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Showing 1 to 6 of 6 entries
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The ingenious mast cell: Contemporary insights into mast cell behavior and function.

Allergy

Dahlin JS, Maurer M, Metcalfe DD, Pejler G, Sagi-Eisenberg R, Nilsson G.
PMID: 33955017
Allergy. 2022 Jan;77(1):83-99. doi: 10.1111/all.14881. Epub 2021 May 20.

Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both...

Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma.

Sarcoma

Merimsky O, Jiveliouk I, Sagi-Eisenberg R.
PMID: 18509482
Sarcoma. 2008;2008:825093. doi: 10.1155/2008/825093.

A 66-year old female with HIV-negative classic Kaposi's sarcoma responded to mTOR targeting by rapamycin. The response was well documented by PET-CT. This case provides supporting evidence that the mTOR pathway may be important in the tumorigenesis of KS...

The actin cytoskeleton and mast cell function.

Current opinion in immunology

Lazki-Hagenbach P, Klein O, Sagi-Eisenberg R.
PMID: 33765561
Curr Opin Immunol. 2021 Oct;72:27-33. doi: 10.1016/j.coi.2021.03.002. Epub 2021 Mar 22.

The application of high and super-resolution microscopy techniques has extended the possibilities of studying actin dynamics in mast cells (MCs). These studies demonstrated the close correlation between actin-driven changes in cell morphology and the functions that MC perform during...

Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation.

Frontiers in immunology

Rudich N, Ravid K, Sagi-Eisenberg R.
PMID: 22675325
Front Immunol. 2012 Jun 04;3:134. doi: 10.3389/fimmu.2012.00134. eCollection 2012.

Adenosine is a metabolite, which has long been implicated in a variety of inflammatory processes. Inhaled adenosine provokes bronchoconstriction in asthmatics or chronic obstructive pulmonary disease patients, but not in non-asthmatics. This hyper responsiveness to adenosine appears to be...

Mast Cells Are Directly Activated by Cancer Cell-Derived Extracellular Vesicles by a CD73- and Adenosine-Dependent Mechanism.

Translational oncology

Gorzalczany Y, Merimsky O, Sagi-Eisenberg R.
PMID: 31493676
Transl Oncol. 2019 Dec;12(12):1549-1556. doi: 10.1016/j.tranon.2019.08.005. Epub 2019 Sep 04.

We have recently shown that mast cells (MCs), which constitute an important part of the tumor microenvironment (TME), can be directly activated by cancer cells under conditions that recapitulate cell to cell contact. However, MCs are often detected in...

The ingenious mast cell: Contemporary insights into mast cell behavior and function.

Allergy

Dahlin JS, Maurer M, Metcalfe DD, Pejler G, Sagi-Eisenberg R, Nilsson G.
PMID: 33955017
Allergy. 2021 May 06; doi: 10.1111/all.14881. Epub 2021 May 06.

Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both...

Showing 1 to 6 of 6 entries