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Syntheses of [.

RSC medicinal chemistry

Ramos-Torres KM, Zhou YP, Yang BY, Guehl NJ, Sung-Hyun M, Telu S, Normandin MD, Pike VW, Brugarolas P.
PMID: 33479620
RSC Med Chem. 2020 Jul 24;11(10):1161-1167. doi: 10.1039/d0md00190b. eCollection 2020 Oct 01.

Trifluoromethyl groups are of great interest in PET radiopharmaceuticals. Radiolabelled 4-aminopyridine (4AP) derivatives have been proposed for imaging demyelinating diseases. Here, we describe methods for producing

Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems.

Israel journal of chemistry

Ramos-Torres KM, Kolemen S, Chang CJ.
PMID: 31263315
Isr J Chem. 2016 Oct 01;56(9):724-737. doi: 10.1002/ijch.201600023. Epub 2016 Jul 25.

Copper is an essential element in biological systems. Its potent redox activity renders it necessary for life, but at the same time, misregulation of its cellular pools can lead to oxidative stress implicated in aging and various disease states....

FormylBODIPYs by PCC-Promoted Selective Oxidation of α-MethylBODIPYs. Synthetic Versatility and Applications.

Organic letters

Ramos-Torres Á, Avellanal-Zaballa E, Prieto-Castañeda A, García-Garrido F, Bañuelos J, Agarrabeitia AR, Ortiz MJ.
PMID: 31179708
Org Lett. 2019 Jun 21;21(12):4563-4566. doi: 10.1021/acs.orglett.9b01465. Epub 2019 Jun 10.

An efficient synthesis of formylBODIPYs has been established based on an oxidation with PCC of 3-methylBODIPYs. It has been demonstrated that this reagent can oxidize methyl groups at such position of the BODIPY core, regardless of its substitution pattern....

Frontiers in physiology

Alpert NM, Pelletier-Galarneau M, Kim SJW, Petibon Y, Sun T, Ramos-Torres KM, Normandin MD, El Fakhri G.
PMID: 32499721
Front Physiol. 2020 May 15;11:491. doi: 10.3389/fphys.2020.00491. eCollection 2020.

BACKGROUND: We recently reported a method using positron emission tomography (PET) and the tracer METHODS: We tested these hypotheses by measuring decreases of RESULTS: Intracoronary BAM15 infusion led to a clear decrease in SUMMARY: This work provides evidence that...

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