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Showing 1 to 12 of 186 entries
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Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Nature genetics

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Segura Lepe MP, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Mägi R, Stanton A, Connell J, Bakker SJL, Metspalu A, Shields DC, Thom S, Brown M, Sever P, Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D, Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JMM, Tobin MD, Munroe PB, Ehret GB, Wain LV, Barnes MR, Tzoulaki I, Caulfield MJ, Elliott P.
PMID: 28951623
Nat Genet. 2017 Sep 27;49(10):1558. doi: 10.1038/ng1017-1558a.

No abstract available.

Genome editing of the germline: broadening the discussion.

Molecular therapy : the journal of the American Society of Gene Therapy

Porteus MH, Dann CT.
PMID: 26022625
Mol Ther. 2015 Jun;23(6):980-982. doi: 10.1038/mt.2015.83.

Genome editing that results in humans with precisely modified germ cells may never become practical. Nonetheless, the implications are great enough that we strongly support the idea of starting the conversation now, providing time for a broad consensus to...

Acyclic N-halamine-immobilized polyurethane: Preparation and antimicrobial and biofilm-controlling functions.

Journal of bioactive and compatible polymers

Luo J, Porteous N, Lin J, Sun Y.
PMID: 26089593
J Bioact Compat Polym. 2015 Mar;30(2):157-166. doi: 10.1177/0883911515569007.

Hydroxyl groups were introduced onto polyurethane surfaces through 1,6-hexamethylene diisocyanate activation, followed by diethanolamine hydroxylation. Polymethacrylamide was covalently attached to the hydroxylated polyurethane through surface grafting polymerization of methacrylamide using cerium (IV) ammonium nitrate as an initiator. After bleach...

Genome Editing of the Blood: Opportunities and Challenges.

Current stem cell reports

Porteus MH.
PMID: 26029496
Curr Stem Cell Rep. 2015 Mar 01;1(1):23-30. doi: 10.1007/s40778-014-0003-z.

The ability to remove blood cells, including hematopoietic stem cells (HSCs), from a person and then re-transplant them (hematopoietic stem cell transplantation (HSCT) is a well-established treatment paradigm that can be used in both the autologous setting or in...

Prevalence of coeliac disease and longitudinal follow-up of antigliadin antibody status in children and adolescents with type 1 diabetes mellitus.

Pediatric diabetes

Smith CM, Clarke CF, Porteous LE, Elsori H, Cameron DJ.
PMID: 15016216
Pediatr Diabetes. 2000 Dec;1(4):199-203. doi: 10.1046/j.1399543x.2000.010405.x.

Coeliac disease (CD) is more prevalent in individuals with type 1 diabetes mellitus (DM), and when untreated is associated with a number of medical complications, including poor glycaemic control. Identification of patients with CD has been facilitated in recent...

Gene mappers at cold spring harbor.

Science (New York, N.Y.)

Porteous DJ.
PMID: 17779556
Science. 1992 Jan 17;255(5042):269. doi: 10.1126/science.255.5042.269-a.

No abstract available.

Amine, Melamine, and Amide N-Halamines as Antimicrobial Additives for Polymers.

Industrial & engineering chemistry research

Sun X, Cao Z, Porteous N, Sun Y.
PMID: 21088762
Ind Eng Chem Res. 2010;49(22):11206-11213. doi: 10.1021/ie101519u.

N-chloro-2,2,6,6-tetramethyl-4-piperidinol laurate (Cl-TMPL) was prepared by reacting 2,2,6,6-tetramethyl-4-piperidinol hydrochloride (TMP·HCl) with lauroyl chloride, followed by chlorination with sodium dichloroisocyanurate. The chemical structure of Cl-TMPL was characterized with FT-IR, NMR, DSC, and TGA analyses. The antimicrobial performance of Cl-TMPL against...

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism.

Wellcome open research

Clarke TK, Zeng Y, Navrady L, Xia C, Haley C, Campbell A, Navarro P, Amador C, Adams MJ, Howard DM, Soler A, Hayward C, Thomson PA, Smith BH, Padmanabhan S, Hocking LJ, Hall LS, Porteous DJ, Deary IJ, McIntosh AM.
PMID: 30756089
Wellcome Open Res. 2019 Jan 14;3:11. doi: 10.12688/wellcomeopenres.13893.2. eCollection 2018.

No abstract available.

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

McCartney DL, Stevenson AJ, Walker RM, Gibson J, Morris SW, Campbell A, Murray AD, Whalley HC, Porteous DJ, McIntosh AM, Evans KL, Deary IJ, Marioni RE.
PMID: 30167451
Alzheimers Dement (Amst). 2018 Jun 21;10:429-437. doi: 10.1016/j.dadm.2018.05.006. eCollection 2018.

INTRODUCTION: The "epigenetic clock" is a DNA methylation-based estimate of biological age and is correlated with chronological age-the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable....

Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

PLoS genetics

Xia C, Amador C, Huffman J, Trochet H, Campbell A, Porteous D, Scotland G, Hastie ND, Hayward C, Vitart V, Navarro P, Haley CS.
PMID: 28196069
PLoS Genet. 2017 Feb 14;13(2):e1006608. doi: 10.1371/journal.pgen.1006608. eCollection 2017 Feb.

[This corrects the article DOI: 10.1371/journal.pgen.1005804.].

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.

Behavior genetics

van den Berg SM, de Moor MH, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abdellaoui A, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Smith GD, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Mbarek H, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Nivard MG, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, Penninx BW, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Martin NG, Boomsma DI.
PMID: 26362575
Behav Genet. 2016 Mar;46(2):170-82. doi: 10.1007/s10519-015-9735-5. Epub 2015 Sep 11.

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively...

Hip and Knee Section, Treatment, Two-Stage Exchange Spacer-Related: Proceedings of International Consensus on Orthopedic Infections.

The Journal of arthroplasty

Abdel MP, Barreira P, Battenberg A, Berry DJ, Blevins K, Font-Vizcarra L, Frommelt L, Goswami K, Greiner J, Janz V, Kendoff DO, Limberg AK, Manrique J, Moretti B, Murylev V, O'Byrne J, Petrie MJ, Porteous A, Saleri S, Sandiford NA, Sharma V, Shubnyakov I, Sporer S, Squire MW, Stockley I, Tibbo ME, Turgeon T, Varshneya A, Wellman S, Zahar A.
PMID: 30348562
J Arthroplasty. 2019 Feb;34(2):S427-S438. doi: 10.1016/j.arth.2018.09.027. Epub 2018 Oct 19.

No abstract available.

Showing 1 to 12 of 186 entries