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A high yield optimized method for the production of acylated ACPs enabling the analysis of enzymes involved in .

Biochemistry and biophysics reports

Lauciello L, Lack G, Scapozza L, Perozzo R.
PMID: 28955970
Biochem Biophys Rep. 2016 Oct 06;8:310-317. doi: 10.1016/j.bbrep.2016.09.017. eCollection 2016 Dec.

The natural substrates of the enzymes involved in type-II fatty acid biosynthesis (FAS-II) are acylated acyl carrier proteins (acyl-ACPs). The state of the art method to produce acyl-ACPs involves the transfer of a phosphopantetheine moiety from CoA to apo-ACP...

Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics.

PLoS neglected tropical diseases

Kuettel S, Mosimann M, Mäser P, Kaiser M, Brun R, Scapozza L, Perozzo R.
PMID: 19707572
PLoS Negl Trop Dis. 2009 Aug 25;3(8):e506. doi: 10.1371/journal.pntd.0000506.

BACKGROUND: Human African trypanosomiasis (HAT), a major parasitic disease spread in Africa, urgently needs novel targets and new efficacious chemotherapeutic agents. Recently, we discovered that 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine (compound 1) exhibits specific antitrypanosomal activity with an IC(50) of 1.0 microM on...

Ion Channel Expression in Human Melanoma Samples: In Silico Identification and Experimental Validation of Molecular Targets.

Cancers

D'Arcangelo D, Scatozza F, Giampietri C, Marchetti P, Facchiano F, Facchiano A.
PMID: 30934896
Cancers (Basel). 2019 Mar 29;11(4). doi: 10.3390/cancers11040446.

Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (

Connecting Dissipation and Phase Slips in a Josephson Junction between Fermionic Superfluids.

Physical review letters

Burchianti A, Scazza F, Amico A, Valtolina G, Seman JA, Fort C, Zaccanti M, Inguscio M, Roati G.
PMID: 29376686
Phys Rev Lett. 2018 Jan 12;120(2):025302. doi: 10.1103/PhysRevLett.120.025302.

We study the emergence of dissipation in an atomic Josephson junction between weakly coupled superfluid Fermi gases. We find that vortex-induced phase slippage is the dominant microscopic source of dissipation across the Bose-Einstein condensate-Bardeen-Cooper-Schrieffer crossover. We explore different dynamical...

Effect of Vedolizumab on Anemia of Chronic Disease in Patients with Inflammatory Bowel Diseases.

Journal of clinical medicine

Scarozza P, De Cristofaro E, Scucchi L, Rocchetti I, Marafini I, Neri B, Salvatori S, Biancone L, Calabrese E, Monteleone G.
PMID: 32640680
J Clin Med. 2020 Jul 06;9(7). doi: 10.3390/jcm9072126.

BACKGROUND: Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD.METHODS: Clinical data of 75 IBD...

Tunneling Transport of Unitary Fermions across the Superfluid Transition.

Physical review letters

Del Pace G, Kwon WJ, Zaccanti M, Roati G, Scazza F.
PMID: 33605753
Phys Rev Lett. 2021 Feb 05;126(5):055301. doi: 10.1103/PhysRevLett.126.055301.

We investigate the transport of a Fermi gas with unitarity-limited interactions across the superfluid phase transition, probing its response to a direct current (dc) drive through a tunnel junction. As the superfluid critical temperature is crossed from below, we...

An AI-Based Algorithm for the Automatic Classification of Thoracic Radiographs in Cats.

Frontiers in veterinary science

Banzato T, Wodzinski M, Tauceri F, Donà C, Scavazza F, Müller H, Zotti A.
PMID: 34722699
Front Vet Sci. 2021 Oct 15;8:731936. doi: 10.3389/fvets.2021.731936. eCollection 2021.

An artificial intelligence (AI)-based computer-aided detection (CAD) algorithm to detect some of the most common radiographic findings in the feline thorax was developed and tested. The database used for training comprised radiographs acquired at two different institutions. Only correctly...

Erratum: Withdrawal notice to 'WITHDRAWN: Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1B and a poly-ARG interferon beta-1B analogue' [International Journal of Pharmaceutics 589 (2020) 119913].

International journal of pharmaceutics: X

Dubey S, Perozzo R, Scapozza L, Kalia YN.
PMID: 33376979
Int J Pharm X. 2020 Dec 11;2:100066. doi: 10.1016/j.ijpx.2020.100066. eCollection 2020 Dec.

[This corrects the article DOI: 10.1016/j.ijpx.2020.100051.].

Identification of Anti-.

Frontiers in microbiology

Hanna N, Kicka S, Chiriano G, Harrison C, Sakouhi HO, Trofimov V, Kranjc A, Nitschke J, Pagni M, Cosson P, Hilbi H, Scapozza L, Soldati T.
PMID: 32153546
Front Microbiol. 2020 Feb 21;11:266. doi: 10.3389/fmicb.2020.00266. eCollection 2020.

Tubercular

Expression of Genes Related to Lipid Handling and the Obesity Paradox in Melanoma: Database Analysis.

JMIR cancer

Giampietri C, Tomaipitinca L, Scatozza F, Facchiano A.
PMID: 32209538
JMIR Cancer. 2020 May 19;6(1):e16974. doi: 10.2196/16974.

BACKGROUND: Publicly available genomic and transcriptomic data in searchable databases allow researchers to investigate specific medical issues in thousands of patients. Many studies have highlighted the role lipids play in cancer initiation and progression and reported nutritional interventions aimed...

A Bioorthogonal Chemical Reporter of Viral Infection.

Angewandte Chemie (Weinheim an der Bergstrasse, Germany)

Neef AB, Pernot L, Schreier VN, Scapozza L, Luedtke NW.
PMID: 32313318
Angew Chem Weinheim Bergstr Ger. 2015 Jun 26;127(27):8022-8025. doi: 10.1002/ange.201500250. Epub 2015 May 14.

Pathogen-selective labeling was achieved by using the novel gemcitabine metabolite analogue 2'-deoxy-2',2'-difluoro-5-ethynyluridine (dF-EdU) and click chemistry. Cells infected with Herpes Simplex Virus-1 (HSV-1), but not uninfected cells, exhibit nuclear staining upon the addition of dF-EdU and a fluorescent azide....

Novel Mechanism for an Old Drug: Phenazopyridine is a Kinase Inhibitor Affecting Autophagy and Cellular Differentiation.

Frontiers in pharmacology

Preynat-Seauve O, Nguyen EB, Westermaier Y, Héritier M, Tardy S, Cambet Y, Feyeux M, Caillon A, Scapozza L, Krause KH.
PMID: 34421588
Front Pharmacol. 2021 Aug 04;12:664608. doi: 10.3389/fphar.2021.664608. eCollection 2021.

Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood. Based on its chemical structure, we hypothesized...

Showing 1 to 12 of 40 entries