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Showing 1 to 12 of 21 entries
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TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling.

Molecular metabolism

Beaton N, Rudigier C, Moest H, Müller S, Mrosek N, Röder E, Rudofsky G, Rülicke T, Ukropec J, Ukropcova B, Augustin R, Neubauer H, Wolfrum C.
PMID: 26629404
Mol Metab. 2015 Aug 28;4(11):795-810. doi: 10.1016/j.molmet.2015.08.003. eCollection 2015 Nov.

OBJECTIVE: Failure to properly dispose of glucose in response to insulin is a serious health problem, occurring during obesity and is associated with type 2 diabetes development. Insulin-stimulated glucose uptake is facilitated by the translocation and plasma membrane fusion...

Cognitive Functional Abilities in Parkinson's Disease: Agreement Between Patients and Informants.

Movement disorders clinical practice

Deck BL, Xie SX, Choi G, Rick J, Siderowf A, Rudovsky S, Chen-Plotkin A, Duda JE, Morley JF, Dahodwala N, Trojanowski JQ, Weintraub D.
PMID: 31392244
Mov Disord Clin Pract. 2019 May 17;6(6):440-445. doi: 10.1002/mdc3.12781. eCollection 2019 Jul.

BACKGROUND: The Penn Parkinson's Daily Activities Questionnaire-15 (PDAQ-15) assesses cognition-related instrumental activities of daily living (IADL) in Parkinson's disease (PD).OBJECTIVES: To assess the degree and predictors of disagreement between patients (PT) and knowledgeable informants (KI) on the PDAQ-15.METHODS: We...

Praxis

Brönnimann A, Rudofsky G, Paganoni R, Studhalter M.
PMID: 29231088
Praxis (Bern 1994). 2017;106(25):1397-1400. doi: 10.1024/1661-8157/a002849.

No abstract available.

Targeting Treatment Resistance in Head and Neck Squamous Cell Carcinoma - Proof of Concept for CT Radiomics-Based Identification of Resistant Sub-Volumes.

Frontiers in oncology

Bogowicz M, Pavic M, Riesterer O, Finazzi T, Garcia Schüler H, Holz-Sapra E, Rudofsky L, Basler L, Spaniol M, Ambrusch A, Hüllner M, Guckenberger M, Tanadini-Lang S.
PMID: 34123824
Front Oncol. 2021 May 27;11:664304. doi: 10.3389/fonc.2021.664304. eCollection 2021.

PURPOSE: Radiomics has already been proposed as a prognostic biomarker in head and neck cancer (HNSCC). However, its predictive power in radiotherapy has not yet been studied. Here, we investigated a local radiomics approach to distinguish between tumor sub-volumes...

Impact of Albumin-to-Creatinine Ratio Point-of-Care Testing on the Diagnosis and Management of Diabetic Kidney Disease.

Journal of diabetes science and technology

Schultes B, Emmerich S, Kistler AD, Mecheri B, Schnell O, Rudofsky G.
PMID: 34709065
J Diabetes Sci Technol. 2021 Oct 28;19322968211054520. doi: 10.1177/19322968211054520. Epub 2021 Oct 28.

BACKGROUND: For the diagnosis of diabetic kidney disease (DKD), quantitative albuminuria measurement using the albumin-to-creatinine ratio (ACR) is recommended according to various guidelines. It can be measured either in specialized laboratories or using ACR point-of-care testing (POCT). This observational...

Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Gnant M, Dueck AC, Frantal S, Martin M, Burstein HJ, Greil R, Fox P, Wolff AC, Chan A, Winer EP, Pfeiler G, Miller KD, Colleoni M, Suga JM, Rubovsky G, Bliss JM, Mayer IA, Singer CF, Nowecki Z, Hahn O, Thomson J, Wolmark N, Amillano K, Rugo HS, Steger GG, Hernando Fernández de Aránguiz B, Haddad TC, Perelló A, Bellet M, Fohler H, Metzger Filho O, Jallitsch-Halper A, Solomon K, Schurmans C, Theall KP, Lu DR, Tenner K, Fesl C, DeMichele A, Mayer EL.
PMID: 34874182
J Clin Oncol. 2022 Jan 20;40(3):282-293. doi: 10.1200/JCO.21.02554. Epub 2021 Dec 07.

PURPOSE: Palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor approved for advanced breast cancer. In the adjuvant setting, the potential value of adding palbociclib to endocrine therapy for hormone receptor-positive breast cancer has not been confirmed.PATIENTS AND METHODS:...

Genetic modulation of the serotonergic pathway: influence on weight reduction and weight maintenance.

Genes & nutrition

Wallmeier D, Winkler JK, Fleming T, Woehning A, Huennemeyer K, Roeder E, Nawroth PP, Friederich HC, Wolfrum C, Schultz JH, Rudofsky G.
PMID: 23797338
Genes Nutr. 2013 Jun 25; doi: 10.1007/s12263-013-0350-x. Epub 2013 Jun 25.

The serotonergic pathway plays a major role in the development of obesity. Its activity can be modulated by the 5-HT transporter-linked polymorphic region in the SLC6A4 gene and the upstream variable number of tandem repeats polymorphism in the MAOA...

Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network.

Molecular metabolism

Mrosek N, Meissburger B, Mataki C, Roeder E, Ukropec J, Klimes I, Gasperikova D, Nawroth PP, Rudofsky G, Auwerx J, Schoonjans K, Wolfrum C.
PMID: 24049743
Mol Metab. 2013 Mar 16;2(3):314-23. doi: 10.1016/j.molmet.2013.03.003. eCollection 2013.

Altered adipose tissue formation is a well-known effectors of obesity and T2D. Here, we describe the role of Lrh1 and its co-repressor Shp in the control of adipocyte formation. Expression of Lrh1 in the pre-adipocyte containing SVF is induced...

No short-term effects of calorie-controlled Mediterranean or fast food dietary interventions on established biomarkers of vascular or metabolic risk in healthy individuals.

Nutrition research and practice

Parcina M, Brune M, Kaese V, Zorn M, Spiegel R, Vojvoda V, Fleming T, Rudofsky G, Paul Nawroth P.
PMID: 25861423
Nutr Res Pract. 2015 Apr;9(2):165-73. doi: 10.4162/nrp.2015.9.2.165. Epub 2014 Dec 10.

BACKGROUND/OBJECTIVES: This study addressed the question whether the composition of supposedly 'healthy' or 'unhealthy' dietary regimes has a calorie-independent short-term effect on biomarkers of metabolic stress and vascular risk in healthy individuals.SUBJECTS/METHODS: Healthy male volunteers (age 29.5 ± 5.9...

Nanotubes from chalcogenide misfit compounds: Sn-S and Nb-Pb-S.

Accounts of chemical research

Radovsky G, Popovitz-Biro R, Stroppa DG, Houben L, Tenne R.
PMID: 24044507
Acc Chem Res. 2014 Feb 18;47(2):406-16. doi: 10.1021/ar400138h. Epub 2013 Sep 17.

Carbon fullerenes and nanotubes revolutionized understandingof the reactivity of nanoscale compounds. Subsequently, our group and others discovered analogous inorganic compounds with hollow, closed nanostructures. Such inorganic nanostructures offer many applications, particularly in the energy and electronics industries. One way...

[Not Available].

Praxis

Rudofsky L, Holz-Sapra E.
PMID: 27524172
Praxis (Bern 1994). 2016 Aug;105(16):982. doi: 10.1024/1661-8157/a002421.

No abstract available.

Switch-to-Semaglutide Study (STS-Study): a Retrospective Cohort Study.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Hepprich M, Zillig D, Florian-Reynoso MA, Donath MY, Rudofsky G.
PMID: 33615400
Diabetes Ther. 2021 Mar;12(3):943-954. doi: 10.1007/s13300-021-01016-y. Epub 2021 Feb 22.

INTRODUCTION: Despite expert consensus guidelines, data is scarce on how to switch patients with type 2 diabetes when treatment with glucagon-like peptide 1 (GLP-1) receptor agonists is not effective and whether a switch to semaglutide brings any benefit on...

Showing 1 to 12 of 21 entries