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Showing 1 to 12 of 21 entries
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Dopamine and the biology of creativity: lessons from Parkinson's disease.

Frontiers in neurology

Lhommée E, Batir A, Quesada JL, Ardouin C, Fraix V, Seigneuret E, Chabardès S, Benabid AL, Pollak P, Krack P.
PMID: 24795692
Front Neurol. 2014 Apr 22;5:55. doi: 10.3389/fneur.2014.00055. eCollection 2014.

BACKGROUND: Parkinson's disease (PD) is characterized by reduced flexibility, conceptualization, and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD. Knowledge about the role of dopamine in creativity so far only stems...

Quantitative analysis of the formation of nucleoprotein complexes between HIV-1 Gag protein and genomic RNA using transmission electron microscopy.

The Journal of biological chemistry

Durand S, Seigneuret F, Burlaud-Gaillard J, Lemoine R, Tassi MF, Moreau A, Mougel M, Roingeard P, Tauber C, de Rocquigny H.
PMID: 34929171
J Biol Chem. 2021 Dec 17;298(1):101500. doi: 10.1016/j.jbc.2021.101500. Epub 2021 Dec 17.

In HIV, the polyprotein precursor Gag orchestrates the formation of the viral capsid. In the current view of this viral assembly, Gag forms low-order oligomers that bind to the viral genomic RNA triggering the formation of high-ordered ribonucleoprotein complexes....

Quantitative analysis of the formation of nucleoprotein complexes between HIV-1 Gag protein and genomic RNA using transmission electron microscopy.

The Journal of biological chemistry

Durand S, Seigneuret F, Burlaud-Gaillard J, Lemoine R, Tassi MF, Moreau A, Mougel M, Roingeard P, Tauber C, de Rocquigny H.
PMID: 34929171
J Biol Chem. 2021 Dec 17;298(1):101500. doi: 10.1016/j.jbc.2021.101500. Epub 2021 Dec 17.

In HIV, the polyprotein precursor Gag orchestrates the formation of the viral capsid. In the current view of this viral assembly, Gag forms low-order oligomers that bind to the viral genomic RNA triggering the formation of high-ordered ribonucleoprotein complexes....

Influence of the critical EEG pattern on blood flow variations measured by single photon computed emission tomography.

Epileptic disorders : international epilepsy journal with videotape

Biraben A, Bernard A, Seigneret E, Scarabin JM.
PMID: 11781199
Epileptic Disord. 2001 Jul;37-43.

Anatomo-electro-clinical correlation's using stereo-electro-encephalography (SEEG) or electro-cortico-graphy (EcoG) are the gold standard for delineating the epileptic zone (EZ) in patients with partial epilepsy. These two techniques reflect the temporal and spatial dimensions of the epileptic fit. More recently, ictal...

Medicines Adaptive Pathways to Patients (MAPPs): A Story of International Collaboration Leading to Implementation.

Therapeutic innovation & regulatory science

Schulthess D, Baird LG, Trusheim M, Unger TF, Lumpkin M, Hoos A, Garner S, Gavin P, Goldman M, Seigneuret N, Chlebus M, Van Baelen K, Bergstrom R, Hirsch G.
PMID: 30227070
Ther Innov Regul Sci. 2016 May;50(3):347-354. doi: 10.1177/2168479015618697.

After nearly a decade of discussion, analysis, and development, the Medicines Adaptive Pathways to Patients (MAPPs) initiative is beginning to see acceptance from regulators, industry, patients, and payers, with the first live pilot project initiated under the guidance of...

Mapping of the detergent-exposed surface of membrane proteins and peptides by 1H solution NMR in detergent: Application to the gramicidin A ion channel.

Journal of biomolecular NMR

Seigneuret M, Le Guernevé C.
PMID: 21080261
J Biomol NMR. 1999 Jan;13(1):31-41. doi: 10.1023/A:1008357824038.

The present work evaluates the use of intermolecular polypeptide-detergent 1H through-space connectivities to determine the bilayer exposed-surface and the bilayer topography of membrane polypeptides solubilized in non- deuterated detergents. For this purpose, the membrane peptide gramicidin A, solubilized in...

[Risk announcement in paediatric cancerology: strengthen the therapeutic alliance].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

Doz F, Davous D, Seigneur E, Heard M.
PMID: 18321689
Arch Pediatr. 2008 Mar;15(3):291-300. doi: 10.1016/j.arcped.2007.11.010. Epub 2008 Mar 05.

Although announcement of the risks related to treatment has become a general rule in the healthcare relationship, doctors, nurses and parents of severely ill children tend to feel uncomfortable in relation to this mandatory information. The work conducted by...

Improved Characterization of Raft-Mimicking Phase-Separation Phenomena in Lipid Bilayers Using Laurdan Fluorescence with Log-Normal Multipeak Analysis.

Langmuir : the ACS journal of surfaces and colloids

Puff N, Staneva G, Angelova MI, Seigneuret M.
PMID: 32233510
Langmuir. 2020 Apr 28;36(16):4347-4356. doi: 10.1021/acs.langmuir.0c00412. Epub 2020 Apr 13.

The study of biomimetic model membrane systems undergoing liquid-ordered (Lo)-liquid-disordered (Ld) phase separation using spectroscopic methods has played an important role in understanding the properties of lipid rafts in plasma membranes. In particular, the membrane-associated fluorescence probe Laurdan has...

Quantitative analysis of the formation of nucleoprotein complexes between HIV-1 Gag protein and genomic RNA using transmission electron microscopy.

The Journal of biological chemistry

Durand S, Seigneuret F, Burlaud-Gaillard J, Lemoine R, Tassi MF, Moreau A, Mougel M, Roingeard P, Tauber C, de Rocquigny H.
PMID: 34929171
J Biol Chem. 2021 Dec 17;101500. doi: 10.1016/j.jbc.2021.101500. Epub 2021 Dec 17.

In HIV the polyprotein precursor Gag orchestrates the formation of the viral capsid. In the current view of this viral assembly, Gag forms low-order oligomers that bind to the viral genomic RNA triggering the formation of high-ordered ribonucleoprotein complexes....

Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.

Molecular psychiatry

Seigneur E, Wang J, Dai J, Polepalli J, Südhof TC.
PMID: 34158618
Mol Psychiatry. 2021 Jun 22; doi: 10.1038/s41380-021-01187-x. Epub 2021 Jun 22.

Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 simultaneously bind to presynaptic neurexins and postsynaptic GluD1 and GluD2, thereby forming trans-synaptic adhesion complexes. Genetic associations...

Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.

Molecular psychiatry

Seigneur E, Wang J, Dai J, Polepalli J, Südhof TC.
PMID: 34158618
Mol Psychiatry. 2021 Jun 22; doi: 10.1038/s41380-021-01187-x. Epub 2021 Jun 22.

Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 simultaneously bind to presynaptic neurexins and postsynaptic GluD1 and GluD2, thereby forming trans-synaptic adhesion complexes. Genetic associations...

Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.

Molecular psychiatry

Seigneur E, Wang J, Dai J, Polepalli J, Südhof TC.
PMID: 34158618
Mol Psychiatry. 2021 Jun 22; doi: 10.1038/s41380-021-01187-x. Epub 2021 Jun 22.

Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 simultaneously bind to presynaptic neurexins and postsynaptic GluD1 and GluD2, thereby forming trans-synaptic adhesion complexes. Genetic associations...

Showing 1 to 12 of 21 entries