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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

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Li S, Weinstein G, Zare H, et al. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020;2(2):fcaa176doi: 10.1093/braincomms/fcaa176.
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H. H. H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications, 2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
Li, Shuo, et al. "The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages." Brain communications vol. 2,2 (2020): fcaa176. doi: https://doi.org/10.1093/braincomms/fcaa176
Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020. PMID: 33345186; PMCID: PMC7734441.
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Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study.

Neurology

Fohner AE, Bartz TM, Tracy RP, Adams HHH, Bis JC, Djousse L, Satizabal CL, Lopez OL, Seshadri S, Mukamal KJ, Kuller LH, Psaty BM, Longstreth WT.
PMID: 34921102
Neurology. 2021 Dec 17; doi: 10.1212/WNL.0000000000013229. Epub 2021 Dec 17.

BACKGROUND AND OBJECTIVES: Neurofilament light chain (NfL) in blood is a sensitive but non-specific marker of brain injury. This study sought to evaluate associations between NfL concentration and MRI findings of vascular brain injury in older adults.METHODS: A longitudinal...

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Fohner AE, Bartz TM, Tracy RP, et al. Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study. Neurology. 2021;doi: 10.1212/WNL.0000000000013229.
Fohner, A. E., Bartz, T. M., Tracy, R. P., Adams, H. H. H., Bis, J. C., Djousse, L., Satizabal, C. L., Lopez, O. L., Seshadri, S., Mukamal, K. J., Kuller, L. H., Psaty, B. M., & Longstreth, W. T. (2021). Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study. Neurology, . https://doi.org/10.1212/WNL.0000000000013229
Fohner, Alison E, et al. "Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study." Neurology vol. (2021). doi: https://doi.org/10.1212/WNL.0000000000013229
Fohner AE, Bartz TM, Tracy RP, Adams HHH, Bis JC, Djousse L, Satizabal CL, Lopez OL, Seshadri S, Mukamal KJ, Kuller LH, Psaty BM, Longstreth WT. Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study. Neurology. 2021 Dec 17; doi: 10.1212/WNL.0000000000013229. Epub 2021 Dec 17. PMID: 34921102.
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Association of low-frequency and rare coding variants with information processing speed.

Translational psychiatry

Bressler J, Davies G, Smith AV, Saba Y, Bis JC, Jian X, Hayward C, Yanek L, Smith JA, Mirza SS, Wang R, Adams HHH, Becker D, Boerwinkle E, Campbell A, Cox SR, Eiriksdottir G, Fawns-Ritchie C, Gottesman RF, Grove ML, Guo X, Hofer E, Kardia SLR, Knol MJ, Koini M, Lopez OL, Marioni RE, Nyquist P, Pattie A, Polasek O, Porteous DJ, Rudan I, Satizabal CL, Schmidt H, Schmidt R, Sidney S, Simino J, Smith BH, Turner ST, van der Lee SJ, Ware EB, Whitmer RA, Yaffe K, Yang Q, Zhao W, Gudnason V, Launer LJ, Fitzpatrick AL, Psaty BM, Fornage M, Arfan Ikram M, van Duijn CM, Seshadri S, Mosley TH, Deary IJ.
PMID: 34864818
Transl Psychiatry. 2021 Dec 04;11(1):613. doi: 10.1038/s41398-021-01736-6.

Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare...

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Bressler J, Davies G, Smith AV, et al. Association of low-frequency and rare coding variants with information processing speed. Transl Psychiatry. 2021;11(1):613doi: 10.1038/s41398-021-01736-6.
Bressler, J., Davies, G., Smith, A. V., Saba, Y., Bis, J. C., Jian, X., Hayward, C., Yanek, L., Smith, J. A., Mirza, S. S., Wang, R., Adams, H. H. H., Becker, D., Boerwinkle, E., Campbell, A., Cox, S. R., Eiriksdottir, G., Fawns-Ritchie, C., Gottesman, R. F., Grove, M. L., Guo, X., Hofer, E., Kardia, S. L. R., Knol, M. J., Koini, M., Lopez, O. L., Marioni, R. E., Nyquist, P., Pattie, A., Polasek, O., Porteous, D. J., Rudan, I., Satizabal, C. L., Schmidt, H., Schmidt, R., Sidney, S., Simino, J., Smith, B. H., Turner, S. T., van der Lee, S. J., Ware, E. B., Whitmer, R. A., Yaffe, K., Yang, Q., Zhao, W., Gudnason, V., Launer, L. J., Fitzpatrick, A. L., Psaty, B. M., Fornage, M., Arfan Ikram, M., van Duijn, C. M., Seshadri, S., Mosley, T. H., & Deary, I. J. (2021). Association of low-frequency and rare coding variants with information processing speed. Translational psychiatry, 11(1), 613. https://doi.org/10.1038/s41398-021-01736-6
Bressler, Jan, et al. "Association of low-frequency and rare coding variants with information processing speed." Translational psychiatry vol. 11,1 (2021): 613. doi: https://doi.org/10.1038/s41398-021-01736-6
Bressler J, Davies G, Smith AV, Saba Y, Bis JC, Jian X, Hayward C, Yanek L, Smith JA, Mirza SS, Wang R, Adams HHH, Becker D, Boerwinkle E, Campbell A, Cox SR, Eiriksdottir G, Fawns-Ritchie C, Gottesman RF, Grove ML, Guo X, Hofer E, Kardia SLR, Knol MJ, Koini M, Lopez OL, Marioni RE, Nyquist P, Pattie A, Polasek O, Porteous DJ, Rudan I, Satizabal CL, Schmidt H, Schmidt R, Sidney S, Simino J, Smith BH, Turner ST, van der Lee SJ, Ware EB, Whitmer RA, Yaffe K, Yang Q, Zhao W, Gudnason V, Launer LJ, Fitzpatrick AL, Psaty BM, Fornage M, Arfan Ikram M, van Duijn CM, Seshadri S, Mosley TH, Deary IJ. Association of low-frequency and rare coding variants with information processing speed. Transl Psychiatry. 2021 Dec 04;11(1):613. doi: 10.1038/s41398-021-01736-6. PMID: 34864818; PMCID: PMC8643353.
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Plasma EFEMP1 Is Associated with Brain Aging and Dementia: The Framingham Heart Study.

Journal of Alzheimer's disease : JAD

McGrath ER, Himali JJ, Levy D, Yang Q, DeCarli CS, Courchesne P, Satizabal CL, Finney R, Vasan RS, Beiser AS, Seshadri S.
PMID: 34958018
J Alzheimers Dis. 2021 Dec 20; doi: 10.3233/JAD-215053. Epub 2021 Dec 20.

BACKGROUND: Epidermal growth factor containing fibulin extracellular matrix protein-1 (EFEMP1) has been associated with increased white matter hyperintensities (WMH) burden and disorders of premature aging and may have a shared pathophysiological role in the development of WMH and dementia.OBJECTIVE:...

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McGrath ER, Himali JJ, Levy D, et al. Plasma EFEMP1 Is Associated with Brain Aging and Dementia: The Framingham Heart Study. J Alzheimers Dis. 2021;doi: 10.3233/JAD-215053.
McGrath, E. R., Himali, J. J., Levy, D., Yang, Q., DeCarli, C. S., Courchesne, P., Satizabal, C. L., Finney, R., Vasan, R. S., Beiser, A. S., & Seshadri, S. (2021). Plasma EFEMP1 Is Associated with Brain Aging and Dementia: The Framingham Heart Study. Journal of Alzheimer's disease : JAD, . https://doi.org/10.3233/JAD-215053
McGrath, Emer R, et al. "Plasma EFEMP1 Is Associated with Brain Aging and Dementia: The Framingham Heart Study." Journal of Alzheimer's disease : JAD vol. (2021). doi: https://doi.org/10.3233/JAD-215053
McGrath ER, Himali JJ, Levy D, Yang Q, DeCarli CS, Courchesne P, Satizabal CL, Finney R, Vasan RS, Beiser AS, Seshadri S. Plasma EFEMP1 Is Associated with Brain Aging and Dementia: The Framingham Heart Study. J Alzheimers Dis. 2021 Dec 20; doi: 10.3233/JAD-215053. Epub 2021 Dec 20. PMID: 34958018.
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Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study.

Journal of Alzheimer's disease : JAD

Spartano NL, Himali JJ, Trinquart L, Yang Q, Weinstein G, Satizabal CL, Dukes KA, Beiser AS, Murabito JM, Vasan RS, Seshadri S.
PMID: 34864673
J Alzheimers Dis. 2021 Nov 29; doi: 10.3233/JAD-215109. Epub 2021 Nov 29.

BACKGROUND: One of the mechanisms suggested to link physical activity (PA) to favorable brain health is through stimulation of neural growth factors such as brain-derived neurotrophic factor (BDNF). Acute bouts of PA stimulate circulating BDNF levels.OBJECTIVE: In this investigation,...

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Spartano NL, Himali JJ, Trinquart L, et al. Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study. J Alzheimers Dis. 2021;doi: 10.3233/JAD-215109.
Spartano, N. L., Himali, J. J., Trinquart, L., Yang, Q., Weinstein, G., Satizabal, C. L., Dukes, K. A., Beiser, A. S., Murabito, J. M., Vasan, R. S., & Seshadri, S. (2021). Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study. Journal of Alzheimer's disease : JAD, . https://doi.org/10.3233/JAD-215109
Spartano, Nicole L, et al. "Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study." Journal of Alzheimer's disease : JAD vol. (2021). doi: https://doi.org/10.3233/JAD-215109
Spartano NL, Himali JJ, Trinquart L, Yang Q, Weinstein G, Satizabal CL, Dukes KA, Beiser AS, Murabito JM, Vasan RS, Seshadri S. Accelerometer-Measured, Habitual Physical Activity and Circulating Brain-Derived Neurotrophic Factor: A Cross-Sectional Study. J Alzheimers Dis. 2021 Nov 29; doi: 10.3233/JAD-215109. Epub 2021 Nov 29. PMID: 34864673.
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Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings.

Alzheimer's & dementia (Amsterdam, Netherlands)

Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA.
PMID: 30976649
Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec.

Advances in technology enable increasing amounts of data collection from individuals for biomedical research. Such technologies, for example, in genetics and medical imaging, have also led to important scientific discoveries about health and disease. The combination of multiple types...

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Adams HHH, Roshchupkin GV, DeCarli C, et al. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019;11:286-290doi: 10.1016/j.dadm.2019.02.003.
Adams, H. H. H., Roshchupkin, G. V., DeCarli, C., Franke, B., Grabe, H. J., Habes, M., Jahanshad, N., Medland, S. E., Niessen, W., Satizabal, C. L., Schmidt, R., Seshadri, S., Teumer, A., Thompson, P. M., Vernooij, M. W., Wittfeld, K., & Ikram, M. A. (2019). Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimer's & dementia (Amsterdam, Netherlands), 11286-290. https://doi.org/10.1016/j.dadm.2019.02.003
Adams, Hieab H H, et al. "Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 11 (2019): 286-290. doi: https://doi.org/10.1016/j.dadm.2019.02.003
Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec. PMID: 30976649; PMCID: PMC6441785.
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Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.

Alzheimer's & dementia (New York, N. Y.)

Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S.
PMID: 29067329
Alzheimers Dement (N Y). 2017 Mar 22;3(2):229-237. doi: 10.1016/j.trci.2017.03.001. eCollection 2017 Jun.

INTRODUCTION: Mechanisms underlying social determinants of stroke and dementia are unclear and brain-derived neurotrophic factor (BDNF) may contribute as a molecular link.METHODS: Using the Framingham Study, we examined social relationship measures as predictors of higher serum BDNF level and...

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Salinas J, Beiser A, Himali JJ, et al. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017;3(2):229-237doi: 10.1016/j.trci.2017.03.001.
Salinas, J., Beiser, A., Himali, J. J., Satizabal, C. L., Aparicio, H. J., Weinstein, G., Mateen, F. J., Berkman, L. F., Rosand, J., & Seshadri, S. (2017). Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimer's & dementia (New York, N. Y.), 3(2), 229-237. https://doi.org/10.1016/j.trci.2017.03.001
Salinas, Joel, et al. "Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia." Alzheimer's & dementia (New York, N. Y.) vol. 3,2 (2017): 229-237. doi: https://doi.org/10.1016/j.trci.2017.03.001
Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017 Mar 22;3(2):229-237. doi: 10.1016/j.trci.2017.03.001. eCollection 2017 Jun. PMID: 29067329; PMCID: PMC5651441.
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Genomic studies across the lifespan point to early mechanisms determining subcortical volumes.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Le Grand Q, Satizabal CL, Sargurupremraj M, Mishra A, Soumaré A, Laurent A, Crivello F, Tsuchida A, Shin J, Macalli M, Singh B, Beiser AS, DeCarli C, Fletcher E, Paus T, Lathrop M, Adams HHH, Bis JC, Seshadri S, Tzourio C, Mazoyer B, Debette S.
PMID: 34700051
Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Oct 23; doi: 10.1016/j.bpsc.2021.10.011. Epub 2021 Oct 23.

BACKGROUND: Subcortical brain structures play a key role in pathological processes of age-related neurodegenerative disorders. Mounting evidence also suggests that early-life factors may have an impact on the development of common late-life neurological diseases, including genetic factors that can...

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Le Grand Q, Satizabal CL, Sargurupremraj M, et al. Genomic studies across the lifespan point to early mechanisms determining subcortical volumes. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021;doi: 10.1016/j.bpsc.2021.10.011.
Le Grand, Q., Satizabal, C. L., Sargurupremraj, M., Mishra, A., Soumaré, A., Laurent, A., Crivello, F., Tsuchida, A., Shin, J., Macalli, M., Singh, B., Beiser, A. S., DeCarli, C., Fletcher, E., Paus, T., Lathrop, M., Adams, H. H. H., Bis, J. C., Seshadri, S., Tzourio, C., Mazoyer, B., & Debette, S. (2021). Genomic studies across the lifespan point to early mechanisms determining subcortical volumes. Biological psychiatry. Cognitive neuroscience and neuroimaging, . https://doi.org/10.1016/j.bpsc.2021.10.011
Le Grand, Quentin, et al. "Genomic studies across the lifespan point to early mechanisms determining subcortical volumes." Biological psychiatry. Cognitive neuroscience and neuroimaging vol. (2021). doi: https://doi.org/10.1016/j.bpsc.2021.10.011
Le Grand Q, Satizabal CL, Sargurupremraj M, Mishra A, Soumaré A, Laurent A, Crivello F, Tsuchida A, Shin J, Macalli M, Singh B, Beiser AS, DeCarli C, Fletcher E, Paus T, Lathrop M, Adams HHH, Bis JC, Seshadri S, Tzourio C, Mazoyer B, Debette S. Genomic studies across the lifespan point to early mechanisms determining subcortical volumes. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Oct 23; doi: 10.1016/j.bpsc.2021.10.011. Epub 2021 Oct 23. PMID: 34700051.
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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Cite
Li S, Weinstein G, Zare H, et al. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020;2(2):fcaa176doi: 10.1093/braincomms/fcaa176.
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H. H. H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications, 2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
Li, Shuo, et al. "The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages." Brain communications vol. 2,2 (2020): fcaa176. doi: https://doi.org/10.1093/braincomms/fcaa176
Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020. PMID: 33345186; PMCID: PMC7734441.
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Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts.

Neurology

Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM.
PMID: 33268560
Neurology. 2020 Dec 02; doi: 10.1212/WNL.0000000000011236. Epub 2020 Dec 02.

OBJECTIVE: To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings.METHODS: We investigated the association of metabolites with risk of stroke in seven prospective cohort studies including 1,791 incident stroke events among 38,797...

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Vojinovic D, Kalaoja M, Trompet S, et al. Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts. Neurology. 2020;doi: 10.1212/WNL.0000000000011236.
Vojinovic, D., Kalaoja, M., Trompet, S., Fischer, K., Shipley, M. J., Li, S., Havulinna, A. S., Perola, M., Salomaa, V., Yang, Q., Sattar, N., Jousilahti, P., Amin, N., Satizabal, C. L., Taba, N., Sabayan, B., Vasan, R. S., Ikram, M. A., Stott, D. J., Ala-Korpela, M., Jukema, J. W., Seshadri, S., Kettunen, J., Kivimaki, M., Esko, T., & van Duijn, C. M. (2020). Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts. Neurology, . https://doi.org/10.1212/WNL.0000000000011236
Vojinovic, Dina, et al. "Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts." Neurology vol. (2020). doi: https://doi.org/10.1212/WNL.0000000000011236
Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM. Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts. Neurology. 2020 Dec 02; doi: 10.1212/WNL.0000000000011236. Epub 2020 Dec 02. PMID: 33268560; PMCID: PMC8055347.
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Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge.

NeuroImage

Liu P, Jiang D, Albert M, Bauer CE, Caprihan A, Gold BT, Greenberg SM, Helmer KG, Jann K, Jicha G, Rodriguez P, Satizabal CL, Seshadri S, Singh H, Thompson JF, Wang DJJ, Lu H.
PMID: 34826595
Neuroimage. 2021 Dec 15;245:118754. doi: 10.1016/j.neuroimage.2021.118754. Epub 2021 Nov 23.

Cerebrovascular reactivity (CVR), which measures the ability of cerebral blood vessels to dilate or constrict in response to vasoactive stimuli such as CO2 inhalation, is an important index of the brain's vascular health. Quantification of CVR using BOLD MRI...

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Liu P, Jiang D, Albert M, et al. Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge. Neuroimage. 2021;245:118754doi: 10.1016/j.neuroimage.2021.118754.
Liu, P., Jiang, D., Albert, M., Bauer, C. E., Caprihan, A., Gold, B. T., Greenberg, S. M., Helmer, K. G., Jann, K., Jicha, G., Rodriguez, P., Satizabal, C. L., Seshadri, S., Singh, H., Thompson, J. F., Wang, D. J. J., & Lu, H. (2021). Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge. NeuroImage, 245118754. https://doi.org/10.1016/j.neuroimage.2021.118754
Liu, Peiying, et al. "Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge." NeuroImage vol. 245 (2021): 118754. doi: https://doi.org/10.1016/j.neuroimage.2021.118754
Liu P, Jiang D, Albert M, Bauer CE, Caprihan A, Gold BT, Greenberg SM, Helmer KG, Jann K, Jicha G, Rodriguez P, Satizabal CL, Seshadri S, Singh H, Thompson JF, Wang DJJ, Lu H. Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge. Neuroimage. 2021 Dec 15;245:118754. doi: 10.1016/j.neuroimage.2021.118754. Epub 2021 Nov 23. PMID: 34826595.
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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Cite
Li S, Weinstein G, Zare H, et al. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020;2(2):fcaa176doi: 10.1093/braincomms/fcaa176.
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H. H. H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications, 2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
Li, Shuo, et al. "The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages." Brain communications vol. 2,2 (2020): fcaa176. doi: https://doi.org/10.1093/braincomms/fcaa176
Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020. PMID: 33345186; PMCID: PMC7734441.
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