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The First Modular Route to Core-Chiral Bispidine Ligands and Their Application in Enantioselective Copper(II)-Catalyzed Henry Reactions.

Chemistry (Weinheim an der Bergstrasse, Germany)

Scharnagel D, Müller A, Prause F, Eck M, Goller J, Milius W, Breuning M.
PMID: 26230668
Chemistry. 2015 Aug 24;21(35):12488-500. doi: 10.1002/chem.201502090. Epub 2015 Jul 31.

The first modular and flexible synthesis of core-chiral bispidines was achieved by using an "inside-out" strategy. The key intermediate, a NBoc-activated bispidine lactam, was constructed in enantiomerically pure form from a chirally modified β-amino acid and 2-(acetoxymethyl)acrylonitrile in just...

Cite
Scharnagel D, Müller A, Prause F, et al. The First Modular Route to Core-Chiral Bispidine Ligands and Their Application in Enantioselective Copper(II)-Catalyzed Henry Reactions. Chemistry. 2015;21(35):12488-500doi: 10.1002/chem.201502090.
Scharnagel, D., Müller, A., Prause, F., Eck, M., Goller, J., Milius, W., & Breuning, M. (2015). The First Modular Route to Core-Chiral Bispidine Ligands and Their Application in Enantioselective Copper(II)-Catalyzed Henry Reactions. Chemistry (Weinheim an der Bergstrasse, Germany), 21(35), 12488-500. https://doi.org/10.1002/chem.201502090
Scharnagel, Dagmar, et al. "The First Modular Route to Core-Chiral Bispidine Ligands and Their Application in Enantioselective Copper(II)-Catalyzed Henry Reactions." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 21,35 (2015): 12488-500. doi: https://doi.org/10.1002/chem.201502090
Scharnagel D, Müller A, Prause F, Eck M, Goller J, Milius W, Breuning M. The First Modular Route to Core-Chiral Bispidine Ligands and Their Application in Enantioselective Copper(II)-Catalyzed Henry Reactions. Chemistry. 2015 Aug 24;21(35):12488-500. doi: 10.1002/chem.201502090. Epub 2015 Jul 31. PMID: 26230668.
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Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PLoS genetics

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YI, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Pérusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparsø TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Thorand B, Tönjes A, Tremblay A, Tsafantakis E, van der Most PJ, Völker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widén E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PI, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Böger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Grönberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliövaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kähönen M, Kajantie E, Kathiresan S, Kiemeney LA, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimäki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mäntyselkä P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polašek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PE, Shuldiner AR, Sinisalo J, Snieder H, Sørensen TI, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek AL, Vermeulen SH, Viikari JS, Vitart V, Völzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJ.
PMID: 27355579
PLoS Genet. 2016 Jun 29;12(6):e1006166. doi: 10.1371/journal.pgen.1006166. eCollection 2016 Jun.

[This corrects the article DOI: 10.1371/journal.pgen.1005378.].

Cite
Winkler TW, Justice AE, Graff M, et al. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet. 2016;12(6):e1006166doi: 10.1371/journal.pgen.1006166.
Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpeläinen, T. O., Lu, Y., Mägi, R., Mihailov, E., Pers, T. H., Rüeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J., Lagou, V., Mahajan, A., Neinast, M. D., Prokopenko, I., Simino, J., Teslovich, T. M., Jansen, R., Westra, H. J., White, C. C., Absher, D., Ahluwalia, T. S., Ahmad, S., Albrecht, E., Alves, A. C., Bragg-Gresham, J. L., de Craen, A. J., Bis, J. C., Bonnefond, A., Boucher, G., Cadby, G., Cheng, Y. C., Chiang, C. W., Delgado, G., Demirkan, A., Dueker, N., Eklund, N., Eiriksdottir, G., Eriksson, J., Feenstra, B., Fischer, K., Frau, F., Galesloot, T. E., Geller, F., Goel, A., Gorski, M., Grammer, T. B., Gustafsson, S., Haitjema, S., Hottenga, J. J., Huffman, J. E., Jackson, A. U., Jacobs, K. B., Johansson, �. �., Kaakinen, M., Kleber, M. E., Lahti, J., Mateo Leach, I., Lehne, B., Liu, Y., Lo, K. S., Lorentzon, M., Luan, J., Madden, P. A., Mangino, M., McKnight, B., Medina-Gomez, C., Monda, K. L., Montasser, M. E., Müller, G., Müller-Nurasyid, M., Nolte, I. M., Panoutsopoulou, K., Pascoe, L., Paternoster, L., Rayner, N. W., Renström, F., Rizzi, F., Rose, L. M., Ryan, K. A., Salo, P., Sanna, S., Scharnagl, H., Shi, J., Smith, A. V., Southam, L., Stančáková, A., Steinthorsdottir, V., Strawbridge, R. J., Sung, Y. J., Tachmazidou, I., Tanaka, T., Thorleifsson, G., Trompet, S., Pervjakova, N., Tyrer, J. P., Vandenput, L., van der Laan, S. W., van der Velde, N., van Setten, J., van Vliet-Ostaptchouk, J. V., Verweij, N., Vlachopoulou, E., Waite, L. L., Wang, S. R., Wang, Z., Wild, S. H., Willenborg, C., Wilson, J. F., Wong, A., Yang, J., Yengo, L., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Andersson, E. A., Bakker, S. J., Baldassarre, D., Banasik, K., Barcella, M., Barlassina, C., Bellis, C., Benaglio, P., Blangero, J., Blüher, M., Bonnet, F., Bonnycastle, L. L., Boyd, H. A., Bruinenberg, M., Buchman, A. S., Campbell, H., Chen, Y. I., Chines, P. S., Claudi-Boehm, S., Cole, J., Collins, F. S., de Geus, E. J., de Groot, L. C., Dimitriou, M., Duan, J., Enroth, S., Eury, E., Farmaki, A. E., Forouhi, N. G., Friedrich, N., Gejman, P. V., Gigante, B., Glorioso, N., Go, A. S., Gottesman, O., Gräßler, J., Grallert, H., Grarup, N., Gu, Y. M., Broer, L., Ham, A. C., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Heath, A. C., Henders, A. K., Hernandez, D., Hillege, H., Holmen, O., Hovingh, K. G., Hui, J., Husemoen, L. L., Hutri-Kähönen, N., Hysi, P. G., Illig, T., De Jager, P. L., Jalilzadeh, S., Jørgensen, T., Jukema, J. W., Juonala, M., Kanoni, S., Karaleftheri, M., Khaw, K. T., Kinnunen, L., Kittner, S. J., Koenig, W., Kolcic, I., Kovacs, P., Krarup, N. T., Kratzer, W., Krüger, J., Kuh, D., Kumari, M., Kyriakou, T., Langenberg, C., Lannfelt, L., Lanzani, C., Lotay, V., Launer, L. J., Leander, K., Lindström, J., Linneberg, A., Liu, Y. P., Lobbens, S., Luben, R., Lyssenko, V., Männistö, S., Magnusson, P. K., McArdle, W. L., Menni, C., Merger, S., Milani, L., Montgomery, G. W., Morris, A. P., Narisu, N., Nelis, M., Ong, K. K., Palotie, A., Pérusse, L., Pichler, I., Pilia, M. G., Pouta, A., Rheinberger, M., Ribel-Madsen, R., Richards, M., Rice, K. M., Rice, T. K., Rivolta, C., Salomaa, V., Sanders, A. R., Sarzynski, M. A., Scholtens, S., Scott, R. A., Scott, W. R., Sebert, S., Sengupta, S., Sennblad, B., Seufferlein, T., Silveira, A., Slagboom, P. E., Smit, J. H., Sparsø, T. H., Stirrups, K., Stolk, R. P., Stringham, H. M., Swertz, M. A., Swift, A. J., Syvänen, A. C., Tan, S. T., Thorand, B., Tönjes, A., Tremblay, A., Tsafantakis, E., van der Most, P. J., Völker, U., Vohl, M. C., Vonk, J. M., Waldenberger, M., Walker, R. W., Wennauer, R., Widén, E., Willemsen, G., Wilsgaard, T., Wright, A. F., Zillikens, M. C., van Dijk, S. C., van Schoor, N. M., Asselbergs, F. W., de Bakker, P. I., Beckmann, J. S., Beilby, J., Bennett, D. A., Bergman, R. N., Bergmann, S., Böger, C. A., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Chambers, J. C., Chanock, S. J., Chasman, D. I., Cucca, F., Cusi, D., Dedoussis, G., Erdmann, J., Eriksson, J. G., Evans, D. A., de Faire, U., Farrall, M., Ferrucci, L., Ford, I., Franke, L., Franks, P. W., Froguel, P., Gansevoort, R. T., Gieger, C., Grönberg, H., Gudnason, V., Gyllensten, U., Hall, P., Hamsten, A., van der Harst, P., Hayward, C., Heliövaara, M., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hofman, A., Hu, F., Huikuri, H. V., Hveem, K., James, A. L., Jordan, J. M., Jula, A., Kähönen, M., Kajantie, E., Kathiresan, S., Kiemeney, L. A., Kivimaki, M., Knekt, P. B., Koistinen, H. A., Kooner, J. S., Koskinen, S., Kuusisto, J., Maerz, W., Martin, N. G., Laakso, M., Lakka, T. A., Lehtimäki, T., Lettre, G., Levinson, D. F., Lind, L., Lokki, M. L., Mäntyselkä, P., Melbye, M., Metspalu, A., Mitchell, B. D., Moll, F. L., Murray, J. C., Musk, A. W., Nieminen, M. S., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Oostra, B. A., Palmer, L. J., Pankow, J. S., Pasterkamp, G., Pedersen, N. L., Pedersen, O., Penninx, B. W., Perola, M., Peters, A., Polašek, O., Pramstaller, P. P., Psaty, B. M., Qi, L., Quertermous, T., Raitakari, O. T., Rankinen, T., Rauramaa, R., Ridker, P. M., Rioux, J. D., Rivadeneira, F., Rotter, J. I., Rudan, I., den Ruijter, H. M., Saltevo, J., Sattar, N., Schunkert, H., Schwarz, P. E., Shuldiner, A. R., Sinisalo, J., Snieder, H., Sørensen, T. I., Spector, T. D., Staessen, J. A., Stefania, B., Thorsteinsdottir, U., Stumvoll, M., Tardif, J. C., Tremoli, E., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Verbeek, A. L., Vermeulen, S. H., Viikari, J. S., Vitart, V., Völzke, H., Vollenweider, P., Waeber, G., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Zeggini, E., Chakravarti, A., Clegg, D. J., Cupples, L. A., Gordon-Larsen, P., Jaquish, C. E., Rao, D. C., Abecasis, G. R., Assimes, T. L., Barroso, I., Berndt, S. I., Boehnke, M., Deloukas, P., Fox, C. S., Groop, L. C., Hunter, D. J., Ingelsson, E., Kaplan, R. C., McCarthy, M. I., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Hirschhorn, J. N., Lindgren, C. M., Heid, I. M., North, K. E., Borecki, I. B., Kutalik, Z., & Loos, R. J. (2016). Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS genetics, 12(6), e1006166. https://doi.org/10.1371/journal.pgen.1006166
Winkler, Thomas W, et al. "Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study." PLoS genetics vol. 12,6 (2016): e1006166. doi: https://doi.org/10.1371/journal.pgen.1006166
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YI, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Pérusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparsø TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Thorand B, Tönjes A, Tremblay A, Tsafantakis E, van der Most PJ, Völker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widén E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PI, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Böger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Grönberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliövaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kähönen M, Kajantie E, Kathiresan S, Kiemeney LA, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimäki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mäntyselkä P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polašek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PE, Shuldiner AR, Sinisalo J, Snieder H, Sørensen TI, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek AL, Vermeulen SH, Viikari JS, Vitart V, Völzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJ. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet. 2016 Jun 29;12(6):e1006166. doi: 10.1371/journal.pgen.1006166. eCollection 2016 Jun. PMID: 27355579; PMCID: PMC4927064.
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Validation of Virus NAT for HIV, HCV, HBV and HAV Using Post-Mortal Blood Samples.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Gubbe K, Scharnagl Y, Grosch S, Tonn T, Schmidt M, Hourfar KM, Karl A, Seifried E, Wilkemeyer I, Kalus U.
PMID: 23801525
Transfus Med Hemother. 2012 Dec;39(6):381-5. doi: 10.1159/000345319. Epub 2012 Nov 13.

OBJECTIVE: Commercial available NAT systems are usually not validated for screening of post-mortem blood samples. NAT testing might be challenging due to inhibitory substances in the cadaveric blood sample that cause false-negative test results. Validation studies have to be...

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Gubbe K, Scharnagl Y, Grosch S, et al. Validation of Virus NAT for HIV, HCV, HBV and HAV Using Post-Mortal Blood Samples. Transfus Med Hemother. 2012;39(6):381-5doi: 10.1159/000345319.
Gubbe, K., Scharnagl, Y., Grosch, S., Tonn, T., Schmidt, M., Hourfar, K. M., Karl, A., Seifried, E., Wilkemeyer, I., & Kalus, U. (2012). Validation of Virus NAT for HIV, HCV, HBV and HAV Using Post-Mortal Blood Samples. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 39(6), 381-5. https://doi.org/10.1159/000345319
Gubbe, Knut, et al. "Validation of Virus NAT for HIV, HCV, HBV and HAV Using Post-Mortal Blood Samples." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 39,6 (2012): 381-5. doi: https://doi.org/10.1159/000345319
Gubbe K, Scharnagl Y, Grosch S, Tonn T, Schmidt M, Hourfar KM, Karl A, Seifried E, Wilkemeyer I, Kalus U. Validation of Virus NAT for HIV, HCV, HBV and HAV Using Post-Mortal Blood Samples. Transfus Med Hemother. 2012 Dec;39(6):381-5. doi: 10.1159/000345319. Epub 2012 Nov 13. PMID: 23801525; PMCID: PMC3678270.
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Author Correction: Cardiovascular risk algorithms in primary care: Results from the DETECT study.

Scientific reports

Grammer TB, Dressel A, Gergei I, Kleber ME, Laufs U, Scharnagl H, Nixdorff U, Klotsche J, Pieper L, Pittrow D, Silber S, Wittchen HU, März W.
PMID: 32231212
Sci Rep. 2020 Mar 31;10(1):5945. doi: 10.1038/s41598-020-59763-0.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Grammer TB, Dressel A, Gergei I, et al. Author Correction: Cardiovascular risk algorithms in primary care: Results from the DETECT study. Sci Rep. 2020;10(1):5945doi: 10.1038/s41598-020-59763-0.
Grammer, T. B., Dressel, A., Gergei, I., Kleber, M. E., Laufs, U., Scharnagl, H., Nixdorff, U., Klotsche, J., Pieper, L., Pittrow, D., Silber, S., Wittchen, H. U., & März, W. (2020). Author Correction: Cardiovascular risk algorithms in primary care: Results from the DETECT study. Scientific reports, 10(1), 5945. https://doi.org/10.1038/s41598-020-59763-0
Grammer, Tanja B, et al. "Author Correction: Cardiovascular risk algorithms in primary care: Results from the DETECT study." Scientific reports vol. 10,1 (2020): 5945. doi: https://doi.org/10.1038/s41598-020-59763-0
Grammer TB, Dressel A, Gergei I, Kleber ME, Laufs U, Scharnagl H, Nixdorff U, Klotsche J, Pieper L, Pittrow D, Silber S, Wittchen HU, März W. Author Correction: Cardiovascular risk algorithms in primary care: Results from the DETECT study. Sci Rep. 2020 Mar 31;10(1):5945. doi: 10.1038/s41598-020-59763-0. PMID: 32231212; PMCID: PMC7105487.
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J-shaped association between circulating apoC-III and cardiovascular mortality.

European journal of preventive cardiology

Silbernagel G, Scharnagl H, Kleber ME, Hoffmann MM, Delgado GE, Stojakovic T, Gary T, Zeng L, Ritsch A, Zewinger S, Speer T, Schunkert H, Landmesser U, März W, Grammer TB.
PMID: 33609030
Eur J Prev Cardiol. 2021 Feb 20; doi: 10.1093/eurjpc/zwaa169. Epub 2021 Feb 20.

No abstract available.

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Silbernagel G, Scharnagl H, Kleber ME, et al. J-shaped association between circulating apoC-III and cardiovascular mortality. Eur J Prev Cardiol. 2021;doi: 10.1093/eurjpc/zwaa169.
Silbernagel, G., Scharnagl, H., Kleber, M. E., Hoffmann, M. M., Delgado, G. E., Stojakovic, T., Gary, T., Zeng, L., Ritsch, A., Zewinger, S., Speer, T., Schunkert, H., Landmesser, U., März, W., & Grammer, T. B. (2021). J-shaped association between circulating apoC-III and cardiovascular mortality. European journal of preventive cardiology, . https://doi.org/10.1093/eurjpc/zwaa169
Silbernagel, Günther, et al. "J-shaped association between circulating apoC-III and cardiovascular mortality." European journal of preventive cardiology vol. (2021). doi: https://doi.org/10.1093/eurjpc/zwaa169
Silbernagel G, Scharnagl H, Kleber ME, Hoffmann MM, Delgado GE, Stojakovic T, Gary T, Zeng L, Ritsch A, Zewinger S, Speer T, Schunkert H, Landmesser U, März W, Grammer TB. J-shaped association between circulating apoC-III and cardiovascular mortality. Eur J Prev Cardiol. 2021 Feb 20; doi: 10.1093/eurjpc/zwaa169. Epub 2021 Feb 20. PMID: 33609030.
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Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix.

iScience

Spitz C, Schlosser C, Guschtschin-Schmidt N, Stelzer W, Menig S, Götz A, Haug-Kröper M, Scharnagl C, Langosch D, Muhle-Goll C, Fluhrer R.
PMID: 33294784
iScience. 2020 Nov 05;23(12):101775. doi: 10.1016/j.isci.2020.101775. eCollection 2020 Dec 18.

Ectodomain (EC) shedding defines the proteolytic removal of a membrane protein EC and acts as an important molecular switch in signaling and other cellular processes. Using tumor necrosis factor (TNF)α as a model substrate, we identify a non-canonical shedding...

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Spitz C, Schlosser C, Guschtschin-Schmidt N, et al. Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix. iScience. 2020;23(12):101775doi: 10.1016/j.isci.2020.101775.
Spitz, C., Schlosser, C., Guschtschin-Schmidt, N., Stelzer, W., Menig, S., Götz, A., Haug-Kröper, M., Scharnagl, C., Langosch, D., Muhle-Goll, C., & Fluhrer, R. (2020). Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix. iScience, 23(12), 101775. https://doi.org/10.1016/j.isci.2020.101775
Spitz, Charlotte, et al. "Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix." iScience vol. 23,12 (2020): 101775. doi: https://doi.org/10.1016/j.isci.2020.101775
Spitz C, Schlosser C, Guschtschin-Schmidt N, Stelzer W, Menig S, Götz A, Haug-Kröper M, Scharnagl C, Langosch D, Muhle-Goll C, Fluhrer R. Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix. iScience. 2020 Nov 05;23(12):101775. doi: 10.1016/j.isci.2020.101775. eCollection 2020 Dec 18. PMID: 33294784; PMCID: PMC7689174.
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Reduction of Nitro Compounds Using 3d-Non-Noble Metal Catalysts.

Chemical reviews

Formenti D, Ferretti F, Scharnagl FK, Beller M.
PMID: 30516963
Chem Rev. 2019 Feb 27;119(4):2611-2680. doi: 10.1021/acs.chemrev.8b00547. Epub 2018 Dec 05.

The reduction of nitro compounds to the corresponding amines is one of the most utilized catalytic processes in the fine and bulk chemical industry. The latest development of catalysts with cheap metals like Fe, Co, Ni, and Cu has...

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Formenti D, Ferretti F, Scharnagl FK, et al. Reduction of Nitro Compounds Using 3d-Non-Noble Metal Catalysts. Chem Rev. 2018;119(4):2611-2680doi: 10.1021/acs.chemrev.8b00547.
Formenti, D., Ferretti, F., Scharnagl, F. K., & Beller, M. (2019). Reduction of Nitro Compounds Using 3d-Non-Noble Metal Catalysts. Chemical reviews, 119(4), 2611-2680. https://doi.org/10.1021/acs.chemrev.8b00547
Formenti, Dario, et al. "Reduction of Nitro Compounds Using 3d-Non-Noble Metal Catalysts." Chemical reviews vol. 119,4 (2019): 2611-2680. doi: https://doi.org/10.1021/acs.chemrev.8b00547
Formenti D, Ferretti F, Scharnagl FK, Beller M. Reduction of Nitro Compounds Using 3d-Non-Noble Metal Catalysts. Chem Rev. 2019 Feb 27;119(4):2611-2680. doi: 10.1021/acs.chemrev.8b00547. Epub 2018 Dec 05. PMID: 30516963.
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Supported Cobalt Nanoparticles for Hydroformylation Reactions.

Chemistry (Weinheim an der Bergstrasse, Germany)

Hertrich MF, Scharnagl FK, Pews-Davtyan A, Kreyenschulte CR, Lund H, Bartling S, Jackstell R, Beller M.
PMID: 30779224
Chemistry. 2019 Apr 11;25(21):5534-5538. doi: 10.1002/chem.201806282. Epub 2019 Mar 19.

Hydroformylation of olefins has been studied in the presence of specific heterogeneous cobalt nanoparticles. The catalytic materials were prepared by pyrolysis of preformed cobalt complexes deposited onto different inorganic supports. Atomic absorption spectroscopy (AAS) measurements indicated a correlation of...

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Hertrich MF, Scharnagl FK, Pews-Davtyan A, et al. Supported Cobalt Nanoparticles for Hydroformylation Reactions. Chemistry. 2019;25(21):5534-5538doi: 10.1002/chem.201806282.
Hertrich, M. F., Scharnagl, F. K., Pews-Davtyan, A., Kreyenschulte, C. R., Lund, H., Bartling, S., Jackstell, R., & Beller, M. (2019). Supported Cobalt Nanoparticles for Hydroformylation Reactions. Chemistry (Weinheim an der Bergstrasse, Germany), 25(21), 5534-5538. https://doi.org/10.1002/chem.201806282
Hertrich, Maximilian Franz, et al. "Supported Cobalt Nanoparticles for Hydroformylation Reactions." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 25,21 (2019): 5534-5538. doi: https://doi.org/10.1002/chem.201806282
Hertrich MF, Scharnagl FK, Pews-Davtyan A, Kreyenschulte CR, Lund H, Bartling S, Jackstell R, Beller M. Supported Cobalt Nanoparticles for Hydroformylation Reactions. Chemistry. 2019 Apr 11;25(21):5534-5538. doi: 10.1002/chem.201806282. Epub 2019 Mar 19. PMID: 30779224.
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Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote .

Journal of the American Chemical Society

Zuccarello G, Mayans JG, Escofet I, Scharnagel D, Kirillova MS, Pérez-Jimeno AH, Calleja P, Boothe JR, Echavarren AM.
PMID: 31290658
J Am Chem Soc. 2019 Jul 31;141(30):11858-11863. doi: 10.1021/jacs.9b06326. Epub 2019 Jul 16.

Chiral gold(I) catalysts have been designed based on a modified JohnPhos ligand with a distal

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Zuccarello G, Mayans JG, Escofet I, et al. Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote . J Am Chem Soc. 2019;141(30):11858-11863doi: 10.1021/jacs.9b06326.
Zuccarello, G., Mayans, J. G., Escofet, I., Scharnagel, D., Kirillova, M. S., Pérez-Jimeno, A. H., Calleja, P., Boothe, J. R., & Echavarren, A. M. (2019). Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote . Journal of the American Chemical Society, 141(30), 11858-11863. https://doi.org/10.1021/jacs.9b06326
Zuccarello, Giuseppe, et al. "Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote ." Journal of the American Chemical Society vol. 141,30 (2019): 11858-11863. doi: https://doi.org/10.1021/jacs.9b06326
Zuccarello G, Mayans JG, Escofet I, Scharnagel D, Kirillova MS, Pérez-Jimeno AH, Calleja P, Boothe JR, Echavarren AM. Enantioselective Folding of Enynes by Gold(I) Catalysts with a Remote . J Am Chem Soc. 2019 Jul 31;141(30):11858-11863. doi: 10.1021/jacs.9b06326. Epub 2019 Jul 16. PMID: 31290658.
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Acute Physiological Responses to Short- and Long-Stage High-Intensity Interval Exercise in Cardiac Rehabilitation: A Pilot Study.

Journal of sports science & medicine

Tschakert G, Kroepfl JM, Mueller A, Harpf H, Harpf L, Traninger H, Wallner-Liebmann S, Stojakovic T, Scharnagl H, Meinitzer A, Pichlhoefer P, Hofmann P.
PMID: 26957930
J Sports Sci Med. 2016 Feb 23;15(1):80-91. eCollection 2016 Mar.

Despite described benefits of aerobic high-intensity interval exercise (HIIE), the acute responses during different HIIE modes and associated health risks have only been sparsely discovered in heart disease patients. Therefore, the aim of this study was to investigate the...

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Tschakert G, Kroepfl JM, Mueller A, et al. Acute Physiological Responses to Short- and Long-Stage High-Intensity Interval Exercise in Cardiac Rehabilitation: A Pilot Study. J Sports Sci Med. 2016;15(1):80-91
Tschakert, G., Kroepfl, J. M., Mueller, A., Harpf, H., Harpf, L., Traninger, H., Wallner-Liebmann, S., Stojakovic, T., Scharnagl, H., Meinitzer, A., Pichlhoefer, P., & Hofmann, P. (2016). Acute Physiological Responses to Short- and Long-Stage High-Intensity Interval Exercise in Cardiac Rehabilitation: A Pilot Study. Journal of sports science & medicine, 15(1), 80-91.
Tschakert, Gerhard, et al. "Acute Physiological Responses to Short- and Long-Stage High-Intensity Interval Exercise in Cardiac Rehabilitation: A Pilot Study." Journal of sports science & medicine vol. 15,1 (2016): 80-91.
Tschakert G, Kroepfl JM, Mueller A, Harpf H, Harpf L, Traninger H, Wallner-Liebmann S, Stojakovic T, Scharnagl H, Meinitzer A, Pichlhoefer P, Hofmann P. Acute Physiological Responses to Short- and Long-Stage High-Intensity Interval Exercise in Cardiac Rehabilitation: A Pilot Study. J Sports Sci Med. 2016 Feb 23;15(1):80-91. eCollection 2016 Mar. PMID: 26957930; PMCID: PMC4763850.
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The Enantioselective Total Synthesis of Bisquinolizidine Alkaloids: A Modular "Inside-Out" Approach.

Angewandte Chemie (International ed. in English)

Scharnagel D, Goller J, Deibl N, Milius W, Breuning M.
PMID: 29359494
Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2432-2435. doi: 10.1002/anie.201712852. Epub 2018 Feb 12.

Bisquinolizidine alkaloids are characterized by a chiral bispidine core (3,7-diazabicyclo[3.3.1]nonane) to which combinations of an α,N-fused 2-pyridone, an endo- or exo-α,N-annulated piperidin(on)e, and an exo-allyl substituent are attached. We developed a modular "inside-out" approach that permits access to most...

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Scharnagel D, Goller J, Deibl N, et al. The Enantioselective Total Synthesis of Bisquinolizidine Alkaloids: A Modular "Inside-Out" Approach. Angew Chem Int Ed Engl. 2018;57(9):2432-2435doi: 10.1002/anie.201712852.
Scharnagel, D., Goller, J., Deibl, N., Milius, W., & Breuning, M. (2018). The Enantioselective Total Synthesis of Bisquinolizidine Alkaloids: A Modular "Inside-Out" Approach. Angewandte Chemie (International ed. in English), 57(9), 2432-2435. https://doi.org/10.1002/anie.201712852
Scharnagel, Dagmar, et al. "The Enantioselective Total Synthesis of Bisquinolizidine Alkaloids: A Modular "Inside-Out" Approach." Angewandte Chemie (International ed. in English) vol. 57,9 (2018): 2432-2435. doi: https://doi.org/10.1002/anie.201712852
Scharnagel D, Goller J, Deibl N, Milius W, Breuning M. The Enantioselective Total Synthesis of Bisquinolizidine Alkaloids: A Modular "Inside-Out" Approach. Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2432-2435. doi: 10.1002/anie.201712852. Epub 2018 Feb 12. PMID: 29359494.
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Serum netrin-1 in relation to gadolinium-enhanced magnetic resonance imaging in early multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical

Voortman MM, Pekar T, Bachmayer D, Archelos JJ, Stojakovic T, Scharnagl H, Ropele S, Pichler A, Enzinger C, Fuchs S, Fazekas F, Seifert-Held T, Khalil M.
PMID: 28856010
Mult Scler J Exp Transl Clin. 2017 Aug 23;3(3):2055217317727294. doi: 10.1177/2055217317727294. eCollection 2017.

BACKGROUND: Netrin-1, a secreted laminin-related protein, is known to regulate not only axonal guidance and neuronal cell migration, but also blood-brain barrier integrity and inflammation. Two preliminary studies reported altered serum netrin-1 levels in multiple sclerosis; however, associations with...

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Voortman MM, Pekar T, Bachmayer D, et al. Serum netrin-1 in relation to gadolinium-enhanced magnetic resonance imaging in early multiple sclerosis. Mult Scler J Exp Transl Clin. 2017;3(3):2055217317727294doi: 10.1177/2055217317727294.
Voortman, M. M., Pekar, T., Bachmayer, D., Archelos, J. J., Stojakovic, T., Scharnagl, H., Ropele, S., Pichler, A., Enzinger, C., Fuchs, S., Fazekas, F., Seifert-Held, T., & Khalil, M. (2017). Serum netrin-1 in relation to gadolinium-enhanced magnetic resonance imaging in early multiple sclerosis. Multiple sclerosis journal - experimental, translational and clinical, 3(3), 2055217317727294. https://doi.org/10.1177/2055217317727294
Voortman, M M, et al. "Serum netrin-1 in relation to gadolinium-enhanced magnetic resonance imaging in early multiple sclerosis." Multiple sclerosis journal - experimental, translational and clinical vol. 3,3 (2017): 2055217317727294. doi: https://doi.org/10.1177/2055217317727294
Voortman MM, Pekar T, Bachmayer D, Archelos JJ, Stojakovic T, Scharnagl H, Ropele S, Pichler A, Enzinger C, Fuchs S, Fazekas F, Seifert-Held T, Khalil M. Serum netrin-1 in relation to gadolinium-enhanced magnetic resonance imaging in early multiple sclerosis. Mult Scler J Exp Transl Clin. 2017 Aug 23;3(3):2055217317727294. doi: 10.1177/2055217317727294. eCollection 2017. PMID: 28856010; PMCID: PMC5571769.
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