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Showing 1 to 12 of 44 entries
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Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Nature chemical biology

Palacino J, Swalley SE, Song C, Cheung AK, Shu L, Zhang X, Van Hoosear M, Shin Y, Chin DN, Keller CG, Beibel M, Renaud NA, Smith TM, Salcius M, Shi X, Hild M, Servais R, Jain M, Deng L, Bullock C, McLellan M, Schuierer S, Murphy L, Blommers MJ, Blaustein C, Berenshteyn F, Lacoste A, Thomas JR, Roma G, Michaud GA, Tseng BS, Porter JA, Myer VE, Tallarico JA, Hamann LG, Curtis D, Fishman MC, Dietrich WF, Dales NA, Sivasankaran R.
PMID: 26991088
Nat Chem Biol. 2016 Apr;12(4):304. doi: 10.1038/nchembio0416-304c.

No abstract available.

Comparative .

Drug metabolism letters

Solà J, Menargues À, Homedes J, Salichs M, Serafini MT, Encina G.
PMID: 34886785
Drug Metab Lett. 2021;14(3):206-218. doi: 10.2174/1872312814666211209161933.

BACKGROUND: Enflicoxib is a non-steroidal anti-inflammatory drug of the coxib family characterized by a long-lasting pharmacological activity that has been attributed to its active metabolite E-6132.OBJECTIVES: The aim of this work was to explore enflicoxib biotransformation In vitro in...

Prevalence and determinants of chronic kidney disease in women with hypertensive disorders in pregnancy in Nigeria: a cohort study.

BMC nephrology

Ishaku SM, Olanrewaju TO, Browne JL, Klipstein-Grobusch K, Kayode GA, Franx A, Grobbee DE, Warren CE.
PMID: 34144676
BMC Nephrol. 2021 Jun 18;22(1):229. doi: 10.1186/s12882-021-02419-6.

BACKGROUND: Worldwide, hypertensive disorders in pregnancy (HDPs) complicate between 5 and 10% of pregnancies. Sub-Saharan Africa (SSA) is disproportionately affected by a high burden of HDPs and chronic kidney disease (CKD). Despite mounting evidence associating HDPs with the development...

CEACAM6's Role as a Chemoresistance and Prognostic Biomarker for Pancreatic Cancer: A Comparison of CEACAM6's Diagnostic and Prognostic Capabilities with Those of CA19-9 and CEA.

Life (Basel, Switzerland)

Kurlinkus B, Ger M, Kaupinis A, Jasiunas E, Valius M, Sileikis A.
PMID: 34207784
Life (Basel). 2021 Jun 09;11(6). doi: 10.3390/life11060542.

Survival rates from pancreatic cancer have remained stagnant for decades due to the heterogenic nature of the disease. This study aimed to find a new advanced biomarker and evaluate its clinical capabilities, thus enabling more individualised pancreatic cancer management....

The impact of wildland fires on calcareous Mediterranean pedosystems (Sardinia, Italy) - An integrated multiple approach.

The Science of the total environment

Capra GF, Tidu S, Lovreglio R, Certini G, Salis M, Bacciu V, Ganga A, Filzmoser P.
PMID: 29929227
Sci Total Environ. 2018 May 15;624:1152-1162. doi: 10.1016/j.scitotenv.2017.12.099. Epub 2017 Dec 27.

Sardinia (Italy), the second largest island of the Mediterranean Sea, is a fire-prone land. Most Sardinian environments over time were shaped by fire, but some of them are too intrinsically fragile to withstand the currently increasing fire frequency. Calcareous...

Selective inhibition of cyclooxygenase-2 by enflicoxib, its enantiomers and its main metabolites in vitro in canine blood.

Journal of veterinary pharmacology and therapeutics

Solà J, Menargues À, Homedes J, Salichs M, Álvarez I, Romero L, Vela JM.
PMID: 35038171
J Vet Pharmacol Ther. 2022 Jan 17; doi: 10.1111/jvp.13042. Epub 2022 Jan 17.

Enflicoxib is approved for the treatment of pain and inflammation in canine osteoarthritis. The objective of this work was to assess the mechanistic basis of enflicoxib therapy investigating the COX inhibitory activity of enflicoxib (racemate), its enantiomers and its...

Molecular Insights into miRNA-Driven Resistance to 5-Fluorouracil and Oxaliplatin Chemotherapy: miR-23b Modulates the Epithelial–Mesenchymal Transition of Colorectal Cancer Cells.

Journal of clinical medicine

Gasiulė S, Dreize N, Kaupinis A, Ražanskas R, Čiupas L, Stankevičius V, Kapustina Ž, Laurinavičius A, Valius M, Vilkaitis G.
PMID: 31810268
J Clin Med. 2019 Dec 02;8(12). doi: 10.3390/jcm8122115.

Although treatment of colorectal cancer with 5-florouracil and oxaliplatin is widely used, it is frequently followed by a relapse. Therefore, there is an urgent need for profound understanding of chemotherapy resistance mechanisms as well as the profiling of predictive...

Biocompatibility Investigation of Hybrid Organometallic Polymers for Sub-Micron 3D Printing via Laser Two-Photon Polymerisation.

Materials (Basel, Switzerland)

Balčiūnas E, Dreižė N, Grubliauskaitė M, Urnikytė S, Šimoliūnas E, Bukelskienė V, Valius M, Baldock SJ, Hardy JG, Baltriukienė D.
PMID: 31783647
Materials (Basel). 2019 Nov 27;12(23). doi: 10.3390/ma12233932.

Hybrid organometallic polymers are a class of functional materials which can be used to produce structures with sub-micron features via laser two-photon polymerisation. Previous studies demonstrated the relative biocompatibility of Al and Zr containing hybrid organometallic polymers in vitro....

The Poor "Wealth" of Brazilian Football: How Poverty May Shape Skill and Expertise of Players.

Frontiers in sports and active living

Uehara L, Falcous M, Button C, Davids K, Araújo D, de Paula AR, Saunders J.
PMID: 33778485
Front Sports Act Living. 2021 Mar 11;3:635241. doi: 10.3389/fspor.2021.635241. eCollection 2021.

Worldwide, 1.3 billion people live in

Adherence to European Association of Urology and National Comprehensive Cancer Network Guidelines Criteria for Inguinal and Pelvic Lymph Node Dissection in Penile Cancer Patients-A Survey Assessment in German-speaking Countries on Behalf of the European Prospective Penile Cancer Study Group.

European urology focus

Suarez-Ibarrola R, Zengerling F, Haccius M, Lebentrau S, Schmid HP, Bier M, Lenart S, Distler FA, Resch I, Oelschlager M, May M, Bolenz C, Gratzke C, Miernik A, Wakileh GA.
PMID: 32089496
Eur Urol Focus. 2021 Jul;7(4):843-849. doi: 10.1016/j.euf.2020.02.005. Epub 2020 Feb 20.

BACKGROUND: Urologists' adherence to European Association of Urology and National Comprehensive Cancer Network guideline recommendations to perform inguinal (ILND) and pelvic (PLND) lymph node dissection in penile cancer (PC) patients is not known.OBJECTIVE: To assess a German-speaking European cohort...

[Knowledge of German-speaking urologists regarding the association between penile cancer and human papilloma virus: results of a survey of the European PROspective Penile Cancer Study (E-PROPS)].

Aktuelle Urologie

Lebentrau S, Wolff I, Hempel MC, Haccius M, Kluth LA, Pycha A, Brookman-May S, Schneider TR, Hermanns T, Distler FA, Boegemann M, Kübler H, Shariat SF, Burger M, May M.
PMID: 31745963
Aktuelle Urol. 2019 Nov 19; doi: 10.1055/a-1032-8086. Epub 2019 Nov 19.

BACKGROUND:  A recent meta-analysis showed that penile cancer (PeC) is associated with the human papilloma virus (HPV) in 50 % of patients in Europe. It is unknown whether urologists are aware of the impact of viral carcinogenesis.METHODS:  A (German-language)...

Assessing Climate Change Impacts on Wildfire Exposure in Mediterranean Areas.

Risk analysis : an official publication of the Society for Risk Analysis

Lozano OM, Salis M, Ager AA, Arca B, Alcasena FJ, Monteiro AT, Finney MA, Del Giudice L, Scoccimarro E, Spano D.
PMID: 27996154
Risk Anal. 2017 Oct;37(10):1898-1916. doi: 10.1111/risa.12739. Epub 2016 Dec 20.

We used simulation modeling to assess potential climate change impacts on wildfire exposure in Italy and Corsica (France). Weather data were obtained from a regional climate model for the period 1981-2070 using the IPCC A1B emissions scenario. Wildfire simulations...

Showing 1 to 12 of 44 entries