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Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin.

Microbial cell (Graz, Austria)

Ring J, Rockenfeller P, Abraham C, Tadic J, Poglitsch M, Schimmel K, Westermayer J, Schauer S, Achleitner B, Schimpel C, Moitzi B, Rechberger GN, Sigrist SJ, Carmona-Gutierrez D, Kroemer G, Büttner S, Eisenberg T, Madeo F.
PMID: 29234670
Microb Cell. 2017 Nov 30;4(12):411-422. doi: 10.15698/mic2017.12.603.

Hereditary spastic paraplegias, a group of neurodegenerative disorders, can be caused by loss-of-function mutations in the protein spartin. However, the physiological role of spartin remains largely elusive. Here we show that heterologous expression of human or

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Ring J, Rockenfeller P, Abraham C, et al. Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin. Microb Cell. 2017;4(12):411-422doi: 10.15698/mic2017.12.603.
Ring, J., Rockenfeller, P., Abraham, C., Tadic, J., Poglitsch, M., Schimmel, K., Westermayer, J., Schauer, S., Achleitner, B., Schimpel, C., Moitzi, B., Rechberger, G. N., Sigrist, S. J., Carmona-Gutierrez, D., Kroemer, G., Büttner, S., Eisenberg, T., & Madeo, F. (2017). Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin. Microbial cell (Graz, Austria), 4(12), 411-422. https://doi.org/10.15698/mic2017.12.603
Ring, Julia, et al. "Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin." Microbial cell (Graz, Austria) vol. 4,12 (2017): 411-422. doi: https://doi.org/10.15698/mic2017.12.603
Ring J, Rockenfeller P, Abraham C, Tadic J, Poglitsch M, Schimmel K, Westermayer J, Schauer S, Achleitner B, Schimpel C, Moitzi B, Rechberger GN, Sigrist SJ, Carmona-Gutierrez D, Kroemer G, Büttner S, Eisenberg T, Madeo F. Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin. Microb Cell. 2017 Nov 30;4(12):411-422. doi: 10.15698/mic2017.12.603. PMID: 29234670; PMCID: PMC5722644.
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Highly Enantioselective Ferrocenyl Palladacycle-Acetate Catalysed Arylation of Aldimines and Ketimines with Arylboroxines.

Chemistry (Weinheim an der Bergstrasse, Germany)

Schrapel C, Frey W, Garnier D, Peters R.
PMID: 27983770
Chemistry. 2017 Feb 16;23(10):2448-2460. doi: 10.1002/chem.201605244. Epub 2017 Jan 20.

Benzylic N-substituted stereocenters constitute a frequent structural motif in drugs. Their highly enantioselective generation is hence of technical importance. An attractive strategy is the arylation of imines with organoboron reagents. Chiral Rh complexes have reached a high level of...

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Schrapel C, Frey W, Garnier D, et al. Highly Enantioselective Ferrocenyl Palladacycle-Acetate Catalysed Arylation of Aldimines and Ketimines with Arylboroxines. Chemistry. 2017;23(10):2448-2460doi: 10.1002/chem.201605244.
Schrapel, C., Frey, W., Garnier, D., & Peters, R. (2017). Highly Enantioselective Ferrocenyl Palladacycle-Acetate Catalysed Arylation of Aldimines and Ketimines with Arylboroxines. Chemistry (Weinheim an der Bergstrasse, Germany), 23(10), 2448-2460. https://doi.org/10.1002/chem.201605244
Schrapel, Carmen, et al. "Highly Enantioselective Ferrocenyl Palladacycle-Acetate Catalysed Arylation of Aldimines and Ketimines with Arylboroxines." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 23,10 (2017): 2448-2460. doi: https://doi.org/10.1002/chem.201605244
Schrapel C, Frey W, Garnier D, Peters R. Highly Enantioselective Ferrocenyl Palladacycle-Acetate Catalysed Arylation of Aldimines and Ketimines with Arylboroxines. Chemistry. 2017 Feb 16;23(10):2448-2460. doi: 10.1002/chem.201605244. Epub 2017 Jan 20. PMID: 27983770.
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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates.

Pharmaceutics

Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T.
PMID: 32585880
Pharmaceutics. 2020 Jun 23;12(6). doi: 10.3390/pharmaceutics12060578.

Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies of buprenorphine in children, particularly neonates, are available as conducting clinical trials in this population is especially...

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Kovar L, Schräpel C, Selzer D, et al. Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics. 2020;12(6)doi: 10.3390/pharmaceutics12060578.
Kovar, L., Schräpel, C., Selzer, D., Kohl, Y., Bals, R., Schwab, M., & Lehr, T. (2020). Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics, 12(6), . https://doi.org/10.3390/pharmaceutics12060578
Kovar, Lukas, et al. "Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates." Pharmaceutics vol. 12,6 (2020). doi: https://doi.org/10.3390/pharmaceutics12060578
Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T. Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics. 2020 Jun 23;12(6). doi: 10.3390/pharmaceutics12060578. PMID: 32585880; PMCID: PMC7355427.
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Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method.

The Journal of supercritical fluids

Merlo-Mas J, Tomsen-Melero J, Corchero JL, González-Mira E, Font A, Pedersen JN, García-Aranda N, Cristóbal-Lecina E, Alcaina-Hernando M, Mendoza R, Garcia-Fruitós E, Lizarraga T, Resch S, Schimpel C, Falk A, Pulido D, Royo M, Schwartz S, Abasolo I, Pedersen JS, Danino D, Soldevila A, Veciana J, Sala S, Ventosa N, Córdoba A.
PMID: 34219919
J Supercrit Fluids. 2021 Jul;173:105204. doi: 10.1016/j.supflu.2021.105204.

Fabry disease is a lysosomal storage disease arising from a deficiency of the enzyme α-galactosidase A (GLA). The enzyme deficiency results in an accumulation of glycolipids, which over time, leads to cardiovascular, cerebrovascular, and renal disease, ultimately leading to...

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Merlo-Mas J, Tomsen-Melero J, Corchero JL, et al. Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method. J Supercrit Fluids. 2021;173:105204doi: 10.1016/j.supflu.2021.105204.
Merlo-Mas, J., Tomsen-Melero, J., Corchero, J. L., González-Mira, E., Font, A., Pedersen, J. N., García-Aranda, N., Cristóbal-Lecina, E., Alcaina-Hernando, M., Mendoza, R., Garcia-Fruitós, E., Lizarraga, T., Resch, S., Schimpel, C., Falk, A., Pulido, D., Royo, M., Schwartz, S., Abasolo, I., Pedersen, J. S., Danino, D., Soldevila, A., Veciana, J., Sala, S., Ventosa, N., & Córdoba, A. (2021). Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method. The Journal of supercritical fluids, 173105204. https://doi.org/10.1016/j.supflu.2021.105204
Merlo-Mas, Josep, et al. "Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method." The Journal of supercritical fluids vol. 173 (2021): 105204. doi: https://doi.org/10.1016/j.supflu.2021.105204
Merlo-Mas J, Tomsen-Melero J, Corchero JL, González-Mira E, Font A, Pedersen JN, García-Aranda N, Cristóbal-Lecina E, Alcaina-Hernando M, Mendoza R, Garcia-Fruitós E, Lizarraga T, Resch S, Schimpel C, Falk A, Pulido D, Royo M, Schwartz S, Abasolo I, Pedersen JS, Danino D, Soldevila A, Veciana J, Sala S, Ventosa N, Córdoba A. Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method. J Supercrit Fluids. 2021 Jul;173:105204. doi: 10.1016/j.supflu.2021.105204. PMID: 34219919; PMCID: PMC8085735.
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Who is on your team? Specialty identity and inter-physician conflict during admissions.

Medical education

Schrepel C, Amick AE, Bann M, Watsjold B, Jauregui J, Ilgen JS, Sebok-Syer SS.
PMID: 34942027
Med Educ. 2021 Dec 23; doi: 10.1111/medu.14715. Epub 2021 Dec 23.

PURPOSE: Despite the implementation of professionalism curricula and standardized communication tools, inter-physician conflict persists. In particular, the interface between emergency medicine (EM) and internal medicine (IM) has long been recognized as a source of conflict. The social nuances of...

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Schrepel C, Amick AE, Bann M, et al. Who is on your team? Specialty identity and inter-physician conflict during admissions. Med Educ. 2021;doi: 10.1111/medu.14715.
Schrepel, C., Amick, A. E., Bann, M., Watsjold, B., Jauregui, J., Ilgen, J. S., & Sebok-Syer, S. S. (2021). Who is on your team? Specialty identity and inter-physician conflict during admissions. Medical education, . https://doi.org/10.1111/medu.14715
Schrepel, Caitlin, et al. "Who is on your team? Specialty identity and inter-physician conflict during admissions." Medical education vol. (2021). doi: https://doi.org/10.1111/medu.14715
Schrepel C, Amick AE, Bann M, Watsjold B, Jauregui J, Ilgen JS, Sebok-Syer SS. Who is on your team? Specialty identity and inter-physician conflict during admissions. Med Educ. 2021 Dec 23; doi: 10.1111/medu.14715. Epub 2021 Dec 23. PMID: 34942027.
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IMProv: A Resource for Cross-link-Driven Structure Modeling that Accommodates Protein Dynamics.

Molecular & cellular proteomics : MCP

Ziemianowicz DS, Saltzberg D, Pells T, Crowder DA, Schräder C, Hepburn M, Sali A, Schriemer DC.
PMID: 34418567
Mol Cell Proteomics. 2021;20:100139. doi: 10.1016/j.mcpro.2021.100139. Epub 2021 Aug 19.

Proteomics methodology has expanded to include protein structural analysis, primarily through cross-linking mass spectrometry (XL-MS) and hydrogen-deuterium exchange mass spectrometry (HX-MS). However, while the structural proteomics community has effective tools for primary data analysis, there is a need for...

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Ziemianowicz DS, Saltzberg D, Pells T, et al. IMProv: A Resource for Cross-link-Driven Structure Modeling that Accommodates Protein Dynamics. Mol Cell Proteomics. 2021;20:100139doi: 10.1016/j.mcpro.2021.100139.
Ziemianowicz, D. S., Saltzberg, D., Pells, T., Crowder, D. A., Schräder, C., Hepburn, M., Sali, A., & Schriemer, D. C. (2021). IMProv: A Resource for Cross-link-Driven Structure Modeling that Accommodates Protein Dynamics. Molecular & cellular proteomics : MCP, 20100139. https://doi.org/10.1016/j.mcpro.2021.100139
Ziemianowicz, Daniel S, et al. "IMProv: A Resource for Cross-link-Driven Structure Modeling that Accommodates Protein Dynamics." Molecular & cellular proteomics : MCP vol. 20 (2021): 100139. doi: https://doi.org/10.1016/j.mcpro.2021.100139
Ziemianowicz DS, Saltzberg D, Pells T, Crowder DA, Schräder C, Hepburn M, Sali A, Schriemer DC. IMProv: A Resource for Cross-link-Driven Structure Modeling that Accommodates Protein Dynamics. Mol Cell Proteomics. 2021;20:100139. doi: 10.1016/j.mcpro.2021.100139. Epub 2021 Aug 19. PMID: 34418567; PMCID: PMC8452774.
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Ischemic ECG Pattern Recognition to Facilitate Interpretation While Task Switching: A Parallel Curriculum.

MedEdPORTAL : the journal of teaching and learning resources

Schrepel C, Amick AE, Sayed M, Chipman AK.
PMID: 34557588
MedEdPORTAL. 2021 Sep 07;17:11182. doi: 10.15766/mep_2374-8265.11182. eCollection 2021.

INTRODUCTION: Interruptions are an inevitable part of working as an emergency physician, yet these can increase cognitive load and precipitate medical error. Emergency physicians learn to balance these responsibilities using a process called task switching. Yet residents have little...

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Schrepel C, Amick AE, Sayed M, et al. Ischemic ECG Pattern Recognition to Facilitate Interpretation While Task Switching: A Parallel Curriculum. MedEdPORTAL. 2021;17:11182doi: 10.15766/mep_2374-8265.11182.
Schrepel, C., Amick, A. E., Sayed, M., & Chipman, A. K. (2021). Ischemic ECG Pattern Recognition to Facilitate Interpretation While Task Switching: A Parallel Curriculum. MedEdPORTAL : the journal of teaching and learning resources, 1711182. https://doi.org/10.15766/mep_2374-8265.11182
Schrepel, Caitlin, et al. "Ischemic ECG Pattern Recognition to Facilitate Interpretation While Task Switching: A Parallel Curriculum." MedEdPORTAL : the journal of teaching and learning resources vol. 17 (2021): 11182. doi: https://doi.org/10.15766/mep_2374-8265.11182
Schrepel C, Amick AE, Sayed M, Chipman AK. Ischemic ECG Pattern Recognition to Facilitate Interpretation While Task Switching: A Parallel Curriculum. MedEdPORTAL. 2021 Sep 07;17:11182. doi: 10.15766/mep_2374-8265.11182. eCollection 2021. PMID: 34557588; PMCID: PMC8421424.
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A pan-Arctic synthesis of CH.

Global change biology

Treat CC, Natali SM, Ernakovich J, Iversen CM, Lupascu M, McGuire AD, Norby RJ, Roy Chowdhury T, Richter A, Šantrůčková H, Schädel C, Schuur EAG, Sloan VL, Turetsky MR, Waldrop MP.
PMID: 25620695
Glob Chang Biol. 2015 Jul;21(7):2787-2803. doi: 10.1111/gcb.12875. Epub 2015 Mar 31.

Permafrost thaw can alter the soil environment through changes in soil moisture, frequently resulting in soil saturation, a shift to anaerobic decomposition, and changes in the plant community. These changes, along with thawing of previously frozen organic material, can...

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Treat CC, Natali SM, Ernakovich J, et al. A pan-Arctic synthesis of CH. Glob Chang Biol. 2015;21(7):2787-2803doi: 10.1111/gcb.12875.
Treat, C. C., Natali, S. M., Ernakovich, J., Iversen, C. M., Lupascu, M., McGuire, A. D., Norby, R. J., Roy Chowdhury, T., Richter, A., Šantrůčková, H., Schädel, C., Schuur, E. A. G., Sloan, V. L., Turetsky, M. R., & Waldrop, M. P. (2015). A pan-Arctic synthesis of CH. Global change biology, 21(7), 2787-2803. https://doi.org/10.1111/gcb.12875
Treat, Claire C, et al. "A pan-Arctic synthesis of CH." Global change biology vol. 21,7 (2015): 2787-2803. doi: https://doi.org/10.1111/gcb.12875
Treat CC, Natali SM, Ernakovich J, Iversen CM, Lupascu M, McGuire AD, Norby RJ, Roy Chowdhury T, Richter A, Šantrůčková H, Schädel C, Schuur EAG, Sloan VL, Turetsky MR, Waldrop MP. A pan-Arctic synthesis of CH. Glob Chang Biol. 2015 Jul;21(7):2787-2803. doi: 10.1111/gcb.12875. Epub 2015 Mar 31. PMID: 25620695.
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Who's on your team? Specialty identity and inter-physician conflict during admissions.

Medical education

Schrepel C, Amick AE, Bann M, Watsjold B, Jauregui J, Ilgen JS, Sebok-Syer SS.
PMID: 34942027
Med Educ. 2021 Dec 23; doi: 10.1111/medu.14715. Epub 2021 Dec 23.

PURPOSE: Despite the implementation of professionalism curricula and standardised communication tools, inter-physician conflict persists. In particular, the interface between emergency medicine (EM) and internal medicine (IM) has long been recognised as a source of conflict. The social nuances of...

Cite
Schrepel C, Amick AE, Bann M, et al. Who's on your team? Specialty identity and inter-physician conflict during admissions. Med Educ. 2021;doi: 10.1111/medu.14715.
Schrepel, C., Amick, A. E., Bann, M., Watsjold, B., Jauregui, J., Ilgen, J. S., & Sebok-Syer, S. S. (2021). Who's on your team? Specialty identity and inter-physician conflict during admissions. Medical education, . https://doi.org/10.1111/medu.14715
Schrepel, Caitlin, et al. "Who's on your team? Specialty identity and inter-physician conflict during admissions." Medical education vol. (2021). doi: https://doi.org/10.1111/medu.14715
Schrepel C, Amick AE, Bann M, Watsjold B, Jauregui J, Ilgen JS, Sebok-Syer SS. Who's on your team? Specialty identity and inter-physician conflict during admissions. Med Educ. 2021 Dec 23; doi: 10.1111/medu.14715. Epub 2021 Dec 23. PMID: 34942027.
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Home treatment as an add-on to family-based treatment in adolescents with anorexia nervosa: A pilot study.

European eating disorders review : the journal of the Eating Disorders Association

Pauli D, Flütsch N, Hilti N, Schräer C, Soumana M, Häberling I, Berger G.
PMID: 35001459
Eur Eat Disord Rev. 2022 Jan 09; doi: 10.1002/erv.2882. Epub 2022 Jan 09.

OBJECTIVE: This pilot study examines the feasibility and the effectiveness of add-on home treatment (HT) to family-based treatment (FBT) in adolescents with anorexia nervosa (AN). The HT intervention is delivered by specialised nurses and aims at supporting patients and...

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Pauli D, Flütsch N, Hilti N, et al. Home treatment as an add-on to family-based treatment in adolescents with anorexia nervosa: A pilot study. Eur Eat Disord Rev. 2022;doi: 10.1002/erv.2882.
Pauli, D., Flütsch, N., Hilti, N., Schräer, C., Soumana, M., Häberling, I., & Berger, G. (2022). Home treatment as an add-on to family-based treatment in adolescents with anorexia nervosa: A pilot study. European eating disorders review : the journal of the Eating Disorders Association, . https://doi.org/10.1002/erv.2882
Pauli, Dagmar, et al. "Home treatment as an add-on to family-based treatment in adolescents with anorexia nervosa: A pilot study." European eating disorders review : the journal of the Eating Disorders Association vol. (2022). doi: https://doi.org/10.1002/erv.2882
Pauli D, Flütsch N, Hilti N, Schräer C, Soumana M, Häberling I, Berger G. Home treatment as an add-on to family-based treatment in adolescents with anorexia nervosa: A pilot study. Eur Eat Disord Rev. 2022 Jan 09; doi: 10.1002/erv.2882. Epub 2022 Jan 09. PMID: 35001459.
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Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote .

Frontiers in cell and developmental biology

Ji H, Qi Z, Schrapel D, Le M, Luo Y, Yan B, Gladkich J, Schaefer M, Liu L, Herr I.
PMID: 34926464
Front Cell Dev Biol. 2021 Dec 03;9:784999. doi: 10.3389/fcell.2021.784999. eCollection 2021.

Broccoli-derived isothiocyanate sulforaphane inhibits inflammation and cancer. Sulforaphane may support healthy aging, but the underlying detailed mechanisms are unclear. We used the

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Ji H, Qi Z, Schrapel D, et al. Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote . Front Cell Dev Biol. 2021;9:784999doi: 10.3389/fcell.2021.784999.
Ji, H., Qi, Z., Schrapel, D., Le, M., Luo, Y., Yan, B., Gladkich, J., Schaefer, M., Liu, L., & Herr, I. (2021). Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote . Frontiers in cell and developmental biology, 9784999. https://doi.org/10.3389/fcell.2021.784999
Ji, Huihui, et al. "Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote ." Frontiers in cell and developmental biology vol. 9 (2021): 784999. doi: https://doi.org/10.3389/fcell.2021.784999
Ji H, Qi Z, Schrapel D, Le M, Luo Y, Yan B, Gladkich J, Schaefer M, Liu L, Herr I. Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote . Front Cell Dev Biol. 2021 Dec 03;9:784999. doi: 10.3389/fcell.2021.784999. eCollection 2021. PMID: 34926464; PMCID: PMC8678450.
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The Correlation of Lung Function Parameters, Blood Pressure and Beta-Blocker Medication in a General Population.

Pneumologie (Stuttgart, Germany)

Schäper C, Ittermann T, Gläser S, Dörr M, Völzke H, Stubbe B, Felix SB, Ewert R, Bollmann T.
PMID: 34341979
Pneumologie. 2021 Aug 02; doi: 10.1055/a-1545-3337. Epub 2021 Aug 02.

OBJECTIVES:  Prior studies have investigated possible links between blood pressure, antihypertensive medication, especially beta-blockers and impairment of lung function. The aim of our study was to investigate an association between blood pressure, antihypertensive medication, focusing on beta-blockers, and its...

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Schäper C, Ittermann T, Gläser S, et al. Die Korrelation von Lungenfunktionswerten, Blutdruck und Betablocker Medikation in einer Bevölkerungsstudie - Ergebnisse der Study of Health in Pomerania. The Correlation of Lung Function Parameters, Blood Pressure and Beta-Blocker Medication in a General Population. Pneumologie. 2021;doi: 10.1055/a-1545-3337.
Schäper, C., Ittermann, T., Gläser, S., Dörr, M., Völzke, H., Stubbe, B., Felix, S. B., Ewert, R., & Bollmann, T. (2021). Die Korrelation von Lungenfunktionswerten, Blutdruck und Betablocker Medikation in einer Bevölkerungsstudie - Ergebnisse der Study of Health in Pomerania. The Correlation of Lung Function Parameters, Blood Pressure and Beta-Blocker Medication in a General Population. Pneumologie (Stuttgart, Germany), . https://doi.org/10.1055/a-1545-3337
Schäper, Christoph, et al. "Die Korrelation von Lungenfunktionswerten, Blutdruck und Betablocker Medikation in einer Bevölkerungsstudie - Ergebnisse der Study of Health in Pomerania." The Correlation of Lung Function Parameters, Blood Pressure and Beta-Blocker Medication in a General Population. Pneumologie (Stuttgart, Germany) vol. (2021). doi: https://doi.org/10.1055/a-1545-3337
Schäper C, Ittermann T, Gläser S, Dörr M, Völzke H, Stubbe B, Felix SB, Ewert R, Bollmann T. Die Korrelation von Lungenfunktionswerten, Blutdruck und Betablocker Medikation in einer Bevölkerungsstudie - Ergebnisse der Study of Health in Pomerania. The Correlation of Lung Function Parameters, Blood Pressure and Beta-Blocker Medication in a General Population. Pneumologie. 2021 Aug 02; doi: 10.1055/a-1545-3337. Epub 2021 Aug 02. PMID: 34341979.
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