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Showing 1 to 12 of 36 entries
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An integrated methodology for recording uncertainties about environmental data.

Water science and technology : a journal of the International Association on Water Pollution Research

Brown JD, Heuvelink GB, Refsgaard JC.
PMID: 16304947
Water Sci Technol. 2005;52(6):153-60.

Understanding the limitations of environmental data is essential both for managing environmental systems effectively and for encouraging the responsible use of scientific research when knowledge is limited and priorities are varied. Using a combination of quantitative and qualitative techniques...

Author Correction: Molecular engineering of safe and efficacious oral basal insulin.

Nature communications

Hubálek F, Refsgaard HHF, Gram-Nielsen S, Madsen P, Nishimura E, Münzel M, Brand CL, Stidsen CE, Claussen CH, Wulff EM, Pridal L, Ribel U, Kildegaard J, Porsgaard T, Johansson E, Steensgaard DB, Hovgaard L, Glendorf T, Hansen BF, Jensen MK, Nielsen PK, Ludvigsen S, Rugh S, Garibay PW, Moore MC, Cherrington AD, Kjeldsen T.
PMID: 34244486
Nat Commun. 2020 Aug 20;11(1):4232. doi: 10.1038/s41467-020-18106-3.

No abstract available.

Head-to-Head Comparison of Modular Vaccines Developed Using Different Capsid Virus-Like Particle Backbones and Antigen Conjugation Systems.

Vaccines

Fredsgaard L, Goksøyr L, Thrane S, Aves KL, Theander TG, Sander AF.
PMID: 34063871
Vaccines (Basel). 2021 May 21;9(6). doi: 10.3390/vaccines9060539.

Capsid virus-like particles (cVLPs) are used as molecular scaffolds to increase the immunogenicity of displayed antigens. Modular platforms have been developed whereby antigens are attached to the surface of pre-assembled cVLPs. However, it remains unknown to what extent the...

Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.

JAMA cardiology

Lam CSP, Giczewska A, Sliwa K, Edelmann F, Refsgaard J, Bocchi E, Ezekowitz JA, Hernandez AF, O'Connor CM, Roessig L, Patel MJ, Pieske B, Anstrom KJ, Armstrong PW.
PMID: 33185650
JAMA Cardiol. 2021 Jun 01;6(6):706-712. doi: 10.1001/jamacardio.2020.6455.

IMPORTANCE: The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH.OBJECTIVE: To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from...

Trace Metal Availability Affects Greenhouse Gas Emissions and Microbial Functional Group Abundance in Freshwater Wetland Sediments.

Frontiers in microbiology

Giannopoulos G, Hartop KR, Brown BL, Song B, Elsgaard L, Franklin RB.
PMID: 33117308
Front Microbiol. 2020 Sep 30;11:560861. doi: 10.3389/fmicb.2020.560861. eCollection 2020.

We investigated the effects of trace metal additions on microbial nitrogen (N) and carbon (C) cycling using freshwater wetland sediment microcosms amended with micromolar concentrations of copper (Cu), molybdenum (Mo), iron (Fe), and all combinations thereof. In addition to...

Mutation analysis of the candidate genes .

Applied & translational genomics

Refsgaard L, Olesen MS, Møller DV, Christiansen M, Haunsø S, Svendsen JH, Christensen AH.
PMID: 27896052
Appl Transl Genom. 2012 Oct 01;1:44-46. doi: 10.1016/j.atg.2012.06.001. eCollection 2012 Dec 01.

INTRODUCTION: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically determined heart disease characterized by fibrofatty infiltrations in the myocardium, right and/or left ventricular involvement, and ventricular tachyarrhythmias. Although ten genes have been associated with ARVC, only about 40% of...

Effect of antianginal medication on resting myocardial perfusion and pharmacologically induced hyperemia.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Bøttcher M, Refsgaard J, Madsen MM, Randsbæk F, Kaltoft A, Bøtker HE, Nielsen TT.
PMID: 12734468
J Nucl Cardiol. 2000;10:E001-E008.

Background. Patients scheduled for myocardial perfusion imaging are often taking several antianginal drugs. There is presently no consensus concerning a regimen of discontinuation before either rest or pharmacologic stress myocardial perfusion imaging. Whether antianginal treatment affects diagnostic sensitivity and...

Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet-induced obesity.

Obesity science & practice

Gradel AKJ, Porsgaard T, Brockhoff PB, Seested T, Lykkesfeldt J, Refsgaard HHF.
PMID: 31275602
Obes Sci Pract. 2019 Mar 18;5(3):281-288. doi: 10.1002/osp4.326. eCollection 2019 Jun.

OBJECTIVE: Obesity is associated with delayed insulin absorption upon subcutaneous (s.c.) dosing in humans. The aim of this study was to investigate whether alterations in depot structure and kinetics of the s.c. injection depot contribute to this delay.METHODS: Rats...

Effects of changes in land use and climate on aquatic ecosystems: Coupling of models and decomposition of uncertainties.

The Science of the total environment

Trolle D, Nielsen A, Andersen HE, Thodsen H, Olesen JE, Børgesen CD, Refsgaard JC, Sonnenborg TO, Karlsson IB, Christensen JP, Markager S, Jeppesen E.
PMID: 30677929
Sci Total Environ. 2019 Mar 20;657:627-633. doi: 10.1016/j.scitotenv.2018.12.055. Epub 2018 Dec 05.

To analyse the potential future ecological state of estuaries located in the temperate climate (here exemplified with the Odense Fjord estuary, Denmark), we combined end-of-the-century climate change projections from four different climate models, four contrasting land use scenarios ("Agriculture...

Shared care versus hospital-based cardiac rehabilitation: a cost-utility analysis based on a randomised controlled trial.

Open heart

Bertelsen JB, Dehbarez NT, Refsgaard J, Kanstrup H, Johnsen SP, Qvist I, Christensen B, Søgaard R, Christensen KL.
PMID: 29531754
Open Heart. 2018 Feb 07;5(1):e000584. doi: 10.1136/openhrt-2016-000584. eCollection 2018.

BACKGROUND: Changes in the organisation of chronic healthcare, an increased awareness of costs and challenges of low adherence in cardiac rehabilitation (CR) call for the exploration of more flexible CR programmes as alternatives to hospital-based CR (H-CR). A model...

"Future Patient" Telerehabilitation for Patients With Heart Failure: Protocol for a Randomized Controlled Trial.

JMIR research protocols

Dinesen B, Dittmann L, Gade JD, Jørgensen CK, Hollingdal M, Leth S, Melholt C, Spindler H, Refsgaard J.
PMID: 31538944
JMIR Res Protoc. 2019 Sep 19;8(9):e14517. doi: 10.2196/14517.

BACKGROUND: Cardiovascular disease is the leading cause of mortality worldwide, accounting for 13%-15% of all deaths. Cardiac rehabilitation has poor compliance and adherence. Telerehabilitation has been introduced to increase patients' participation, access, and adherence with the help of digital...

Methane fluxes from a rewetted agricultural fen during two initial years of paludiculture.

The Science of the total environment

Kandel TP, Karki S, Elsgaard L, Labouriau R, Lærke PE.
PMID: 32019030
Sci Total Environ. 2020 Apr 15;713:136670. doi: 10.1016/j.scitotenv.2020.136670. Epub 2020 Jan 13.

Rewetting agricultural peatland abates carbon dioxide (CO

Showing 1 to 12 of 36 entries