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Showing 1 to 12 of 100 entries
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Right ventricular reverse remodeling after pulmonary endarterectomy: magnetic resonance imaging and clinical and right heart catheterization assessment.

Pulmonary circulation

Berman M, Gopalan D, Sharples L, Screaton N, Maccan C, Sheares K, Pepke-Zaba J, Dunning J, Tsui S, Jenkins DP.
PMID: 25006419
Pulm Circ. 2014 Mar;4(1):36-44. doi: 10.1086/674884.

The objective of this study was to assess the effect of pulmonary endarterectomy (PEA) on right ventricular (RV) reverse remodeling using magnetic resonance imaging (MRI) and to correlate MRI findings with clinical and hemodynamic outcomes postsurgery. We performed a...

An immunodominant NP.

Nature immunology

Peng Y, Felce SL, Dong D, Penkava F, Mentzer AJ, Yao X, Liu G, Yin Z, Chen JL, Lu Y, Wellington D, Wing PAC, Dominey-Foy DCC, Jin C, Wang W, Hamid MA, Fernandes RA, Wang B, Fries A, Zhuang X, Ashley N, Rostron T, Waugh C, Sopp P, Hublitz P, Beveridge R, Tan TK, Dold C, Kwok AJ, Rich-Griffin C, Dejnirattisa W, Liu C, Kurupati P, Nassiri I, Watson RA, Tong O, Taylor CA, Kumar Sharma P, Sun B, Curion F, Revale S, Garner LC, Jansen K, Ferreira RC, Attar M, Fry JW, Russell RA, Stauss HJ, James W, Townsend A, Ho LP, Klenerman P, Mongkolsapaya J, Screaton GR, Dendrou C, Sansom SN, Bashford-Rogers R, Chain B, Smith GL, McKeating JA, Fairfax BP, Bowness P, McMichael AJ, Ogg G, Knight JC, Dong T.
PMID: 34853448
Nat Immunol. 2022 Jan;23(1):50-61. doi: 10.1038/s41590-021-01084-z. Epub 2021 Dec 01.

NP

Co-infections and antimicrobial use among hospitalized COVID-19 patients in Punjab, Pakistan: findings from a multicenter, point prevalence survey.

Pathogens and global health

Mustafa ZU, Saleem MS, Ikram MN, Salman M, Butt SA, Khan S, Godman B, Seaton RA.
PMID: 34783630
Pathog Glob Health. 2021 Nov 16;1-7. doi: 10.1080/20477724.2021.1999716. Epub 2021 Nov 16.

There are reports of high rates of antibiotic prescribing among hospitalized patients with COVID-19 around the world. To date, however, there are few reports of prescribing in relation to COVID-19 in Pakistan. Herein, we describe a point prevalence survey...

Multiple Anterior and Posterior Circulation Intracranial Fenestrations presenting With Aneurysmal Subarachnoid Hemorrhage.

Cureus

Scranton RA, Jenson AV, Suresh R, Britz G.
PMID: 33604207
Cureus. 2021 Jan 12;13(1):e12667. doi: 10.7759/cureus.12667.

No abstract available.

Antibiotic use towards the end of life: development of good practice recommendations.

BMJ supportive & palliative care

Seaton RA, Cooper L, Fairweather J, Fenning S, Ferguson L, Galbraith S, Duffy T, Sneddon J.
PMID: 33468509
BMJ Support Palliat Care. 2021 Jan 19; doi: 10.1136/bmjspcare-2020-002732. Epub 2021 Jan 19.

OBJECTIVES: Development of evidence-based good practice recommendations for clinicians considering the use of antibiotics in patients towards the end of life.DESIGN: A multiprofessional group of experts in end-of-life care and antimicrobial stewardship was convened. Findings from a scoping review...

Factors influencing the stewardship activities of Antimicrobial Management Teams: a national cross-sectional survey.

The Journal of hospital infection

Ness V, Sneddon J, Seaton RA, Malcolm W, Currie K.
PMID: 34710498
J Hosp Infect. 2021 Oct 26;119:1-8. doi: 10.1016/j.jhin.2021.10.012. Epub 2021 Oct 26.

BACKGROUND: The link between inappropriate antibiotic prescribing and the global threat of antimicrobial resistance is well documented. International strategies recommend antimicrobial stewardship (AMS) programmes, with improvement interventions to safeguard antibiotics.AIM: This study sought to systematically evaluate the impact of...

An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Sneddon J, Cooper L, Ritchie N, Steele C, Spears M, McEwen J, Dempsey Z, Sutherland R, Khatamzas E, Seaton RA.
PMID: 33811406
Clin Exp Allergy. 2021 Sep;51(9):1229-1232. doi: 10.1111/cea.13878. Epub 2021 Apr 12.

No abstract available.

Factors influencing the stewardship activities of Antimicrobial Management Teams: a national cross-sectional survey.

The Journal of hospital infection

Ness V, Sneddon J, Seaton RA, Malcolm W, Currie K.
PMID: 34710498
J Hosp Infect. 2021 Oct 26;119:1-8. doi: 10.1016/j.jhin.2021.10.012. Epub 2021 Oct 26.

BACKGROUND: The link between inappropriate antibiotic prescribing and the global threat of antimicrobial resistance is well documented. International strategies recommend antimicrobial stewardship (AMS) programmes, with improvement interventions to safeguard antibiotics.AIM: This study sought to systematically evaluate the impact of...

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.

Cell host & microbe

Liu C, Zhou D, Nutalai R, Duyvesteyn HME, Tuekprakhon A, Ginn HM, Dejnirattisai W, Supasa P, Mentzer AJ, Wang B, Case JB, Zhao Y, Skelly DT, Chen RE, Johnson SA, Ritter TG, Mason C, Malik T, Temperton N, Paterson NG, Williams MA, Hall DR, Clare DK, Howe A, Goulder PJR, Fry EE, Diamond MS, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR.
PMID: 34921776
Cell Host Microbe. 2021 Nov 27; doi: 10.1016/j.chom.2021.11.013. Epub 2021 Nov 27.

Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the antigenic structure of S, causing escape from natural or vaccine-induced immunity. Beta is particularly difficult to neutralize using serum...

Antimicrobial point prevalence surveys in two Ghanaian hospitals: opportunities for antimicrobial stewardship.

JAC-antimicrobial resistance

Afriyie DK, Sefah IA, Sneddon J, Malcolm W, McKinney R, Cooper L, Kurdi A, Godman B, Seaton RA.
PMID: 34222959
JAC Antimicrob Resist. 2020 Feb 18;2(1):dlaa001. doi: 10.1093/jacamr/dlaa001. eCollection 2020 Mar.

BACKGROUND: Improved knowledge regarding antimicrobial use in Ghana is needed to reduce antimicrobial resistance (AMR). This includes point prevalence studies (PPSs) in hospitals. Objectives were to: (i) provide baseline data in two hospitals [Keta Municipal Hospital (KMH) and Ghana...

Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics.

Cell

Lim XX, Shu B, Zhang S, Tan AWK, Ng TS, Lim XN, Chew VS, Shi J, Screaton GR, Lok SM, Anand GS.
PMID: 34852238
Cell. 2021 Dec 09;184(25):6067-6080.e13. doi: 10.1016/j.cell.2021.11.009. Epub 2021 Nov 30.

The human monoclonal antibody (HmAb) C10 potently cross-neutralizes Zika virus (ZIKV) and dengue virus. Analysis of antibody fragment (Fab) C10 interactions with ZIKV and dengue virus serotype 2 (DENV2) particles by cryoelectron microscopy (cryo-EM) and amide hydrogen/deuterium exchange mass...

The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses.

Cell

Sharma A, Zhang X, Dejnirattisai W, Dai X, Gong D, Wongwiwat W, Duquerroy S, Rouvinski A, Vaney MC, Guardado-Calvo P, Haouz A, England P, Sun R, Zhou ZH, Mongkolsapaya J, Screaton GR, Rey FA.
PMID: 34852239
Cell. 2021 Dec 09;184(25):6052-6066.e18. doi: 10.1016/j.cell.2021.11.010. Epub 2021 Nov 30.

The human monoclonal antibody C10 exhibits extraordinary cross-reactivity, potently neutralizing Zika virus (ZIKV) and the four serotypes of dengue virus (DENV1-DENV4). Here we describe a comparative structure-function analysis of C10 bound to the envelope (E) protein dimers of the...

Showing 1 to 12 of 100 entries