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Showing 1 to 12 of 128 entries
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Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells.

PloS one

Acanda de la Rocha AM, López-Bertoni H, Guruceaga E, González-Huarriz M, Martínez-Vélez N, Xipell E, Fueyo J, Gomez-Manzano C, Alonso MM.
PMID: 27669421
PLoS One. 2016 Sep 26;11(9):e0163155. doi: 10.1371/journal.pone.0163155. eCollection 2016.

INTRODUCTION: Glioblastoma is the most malignant brain tumor in adults and is associated with poor survival despite multimodal treatments. Glioma stem-like cells (GSCs) are cells functionally defined by their self-renewal potential and the ability to reconstitute the original tumor...

An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models.

Molecular therapy. Methods & clinical development

Gérard C, Xiao X, Filali M, Coulombe Z, Arsenault M, Couet J, Li J, Drolet MC, Chapdelaine P, Chikh A, Tremblay JP.
PMID: 26015982
Mol Ther Methods Clin Dev. 2014 Oct 08;1:14044. doi: 10.1038/mtm.2014.44. eCollection 2014.

Friedreich ataxia (FRDA) is a genetic disease due to increased repeats of the GAA trinucleotide in intron 1 of the frataxin gene. This mutation leads to a reduced expression of frataxin. We have produced an adeno-associated virus (AAV)9 coding...

Short-Term Vitamin B-6 Restriction Does Not Affect Plasma Concentrations of Hydrogen Sulfide Biomarkers Lanthionine and Homolanthionine in Healthy Men and Women.

The Journal of nutrition

DeRatt BN, Ralat MA, Gregory JF.
PMID: 26962179
J Nutr. 2015 Apr 01;146(4):714-719. doi: 10.3945/jn.115.227819.

BACKGROUND: Suboptimal vitamin B-6 status is associated with increased cardiovascular disease risk, although the mechanism is unknown. The synthesis of the vasodilator hydrogen sulfide occurs through side reactions of the transsulfuration enzymes cystathionine β-synthase and cystathionine γ-lyase, with pyridoxal...

Cell growth and death rates as factors in the long-term performance, modeling, and design of immobilized cell reactors.

Biotechnology and bioengineering

Dale MC, Chen C, Okos MR.
PMID: 18595036
Biotechnol Bioeng. 1990 Dec 05;36(10):983-92. doi: 10.1002/bit.260361003.

The viable fraction of immobilized cells in a bioreactor may be critical in predicting long-term or steady-state reactor performance. The assumption of near 100% viable cells in a bioreactor may not be valid for portions of immobilized cell reactors...

Minimal nutritional requirements for immobilized yeast.

Biotechnology and bioengineering

Chen C, Dale MC, Okos MR.
PMID: 18595037
Biotechnol Bioeng. 1990 Dec 05;36(10):993-1001. doi: 10.1002/bit.260361004.

The effect of reduced nutritional levels (particularly nitrogen source) for immobilized K. fragilis type yeast were studied using a trickle flow, "differential" plug flow type reactor with cells immobilized by adsorption onto an absorbant packing matrix. Minimizing nutrient levels...

Long-term Site Fidelity and Individual Home Range Shifts in Lophocebus albigena.

International journal of primatology

Janmaat KR, Olupot W, Chancellor RL, Arlet ME, Waser PM.
PMID: 20376178
Int J Primatol. 2009 Jun;30(3):443-466. doi: 10.1007/s10764-009-9352-3. Epub 2009 Mar 10.

We investigated long-term site fidelity of gray-cheeked mangabey (Lophocebus albigena) groups in Kibale National Park, Uganda. Concurrently, we monitored shifts in home range by individual females and subadult and adult males. We documented home range stability by calculating the...

EMS-STARS: Emergency Medical Services "Superuser" Transport Associations: An Adult Retrospective Study.

Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors

Hall MK, Raven MC, Hall J, Yeh C, Allen E, Rodriguez RM, Tangherlini NL, Sporer KA, Brown JF.
PMID: 25093273
Prehosp Emerg Care. 2015 January-March;19(1):61-67. doi: 10.3109/10903127.2014.936630. Epub 2014 Aug 05.

Abstract Objective. Emergency medical services (EMS) "superusers" -those who use EMS services at extremely high rates -have not been well characterized. Recent interest in the small group of individuals who account for a disproportionate share of health-care expenditures has...

Genome Sequence of Staphylococcus pseudintermedius Strain E140, an ST71 European-Associated Methicillin-Resistant Isolate.

Genome announcements

Moodley A, Riley MC, Kania SA, Guardabassi L.
PMID: 23516230
Genome Announc. 2013 Mar 07;1(2):e0020712. doi: 10.1128/genomeA.00207-12.

We report the first genome sequence of the methicillin-resistant Staphylococcus pseudintermedius (MRSP) strain E140, isolated from a canine bite wound infection in Denmark. This strain represents the dominant clonal lineage associated with canine MRSP infections in Europe.

Magnetic interactions in amorphous spin-glass-superconducting multilayers.

Physical review. B, Condensed matter

Kes PH, Maurer M, Meiresonne J, Menny A, Mydosh JY, Ravet MF.
PMID: 9992528
Phys Rev B Condens Matter. 1989 Sep 01;40(7):5198-5200. doi: 10.1103/physrevb.40.5198.

No abstract available.

The prevention and treatment of glucocorticoid-induced osteopaenia in juvenile rheumatic disease: A randomised double-blind controlled trial.

EClinicalMedicine

Rooney M, Bishop N, Davidson J, Beresford MW, Pilkington C, Donagh JM, Wyatt S, Gardner-Medwin J, Satyapal R, Clinch J, Foster H, Elliott M, Verghis R.
PMID: 31388666
EClinicalMedicine. 2019 Jul 03;12:79-87. doi: 10.1016/j.eclinm.2019.06.004. eCollection 2019 Jul.

BACKGROUND: Children and young people (CYP) with chronic rheumatic conditions; Juvenile Idiopathic Arthritis, Juvenile Systemic Lupus Erythematosus, Juvenile Dermatomyositis and Juvenile Vasculitis, treated with steroids, have low bone density, increased fracture risk and are likely to have suboptimal peak...

Corrigendum: Complex pectin metabolism by gut bacteria reveals novel catalytic functions.

Nature

Ndeh D, Rogowski A, Cartmell A, Luis AS, Baslé A, Gray J, Venditto I, Briggs J, Zhang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, O'Neill MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, Gilbert HJ.
PMID: 29411780
Nature. 2017 Aug 31;548(7669):612. doi: 10.1038/nature23659. Epub 2017 Aug 23.

This corrects the article DOI: 10.1038/nature21725.

Multiple short-chain dehydrogenases/reductases are regulated in pathological cardiac hypertrophy.

FEBS open bio

Roussel E, Drolet MC, Lavigne AM, Arsenault M, Couet J.
PMID: 30338214
FEBS Open Bio. 2018 Sep 17;8(10):1624-1635. doi: 10.1002/2211-5463.12506. eCollection 2018 Oct.

Cardiac hypertrophy (CH) is an important and independent predictor of morbidity and mortality. Through expression profiling, we recently identified a subset of genes (

Showing 1 to 12 of 128 entries