levy, D. E. (2021). Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial. JAMA network open, 4(6), e2112528. https://doi.org/10.1001/jamanetworkopen.2021.12528
Thorndike, Anne N, et al. "Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial." JAMA network open vol. 4,6 (2021): e2112528. doi: https://doi.org/10.1001/jamanetworkopen.2021.12528
Thorndike AN, McCurley JL, Gelsomin ED, Anderson E, Chang Y, Porneala B, Johnson C, Rimm EB, Levy DE. Automated Behavioral Workplace Intervention to Prevent Weight Gain and Improve Diet: The ChooseWell 365 Randomized Clinical Trial. JAMA Netw Open. 2021 Jun 01;4(6):e2112528. doi: 10.1001/jamanetworkopen.2021.12528. PMID: 34097048; PMCID: PMC8185595.
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Simultaneous Consideration of HbA.

Diabetes care

Meigs JB, Porneala B, Leong A, Shiffman D, Devlin JJ, McPhaul MJ.
PMID: 32532754
Diabetes Care. 2020 Aug;43(8):e90-e92. doi: 10.2337/dc20-0718. Epub 2020 Jun 12.

No abstract available.

Cite
Meigs JB, Porneala B, Leong A, et al. Simultaneous Consideration of HbA. Diabetes Care. 2020;43(8):e90-e92doi: 10.2337/dc20-0718.
Meigs, J. B., Porneala, B., Leong, A., Shiffman, D., Devlin, J. J., & McPhaul, M. J. (2020). Simultaneous Consideration of HbA. Diabetes care, 43(8), e90-e92. https://doi.org/10.2337/dc20-0718
Meigs, James B, et al. "Simultaneous Consideration of HbA." Diabetes care vol. 43,8 (2020): e90-e92. doi: https://doi.org/10.2337/dc20-0718
Meigs JB, Porneala B, Leong A, Shiffman D, Devlin JJ, McPhaul MJ. Simultaneous Consideration of HbA. Diabetes Care. 2020 Aug;43(8):e90-e92. doi: 10.2337/dc20-0718. Epub 2020 Jun 12. PMID: 32532754; PMCID: PMC7372061.
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Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.

Gut

Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC.
PMID: 34127525
Gut. 2021 Jun 14; doi: 10.1136/gutjnl-2021-324053. Epub 2021 Jun 14.

OBJECTIVE: Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota.METHOD: We...

Cite
Qi Q, Li J, Yu B, et al. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2021;doi: 10.1136/gutjnl-2021-324053.
Qi, Q., Li, J., Yu, B., Moon, J. Y., Chai, J. C., Merino, J., Hu, J., Ruiz-Canela, M., Rebholz, C., Wang, Z., Usyk, M., Chen, G. C., Porneala, B. C., Wang, W., Nguyen, N. Q., Feofanova, E. V., Grove, M. L., Wang, T. J., Gerszten, R. E., Dupuis, J., Salas-Salvadó, J., Bao, W., Perkins, D. L., Daviglus, M. L., Thyagarajan, B., Cai, J., Wang, T., Manson, J. E., Martínez-González, M. A., Selvin, E., Rexrode, K. M., Clish, C. B., Hu, F. B., Meigs, J. B., Knight, R., Burk, R. D., Boerwinkle, E., & Kaplan, R. C. (2021). Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut, . https://doi.org/10.1136/gutjnl-2021-324053
Qi, Qibin, et al. "Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies." Gut vol. (2021). doi: https://doi.org/10.1136/gutjnl-2021-324053
Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2021 Jun 14; doi: 10.1136/gutjnl-2021-324053. Epub 2021 Jun 14. PMID: 34127525; PMCID: PMC8697256.
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