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Showing 1 to 12 of 130 entries
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A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis.

ACS central science

Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P.
PMID: 27725964
ACS Cent Sci. 2016 Sep 28;2(9):653-659. doi: 10.1021/acscentsci.6b00199. Epub 2016 Sep 07.

Discovering compounds and mechanisms for inhibiting ferroptosis, a form of regulated, nonapoptotic cell death, has been of great interest in recent years. In this study, we demonstrate the ability of XJB-5-131, JP4-039, and other nitroxide-based lipid peroxidation mitigators to...

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Krainz T, Gaschler MM, Lim C, et al. A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. ACS Cent Sci. 2016;2(9):653-659doi: 10.1021/acscentsci.6b00199.
Krainz, T., Gaschler, M. M., Lim, C., Sacher, J. R., Stockwell, B. R., & Wipf, P. (2016). A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. ACS central science, 2(9), 653-659. https://doi.org/10.1021/acscentsci.6b00199
Krainz, Tanja, et al. "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis." ACS central science vol. 2,9 (2016): 653-659. doi: https://doi.org/10.1021/acscentsci.6b00199
Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P. A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. ACS Cent Sci. 2016 Sep 28;2(9):653-659. doi: 10.1021/acscentsci.6b00199. Epub 2016 Sep 07. PMID: 27725964; PMCID: PMC5043442.
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The Most Favourable Procedure for the Isolation of Cell-Free DNA from the Plasma of Iso-Immunized RHD-Negative Pregnant Women.

Journal of circulating biomarkers

Rather RA, Saha SC, Dhawan V, Jago R, Fox KR.
PMID: 28936248
J Circ Biomark. 2015 Dec 09;4:12. doi: 10.5772/62113. eCollection 2015.

BACKGROUND: The ability to achieve quality recovery of cell-free foetal DNA is important for making non-invasive prenatal diagnoses. In this study, we performed quantitative and qualitative analyses of isolated DNA from maternal plasma, using different DNA-isolation methods.METHOD: DNA was...

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Rather RA, Saha SC, Dhawan V, et al. The Most Favourable Procedure for the Isolation of Cell-Free DNA from the Plasma of Iso-Immunized RHD-Negative Pregnant Women. J Circ Biomark. 2015;4:12doi: 10.5772/62113.
Rather, R. A., Saha, S. C., Dhawan, V., Jago, R., & Fox, K. R. (2015). The Most Favourable Procedure for the Isolation of Cell-Free DNA from the Plasma of Iso-Immunized RHD-Negative Pregnant Women. Journal of circulating biomarkers, 412. https://doi.org/10.5772/62113
Rather, Riyaz Ahmad, et al. "The Most Favourable Procedure for the Isolation of Cell-Free DNA from the Plasma of Iso-Immunized RHD-Negative Pregnant Women." Journal of circulating biomarkers vol. 4 (2015): 12. doi: https://doi.org/10.5772/62113
Rather RA, Saha SC, Dhawan V, Jago R, Fox KR. The Most Favourable Procedure for the Isolation of Cell-Free DNA from the Plasma of Iso-Immunized RHD-Negative Pregnant Women. J Circ Biomark. 2015 Dec 09;4:12. doi: 10.5772/62113. eCollection 2015. PMID: 28936248; PMCID: PMC5548194.
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The stochastic theory of mortality.

Annals of the New York Academy of Sciences

SACHER GA, TRUCCO E.
PMID: 14495830
Ann N Y Acad Sci. 1962 Mar 02;96:985-1007. doi: 10.1111/j.1749-6632.1962.tb54116.x.

No abstract available.

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SACHER GA, TRUCCO E. The stochastic theory of mortality. Ann N Y Acad Sci. 1962;96:985-1007doi: 10.1111/j.1749-6632.1962.tb54116.x.
SACHER, G. A., & TRUCCO, E. (1962). The stochastic theory of mortality. Annals of the New York Academy of Sciences, 96985-1007. https://doi.org/10.1111/j.1749-6632.1962.tb54116.x
SACHER, G A, and TRUCCO, E. "The stochastic theory of mortality." Annals of the New York Academy of Sciences vol. 96 (1962): 985-1007. doi: https://doi.org/10.1111/j.1749-6632.1962.tb54116.x
SACHER GA, TRUCCO E. The stochastic theory of mortality. Ann N Y Acad Sci. 1962 Mar 02;96:985-1007. doi: 10.1111/j.1749-6632.1962.tb54116.x. PMID: 14495830.
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Senescense: association of synthesis of Acid phosphatase with banana ripening.

Plant physiology

De Leo P, Sacher JA.
PMID: 16657436
Plant Physiol. 1970 Aug;46(2):208-11. doi: 10.1104/pp.46.2.208.

During ripening of banana (Musa sapientum L., var. Gros Michel or Valery) acid phosphatase activity increases 13-to 26-fold in the precipitate and 2- to 4-fold in the supernatant fraction of tissue homogenates. These increases are closely correlated with the...

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De Leo P, Sacher JA. Senescense: association of synthesis of Acid phosphatase with banana ripening. Plant Physiol. 1970;46(2):208-11doi: 10.1104/pp.46.2.208.
De Leo, P., & Sacher, J. A. (1970). Senescense: association of synthesis of Acid phosphatase with banana ripening. Plant physiology, 46(2), 208-11. https://doi.org/10.1104/pp.46.2.208
De Leo, P, and Sacher, J A. "Senescense: association of synthesis of Acid phosphatase with banana ripening." Plant physiology vol. 46,2 (1970): 208-11. doi: https://doi.org/10.1104/pp.46.2.208
De Leo P, Sacher JA. Senescense: association of synthesis of Acid phosphatase with banana ripening. Plant Physiol. 1970 Aug;46(2):208-11. doi: 10.1104/pp.46.2.208. PMID: 16657436; PMCID: PMC396564.
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First Report of the U. S. Atomic Energy Commission.

Science (New York, N.Y.)

Lilienthal DE, Bacher RF, Pike ST, Strauss LL, Waymack WW.
PMID: 17737874
Science. 1947 Feb 21;105(2721):199-204. doi: 10.1126/science.105.2721.199.

No abstract available.

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Lilienthal DE, Bacher RF, Pike ST, et al. First Report of the U. S. Atomic Energy Commission. Science. 1947;105(2721):199-204doi: 10.1126/science.105.2721.199.
Lilienthal, D. E., Bacher, R. F., Pike, S. T., Strauss, L. L., & Waymack, W. W. (1947). First Report of the U. S. Atomic Energy Commission. Science (New York, N.Y.), 105(2721), 199-204. https://doi.org/10.1126/science.105.2721.199
Lilienthal, D E, et al. "First Report of the U. S. Atomic Energy Commission." Science (New York, N.Y.) vol. 105,2721 (1947): 199-204. doi: https://doi.org/10.1126/science.105.2721.199
Lilienthal DE, Bacher RF, Pike ST, Strauss LL, Waymack WW. First Report of the U. S. Atomic Energy Commission. Science. 1947 Feb 21;105(2721):199-204. doi: 10.1126/science.105.2721.199. PMID: 17737874.
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REMOVAL OF OPEN SAFETY-PIN, SIX WEEKS IN INFANT'S HYPOPHARYNX.

California and western medicine

Bacher JA.
PMID: 18739888
Cal West Med. 1926 Feb;24(2):220.

No abstract available.

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Bacher JA. REMOVAL OF OPEN SAFETY-PIN, SIX WEEKS IN INFANT'S HYPOPHARYNX. Cal West Med. 1926;24(2):220
Bacher, J. A. (1926). REMOVAL OF OPEN SAFETY-PIN, SIX WEEKS IN INFANT'S HYPOPHARYNX. California and western medicine, 24(2), 220.
Bacher, J A. "REMOVAL OF OPEN SAFETY-PIN, SIX WEEKS IN INFANT'S HYPOPHARYNX." California and western medicine vol. 24,2 (1926): 220.
Bacher JA. REMOVAL OF OPEN SAFETY-PIN, SIX WEEKS IN INFANT'S HYPOPHARYNX. Cal West Med. 1926 Feb;24(2):220. PMID: 18739888; PMCID: PMC1655012.
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THE MECHANISM OF THE VOMITING INDUCED BY ANTIMONY AND POTASSIUM TARTRATE (TARTAR EMETIC).

The Journal of experimental medicine

Weiss S, Hatcher RA.
PMID: 19868716
J Exp Med. 1923 Jan 01;37(1):97-111. doi: 10.1084/jem.37.1.97.

1. It has been shown that tartar emetic acts on the stomach to induce emesis after its oral administration, that only traces are present in the vomitus following its intravenous injection (Kleimann and Simonowitsch), and that it does not...

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Weiss S, Hatcher RA. THE MECHANISM OF THE VOMITING INDUCED BY ANTIMONY AND POTASSIUM TARTRATE (TARTAR EMETIC). J Exp Med. 1923;37(1):97-111doi: 10.1084/jem.37.1.97.
Weiss, S., & Hatcher, R. A. (1923). THE MECHANISM OF THE VOMITING INDUCED BY ANTIMONY AND POTASSIUM TARTRATE (TARTAR EMETIC). The Journal of experimental medicine, 37(1), 97-111. https://doi.org/10.1084/jem.37.1.97
Weiss, S, and Hatcher, R A. "THE MECHANISM OF THE VOMITING INDUCED BY ANTIMONY AND POTASSIUM TARTRATE (TARTAR EMETIC)." The Journal of experimental medicine vol. 37,1 (1923): 97-111. doi: https://doi.org/10.1084/jem.37.1.97
Weiss S, Hatcher RA. THE MECHANISM OF THE VOMITING INDUCED BY ANTIMONY AND POTASSIUM TARTRATE (TARTAR EMETIC). J Exp Med. 1923 Jan 01;37(1):97-111. doi: 10.1084/jem.37.1.97. PMID: 19868716; PMCID: PMC2128404.
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Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc.

Journal of cell communication and signaling

McCann MR, Bacher CA, Séguin CA.
PMID: 21484587
J Cell Commun Signal. 2011 Mar;5(1):39-43. doi: 10.1007/s12079-010-0116-9. Epub 2011 Jan 16.

The nucleus pulposus is an avascular and aneural tissue that has significant influence on the homeostasis and overall function of the intervertebral disc. The nucleus pulposus is comprised of a heterogeneous population of cells including large notochord cells and...

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McCann MR, Bacher CA, Séguin CA. Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc. J Cell Commun Signal. 2011;5(1):39-43doi: 10.1007/s12079-010-0116-9.
McCann, M. R., Bacher, C. A., & Séguin, C. A. (2011). Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc. Journal of cell communication and signaling, 5(1), 39-43. https://doi.org/10.1007/s12079-010-0116-9
McCann, Matthew R, et al. "Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc." Journal of cell communication and signaling vol. 5,1 (2011): 39-43. doi: https://doi.org/10.1007/s12079-010-0116-9
McCann MR, Bacher CA, Séguin CA. Exploiting notochord cells for stem cell-based regeneration of the intervertebral disc. J Cell Commun Signal. 2011 Mar;5(1):39-43. doi: 10.1007/s12079-010-0116-9. Epub 2011 Jan 16. PMID: 21484587; PMCID: PMC3058196.
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An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.

ACS medicinal chemistry letters

Skoda EM, Sacher JR, Kazancioglu MZ, Saha J, Wipf P.
PMID: 25147611
ACS Med Chem Lett. 2014 Jun 27;5(8):900-4. doi: 10.1021/ml5001504. eCollection 2014 Aug 14.

Low aqueous solubility is a common challenge in drug discovery and development and can lead to inconclusive biological assay results. Attaching small, polar groups that do not interfere with the bioactivity of the pharmacophore often improves solubility, but there...

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Skoda EM, Sacher JR, Kazancioglu MZ, et al. An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. ACS Med Chem Lett. 2014;5(8):900-4doi: 10.1021/ml5001504.
Skoda, E. M., Sacher, J. R., Kazancioglu, M. Z., Saha, J., & Wipf, P. (2014). An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. ACS medicinal chemistry letters, 5(8), 900-4. https://doi.org/10.1021/ml5001504
Skoda, Erin M, et al. "An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility." ACS medicinal chemistry letters vol. 5,8 (2014): 900-4. doi: https://doi.org/10.1021/ml5001504
Skoda EM, Sacher JR, Kazancioglu MZ, Saha J, Wipf P. An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. ACS Med Chem Lett. 2014 Jun 27;5(8):900-4. doi: 10.1021/ml5001504. eCollection 2014 Aug 14. PMID: 25147611; PMCID: PMC4137373.
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Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy.

Cancer discovery

Hinze L, Labrosse R, Degar J, Han T, Schatoff EM, Schreek S, Karim S, McGuckin C, Sacher JR, Wagner F, Stanulla M, Yuan C, Sicinska E, Giannakis M, Ng K, Dow LE, Gutierrez A.
PMID: 32703769
Cancer Discov. 2020 Nov;10(11):1690-1705. doi: 10.1158/2159-8290.CD-19-1472. Epub 2020 Jul 23.

Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found that activating a β-catenin-independent branch of WNT signaling...

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Hinze L, Labrosse R, Degar J, et al. Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discov. 2020;10(11):1690-1705doi: 10.1158/2159-8290.CD-19-1472.
Hinze, L., Labrosse, R., Degar, J., Han, T., Schatoff, E. M., Schreek, S., Karim, S., McGuckin, C., Sacher, J. R., Wagner, F., Stanulla, M., Yuan, C., Sicinska, E., Giannakis, M., Ng, K., Dow, L. E., & Gutierrez, A. (2020). Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer discovery, 10(11), 1690-1705. https://doi.org/10.1158/2159-8290.CD-19-1472
Hinze, Laura, et al. "Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy." Cancer discovery vol. 10,11 (2020): 1690-1705. doi: https://doi.org/10.1158/2159-8290.CD-19-1472
Hinze L, Labrosse R, Degar J, Han T, Schatoff EM, Schreek S, Karim S, McGuckin C, Sacher JR, Wagner F, Stanulla M, Yuan C, Sicinska E, Giannakis M, Ng K, Dow LE, Gutierrez A. Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discov. 2020 Nov;10(11):1690-1705. doi: 10.1158/2159-8290.CD-19-1472. Epub 2020 Jul 23. PMID: 32703769; PMCID: PMC7642035.
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Chemical, biological and .

Heliyon

Bhagat M, Sangral M, Kumar A, Rather RA, Arya K.
PMID: 32613108
Heliyon. 2020 Jun 23;6(6):e04209. doi: 10.1016/j.heliyon.2020.e04209. eCollection 2020 Jun.

MAIN METHODS: Characterization of essential oil was done by GCMS, antimicrobial by agar well diffusion methods, KEY FINDINGS: Essential oil from aerial parts (leaf) of SIGNIFICANCE: Taken together, our results indicate that EO possesses potent antimicrobial and anticancer properties,...

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Bhagat M, Sangral M, Kumar A, et al. Chemical, biological and . Heliyon. 2020;6(6):e04209doi: 10.1016/j.heliyon.2020.e04209.
Bhagat, M., Sangral, M., Kumar, A., Rather, R. A., & Arya, K. (2020). Chemical, biological and . Heliyon, 6(6), e04209. https://doi.org/10.1016/j.heliyon.2020.e04209
Bhagat, Madhulika, et al. "Chemical, biological and ." Heliyon vol. 6,6 (2020): e04209. doi: https://doi.org/10.1016/j.heliyon.2020.e04209
Bhagat M, Sangral M, Kumar A, Rather RA, Arya K. Chemical, biological and . Heliyon. 2020 Jun 23;6(6):e04209. doi: 10.1016/j.heliyon.2020.e04209. eCollection 2020 Jun. PMID: 32613108; PMCID: PMC7322124.
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An approach to student-to-faculty feedback in the basic sciences.

Academic medicine : journal of the Association of American Medical Colleges

Saffran M, Conran PB, Lacher DA.
PMID: 8086055
Acad Med. 1994 May;69(5):413. doi: 10.1097/00001888-199405000-00027.

No abstract available.

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Saffran M, Conran PB, Lacher DA. An approach to student-to-faculty feedback in the basic sciences. Acad Med. 1994;69(5):413doi: 10.1097/00001888-199405000-00027.
Saffran, M., Conran, P. B., & Lacher, D. A. (1994). An approach to student-to-faculty feedback in the basic sciences. Academic medicine : journal of the Association of American Medical Colleges, 69(5), 413. https://doi.org/10.1097/00001888-199405000-00027
Saffran, M, et al. "An approach to student-to-faculty feedback in the basic sciences." Academic medicine : journal of the Association of American Medical Colleges vol. 69,5 (1994): 413. doi: https://doi.org/10.1097/00001888-199405000-00027
Saffran M, Conran PB, Lacher DA. An approach to student-to-faculty feedback in the basic sciences. Acad Med. 1994 May;69(5):413. doi: 10.1097/00001888-199405000-00027. PMID: 8086055.
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Showing 1 to 12 of 130 entries