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Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial.

International journal of endocrinology

Rejnmark L, Vestergaard P, Heickendorff L, Mosekilde L.
PMID: 20016680
Int J Endocrinol. 2010;2010:957174. doi: 10.1155/2010/957174. Epub 2009 Jul 21.

Objectives. Statin drugs act as inhibitors of the 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase enzyme early in the mevalonate pathway, thereby reducing the endogenous cholesterol synthesis. In recent studies, it has been suggested from epidemiological data that statins also may...

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Rejnmark L, Vestergaard P, Heickendorff L, et al. Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial. Int J Endocrinol. 2009;2010:957174doi: 10.1155/2010/957174.
Rejnmark, L., Vestergaard, P., Heickendorff, L., & Mosekilde, L. (2010). Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial. International journal of endocrinology, 2010957174. https://doi.org/10.1155/2010/957174
Rejnmark, Lars, et al. "Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial." International journal of endocrinology vol. 2010 (2010): 957174. doi: https://doi.org/10.1155/2010/957174
Rejnmark L, Vestergaard P, Heickendorff L, Mosekilde L. Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial. Int J Endocrinol. 2010;2010:957174. doi: 10.1155/2010/957174. Epub 2009 Jul 21. PMID: 20016680; PMCID: PMC2778175.
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Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials.

Therapeutic advances in chronic disease

Rejnmark L.
PMID: 23251739
Ther Adv Chronic Dis. 2011 Jan;2(1):25-37. doi: 10.1177/2040622310381934.

Vitamin D insufficiency is frequent in the general population. Meta-analyses of randomized controlled trials (RCTs) have shown a decreased risk of falls in elderly treated with vitamin D supplements, which may be due to an improved neuromuscular function in...

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Rejnmark L. Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis. 2011;2(1):25-37doi: 10.1177/2040622310381934.
Rejnmark, L. (2011). Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Therapeutic advances in chronic disease, 2(1), 25-37. https://doi.org/10.1177/2040622310381934
Rejnmark, Lars. "Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials." Therapeutic advances in chronic disease vol. 2,1 (2011): 25-37. doi: https://doi.org/10.1177/2040622310381934
Rejnmark L. Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis. 2011 Jan;2(1):25-37. doi: 10.1177/2040622310381934. PMID: 23251739; PMCID: PMC3513873.
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Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates.

Kidney international reports

Jørgensen HS, Winther S, Bøttcher M, Hauge EM, Rejnmark L, Svensson M, Ivarsen P.
PMID: 29854974
Kidney Int Rep. 2018 Feb 02;3(3):661-670. doi: 10.1016/j.ekir.2018.01.009. eCollection 2018 May.

INTRODUCTION: Low levels of sex hormones are common in patients with chronic kidney disease (CKD) and may be a contributing factor to bone fragility. We investigated associations between levels of sex hormones and bone mineral density (BMD) in adult...

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Jørgensen HS, Winther S, Bøttcher M, et al. Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates. Kidney Int Rep. 2018;3(3):661-670doi: 10.1016/j.ekir.2018.01.009.
Jørgensen, H. S., Winther, S., Bøttcher, M., Hauge, E. M., Rejnmark, L., Svensson, M., & Ivarsen, P. (2018). Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates. Kidney international reports, 3(3), 661-670. https://doi.org/10.1016/j.ekir.2018.01.009
Jørgensen, Hanne Skou, et al. "Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates." Kidney international reports vol. 3,3 (2018): 661-670. doi: https://doi.org/10.1016/j.ekir.2018.01.009
Jørgensen HS, Winther S, Bøttcher M, Hauge EM, Rejnmark L, Svensson M, Ivarsen P. Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates. Kidney Int Rep. 2018 Feb 02;3(3):661-670. doi: 10.1016/j.ekir.2018.01.009. eCollection 2018 May. PMID: 29854974; PMCID: PMC5976823.
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Mapping the 3D orientation of nanocrystals and nanostructures in human bone: Indications of novel structural features.

Science advances

Grünewald TA, Liebi M, Wittig NK, Johannes A, Sikjaer T, Rejnmark L, Gao Z, Rosenthal M, Guizar-Sicairos M, Birkedal H, Burghammer M.
PMID: 32582855
Sci Adv. 2020 Jun 12;6(24):eaba4171. doi: 10.1126/sciadv.aba4171. eCollection 2020 Jun.

Bone is built from collagen fibrils and biomineral nanoparticles. In humans, they are organized in lamellar twisting patterns on the microscale. It has been a central tenet that the biomineral nanoparticles are co-aligned with the bone nanostructure. Here, we...

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Grünewald TA, Liebi M, Wittig NK, et al. Mapping the 3D orientation of nanocrystals and nanostructures in human bone: Indications of novel structural features. Sci Adv. 2020;6(24):eaba4171doi: 10.1126/sciadv.aba4171.
Grünewald, T. A., Liebi, M., Wittig, N. K., Johannes, A., Sikjaer, T., Rejnmark, L., Gao, Z., Rosenthal, M., Guizar-Sicairos, M., Birkedal, H., & Burghammer, M. (2020). Mapping the 3D orientation of nanocrystals and nanostructures in human bone: Indications of novel structural features. Science advances, 6(24), eaba4171. https://doi.org/10.1126/sciadv.aba4171
Grünewald, Tilman A, et al. "Mapping the 3D orientation of nanocrystals and nanostructures in human bone: Indications of novel structural features." Science advances vol. 6,24 (2020): eaba4171. doi: https://doi.org/10.1126/sciadv.aba4171
Grünewald TA, Liebi M, Wittig NK, Johannes A, Sikjaer T, Rejnmark L, Gao Z, Rosenthal M, Guizar-Sicairos M, Birkedal H, Burghammer M. Mapping the 3D orientation of nanocrystals and nanostructures in human bone: Indications of novel structural features. Sci Adv. 2020 Jun 12;6(24):eaba4171. doi: 10.1126/sciadv.aba4171. eCollection 2020 Jun. PMID: 32582855; PMCID: PMC7292642.
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Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review : Renal disease in chronic hypoparathyroidism.

Reviews in endocrine & metabolic disorders

Gosmanova EO, Houillier P, Rejnmark L, Marelli C, Bilezikian JP.
PMID: 33599907
Rev Endocr Metab Disord. 2021 Jun;22(2):297-316. doi: 10.1007/s11154-020-09613-1. Epub 2021 Feb 18.

A systematic literature review was performed to summarize the frequency and nature of renal complications in patients with chronic hypoparathyroidism managed with conventional therapy. Methodology was consistent with the recommendations outlined in the Preferred Reporting Items for Systematic Reviews...

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Gosmanova EO, Houillier P, Rejnmark L, et al. Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review : Renal disease in chronic hypoparathyroidism. Rev Endocr Metab Disord. 2021;22(2):297-316doi: 10.1007/s11154-020-09613-1.
Gosmanova, E. O., Houillier, P., Rejnmark, L., Marelli, C., & Bilezikian, J. P. (2021). Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review : Renal disease in chronic hypoparathyroidism. Reviews in endocrine & metabolic disorders, 22(2), 297-316. https://doi.org/10.1007/s11154-020-09613-1
Gosmanova, Elvira O, et al. "Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review : Renal disease in chronic hypoparathyroidism." Reviews in endocrine & metabolic disorders vol. 22,2 (2021): 297-316. doi: https://doi.org/10.1007/s11154-020-09613-1
Gosmanova EO, Houillier P, Rejnmark L, Marelli C, Bilezikian JP. Renal complications in patients with chronic hypoparathyroidism on conventional therapy: a systematic literature review : Renal disease in chronic hypoparathyroidism. Rev Endocr Metab Disord. 2021 Jun;22(2):297-316. doi: 10.1007/s11154-020-09613-1. Epub 2021 Feb 18. PMID: 33599907; PMCID: PMC8087595.
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Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging.

Journal of structural biology

Wittig NK, Østergaard M, Palle J, Christensen TEK, Langdahl BL, Rejnmark L, Hauge EM, Brüel A, Thomsen JS, Birkedal H.
PMID: 34902560
J Struct Biol. 2021 Dec 10;214(1):107822. doi: 10.1016/j.jsb.2021.107822. Epub 2021 Dec 10.

Biominerals typically have complex hierarchical structures traversing many length scales. This makes their structural characterization complicated, since it requires 3D techniques that can probe full specimens at down to nanometer-resolution, a combination that is difficult - if not impossible...

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Wittig NK, Østergaard M, Palle J, et al. Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging. J Struct Biol. 2021;214(1):107822doi: 10.1016/j.jsb.2021.107822.
Wittig, N. K., Østergaard, M., Palle, J., Christensen, T. E. K., Langdahl, B. L., Rejnmark, L., Hauge, E. M., Brüel, A., Thomsen, J. S., & Birkedal, H. (2021). Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging. Journal of structural biology, 214(1), 107822. https://doi.org/10.1016/j.jsb.2021.107822
Wittig, Nina Kølln, et al. "Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging." Journal of structural biology vol. 214,1 (2021): 107822. doi: https://doi.org/10.1016/j.jsb.2021.107822
Wittig NK, Østergaard M, Palle J, Christensen TEK, Langdahl BL, Rejnmark L, Hauge EM, Brüel A, Thomsen JS, Birkedal H. Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging. J Struct Biol. 2021 Dec 10;214(1):107822. doi: 10.1016/j.jsb.2021.107822. Epub 2021 Dec 10. PMID: 34902560.
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Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging.

Journal of structural biology

Wittig NK, Østergaard M, Palle J, Christensen TEK, Langdahl BL, Rejnmark L, Hauge EM, Brüel A, Thomsen JS, Birkedal H.
PMID: 34902560
J Struct Biol. 2021 Dec 10;214(1):107822. doi: 10.1016/j.jsb.2021.107822. Epub 2021 Dec 10.

Biominerals typically have complex hierarchical structures traversing many length scales. This makes their structural characterization complicated, since it requires 3D techniques that can probe full specimens at down to nanometer-resolution, a combination that is difficult - if not impossible...

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Wittig NK, Østergaard M, Palle J, et al. Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging. J Struct Biol. 2021;214(1):107822doi: 10.1016/j.jsb.2021.107822.
Wittig, N. K., Østergaard, M., Palle, J., Christensen, T. E. K., Langdahl, B. L., Rejnmark, L., Hauge, E. M., Brüel, A., Thomsen, J. S., & Birkedal, H. (2021). Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging. Journal of structural biology, 214(1), 107822. https://doi.org/10.1016/j.jsb.2021.107822
Wittig, Nina Kølln, et al. "Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging." Journal of structural biology vol. 214,1 (2021): 107822. doi: https://doi.org/10.1016/j.jsb.2021.107822
Wittig NK, Østergaard M, Palle J, Christensen TEK, Langdahl BL, Rejnmark L, Hauge EM, Brüel A, Thomsen JS, Birkedal H. Opportunities for biomineralization research using multiscale computed X-ray tomography as exemplified by bone imaging. J Struct Biol. 2021 Dec 10;214(1):107822. doi: 10.1016/j.jsb.2021.107822. Epub 2021 Dec 10. PMID: 34902560.
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Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls.

European thyroid journal

Grove-Laugesen D, Malmstroem S, Ebbehoj E, Riis AL, Watt T, Rejnmark L, Würgler Hansen K.
PMID: 32523891
Eur Thyroid J. 2020 May;9(3):148-156. doi: 10.1159/000505873. Epub 2020 Feb 14.

INTRODUCTION AND OBJECTIVE: The excess cardiovascular morbidity and mortality in hyperthyroidism and Graves' disease (GD) is inadequately understood. We aimed to elucidate whether well-established cardiovascular risk factors such as arterial stiffness in terms of pulse wave velocity (PWV) and...

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Grove-Laugesen D, Malmstroem S, Ebbehoj E, et al. Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls. Eur Thyroid J. 2020;9(3):148-156doi: 10.1159/000505873.
Grove-Laugesen, D., Malmstroem, S., Ebbehoj, E., Riis, A. L., Watt, T., Rejnmark, L., & Würgler Hansen, K. (2020). Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls. European thyroid journal, 9(3), 148-156. https://doi.org/10.1159/000505873
Grove-Laugesen, Diana, et al. "Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls." European thyroid journal vol. 9,3 (2020): 148-156. doi: https://doi.org/10.1159/000505873
Grove-Laugesen D, Malmstroem S, Ebbehoj E, Riis AL, Watt T, Rejnmark L, Würgler Hansen K. Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls. Eur Thyroid J. 2020 May;9(3):148-156. doi: 10.1159/000505873. Epub 2020 Feb 14. PMID: 32523891; PMCID: PMC7265727.
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Milk Products in the Treatment of Hypophosphatemic Rickets: A Pilot Study.

International journal of endocrinology and metabolism

Jørgensen CS, Poulsen VML, Sandahl M, Underbjerg L, Kristensen SB, Piec I, Beck-Nielsen SS, Rejnmark L, Birkebæk NH.
PMID: 31903094
Int J Endocrinol Metab. 2019 Oct 06;17(4):e91454. doi: 10.5812/ijem.91454. eCollection 2019 Oct.

BACKGROUND: Standard treatment of hypophosphatemic rickets (HR) is oral phosphate tablets plus vitamin D. Due to the rapid absorption of phosphate tablets, frequent daily doses are necessary, which is cumbersome and may cause fluctuations in plasma phosphate and risk...

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Jørgensen CS, Poulsen VML, Sandahl M, et al. Milk Products in the Treatment of Hypophosphatemic Rickets: A Pilot Study. Int J Endocrinol Metab. 2019;17(4):e91454doi: 10.5812/ijem.91454.
Jørgensen, C. S., Poulsen, V. M. L., Sandahl, M., Underbjerg, L., Kristensen, S. B., Piec, I., Beck-Nielsen, S. S., Rejnmark, L., & Birkebæk, N. H. (2019). Milk Products in the Treatment of Hypophosphatemic Rickets: A Pilot Study. International journal of endocrinology and metabolism, 17(4), e91454. https://doi.org/10.5812/ijem.91454
Jørgensen, Cecilie Siggaard, et al. "Milk Products in the Treatment of Hypophosphatemic Rickets: A Pilot Study." International journal of endocrinology and metabolism vol. 17,4 (2019): e91454. doi: https://doi.org/10.5812/ijem.91454
Jørgensen CS, Poulsen VML, Sandahl M, Underbjerg L, Kristensen SB, Piec I, Beck-Nielsen SS, Rejnmark L, Birkebæk NH. Milk Products in the Treatment of Hypophosphatemic Rickets: A Pilot Study. Int J Endocrinol Metab. 2019 Oct 06;17(4):e91454. doi: 10.5812/ijem.91454. eCollection 2019 Oct. PMID: 31903094; PMCID: PMC6935710.
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Cardiovascular consequences of parathyroid disorders in adults.

Annales d'endocrinologie

Bollerslev J, Sjöstedt E, Rejnmark L.
PMID: 32192790
Ann Endocrinol (Paris). 2021 Jun;82(3):151-157. doi: 10.1016/j.ando.2020.02.003. Epub 2020 Feb 28.

PTH is a metabolic active hormone primarily regulating calcium and phosphate homeostasis in a very tight and short term-manner. Parathyroid disorders in adult patients reflect a variety of different conditions related either to the parathyroid glands itself or to...

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Bollerslev J, Sjöstedt E, Rejnmark L. Cardiovascular consequences of parathyroid disorders in adults. Ann Endocrinol (Paris). 2020;82(3):151-157doi: 10.1016/j.ando.2020.02.003.
Bollerslev, J., Sjöstedt, E., & Rejnmark, L. (2021). Cardiovascular consequences of parathyroid disorders in adults. Annales d'endocrinologie, 82(3), 151-157. https://doi.org/10.1016/j.ando.2020.02.003
Bollerslev, Jens, et al. "Cardiovascular consequences of parathyroid disorders in adults." Annales d'endocrinologie vol. 82,3 (2021): 151-157. doi: https://doi.org/10.1016/j.ando.2020.02.003
Bollerslev J, Sjöstedt E, Rejnmark L. Cardiovascular consequences of parathyroid disorders in adults. Ann Endocrinol (Paris). 2021 Jun;82(3):151-157. doi: 10.1016/j.ando.2020.02.003. Epub 2020 Feb 28. PMID: 32192790.
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Endocrine Disorders with Parathyroid Hormone-Independent Hypercalcemia.

Endocrinology and metabolism clinics of North America

Simonsen JK, Rejnmark L.
PMID: 34774242
Endocrinol Metab Clin North Am. 2021 Dec;50(4):711-720. doi: 10.1016/j.ecl.2021.07.002.

The most common causes of hypercalcemia are primary hyperparathyroidism and malignancy, constituting 80% to 90% of all cases. Although less common, several nonparathyroid endocrine disorders are associated with hypercalcemia. The most well described is hyperthyroidism, although the reported prevalence...

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Simonsen JK, Rejnmark L. Endocrine Disorders with Parathyroid Hormone-Independent Hypercalcemia. Endocrinol Metab Clin North Am. 2021;50(4):711-720doi: 10.1016/j.ecl.2021.07.002.
Simonsen, J. K., & Rejnmark, L. (2021). Endocrine Disorders with Parathyroid Hormone-Independent Hypercalcemia. Endocrinology and metabolism clinics of North America, 50(4), 711-720. https://doi.org/10.1016/j.ecl.2021.07.002
Simonsen, Jo Krogsgaard, and Rejnmark, Lars. "Endocrine Disorders with Parathyroid Hormone-Independent Hypercalcemia." Endocrinology and metabolism clinics of North America vol. 50,4 (2021): 711-720. doi: https://doi.org/10.1016/j.ecl.2021.07.002
Simonsen JK, Rejnmark L. Endocrine Disorders with Parathyroid Hormone-Independent Hypercalcemia. Endocrinol Metab Clin North Am. 2021 Dec;50(4):711-720. doi: 10.1016/j.ecl.2021.07.002. PMID: 34774242.
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The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics.

BMC endocrine disorders

Gittoes N, Rejnmark L, Ing SW, Brandi ML, Björnsdottir S, Hahner S, Hofbauer LC, Houillier P, Khan AA, Levine MA, Mannstadt M, Shoback DM, Vokes TJ, Zhang P, Marelli C, Germak J, Clarke BL.
PMID: 34801015
BMC Endocr Disord. 2021 Nov 20;21(1):232. doi: 10.1186/s12902-021-00888-2.

BACKGROUND: The PARADIGHM registry of adult and pediatric patients with chronic hypoparathyroidism evaluates the long-term safety and effectiveness of treatment with recombinant human parathyroid hormone, rhPTH(1-84), and describes the clinical disease course under conditions of routine clinical practice. In...

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Gittoes N, Rejnmark L, Ing SW, et al. The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics. BMC Endocr Disord. 2021;21(1):232doi: 10.1186/s12902-021-00888-2.
Gittoes, N., Rejnmark, L., Ing, S. W., Brandi, M. L., Björnsdottir, S., Hahner, S., Hofbauer, L. C., Houillier, P., Khan, A. A., Levine, M. A., Mannstadt, M., Shoback, D. M., Vokes, T. J., Zhang, P., Marelli, C., Germak, J., & Clarke, B. L. (2021). The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics. BMC endocrine disorders, 21(1), 232. https://doi.org/10.1186/s12902-021-00888-2
Gittoes, Neil, et al. "The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics." BMC endocrine disorders vol. 21,1 (2021): 232. doi: https://doi.org/10.1186/s12902-021-00888-2
Gittoes N, Rejnmark L, Ing SW, Brandi ML, Björnsdottir S, Hahner S, Hofbauer LC, Houillier P, Khan AA, Levine MA, Mannstadt M, Shoback DM, Vokes TJ, Zhang P, Marelli C, Germak J, Clarke BL. The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics. BMC Endocr Disord. 2021 Nov 20;21(1):232. doi: 10.1186/s12902-021-00888-2. PMID: 34801015; PMCID: PMC8606089.
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