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Showing 1 to 12 of 71 entries
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Galectin-3 and Venous Thromboembolism Incidence: the Atherosclerosis Risk in Communities (ARIC) Study.

Research and practice in thrombosis and haemostasis

Fashanu OE, Heckbert SR, Aguilar D, Jensen PN, Ballantyne CM, Basu S, Hoogeveen RC, deFilippi C, Cushman M, Folsom AR.
PMID: 29152608
Res Pract Thromb Haemost. 2017 Oct;1(2):223-230. doi: 10.1002/rth2.12038. Epub 2017 Sep 04.

BACKGROUND: The inflammatory biomarker galectin-3 contributes to pathologic conditions such as heart failure and stimulates murine thrombogenesis. Its association with venous thromboembolism (VTE) has been sparsely studied.OBJECTIVES: To assess the prospective association of plasma galectin-3 and the METHODS: We...

Cognitive Impairment After Stroke.

Cureus

Renjen PN, Gauba C, Chaudhari D.
PMID: 26543693
Cureus. 2015 Sep 29;7(9):e335. doi: 10.7759/cureus.335.

BACKGROUND: Vascular dementia is extremely common and contributes to stroke-associated morbidity and mortality. The study of vascular dementia may help to plan preventive interventions.AIMS: To study the frequency of cognitive impairment after stroke in a series of consecutive patients...

Integrated (18)F-fluorodeoxyglucose positron emission tomography magnetic resonance imaging ((18)F-FDG PET/MRI), a multimodality approach for comprehensive evaluation of dementia patients: A pictorial essay.

The Indian journal of radiology & imaging

Jena A, Renjen PN, Taneja S, Gambhir A, Negi P.
PMID: 26752814
Indian J Radiol Imaging. 2015 Oct-Dec;25(4):342-52. doi: 10.4103/0971-3026.169449.

Dementia, caused by irreversible neurodegenerative disorders such as Alzheimer's disease or reversible non-degenerative conditions, is rapidly becoming one of the most alarming health problems in our aging society. This cognitive disorder associated with a multitude of clinical differentials with...

LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men.

Metabolomics : Official journal of the Metabolomic Society

Boon MR, Bakker LEH, Prehn C, Adamski J, Vosselman MJ, Jazet IM, Arias-Bouda LMP, van Lichtenbelt WDM, van Dijk KW, Rensen PCN, Mook-Kanamori DO.
PMID: 28316560
Metabolomics. 2017;13(5):48. doi: 10.1007/s11306-017-1185-z. Epub 2017 Mar 03.

INTRODUCTION: Brown adipose tissue (BAT) recently emerged as a potential therapeutic target in the treatment of obesity and associated disorders due to its fat-burning capacity. The current gold standard in assessing BAT activity is [OBJECTIVE: We aimed to identify...

Cryo-electron microscopy of extracellular vesicles in fresh plasma.

Journal of extracellular vesicles

Yuana Y, Koning RI, Kuil ME, Rensen PC, Koster AJ, Bertina RM, Osanto S.
PMID: 24455109
J Extracell Vesicles. 2013 Dec 31;2. doi: 10.3402/jev.v2i0.21494. eCollection 2013 Dec 31.

INTRODUCTION: Extracellular vesicles (EV) are phospholipid bilayer-enclosed vesicles recognized as new mediators in intercellular communication and potential biomarkers of disease. They are found in many body fluids and mainly studied in fractions isolated from blood plasma in view of...

Evaluation of effect of measures taken after a DON outbreak.

Mycotoxin research

Spanjer MC, Scholten JM, Rensen PM.
PMID: 23606092
Mycotoxin Res. 2002 Mar;18:43-7. doi: 10.1007/BF02946061.

In April 1999 an amount of 2600 μg/kg DON was found in a sample breakfast cereals in the Netherlands. This event was the start of a lot of activities, which dealt with the prevention, control, health and consumer aspects...

Androgens modulate glucocorticoid receptor activity in adipose tissue and liver.

The Journal of endocrinology

Spaanderman DCE, Nixon M, Buurstede JC, Sips HC, Schilperoort M, Kuipers EN, Backer EA, Kooijman S, Rensen PCN, Homer NZM, Walker BR, Meijer OC, Kroon J.
PMID: 30400038
J Endocrinol. 2018 Oct 01; doi: 10.1530/JOE-18-0503. Epub 2018 Oct 01.

Glucocorticoid signaling is context-dependent, and in certain scenarios glucocorticoid receptors (GR) are able to engage with other members of the nuclear receptor subfamily. Glucocorticoid signaling can exert sexually dimorphic effects, suggesting a possible interaction with androgen sex hormones. We...

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity.

Molecular psychiatry

Wang XL, Kooijman S, Gao Y, Tzeplaeff L, Cosquer B, Milanova I, Wolff SEC, Korpel N, Champy MF, Petit-Demoulière B, Goncalves Da Cruz I, Sorg-Guss T, Rensen PCN, Cassel JC, Kalsbeek A, Boutillier AL, Yi CX.
PMID: 34050326
Mol Psychiatry. 2021 Nov;26(11):6336-6349. doi: 10.1038/s41380-021-01169-z. Epub 2021 May 28.

Microglia play a critical role in maintaining neural function. While microglial activity follows a circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in stimulated conditions such as in the control of systemic...

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice.

Journal of lipid research

van Eenige R, Ying Z, Tambyrajah L, Pronk ACM, Blomberg N, Giera M, Wang Y, Coskun T, van der Stelt M, Rensen PCN, Kooijman S.
PMID: 33766515
J Lipid Res. 2021 Mar 23;62:100070. doi: 10.1016/j.jlr.2021.100070. Epub 2021 Mar 23.

Pharmacological blockade of the cannabinoid type 1 receptor, a G protein-coupled receptor expressed in the central nervous system and various peripheral tissues, reverses diet-induced obesity and dyslipidemia through the reduction of food intake and altered nutrient partitioning. This strategy...

An Atypical Presentation of Left Lateral Medullary Syndrome - A Case Report.

Neurology India

Renjen PN, Krishnan R, Chaudhari D, Ahmad K.
PMID: 34979701
Neurol India. 2021 Nov-Dec;69(6):1831-1834. doi: 10.4103/0028-3886.333445.

Lateral medullary syndrome (LMS), known as Wallenberg's syndrome and posterior inferior cerebellar artery syndrome, is a rare cause of stroke. It often results from thrombosis or emboli of the vertebral artery or posterior inferior cerebellar artery. The triad of...

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice.

Journal of lipid research

van Eenige R, Ying Z, Tambyrajah L, Pronk ACM, Blomberg N, Giera M, Wang Y, Coskun T, van der Stelt M, Rensen PCN, Kooijman S.
PMID: 33766515
J Lipid Res. 2021;62:100070. doi: 10.1016/j.jlr.2021.100070. Epub 2021 Mar 23.

Pharmacological blockade of the cannabinoid type 1 receptor, a G protein-coupled receptor expressed in the central nervous system and various peripheral tissues, reverses diet-induced obesity and dyslipidemia through the reduction of food intake and altered nutrient partitioning. This strategy...

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity.

Molecular psychiatry

Wang XL, Kooijman S, Gao Y, Tzeplaeff L, Cosquer B, Milanova I, Wolff SEC, Korpel N, Champy MF, Petit-Demoulière B, Goncalves Da Cruz I, Sorg-Guss T, Rensen PCN, Cassel JC, Kalsbeek A, Boutillier AL, Yi CX.
PMID: 34050326
Mol Psychiatry. 2021 May 28; doi: 10.1038/s41380-021-01169-z. Epub 2021 May 28.

Microglia play a critical role in maintaining neural function. While microglial activity follows a circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in stimulated conditions such as in the control of systemic...

Showing 1 to 12 of 71 entries