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2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.

ACS medicinal chemistry letters

Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, Wienke D, Clarke PA, Raynaud FI, Eccles SA, Esdar C, Rohdich F, Blagg J.
PMID: 27326329
ACS Med Chem Lett. 2016 Mar 28;7(6):573-8. doi: 10.1021/acsmedchemlett.6b00022. eCollection 2016 Jun 09.

We demonstrate a designed scaffold-hop approach to the discovery of 2,8-disubstituted-1,6-naphthyridine- and 4,6-disubstituted-isoquinoline-based dual CDK8/19 ligands. Optimized compounds in both series exhibited rapid aldehyde oxidase-mediated metabolism, which could be abrogated by introduction of an amino substituent at C5 of...

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Mallinger A, Schiemann K, Rink C, et al. 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. ACS Med Chem Lett. 2016;7(6):573-8doi: 10.1021/acsmedchemlett.6b00022.
Mallinger, A., Schiemann, K., Rink, C., Sejberg, J., Honey, M. A., Czodrowski, P., Stubbs, M., Poeschke, O., Busch, M., Schneider, R., Schwarz, D., Musil, D., Burke, R., Urbahns, K., Workman, P., Wienke, D., Clarke, P. A., Raynaud, F. I., Eccles, S. A., Esdar, C., Rohdich, F., & Blagg, J. (2016). 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. ACS medicinal chemistry letters, 7(6), 573-8. https://doi.org/10.1021/acsmedchemlett.6b00022
Mallinger, Aurélie, et al. "2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19." ACS medicinal chemistry letters vol. 7,6 (2016): 573-8. doi: https://doi.org/10.1021/acsmedchemlett.6b00022
Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, Wienke D, Clarke PA, Raynaud FI, Eccles SA, Esdar C, Rohdich F, Blagg J. 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. ACS Med Chem Lett. 2016 Mar 28;7(6):573-8. doi: 10.1021/acsmedchemlett.6b00022. eCollection 2016 Jun 09. PMID: 27326329; PMCID: PMC4904262.
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Canadian Study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE study): a cohort study protocol examining the mechanisms of obesity in survivors of childhood brain tumours.

BMJ open

Samaan MC, Thabane L, Burrow S, Dillenburg RF, Scheinemann K.
PMID: 23794554
BMJ Open. 2013 Jun 20;3(6). doi: 10.1136/bmjopen-2013-002869.

BACKGROUND: Childhood obesity has reached epidemic proportions and is impacting children's health globally. In adults, obesity is associated with chronic low-grade inflammation that leads to insulin resistance, which is one of the important mechanisms through which dysregulation of metabolism...

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Samaan MC, Thabane L, Burrow S, et al. Canadian Study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE study): a cohort study protocol examining the mechanisms of obesity in survivors of childhood brain tumours. BMJ Open. 2013;3(6)doi: 10.1136/bmjopen-2013-002869.
Samaan, M. C., Thabane, L., Burrow, S., Dillenburg, R. F., & Scheinemann, K. (2013). Canadian Study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE study): a cohort study protocol examining the mechanisms of obesity in survivors of childhood brain tumours. BMJ open, 3(6), . https://doi.org/10.1136/bmjopen-2013-002869
Samaan, M Constantine, et al. "Canadian Study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE study): a cohort study protocol examining the mechanisms of obesity in survivors of childhood brain tumours." BMJ open vol. 3,6 (2013). doi: https://doi.org/10.1136/bmjopen-2013-002869
Samaan MC, Thabane L, Burrow S, Dillenburg RF, Scheinemann K. Canadian Study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE study): a cohort study protocol examining the mechanisms of obesity in survivors of childhood brain tumours. BMJ Open. 2013 Jun 20;3(6). doi: 10.1136/bmjopen-2013-002869. PMID: 23794554; PMCID: PMC3686178.
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Fractal properties of trivelpiece-gould waves in periodic plasma-filled waveguides.

Physical review letters

Zaginaylov GI, Grudiev A, Schünemann K, Turbin PV.
PMID: 12005642
Phys Rev Lett. 2002 May 13;88(19):195005. doi: 10.1103/PhysRevLett.88.195005. Epub 2002 Apr 29.

It is shown that dispersion curves describing a spectrum of Trivelpiece-Gould (TG) waves in periodic plasma-filled waveguides have a fractal nature. They are not solid lines as for other types of waves in periodic waveguides but suffer from discontinuities...

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Zaginaylov GI, Grudiev A, Schünemann K, et al. Fractal properties of trivelpiece-gould waves in periodic plasma-filled waveguides. Phys Rev Lett. 2002;88(19):195005doi: 10.1103/PhysRevLett.88.195005.
Zaginaylov, G. I., Grudiev, A., Schünemann, K., & Turbin, P. V. (2002). Fractal properties of trivelpiece-gould waves in periodic plasma-filled waveguides. Physical review letters, 88(19), 195005. https://doi.org/10.1103/PhysRevLett.88.195005
Zaginaylov, G I, et al. "Fractal properties of trivelpiece-gould waves in periodic plasma-filled waveguides." Physical review letters vol. 88,19 (2002): 195005. doi: https://doi.org/10.1103/PhysRevLett.88.195005
Zaginaylov GI, Grudiev A, Schünemann K, Turbin PV. Fractal properties of trivelpiece-gould waves in periodic plasma-filled waveguides. Phys Rev Lett. 2002 May 13;88(19):195005. doi: 10.1103/PhysRevLett.88.195005. Epub 2002 Apr 29. PMID: 12005642.
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Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood.

International journal of epidemiology

Gottschick C, Raupach-Rosin H, Langer S, Hassan L, Horn J, Dorendorf E, Caputo M, Bittner M, Beier L, Rübsamen N, Schlinkmann K, Zoch B, Guzman CA, Hansen G, Heselich V, Holzapfel E, Hübner J, Pietschmann T, Pieper DH, Pletz M, Riese P, Schmidt-Pokrzywniak A, Hartwig S, von Kaisenberg C, Aydogdu M, Buhles M, Dressler F, Eberl W, Haase R, von Koch FE, Feidicker S, Frambach T, Franz HGB, Guthmann F, Koch HG, Seeger S, Oberhoff C, Pauker W, Petry KU, Schild RL, Tchirikov M, Röhrig E, Karch A, Mikolajczyk R.
PMID: 30938437
Int J Epidemiol. 2019 Aug 01;48(4):1382-1383. doi: 10.1093/ije/dyz069.

No abstract available.

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Gottschick C, Raupach-Rosin H, Langer S, et al. Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood. Int J Epidemiol. 2019;48(4):1382-1383doi: 10.1093/ije/dyz069.
Gottschick, C., Raupach-Rosin, H., Langer, S., Hassan, L., Horn, J., Dorendorf, E., Caputo, M., Bittner, M., Beier, L., Rübsamen, N., Schlinkmann, K., Zoch, B., Guzman, C. A., Hansen, G., Heselich, V., Holzapfel, E., Hübner, J., Pietschmann, T., Pieper, D. H., Pletz, M., Riese, P., Schmidt-Pokrzywniak, A., Hartwig, S., von Kaisenberg, C., Aydogdu, M., Buhles, M., Dressler, F., Eberl, W., Haase, R., von Koch, F. E., Feidicker, S., Frambach, T., Franz, H. G. B., Guthmann, F., Koch, H. G., Seeger, S., Oberhoff, C., Pauker, W., Petry, K. U., Schild, R. L., Tchirikov, M., Röhrig, E., Karch, A., & Mikolajczyk, R. (2019). Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood. International journal of epidemiology, 48(4), 1382-1383. https://doi.org/10.1093/ije/dyz069
Gottschick, Cornelia, et al. "Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood." International journal of epidemiology vol. 48,4 (2019): 1382-1383. doi: https://doi.org/10.1093/ije/dyz069
Gottschick C, Raupach-Rosin H, Langer S, Hassan L, Horn J, Dorendorf E, Caputo M, Bittner M, Beier L, Rübsamen N, Schlinkmann K, Zoch B, Guzman CA, Hansen G, Heselich V, Holzapfel E, Hübner J, Pietschmann T, Pieper DH, Pletz M, Riese P, Schmidt-Pokrzywniak A, Hartwig S, von Kaisenberg C, Aydogdu M, Buhles M, Dressler F, Eberl W, Haase R, von Koch FE, Feidicker S, Frambach T, Franz HGB, Guthmann F, Koch HG, Seeger S, Oberhoff C, Pauker W, Petry KU, Schild RL, Tchirikov M, Röhrig E, Karch A, Mikolajczyk R. Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood. Int J Epidemiol. 2019 Aug 01;48(4):1382-1383. doi: 10.1093/ije/dyz069. PMID: 30938437; PMCID: PMC7263872.
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Nucleation and initial growth phase of diamond thin films on (100) silicon.

Physical review. B, Condensed matter

Jiang X, Klages C, Schiffmann K.
PMID: 9974858
Phys Rev B Condens Matter. 1994 Sep 15;50(12):8402-8410. doi: 10.1103/physrevb.50.8402.

No abstract available.

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Jiang X, Klages C, Schiffmann K. Nucleation and initial growth phase of diamond thin films on (100) silicon. Phys Rev B Condens Matter. 1994;50(12):8402-8410doi: 10.1103/physrevb.50.8402.
Jiang, X., Klages, C., & Schiffmann, K. (1994). Nucleation and initial growth phase of diamond thin films on (100) silicon. Physical review. B, Condensed matter, 50(12), 8402-8410. https://doi.org/10.1103/physrevb.50.8402
Jiang, et al. "Nucleation and initial growth phase of diamond thin films on (100) silicon." Physical review. B, Condensed matter vol. 50,12 (1994): 8402-8410. doi: https://doi.org/10.1103/physrevb.50.8402
Jiang X, Klages C, Schiffmann K. Nucleation and initial growth phase of diamond thin films on (100) silicon. Phys Rev B Condens Matter. 1994 Sep 15;50(12):8402-8410. doi: 10.1103/physrevb.50.8402. PMID: 9974858.
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Surgical Management of Failed Revascularization in Moyamoya Vasculopathy.

Frontiers in neurology

Lucia K, Acker G, Schlinkmann N, Georgiev S, Vajkoczy P.
PMID: 34267719
Front Neurol. 2021 Jun 29;12:652967. doi: 10.3389/fneur.2021.652967. eCollection 2021.

No abstract available.

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Lucia K, Acker G, Schlinkmann N, et al. Surgical Management of Failed Revascularization in Moyamoya Vasculopathy. Front Neurol. 2021;12:652967doi: 10.3389/fneur.2021.652967.
Lucia, K., Acker, G., Schlinkmann, N., Georgiev, S., & Vajkoczy, P. (2021). Surgical Management of Failed Revascularization in Moyamoya Vasculopathy. Frontiers in neurology, 12652967. https://doi.org/10.3389/fneur.2021.652967
Lucia, Kristin, et al. "Surgical Management of Failed Revascularization in Moyamoya Vasculopathy." Frontiers in neurology vol. 12 (2021): 652967. doi: https://doi.org/10.3389/fneur.2021.652967
Lucia K, Acker G, Schlinkmann N, Georgiev S, Vajkoczy P. Surgical Management of Failed Revascularization in Moyamoya Vasculopathy. Front Neurol. 2021 Jun 29;12:652967. doi: 10.3389/fneur.2021.652967. eCollection 2021. PMID: 34267719; PMCID: PMC8275848.
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Young Survivors at KSA: registry for standardised assessment of long-term and late-onset health events in survivors of childhood and adolescent cancer-a study protocol.

BMJ open

Otth M, Drozdov D, Hügli C, Scheinemann K.
PMID: 34862296
BMJ Open. 2021 Dec 03;11(12):e053749. doi: 10.1136/bmjopen-2021-053749.

INTRODUCTION: A high proportion of survivors of childhood and adolescent cancer experience chronic medical conditions - late effects. Most studies on late effects have a retrospective or questionnaire-based design, which leads to unavoidable limitations such as missing data or...

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Otth M, Drozdov D, Hügli C, et al. Young Survivors at KSA: registry for standardised assessment of long-term and late-onset health events in survivors of childhood and adolescent cancer-a study protocol. BMJ Open. 2021;11(12):e053749doi: 10.1136/bmjopen-2021-053749.
Otth, M., Drozdov, D., Hügli, C., & Scheinemann, K. (2021). Young Survivors at KSA: registry for standardised assessment of long-term and late-onset health events in survivors of childhood and adolescent cancer-a study protocol. BMJ open, 11(12), e053749. https://doi.org/10.1136/bmjopen-2021-053749
Otth, Maria, et al. "Young Survivors at KSA: registry for standardised assessment of long-term and late-onset health events in survivors of childhood and adolescent cancer-a study protocol." BMJ open vol. 11,12 (2021): e053749. doi: https://doi.org/10.1136/bmjopen-2021-053749
Otth M, Drozdov D, Hügli C, Scheinemann K. Young Survivors at KSA: registry for standardised assessment of long-term and late-onset health events in survivors of childhood and adolescent cancer-a study protocol. BMJ Open. 2021 Dec 03;11(12):e053749. doi: 10.1136/bmjopen-2021-053749. PMID: 34862296; PMCID: PMC8647540.
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Aftercare of Childhood Cancer Survivors in Switzerland: Protocol for a Prospective Multicenter Observational Study.

JMIR research protocols

Denzler S, Otth M, Scheinemann K.
PMID: 32845247
JMIR Res Protoc. 2020 Aug 26;9(8):e18898. doi: 10.2196/18898.

BACKGROUND: Most children and adolescents diagnosed with cancer become long-term survivors. For most of them, regular follow-up examinations to detect and treat late effects are necessary, especially in adulthood. The transition from pediatric to adult-focused follow-up care is a...

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Denzler S, Otth M, Scheinemann K. Aftercare of Childhood Cancer Survivors in Switzerland: Protocol for a Prospective Multicenter Observational Study. JMIR Res Protoc. 2020;9(8):e18898doi: 10.2196/18898.
Denzler, S., Otth, M., & Scheinemann, K. (2020). Aftercare of Childhood Cancer Survivors in Switzerland: Protocol for a Prospective Multicenter Observational Study. JMIR research protocols, 9(8), e18898. https://doi.org/10.2196/18898
Denzler, Sibylle, et al. "Aftercare of Childhood Cancer Survivors in Switzerland: Protocol for a Prospective Multicenter Observational Study." JMIR research protocols vol. 9,8 (2020): e18898. doi: https://doi.org/10.2196/18898
Denzler S, Otth M, Scheinemann K. Aftercare of Childhood Cancer Survivors in Switzerland: Protocol for a Prospective Multicenter Observational Study. JMIR Res Protoc. 2020 Aug 26;9(8):e18898. doi: 10.2196/18898. PMID: 32845247; PMCID: PMC7481869.
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Does stereoscopic imaging improve the memorization of medical imaging by neurosurgeons? Experience of a single institution.

Neurosurgical review

Schlinkmann N, Khakhar R, Picht T, Piper SK, Fekonja LS, Vajkoczy P, Acker G.
PMID: 34550492
Neurosurg Rev. 2021 Sep 22; doi: 10.1007/s10143-021-01623-0. Epub 2021 Sep 22.

Stereoscopic imaging has increasingly been used in anatomical teaching and neurosurgery. The aim of our study was to analyze the potential utility of stereoscopic imaging as a tool for memorizing neurosurgical patient cases compared to conventional monoscopic visualization. A...

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Schlinkmann N, Khakhar R, Picht T, et al. Does stereoscopic imaging improve the memorization of medical imaging by neurosurgeons? Experience of a single institution. Neurosurg Rev. 2021;doi: 10.1007/s10143-021-01623-0.
Schlinkmann, N., Khakhar, R., Picht, T., Piper, S. K., Fekonja, L. S., Vajkoczy, P., & Acker, G. (2021). Does stereoscopic imaging improve the memorization of medical imaging by neurosurgeons? Experience of a single institution. Neurosurgical review, . https://doi.org/10.1007/s10143-021-01623-0
Schlinkmann, Nicolas, et al. "Does stereoscopic imaging improve the memorization of medical imaging by neurosurgeons? Experience of a single institution." Neurosurgical review vol. (2021). doi: https://doi.org/10.1007/s10143-021-01623-0
Schlinkmann N, Khakhar R, Picht T, Piper SK, Fekonja LS, Vajkoczy P, Acker G. Does stereoscopic imaging improve the memorization of medical imaging by neurosurgeons? Experience of a single institution. Neurosurg Rev. 2021 Sep 22; doi: 10.1007/s10143-021-01623-0. Epub 2021 Sep 22. PMID: 34550492.
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Longitudinal lung function in childhood cancer survivors after hematopoietic stem cell transplantation.

Bone marrow transplantation

Otth M, Yammine S, Usemann J, Latzin P, Mader L, Spycher B, Güngör T, Scheinemann K, Kuehni CE.
PMID: 34750563
Bone Marrow Transplant. 2021 Nov 08; doi: 10.1038/s41409-021-01509-1. Epub 2021 Nov 08.

Longitudinal data on pulmonary function after pediatric allogeneic or autologous hematopoietic stem cell transplantation (HSCT) are rare. We examined pulmonary function and associated risk factors in 5-year childhood cancer survivors (CCSs) longitudinally. We included 74 CCSs diagnosed between 1976...

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Otth M, Yammine S, Usemann J, et al. Longitudinal lung function in childhood cancer survivors after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2021;doi: 10.1038/s41409-021-01509-1.
Otth, M., Yammine, S., Usemann, J., Latzin, P., Mader, L., Spycher, B., Güngör, T., Scheinemann, K., Kuehni, C. E. (2021). Longitudinal lung function in childhood cancer survivors after hematopoietic stem cell transplantation. Bone marrow transplantation, . https://doi.org/10.1038/s41409-021-01509-1
Otth, Maria, et al. "Longitudinal lung function in childhood cancer survivors after hematopoietic stem cell transplantation." Bone marrow transplantation vol. (2021). doi: https://doi.org/10.1038/s41409-021-01509-1
Otth M, Yammine S, Usemann J, Latzin P, Mader L, Spycher B, Güngör T, Scheinemann K, Kuehni CE. Longitudinal lung function in childhood cancer survivors after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2021 Nov 08; doi: 10.1038/s41409-021-01509-1. Epub 2021 Nov 08. PMID: 34750563.
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The effect of CS-US contingency variation on GSR and on subjective CS-US relational awareness.

Memory & cognition

Schiffmann K, Furedy JJ.
PMID: 24202823
Mem Cognit. 1977 Mar;5(2):273-7. doi: 10.3758/BF03197374.

Ninety subjects were tested in a single-cue Pavlovian conditioning paradigm involving three groups which differed with regard to the contingency relationship between CS and US (negative contingency, zero contingency, positive contingency). To examine the relationship between conditioned GSR performance...

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Schiffmann K, Furedy JJ. The effect of CS-US contingency variation on GSR and on subjective CS-US relational awareness. Mem Cognit. 1977;5(2):273-7doi: 10.3758/BF03197374.
Schiffmann, K., & Furedy, J. J. (1977). The effect of CS-US contingency variation on GSR and on subjective CS-US relational awareness. Memory & cognition, 5(2), 273-7. https://doi.org/10.3758/BF03197374
Schiffmann, K, and Furedy, J J. "The effect of CS-US contingency variation on GSR and on subjective CS-US relational awareness." Memory & cognition vol. 5,2 (1977): 273-7. doi: https://doi.org/10.3758/BF03197374
Schiffmann K, Furedy JJ. The effect of CS-US contingency variation on GSR and on subjective CS-US relational awareness. Mem Cognit. 1977 Mar;5(2):273-7. doi: 10.3758/BF03197374. PMID: 24202823.
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How should a fixed budget of dwell time be spent in scanning electron microscopy to optimize image quality?.

Ultramicroscopy

Trampert P, Bourghorbel F, Potocek P, Peemen M, Schlinkmann C, Dahmen T, Slusallek P.
PMID: 29715521
Ultramicroscopy. 2018 Aug;191:11-17. doi: 10.1016/j.ultramic.2018.03.007. Epub 2018 Apr 06.

In scanning electron microscopy, the achievable image quality is often limited by a maximum feasible acquisition time per dataset. Particularly with regard to three-dimensional or large field-of-view imaging, a compromise must be found between a high amount of shot...

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Trampert P, Bourghorbel F, Potocek P, et al. How should a fixed budget of dwell time be spent in scanning electron microscopy to optimize image quality?. Ultramicroscopy. 2018;191:11-17doi: 10.1016/j.ultramic.2018.03.007.
Trampert, P., Bourghorbel, F., Potocek, P., Peemen, M., Schlinkmann, C., Dahmen, T., & Slusallek, P. (2018). How should a fixed budget of dwell time be spent in scanning electron microscopy to optimize image quality?. Ultramicroscopy, 19111-17. https://doi.org/10.1016/j.ultramic.2018.03.007
Trampert, Patrick, et al. "How should a fixed budget of dwell time be spent in scanning electron microscopy to optimize image quality?." Ultramicroscopy vol. 191 (2018): 11-17. doi: https://doi.org/10.1016/j.ultramic.2018.03.007
Trampert P, Bourghorbel F, Potocek P, Peemen M, Schlinkmann C, Dahmen T, Slusallek P. How should a fixed budget of dwell time be spent in scanning electron microscopy to optimize image quality?. Ultramicroscopy. 2018 Aug;191:11-17. doi: 10.1016/j.ultramic.2018.03.007. Epub 2018 Apr 06. PMID: 29715521.
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