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Showing 1 to 12 of 75 entries
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Surgical management of hepatocellular carcinoma after Fontan procedure.

Journal of gastrointestinal oncology

Kwon S, Scovel L, Yeh M, Dorsey D, Dembo G, Krieger EV, Bakthavatsalam R, Park JO, Riggle KM, Riehle KJ, Yeung RS.
PMID: 26029468
J Gastrointest Oncol. 2015 Jun;6(3):E55-60. doi: 10.3978/j.issn.2078-6891.2015.009.

The Fontan operation has successfully prolonged the lives of patients born with single-ventricle physiology. A long-term consequence of post-Fontan elevation in systemic venous pressure and low cardiac output is chronic liver inflammation and cirrhosis, which lead to an increased...

de Sitter Vacua from an Anomalous Gauge Symmetry.

Physical review letters

Buchmuller W, Dierigl M, Ruehle F, Schweizer J.
PMID: 27314713
Phys Rev Lett. 2016 Jun 03;116(22):221303. doi: 10.1103/PhysRevLett.116.221303. Epub 2016 Jun 03.

We find a new class of metastable de Sitter solutions in compactifications of six-dimensional supergravity motivated by type IIB or heterotic string vacua. Two Fayet-Iliopoulos terms of a local U(1) symmetry are generated by magnetic flux and by the...

Electrochemical and spectroscopic characterization of the novel charge-transfer ground state in diimine complexes of ytterbocene.

Inorganic chemistry

Da Re RE, Kuehl CJ, Brown MG, Rocha RC, Bauer ED, John KD, Morris DE, Shreve AP, Sarrao JL.
PMID: 12950203
Inorg Chem. 2003 Sep 08;42(18):5551-9. doi: 10.1021/ic030069i.

The novel charge-transfer ground state found in alpha,alpha'-diimine adducts of ytterbocene (C(5)Me(5))(2)Yb(L) [L = 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen)] in which an electron is spontaneously transferred from the f(14) metal center into the lowest unoccupied (pi*) molecular orbital (LUMO)...

Toward new paradigms in mixed-valency: ytterbocene-terpyridine charge-transfer complexes.

Chemical communications (Cambridge, England)

Kuehl CJ, Da Re RE, Scott BL, Morris DE, John KD.
PMID: 14518902
Chem Commun (Camb). 2003 Sep 21;(18):2336-7. doi: 10.1039/b306484k.

(C5Me5)2Yb x OEt2 reacts with terpyridine and tetrapyridinylpyrazine to afford new mixed-valent systems.

Occurrence, Parasitism, and Pathogenicity of Nematodes Associated with Sycamore (Platanus occidentalis L.).

Journal of nematology

Churchill RC, Ruehle JL.
PMID: 19322367
J Nematol. 1971 Apr;3(2):189-96.

Ten species of stylet-bearing nematodes were recovered in a survey of sycamore (Platanus occidentalis L. ) stands in Georgia. Helicotylenchus, Xiphinema, and Criconemoides were the genera found most frequently. Populations of Hoplolaimus galeatus, Scutellonema brachyurum, Helicotylenchus dihystera and H....

Worldwide data sets constrain the water vapor uptake coefficient in cloud formation.

Proceedings of the National Academy of Sciences of the United States of America

Raatikainen T, Nenes A, Seinfeld JH, Morales R, Moore RH, Lathem TL, Lance S, Padró LT, Lin JJ, Cerully KM, Bougiatioti A, Cozic J, Ruehl CR, Chuang PY, Anderson BE, Flagan RC, Jonsson H, Mihalopoulos N, Smith JN.
PMID: 23431189
Proc Natl Acad Sci U S A. 2013 Mar 05;110(10):3760-4. doi: 10.1073/pnas.1219591110. Epub 2013 Feb 19.

Cloud droplet formation depends on the condensation of water vapor on ambient aerosols, the rate of which is strongly affected by the kinetics of water uptake as expressed by the condensation (or mass accommodation) coefficient, αc. Estimates of αc...

Neurotensin as a source of cyclic AMP and co-mitogen in fibrolamellar hepatocellular carcinoma.

Oncotarget

Riehle KJ, Kenerson HL, Riggle KM, Turnham R, Sullivan K, Bauer R, Scott JD, Yeung RS.
PMID: 31489118
Oncotarget. 2019 Aug 20;10(49):5092-5102. doi: 10.18632/oncotarget.27149. eCollection 2019 Aug 20.

Fibrolamellar hepatocellular carcinomas (FL-HCCs) possess a unique mutation that encodes a chimeric form of protein kinase A (DNAJ-PKAc), which includes a chaperonin binding domain. DNAJ-PKAc retains most of the biochemical properties of the native enzyme, however, and activity remains...

Design and Characterization of an "All-in-One" Lentiviral Vector System Combining Constitutive Anti-G.

Cancers

Zimmermann K, Kuehle J, Dragon AC, Galla M, Kloth C, Rudek LS, Sandalcioglu IE, Neyazi B, Moritz T, Meyer J, Rossig C, Altvater B, Eiz-Vesper B, Morgan MA, Abken H, Schambach A.
PMID: 32041222
Cancers (Basel). 2020 Feb 06;12(2). doi: 10.3390/cancers12020375.

Genetically modified T cells expressing chimeric antigen receptors (CARs) so far have mostly failed in the treatment of solid tumors owing to a number of limitations, including an immunosuppressive tumor microenvironment and insufficient CAR T cell activation and persistence....

PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model.

Molecular therapy oncolytics

Alzubi J, Dettmer-Monaco V, Kuehle J, Thorausch N, Seidl M, Taromi S, Schamel W, Zeiser R, Abken H, Cathomen T, Wolf P.
PMID: 32728611
Mol Ther Oncolytics. 2020 Jun 24;18:226-235. doi: 10.1016/j.omto.2020.06.014. eCollection 2020 Sep 25.

While chimeric antigen receptor (CAR) T cell immunotherapy targeting CD19 has shown remarkable success in patients with lymphoid malignancies, the potency of CAR T cells in solid tumors is low so far. To improve the efficacy of CAR T...

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.

Molecular cell

Liu L, Chen X, Li J, Wang H, Buehl CJ, Goff NJ, Meek K, Yang W, Gellert M.
PMID: 34936881
Mol Cell. 2022 Jan 06;82(1):177-189.e4. doi: 10.1016/j.molcel.2021.11.025. Epub 2021 Dec 21.

The DNA-dependent protein kinase (DNA-PK) initially protects broken DNA ends but then promotes their processing during non-homologous end joining (NHEJ). Before ligation by NHEJ, DNA hairpin ends generated during V(D)J recombination must be opened by the Artemis nuclease, together...

The impact of bridging therapy prior to CD19-directed chimeric antigen receptor T-cell therapy in patients with large B-cell lymphoma.

British journal of haematology

Lutfi F, Holtzman NG, Kansagra AJ, Mustafa Ali M, Bukhari A, Yan J, Samanta S, Gottlieb D, Kim DW, Matsumoto LR, Gahres N, Ruehle K, Lee ST, Law JY, Kocoglu MH, Atanackovic D, Yared JA, Hardy NM, Molitoris J, Mohindra P, Rapoport AP, Dahiya S.
PMID: 34500492
Br J Haematol. 2021 Nov;195(3):405-412. doi: 10.1111/bjh.17738. Epub 2021 Sep 09.

In the relapsed/refractory setting for treatment of large B-cell lymphoma (LBCL), chimeric antigen receptor T-cell (CAR-T) therapy has emerged as an effective treatment modality. Patients often have aggressive disease that requires prompt treatment in the form of bridging therapy...

Efficacy of Drug-Eluting Stents in Diabetic Patients Admitted with ST-Elevation Myocardial Infarctions Treated with Primary Percutaneous Coronary Intervention.

Journal of cardiovascular development and disease

Schmucker J, Fach A, Osteresch R, Mata Marin LA, Ruehle S, Retzlaff T, Garstka D, Eitel I, Hambrecht R, Wienbergen H.
PMID: 34436225
J Cardiovasc Dev Dis. 2021 Jul 21;8(8). doi: 10.3390/jcdd8080083.

BACKGROUND: Diabetic patients show higher adverse ischemic event rates and mortality when undergoing percutaneous coronary intervention (PCI) in acute myocardial infarctions. Therefore, diabetic patients might benefit even more from modern-generation drug-eluting stents (DES). The aim of the present study...

Showing 1 to 12 of 75 entries