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Showing 1 to 12 of 12 entries
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Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.

International journal of molecular epidemiology and genetics

Curtin K, Ulrich CM, Samowitz WS, Wolff RK, Duggan DJ, Makar KW, Caan BJ, Slattery ML.
PMID: 21537397
Int J Mol Epidemiol Genet. 2011 Jan 01;2(1):1-8. Epub 2010 Nov 05.

We examined candidate polymorphisms in genes involved in the folate-mediated, one-carbon metabolism pathway, DNMT1 1311V, MTHFD1 R134K and R653Q, MTHFR R594Q, MTR D919G, MTRR H595Y and I22M, SHMT1 L474F, SLC19A1 H27R, and TDG G199S, and associations with rectal tumor...

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Curtin K, Ulrich CM, Samowitz WS, et al. Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. Int J Mol Epidemiol Genet. 2010;2(1):1-8
Curtin, K., Ulrich, C. M., Samowitz, W. S., Wolff, R. K., Duggan, D. J., Makar, K. W., Caan, B. J., & Slattery, M. L. (2011). Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. International journal of molecular epidemiology and genetics, 2(1), 1-8.
Curtin, Karen, et al. "Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations." International journal of molecular epidemiology and genetics vol. 2,1 (2011): 1-8.
Curtin K, Ulrich CM, Samowitz WS, Wolff RK, Duggan DJ, Makar KW, Caan BJ, Slattery ML. Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. Int J Mol Epidemiol Genet. 2011 Jan 01;2(1):1-8. Epub 2010 Nov 05. PMID: 21537397; PMCID: PMC3077233.
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CpG island methylation in colorectal cancer: past, present and future.

Pathology research international

Curtin K, Slattery ML, Samowitz WS.
PMID: 21559209
Patholog Res Int. 2011 Apr 12;2011:902674. doi: 10.4061/2011/902674.

The concept of a CpG island methylator phenotype, or CIMP, quickly became the focus of several colorectal cancer studies describing its clinical and pathological features after its introduction in 1999 by Toyota and colleagues. Further characterization of CIMP in...

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Curtin K, Slattery ML, Samowitz WS. CpG island methylation in colorectal cancer: past, present and future. Patholog Res Int. 2011;2011:902674doi: 10.4061/2011/902674.
Curtin, K., Slattery, M. L., & Samowitz, W. S. (2011). CpG island methylation in colorectal cancer: past, present and future. Pathology research international, 2011902674. https://doi.org/10.4061/2011/902674
Curtin, Karen, et al. "CpG island methylation in colorectal cancer: past, present and future." Pathology research international vol. 2011 (2011): 902674. doi: https://doi.org/10.4061/2011/902674
Curtin K, Slattery ML, Samowitz WS. CpG island methylation in colorectal cancer: past, present and future. Patholog Res Int. 2011 Apr 12;2011:902674. doi: 10.4061/2011/902674. PMID: 21559209; PMCID: PMC3090226.
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Expression Profiles of miRNA Subsets Distinguish Human Colorectal Carcinoma and Normal Colonic Mucosa.

Clinical and translational gastroenterology

Pellatt DF, Stevens JR, Wolff RK, Mullany LE, Herrick JS, Samowitz W, Slattery ML.
PMID: 26963002
Clin Transl Gastroenterol. 2016 Mar 10;7:e152. doi: 10.1038/ctg.2016.11.

OBJECTIVES: MicroRNAs (miRNAs) are small, non-protein-coding RNA molecules that are commonly dysregulated in colorectal tumors. The objective of this study was to identify smaller subsets of highly predictive miRNAs.METHODS: Data come from population-based studies of colorectal cancer conducted in...

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Pellatt DF, Stevens JR, Wolff RK, et al. Expression Profiles of miRNA Subsets Distinguish Human Colorectal Carcinoma and Normal Colonic Mucosa. Clin Transl Gastroenterol. 2016;7:e152doi: 10.1038/ctg.2016.11.
Pellatt, D. F., Stevens, J. R., Wolff, R. K., Mullany, L. E., Herrick, J. S., Samowitz, W., & Slattery, M. L. (2016). Expression Profiles of miRNA Subsets Distinguish Human Colorectal Carcinoma and Normal Colonic Mucosa. Clinical and translational gastroenterology, 7e152. https://doi.org/10.1038/ctg.2016.11
Pellatt, Daniel F, et al. "Expression Profiles of miRNA Subsets Distinguish Human Colorectal Carcinoma and Normal Colonic Mucosa." Clinical and translational gastroenterology vol. 7 (2016): e152. doi: https://doi.org/10.1038/ctg.2016.11
Pellatt DF, Stevens JR, Wolff RK, Mullany LE, Herrick JS, Samowitz W, Slattery ML. Expression Profiles of miRNA Subsets Distinguish Human Colorectal Carcinoma and Normal Colonic Mucosa. Clin Transl Gastroenterol. 2016 Mar 10;7:e152. doi: 10.1038/ctg.2016.11. PMID: 26963002; PMCID: PMC4822091.
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MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer.

Genes & cancer

Mullany LE, Herrick JS, Sakoda LC, Samowitz W, Stevens JR, Wolff RK, Slattery ML.
PMID: 30603058
Genes Cancer. 2018 May;9(5):232-246. doi: 10.18632/genesandcancer.177.

JAK-STAT signaling influences many downstream processes that, unchecked, contribute to carcinogenesis and metastasis. MicroRNAs (miRNAs) are hypothesized as a mechanism to prevent uncontrolled growth from continuous JAK-STAT activation. We investigated differential expression between paired carcinoma and normal colorectal mucosa...

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Mullany LE, Herrick JS, Sakoda LC, et al. MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer. Genes Cancer. 2018;9(5):232-246doi: 10.18632/genesandcancer.177.
Mullany, L. E., Herrick, J. S., Sakoda, L. C., Samowitz, W., Stevens, J. R., Wolff, R. K., & Slattery, M. L. (2018). MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer. Genes & cancer, 9(5), 232-246. https://doi.org/10.18632/genesandcancer.177
Mullany, Lila E, et al. "MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer." Genes & cancer vol. 9,5 (2018): 232-246. doi: https://doi.org/10.18632/genesandcancer.177
Mullany LE, Herrick JS, Sakoda LC, Samowitz W, Stevens JR, Wolff RK, Slattery ML. MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer. Genes Cancer. 2018 May;9(5):232-246. doi: 10.18632/genesandcancer.177. PMID: 30603058; PMCID: PMC6305104.
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miRNA involvement in cell cycle regulation in colorectal cancer cases.

Genes & cancer

Mullany LE, Herrick JS, Sakoda LC, Samowitz W, Stevens JR, Wolff RK, Slattery ML.
PMID: 29725503
Genes Cancer. 2018 Jan;9(1):53-65. doi: 10.18632/genesandcancer.167.

Uncontrolled cell replication is a key component of carcinogenesis. MicroRNAs (miRNAs) regulate genes involved in checkpoints, DNA repair, and genes encoding for key proteins regulating the cell cycle. We investigated how miRNAs and mRNAs in colorectal cancer subjects interact...

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Mullany LE, Herrick JS, Sakoda LC, et al. miRNA involvement in cell cycle regulation in colorectal cancer cases. Genes Cancer. 2018;9(1):53-65doi: 10.18632/genesandcancer.167.
Mullany, L. E., Herrick, J. S., Sakoda, L. C., Samowitz, W., Stevens, J. R., Wolff, R. K., & Slattery, M. L. (2018). miRNA involvement in cell cycle regulation in colorectal cancer cases. Genes & cancer, 9(1), 53-65. https://doi.org/10.18632/genesandcancer.167
Mullany, Lila E, et al. "miRNA involvement in cell cycle regulation in colorectal cancer cases." Genes & cancer vol. 9,1 (2018): 53-65. doi: https://doi.org/10.18632/genesandcancer.167
Mullany LE, Herrick JS, Sakoda LC, Samowitz W, Stevens JR, Wolff RK, Slattery ML. miRNA involvement in cell cycle regulation in colorectal cancer cases. Genes Cancer. 2018 Jan;9(1):53-65. doi: 10.18632/genesandcancer.167. PMID: 29725503; PMCID: PMC5931252.
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Targeting the Root Cause of Mucopolysaccharidosis IIIA with a New scAAV9 Gene Replacement Vector.

Molecular therapy. Methods & clinical development

Bobo TA, Samowitz PN, Robinson MI, Fu H.
PMID: 33313335
Mol Ther Methods Clin Dev. 2020 Oct 22;19:474-485. doi: 10.1016/j.omtm.2020.10.014. eCollection 2020 Dec 11.

No treatment is available to address the unmet needs of mucopolysaccharidosis (MPS) IIIA patients. Targeting the root cause, we developed a new self-complementary adeno-associated virus 9 (scAAV9) vector to deliver the human

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Bobo TA, Samowitz PN, Robinson MI, et al. Targeting the Root Cause of Mucopolysaccharidosis IIIA with a New scAAV9 Gene Replacement Vector. Mol Ther Methods Clin Dev. 2020;19:474-485doi: 10.1016/j.omtm.2020.10.014.
Bobo, T. A., Samowitz, P. N., Robinson, M. I., & Fu, H. (2020). Targeting the Root Cause of Mucopolysaccharidosis IIIA with a New scAAV9 Gene Replacement Vector. Molecular therapy. Methods & clinical development, 19474-485. https://doi.org/10.1016/j.omtm.2020.10.014
Bobo, Tierra A, et al. "Targeting the Root Cause of Mucopolysaccharidosis IIIA with a New scAAV9 Gene Replacement Vector." Molecular therapy. Methods & clinical development vol. 19 (2020): 474-485. doi: https://doi.org/10.1016/j.omtm.2020.10.014
Bobo TA, Samowitz PN, Robinson MI, Fu H. Targeting the Root Cause of Mucopolysaccharidosis IIIA with a New scAAV9 Gene Replacement Vector. Mol Ther Methods Clin Dev. 2020 Oct 22;19:474-485. doi: 10.1016/j.omtm.2020.10.014. eCollection 2020 Dec 11. PMID: 33313335; PMCID: PMC7704409.
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Infrequently expressed miRNAs influence survival after diagnosis with colorectal cancer.

Oncotarget

Slattery ML, Pellatt AJ, Lee FY, Herrick JS, Samowitz WS, Stevens JR, Wolff RK, Mullany LE.
PMID: 29137387
Oncotarget. 2017 Aug 03;8(48):83845-83859. doi: 10.18632/oncotarget.19863. eCollection 2017 Oct 13.

Half of miRNAs expressed in colorectal tissue are expressed < 50% of the population. Many infrequently expressed miRNAs have low levels of expression. We hypothesize that less frequently expressed miRNAs, when expressed at higher levels, influence both disease stage...

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Slattery ML, Pellatt AJ, Lee FY, et al. Infrequently expressed miRNAs influence survival after diagnosis with colorectal cancer. Oncotarget. 2017;8(48):83845-83859doi: 10.18632/oncotarget.19863.
Slattery, M. L., Pellatt, A. J., Lee, F. Y., Herrick, J. S., Samowitz, W. S., Stevens, J. R., Wolff, R. K., & Mullany, L. E. (2017). Infrequently expressed miRNAs influence survival after diagnosis with colorectal cancer. Oncotarget, 8(48), 83845-83859. https://doi.org/10.18632/oncotarget.19863
Slattery, Martha L, et al. "Infrequently expressed miRNAs influence survival after diagnosis with colorectal cancer." Oncotarget vol. 8,48 (2017): 83845-83859. doi: https://doi.org/10.18632/oncotarget.19863
Slattery ML, Pellatt AJ, Lee FY, Herrick JS, Samowitz WS, Stevens JR, Wolff RK, Mullany LE. Infrequently expressed miRNAs influence survival after diagnosis with colorectal cancer. Oncotarget. 2017 Aug 03;8(48):83845-83859. doi: 10.18632/oncotarget.19863. eCollection 2017 Oct 13. PMID: 29137387; PMCID: PMC5663559.
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Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer.

Oncotarget

Slattery ML, Mullany LE, Sakoda LC, Samowitz WS, Wolff RK, Stevens JR, Herrick JS.
PMID: 29464056
Oncotarget. 2017 Dec 23;9(5):6075-6085. doi: 10.18632/oncotarget.23636. eCollection 2018 Jan 19.

The Wnt-signaling pathway functions in regulating cell growth and thus is involved in the carcinogenic process of several cancers, including colorectal cancer. We tested the hypothesis that multiple genes in this signaling pathway are dysregulated and that miRNAs are...

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Slattery ML, Mullany LE, Sakoda LC, et al. Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer. Oncotarget. 2017;9(5):6075-6085doi: 10.18632/oncotarget.23636.
Slattery, M. L., Mullany, L. E., Sakoda, L. C., Samowitz, W. S., Wolff, R. K., Stevens, J. R., & Herrick, J. S. (2018). Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer. Oncotarget, 9(5), 6075-6085. https://doi.org/10.18632/oncotarget.23636
Slattery, Martha L, et al. "Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer." Oncotarget vol. 9,5 (2018): 6075-6085. doi: https://doi.org/10.18632/oncotarget.23636
Slattery ML, Mullany LE, Sakoda LC, Samowitz WS, Wolff RK, Stevens JR, Herrick JS. Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer. Oncotarget. 2017 Dec 23;9(5):6075-6085. doi: 10.18632/oncotarget.23636. eCollection 2018 Jan 19. PMID: 29464056; PMCID: PMC5814196.
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A 30-Year-Old Man with Three Primary Malignancies: A Case of Constitutional Mismatch Repair Deficiency.

ACG case reports journal

Rengifo-Cam W, Jasperson K, Garrido-Laguna I, Colman H, Scaife C, Samowitz W, Samadder NJ.
PMID: 28286799
ACG Case Rep J. 2017 Mar 01;4:e34. doi: 10.14309/crj.2017.34. eCollection 2017.

Constitutional mismatch repair deficiency (CMMRD) is a devastating cancer predisposition syndrome for which clinical manifestations, genetic screening, and cancer prevention strategies are limited. We report a case of CMMRD presenting with metachronous colorectal cancer and brain cancer. Oncologists and...

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Rengifo-Cam W, Jasperson K, Garrido-Laguna I, et al. A 30-Year-Old Man with Three Primary Malignancies: A Case of Constitutional Mismatch Repair Deficiency. ACG Case Rep J. 2017;4:e34doi: 10.14309/crj.2017.34.
Rengifo-Cam, W., Jasperson, K., Garrido-Laguna, I., Colman, H., Scaife, C., Samowitz, W., & Samadder, N. J. (2017). A 30-Year-Old Man with Three Primary Malignancies: A Case of Constitutional Mismatch Repair Deficiency. ACG case reports journal, 4e34. https://doi.org/10.14309/crj.2017.34
Rengifo-Cam, William, et al. "A 30-Year-Old Man with Three Primary Malignancies: A Case of Constitutional Mismatch Repair Deficiency." ACG case reports journal vol. 4 (2017): e34. doi: https://doi.org/10.14309/crj.2017.34
Rengifo-Cam W, Jasperson K, Garrido-Laguna I, Colman H, Scaife C, Samowitz W, Samadder NJ. A 30-Year-Old Man with Three Primary Malignancies: A Case of Constitutional Mismatch Repair Deficiency. ACG Case Rep J. 2017 Mar 01;4:e34. doi: 10.14309/crj.2017.34. eCollection 2017. PMID: 28286799; PMCID: PMC5340720.
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Molecular Pathology of Gastrointestinal Cancer.

Surgical pathology clinics

Yantiss RK, Samowitz WS.
PMID: 26838505
Surg Pathol Clin. 2012 Dec;5(4):821-42. doi: 10.1016/j.path.2012.08.002. Epub 2012 Sep 30.

The purpose of this review is to discuss important molecular changes that aid decision making in patient management and play a role in emerging treatment strategies for gastrointestinal malignancies. Although screening and surveillance practices have had an impact on...

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Yantiss RK, Samowitz WS. Molecular Pathology of Gastrointestinal Cancer. Surg Pathol Clin. 2012;5(4):821-42doi: 10.1016/j.path.2012.08.002.
Yantiss, R. K., & Samowitz, W. S. (2012). Molecular Pathology of Gastrointestinal Cancer. Surgical pathology clinics, 5(4), 821-42. https://doi.org/10.1016/j.path.2012.08.002
Yantiss, Rhonda K, and Samowitz, Wade S. "Molecular Pathology of Gastrointestinal Cancer." Surgical pathology clinics vol. 5,4 (2012): 821-42. doi: https://doi.org/10.1016/j.path.2012.08.002
Yantiss RK, Samowitz WS. Molecular Pathology of Gastrointestinal Cancer. Surg Pathol Clin. 2012 Dec;5(4):821-42. doi: 10.1016/j.path.2012.08.002. Epub 2012 Sep 30. PMID: 26838505.
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The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs.

Cancer informatics

Slattery ML, Mullany LE, Sakoda LC, Wolff RK, Samowitz WS, Herrick JS.
PMID: 29636593
Cancer Inform. 2018 Mar 26;17:1176935118766522. doi: 10.1177/1176935118766522. eCollection 2018.

Mitogen-activated protein kinase (MAPK) pathways regulate many cellular functions including cell proliferation and apoptosis. We examined associations of differential gene and microRNA (miRNA) expression between carcinoma and paired normal mucosa for 241 genes in the KEGG-identified MAPK-signaling pathway among...

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Slattery ML, Mullany LE, Sakoda LC, et al. The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs. Cancer Inform. 2018;17:1176935118766522doi: 10.1177/1176935118766522.
Slattery, M. L., Mullany, L. E., Sakoda, L. C., Wolff, R. K., Samowitz, W. S., & Herrick, J. S. (2018). The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs. Cancer informatics, 171176935118766522. https://doi.org/10.1177/1176935118766522
Slattery, Martha L, et al. "The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs." Cancer informatics vol. 17 (2018): 1176935118766522. doi: https://doi.org/10.1177/1176935118766522
Slattery ML, Mullany LE, Sakoda LC, Wolff RK, Samowitz WS, Herrick JS. The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs. Cancer Inform. 2018 Mar 26;17:1176935118766522. doi: 10.1177/1176935118766522. eCollection 2018. PMID: 29636593; PMCID: PMC5888819.
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Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Slattery ML, Lee FY, Pellatt AJ, Mullany LE, Stevens JR, Samowitz WS, Wolff RK, Herrick JS.
PMID: 29302080
Mod Pathol. 2018 Jan;31(1):209. doi: 10.1038/modpathol.2017.118.

This corrects the article DOI: 10.1038/modpathol.2017.38.

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Slattery ML, Lee FY, Pellatt AJ, et al. Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype. Mod Pathol. 2018;31(1):209doi: 10.1038/modpathol.2017.118.
Slattery, M. L., Lee, F. Y., Pellatt, A. J., Mullany, L. E., Stevens, J. R., Samowitz, W. S., Wolff, R. K., & Herrick, J. S. (2018). Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 31(1), 209. https://doi.org/10.1038/modpathol.2017.118
Slattery, Martha L, et al. "Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 31,1 (2018): 209. doi: https://doi.org/10.1038/modpathol.2017.118
Slattery ML, Lee FY, Pellatt AJ, Mullany LE, Stevens JR, Samowitz WS, Wolff RK, Herrick JS. Infrequently expressed miRNAs in colorectal cancer tissue and tumor molecular phenotype. Mod Pathol. 2018 Jan;31(1):209. doi: 10.1038/modpathol.2017.118. PMID: 29302080; PMCID: PMC7609336.
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Showing 1 to 12 of 12 entries