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Showing 1 to 12 of 51 entries
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Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types.

Nature medicine

Hause RJ, Pritchard CC, Shendure J, Salipante SJ.
PMID: 28985213
Nat Med. 2017 Oct 06;23(10):1241. doi: 10.1038/nm1017-1241a.

This corrects the article DOI: 10.1038/nm.4191.

Jetting of a shear banding fluid in rectangular ducts.

Physical review fluids

Salipante PF, Little CAE, Hudson SD.
PMID: 28691108
Phys Rev Fluids. 2017 Mar;2(3). doi: 10.1103/PhysRevFluids.2.033302. Epub 2017 Mar 14.

Non-Newtonian fluids are susceptible to flow instabilities such as shear banding, in which the fluid may exhibit a markedly discontinuous viscosity at a critical stress. Here we report the characteristics and causes of a jetting flow instability of shear...

Flow Resistance and Structures in Viscoelastic Channel Flows at Low Re.

Physical review letters

Qin B, Salipante PF, Hudson SD, Arratia PE.
PMID: 31765176
Phys Rev Lett. 2019 Nov 08;123(19):194501. doi: 10.1103/PhysRevLett.123.194501.

The flow of viscoelastic fluids in channels and pipes remains poorly understood, particularly at low Reynolds numbers. Here, we investigate the flow of polymeric solutions in straight channels using pressure measurements and particle tracking. The flow friction factor f_{η}...

Blood vessel-on-a-chip examines the biomechanics of microvasculature.

Soft matter

Salipante PF, Hudson SD, Alimperti S.
PMID: 34816867
Soft Matter. 2021 Nov 24; doi: 10.1039/d1sm01312b. Epub 2021 Nov 24.

We use a three-dimensional (3D) microvascular platform to measure the elasticity and membrane permeability of the endothelial cell layer. The microfluidic platform is connected with a pneumatic pressure controller to apply hydrostatic pressure. The deformation is measured by tracking...

Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancer.

JCI insight

De Sarkar N, Dasgupta S, Chatterjee P, Coleman I, Ha G, Ang LS, Kohlbrenner EA, Frank SB, Nunez TA, Salipante SJ, Corey E, Morrissey C, Van Allen E, Schweizer MT, Haffner MC, Patel R, Hanratty B, Lucas JM, Dumpit RF, Pritchard CC, Montgomery RB, Nelson PS.
PMID: 34877933
JCI Insight. 2021 Dec 08;6(23). doi: 10.1172/jci.insight.152789.

Cancers with homology-directed DNA repair (HRR) deficiency exhibit high response rates to poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum chemotherapy. Though mutations disrupting BRCA1 and BRCA2 associate with HRR deficiency (HRRd), patterns of genomic aberrations and mutation signatures may be...

Characterizing the molecular composition and diagnostic potential of Mycobacterium tuberculosis urinary cell-free DNA using next-generation sequencing.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Oreskovic A, Waalkes A, Holmes EA, Rosenthal CA, Wilson DPK, Shapiro AE, Drain PK, Lutz BR, Salipante SJ.
PMID: 34562627
Int J Infect Dis. 2021 Nov;112:330-337. doi: 10.1016/j.ijid.2021.09.042. Epub 2021 Sep 22.

BACKGROUND: Urine cell-free DNA (cfDNA) is an attractive target for diagnosing pulmonary Mycobacterium tuberculosis (MTB) infection, but has not been thoroughly characterized as a biomarker.METHODS: This study was performed to investigate the size and composition of urine cfDNA from...

Erratum for Penewit et al., "Efficient and Scalable Precision Genome Editing in Staphylococcus aureus through Conditional Recombineering and CRISPR/Cas9-Mediated Counterselection".

mBio

Penewit K, Holmes EA, McLean K, Ren M, Waalkes A, Salipante SJ.
PMID: 30647160
mBio. 2019 Jan 15;10(1). doi: 10.1128/mBio.02698-18.

No abstract available.

Whole Genome Sequencing of Peruvian .

Open forum infectious diseases

Roach D, Waalkes A, Abanto J, Zunt J, Cucho C, Soria J, Salipante SJ.
PMID: 32760750
Open Forum Infect Dis. 2020 Jul 02;7(8):ofaa266. doi: 10.1093/ofid/ofaa266. eCollection 2020 Aug.

METHODS: In this study, using whole genome sequencing, we show that 3 distinct lineages encompass almost all CRKP identified in the hospital where it was first reported in Peru.RESULTS: The most prevalent lineage, ST348, has not been described outside...

Three-dimensional structures and symmetry breaking in viscoelastic cross-channel flow.

Soft matter

Qin B, Ran R, Salipante PF, Hudson SD, Arratia PE.
PMID: 32525504
Soft Matter. 2020 Aug 14;16(30):6969-6974. doi: 10.1039/d0sm00555j. Epub 2020 Jun 11.

Using holographic particle tracking, we report the three-dimensional flow structure organizing the viscoelastic instability in cross-channel flow. Beyond a critical Wi, the advective core flow undergoes an out-of-plane instability marked by the emergence of tertiary flow, resembling that of...

Neutrophilic inflammation in gallbladder carcinoma correlates with patient survival: A case-control study.

Annals of diagnostic pathology

Bosch DE, Salipante SJ, Schmidt RA, Swanson PE, Bryan A, SenGupta DJ, Truong CD, Yeh MM.
PMID: 34763224
Ann Diagn Pathol. 2021 Oct 30;56:151845. doi: 10.1016/j.anndiagpath.2021.151845. Epub 2021 Oct 30.

Gallbladder carcinoma is an uncommon malignancy with an overall 5-year survival of less than 5%. Gallbladder carcinoma has been strongly linked with cholelithiasis and chronic inflammation. Case reports and series have described cholecystitis with acute (neutrophilic) inflammation in association...

A population-level strain genotyping method to study pathogen strain dynamics in human infections.

JCI insight

Morgan SJ, Durfey SL, Ravishankar S, Jorth P, Ni W, Skerrett DT, Aitken ML, McKone EF, Salipante SJ, Radey MC, Singh PK.
PMID: 34935640
JCI Insight. 2021 Dec 22;6(24). doi: 10.1172/jci.insight.152472.

A hallmark of chronic bacterial infections is the long-term persistence of 1 or more pathogen species at the compromised site. Repeated detection of the same bacterial species can suggest that a single strain or lineage is continually present. However,...

Entrance effects and high shear rate rheology of shear banding wormlike micelle fluids in a microcapillary flow.

Journal of rheology

Salipante PF, Dharmaraj V, Hudson SD.
PMID: 33071392
J Rheol (N Y N Y). 2020;64(3).

The viscosity of a shear-banding wormlike micelle solution at high shear rates is investigated using capillary rheology and particle streak velocimetry. Measurements of the flow profile and pressure gradient show an extended entrance region, which exceeds a length to...

Showing 1 to 12 of 51 entries