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Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus.

Molecular therapy oncolytics

Illingworth S, Di Y, Bauzon M, Lei J, Duffy MR, Alvis S, Champion B, Lieber A, Hermiston T, Seymour LW, Beadle J, Fisher K.
PMID: 28480328
Mol Ther Oncolytics. 2017 Mar 29;5:62-74. doi: 10.1016/j.omto.2017.03.003. eCollection 2017 Jun 16.

Enadenotucirev is an oncolytic group B adenovirus identified by a process of bio-selection for the ability to selectively propagate in and rapidly kill carcinoma cells. It is resistant to inactivation by human blood components, potentially enabling intravenous dosing in...

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Illingworth S, Di Y, Bauzon M, et al. Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus. Mol Ther Oncolytics. 2017;5:62-74doi: 10.1016/j.omto.2017.03.003.
Illingworth, S., Di, Y., Bauzon, M., Lei, J., Duffy, M. R., Alvis, S., Champion, B., Lieber, A., Hermiston, T., Seymour, L. W., Beadle, J., & Fisher, K. (2017). Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus. Molecular therapy oncolytics, 562-74. https://doi.org/10.1016/j.omto.2017.03.003
Illingworth, Sam, et al. "Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus." Molecular therapy oncolytics vol. 5 (2017): 62-74. doi: https://doi.org/10.1016/j.omto.2017.03.003
Illingworth S, Di Y, Bauzon M, Lei J, Duffy MR, Alvis S, Champion B, Lieber A, Hermiston T, Seymour LW, Beadle J, Fisher K. Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus. Mol Ther Oncolytics. 2017 Mar 29;5:62-74. doi: 10.1016/j.omto.2017.03.003. eCollection 2017 Jun 16. PMID: 28480328; PMCID: PMC5415321.
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Poly(alkyl methacrylate) Brush-Grafted Silica Nanoparticles as Oil Lubricant Additives: Effects of Alkyl Pendant Groups on Oil Dispersibility, Stability, and Lubrication Property.

ACS applied materials & interfaces

Seymour BT, Wright RAE, Parrott AC, Gao H, Martini A, Qu J, Dai S, Zhao B.
PMID: 28670899
ACS Appl Mater Interfaces. 2017 Jul 26;9(29):25038-25048. doi: 10.1021/acsami.7b06714. Epub 2017 Jul 12.

This article reports on the synthesis of a series of poly(alkyl methacrylate) brush-grafted, 23 nm silica nanoparticles (hairy NPs) and the study of the effect of alkyl pendant length on their use as oil lubricant additives for friction and...

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Seymour BT, Wright RAE, Parrott AC, et al. Poly(alkyl methacrylate) Brush-Grafted Silica Nanoparticles as Oil Lubricant Additives: Effects of Alkyl Pendant Groups on Oil Dispersibility, Stability, and Lubrication Property. ACS Appl Mater Interfaces. 2017;9(29):25038-25048doi: 10.1021/acsami.7b06714.
Seymour, B. T., Wright, R. A. E., Parrott, A. C., Gao, H., Martini, A., Qu, J., Dai, S., & Zhao, B. (2017). Poly(alkyl methacrylate) Brush-Grafted Silica Nanoparticles as Oil Lubricant Additives: Effects of Alkyl Pendant Groups on Oil Dispersibility, Stability, and Lubrication Property. ACS applied materials & interfaces, 9(29), 25038-25048. https://doi.org/10.1021/acsami.7b06714
Seymour, Bryan T, et al. "Poly(alkyl methacrylate) Brush-Grafted Silica Nanoparticles as Oil Lubricant Additives: Effects of Alkyl Pendant Groups on Oil Dispersibility, Stability, and Lubrication Property." ACS applied materials & interfaces vol. 9,29 (2017): 25038-25048. doi: https://doi.org/10.1021/acsami.7b06714
Seymour BT, Wright RAE, Parrott AC, Gao H, Martini A, Qu J, Dai S, Zhao B. Poly(alkyl methacrylate) Brush-Grafted Silica Nanoparticles as Oil Lubricant Additives: Effects of Alkyl Pendant Groups on Oil Dispersibility, Stability, and Lubrication Property. ACS Appl Mater Interfaces. 2017 Jul 26;9(29):25038-25048. doi: 10.1021/acsami.7b06714. Epub 2017 Jul 12. PMID: 28670899.
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Investigation of short-range cedar pollen forecasting.

Physical review. E, Statistical, nonlinear, and soft matter physics

Delaunay JJ, Seymour C, Fouillet V.
PMID: 15697491
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Dec;70(6):066214. doi: 10.1103/PhysRevE.70.066214. Epub 2004 Dec 23.

Pollen forecasting is of increasing interest as a way to help the general public avoid contact with allergy-inducing pollen. It was recently reported that the dynamics underlying pollen concentration series is very similar to that of low-dimensional deterministic chaos,...

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Delaunay JJ, Seymour C, Fouillet V. Investigation of short-range cedar pollen forecasting. Phys Rev E Stat Nonlin Soft Matter Phys. 2004;70(6):066214doi: 10.1103/PhysRevE.70.066214.
Delaunay, J. J., Seymour, C., & Fouillet, V. (2004). Investigation of short-range cedar pollen forecasting. Physical review. E, Statistical, nonlinear, and soft matter physics, 70(6), 066214. https://doi.org/10.1103/PhysRevE.70.066214
Delaunay, J-J, et al. "Investigation of short-range cedar pollen forecasting." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 70,6 (2004): 066214. doi: https://doi.org/10.1103/PhysRevE.70.066214
Delaunay JJ, Seymour C, Fouillet V. Investigation of short-range cedar pollen forecasting. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Dec;70(6):066214. doi: 10.1103/PhysRevE.70.066214. Epub 2004 Dec 23. PMID: 15697491.
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Barriers to Gene Delivery Using Synthetic Vectors.

Advances in genetics

Read ML, Logan A, Seymour LW.
PMID: 16243059
Adv Genet. 2005;53:19-46. doi: 10.1016/S0065-2660(05)53002-5.

Progress has been made in the development of different types of nucleic acids such as DNA and siRNA with the potential to form the basis of new treatments for genetic and acquired disorders. The lack of suitable vectors for...

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Read ML, Logan A, Seymour LW. Barriers to Gene Delivery Using Synthetic Vectors. Adv Genet. 2005;53:19-46doi: 10.1016/S0065-2660(05)53002-5.
Read, M. L., Logan, A., & Seymour, L. W. (2005). Barriers to Gene Delivery Using Synthetic Vectors. Advances in genetics, 5319-46. https://doi.org/10.1016/S0065-2660(05)53002-5
Read, Martin L, et al. "Barriers to Gene Delivery Using Synthetic Vectors." Advances in genetics vol. 53 (2005): 19-46. doi: https://doi.org/10.1016/S0065-2660(05)53002-5
Read ML, Logan A, Seymour LW. Barriers to Gene Delivery Using Synthetic Vectors. Adv Genet. 2005;53:19-46. doi: 10.1016/S0065-2660(05)53002-5. PMID: 16243059.
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Radiation induced bystander effects in mice given low doses of radiation in vivo.

Dose-response : a publication of International Hormesis Society

Singh H, Saroya R, Smith R, Mantha R, Guindon L, Mitchel RE, Seymour C, Mothersill C.
PMID: 21731538
Dose Response. 2011;9(2):225-42. doi: 10.2203/dose-response.09-062.Singh. Epub 2010 May 13.

The 'bystander effect' phenomenon has challenged the traditional framework for assessing radiation damage by showing radiation induced changes in cells which have not been directly targeted, but are neighbors to or receive medium from directly hit cells. Our group...

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Singh H, Saroya R, Smith R, et al. Radiation induced bystander effects in mice given low doses of radiation in vivo. Dose Response. 2010;9(2):225-42doi: 10.2203/dose-response.09-062.Singh.
Singh, H., Saroya, R., Smith, R., Mantha, R., Guindon, L., Mitchel, R. E., Seymour, C., & Mothersill, C. (2011). Radiation induced bystander effects in mice given low doses of radiation in vivo. Dose-response : a publication of International Hormesis Society, 9(2), 225-42. https://doi.org/10.2203/dose-response.09-062.Singh
Singh, Harleen, et al. "Radiation induced bystander effects in mice given low doses of radiation in vivo." Dose-response : a publication of International Hormesis Society vol. 9,2 (2011): 225-42. doi: https://doi.org/10.2203/dose-response.09-062.Singh
Singh H, Saroya R, Smith R, Mantha R, Guindon L, Mitchel RE, Seymour C, Mothersill C. Radiation induced bystander effects in mice given low doses of radiation in vivo. Dose Response. 2011;9(2):225-42. doi: 10.2203/dose-response.09-062.Singh. Epub 2010 May 13. PMID: 21731538; PMCID: PMC3118769.
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Simple x-ray standing-wave technique and its application to the investigation of the Cu(111) ( sqrt 3 sqrt 3 )R30 degrees -Cl structure.

Physical review letters

Crapper MD, Jones RG, McConville CF, Prince NP, Riley CE, Seymour DL, Woodruff DP.
PMID: 10034442
Phys Rev Lett. 1987 Apr 06;58(14):1460-1462. doi: 10.1103/PhysRevLett.58.1460.

No abstract available.

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Crapper MD, Jones RG, McConville CF, et al. Simple x-ray standing-wave technique and its application to the investigation of the Cu(111) ( sqrt 3 sqrt 3 )R30 degrees -Cl structure. Phys Rev Lett. 1987;58(14):1460-1462doi: 10.1103/PhysRevLett.58.1460.
Crapper, M. D., Jones, R. G., McConville, C. F., Prince, N. P., Riley, C. E., Seymour, D. L., & Woodruff, D. P. (1987). Simple x-ray standing-wave technique and its application to the investigation of the Cu(111) ( sqrt 3 sqrt 3 )R30 degrees -Cl structure. Physical review letters, 58(14), 1460-1462. https://doi.org/10.1103/PhysRevLett.58.1460
Crapper, et al. "Simple x-ray standing-wave technique and its application to the investigation of the Cu(111) ( sqrt 3 sqrt 3 )R30 degrees -Cl structure." Physical review letters vol. 58,14 (1987): 1460-1462. doi: https://doi.org/10.1103/PhysRevLett.58.1460
Crapper MD, Jones RG, McConville CF, Prince NP, Riley CE, Seymour DL, Woodruff DP. Simple x-ray standing-wave technique and its application to the investigation of the Cu(111) ( sqrt 3 sqrt 3 )R30 degrees -Cl structure. Phys Rev Lett. 1987 Apr 06;58(14):1460-1462. doi: 10.1103/PhysRevLett.58.1460. PMID: 10034442.
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Nuclear-magnetic-resonance evidence for a change in local electronic structure accompanying hydrogen pairing in yttrium-hydrogen solid solutions.

Physical review. B, Condensed matter

Barnes RG, Chang CT, Seymour EF, Torgeson DR, West GW.
PMID: 9998956
Phys Rev B Condens Matter. 1991 Nov 01;44(17):9692-9695. doi: 10.1103/physrevb.44.9692.

No abstract available.

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Barnes RG, Chang CT, Seymour EF, et al. Nuclear-magnetic-resonance evidence for a change in local electronic structure accompanying hydrogen pairing in yttrium-hydrogen solid solutions. Phys Rev B Condens Matter. 1991;44(17):9692-9695doi: 10.1103/physrevb.44.9692.
Barnes, R. G., Chang, C. T., Seymour, E. F., Torgeson, D. R., & West, G. W. (1991). Nuclear-magnetic-resonance evidence for a change in local electronic structure accompanying hydrogen pairing in yttrium-hydrogen solid solutions. Physical review. B, Condensed matter, 44(17), 9692-9695. https://doi.org/10.1103/physrevb.44.9692
Barnes, et al. "Nuclear-magnetic-resonance evidence for a change in local electronic structure accompanying hydrogen pairing in yttrium-hydrogen solid solutions." Physical review. B, Condensed matter vol. 44,17 (1991): 9692-9695. doi: https://doi.org/10.1103/physrevb.44.9692
Barnes RG, Chang CT, Seymour EF, Torgeson DR, West GW. Nuclear-magnetic-resonance evidence for a change in local electronic structure accompanying hydrogen pairing in yttrium-hydrogen solid solutions. Phys Rev B Condens Matter. 1991 Nov 01;44(17):9692-9695. doi: 10.1103/physrevb.44.9692. PMID: 9998956.
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Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players.

Cancers

Mothersill C, Rusin A, Seymour C.
PMID: 31450803
Cancers (Basel). 2019 Aug 23;11(9). doi: 10.3390/cancers11091236.

Non-targeted effects (NTE) such as bystander effects or genomic instability have been known for many years but their significance for radiotherapy or medical diagnostic radiology are far from clear. Central to the issue are reported differences in the response...

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Mothersill C, Rusin A, Seymour C. Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players. Cancers (Basel). 2019;11(9)doi: 10.3390/cancers11091236.
Mothersill, C., Rusin, A., & Seymour, C. (2019). Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players. Cancers, 11(9), . https://doi.org/10.3390/cancers11091236
Mothersill, Carmel, et al. "Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players." Cancers vol. 11,9 (2019). doi: https://doi.org/10.3390/cancers11091236
Mothersill C, Rusin A, Seymour C. Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players. Cancers (Basel). 2019 Aug 23;11(9). doi: 10.3390/cancers11091236. PMID: 31450803; PMCID: PMC6770832.
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Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness.

Critical care (London, England)

Seymour CW, Gomez H, Chang CH, Clermont G, Kellum JA, Kennedy J, Yende S, Angus DC.
PMID: 29047353
Crit Care. 2017 Oct 18;21(1):257. doi: 10.1186/s13054-017-1836-5.

All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field of critical care may be tempted to envision that...

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Seymour CW, Gomez H, Chang CH, et al. Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness. Crit Care. 2017;21(1):257doi: 10.1186/s13054-017-1836-5.
Seymour, C. W., Gomez, H., Chang, C. H., Clermont, G., Kellum, J. A., Kennedy, J., Yende, S., & Angus, D. C. (2017). Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness. Critical care (London, England), 21(1), 257. https://doi.org/10.1186/s13054-017-1836-5
Seymour, Christopher W, et al. "Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness." Critical care (London, England) vol. 21,1 (2017): 257. doi: https://doi.org/10.1186/s13054-017-1836-5
Seymour CW, Gomez H, Chang CH, Clermont G, Kellum JA, Kennedy J, Yende S, Angus DC. Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness. Crit Care. 2017 Oct 18;21(1):257. doi: 10.1186/s13054-017-1836-5. PMID: 29047353; PMCID: PMC5648512.
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Google Search Trends in Oncology and the Impact of Celebrity Cancer Awareness.

Cureus

Kaleem T, Malouff TD, Stross WC, Waddle MR, Miller DH, Seymour AL, Zaorsky NG, Miller RC, Trifiletti DM, Vallow L.
PMID: 31608195
Cureus. 2019 Aug 10;11(8):e5360. doi: 10.7759/cureus.5360.

Introduction There is widespread public interest when celebrities are diagnosed with cancer. We sought to assess how this interest impacts awareness of prevalent cancers. Methods We reviewed common cancer-related search terms using Google Trends (Google LLC, Mountain View, CA)...

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Kaleem T, Malouff TD, Stross WC, et al. Google Search Trends in Oncology and the Impact of Celebrity Cancer Awareness. Cureus. 2019;11(8):e5360doi: 10.7759/cureus.5360.
Kaleem, T., Malouff, T. D., Stross, W. C., Waddle, M. R., Miller, D. H., Seymour, A. L., Zaorsky, N. G., Miller, R. C., Trifiletti, D. M., & Vallow, L. (2019). Google Search Trends in Oncology and the Impact of Celebrity Cancer Awareness. Cureus, 11(8), e5360. https://doi.org/10.7759/cureus.5360
Kaleem, Tasneem, et al. "Google Search Trends in Oncology and the Impact of Celebrity Cancer Awareness." Cureus vol. 11,8 (2019): e5360. doi: https://doi.org/10.7759/cureus.5360
Kaleem T, Malouff TD, Stross WC, Waddle MR, Miller DH, Seymour AL, Zaorsky NG, Miller RC, Trifiletti DM, Vallow L. Google Search Trends in Oncology and the Impact of Celebrity Cancer Awareness. Cureus. 2019 Aug 10;11(8):e5360. doi: 10.7759/cureus.5360. PMID: 31608195; PMCID: PMC6783227.
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Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report.

American journal of respiratory and critical care medicine

Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA.
PMID: 32150460
Am J Respir Crit Care Med. 2020 Mar 09; doi: 10.1164/rccm.201908-1595WS. Epub 2020 Mar 09.

Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory...

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Semler MW, Bernard GR, Aaron SD, et al. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med. 2020;doi: 10.1164/rccm.201908-1595WS.
Semler, M. W., Bernard, G. R., Aaron, S. D., Angus, D. C., Biros, M. H., Brower, R. G., Calfee, C. S., Colantuoni, E. A., Ferguson, N. D., Gong, M. N., Hopkins, R. O., Hough, C. L., Iwashyna, T. J., Levy, B. D., Martin, T. R., Matthay, M. A., Mizgerd, J. P., Moss, M., Needham, D. M., Self, W. H., Seymour, C. W., Stapleton, R. D., Thompson, B. T., Wunderink, R. G., Aggarwal, N. R., & Reineck, L. A. (2020). Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. American journal of respiratory and critical care medicine, . https://doi.org/10.1164/rccm.201908-1595WS
Semler, Matthew W, et al. "Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report." American journal of respiratory and critical care medicine vol. (2020). doi: https://doi.org/10.1164/rccm.201908-1595WS
Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med. 2020 Mar 09; doi: 10.1164/rccm.201908-1595WS. Epub 2020 Mar 09. PMID: 32150460; PMCID: PMC7427373.
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Impact of Intravenous Iron on Oxidative Stress and Mitochondrial Function in Experimental Chronic Kidney Disease.

Antioxidants (Basel, Switzerland)

Nuhu F, Seymour AM, Bhandari S.
PMID: 31640237
Antioxidants (Basel). 2019 Oct 21;8(10). doi: 10.3390/antiox8100498.

BACKGROUND: Mitochondrial dysfunction is observed in chronic kidney disease (CKD). Iron deficiency anaemia (IDA), a common complication in CKD, is associated with poor clinical outcomes affecting mitochondrial function and exacerbating oxidative stress. Intravenous (iv) iron, that is used to...

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Nuhu F, Seymour AM, Bhandari S. Impact of Intravenous Iron on Oxidative Stress and Mitochondrial Function in Experimental Chronic Kidney Disease. Antioxidants (Basel). 2019;8(10)doi: 10.3390/antiox8100498.
Nuhu, F., Seymour, A. M., & Bhandari, S. (2019). Impact of Intravenous Iron on Oxidative Stress and Mitochondrial Function in Experimental Chronic Kidney Disease. Antioxidants (Basel, Switzerland), 8(10), . https://doi.org/10.3390/antiox8100498
Nuhu, Faisal, et al. "Impact of Intravenous Iron on Oxidative Stress and Mitochondrial Function in Experimental Chronic Kidney Disease." Antioxidants (Basel, Switzerland) vol. 8,10 (2019). doi: https://doi.org/10.3390/antiox8100498
Nuhu F, Seymour AM, Bhandari S. Impact of Intravenous Iron on Oxidative Stress and Mitochondrial Function in Experimental Chronic Kidney Disease. Antioxidants (Basel). 2019 Oct 21;8(10). doi: 10.3390/antiox8100498. PMID: 31640237; PMCID: PMC6826506.
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Showing 1 to 12 of 145 entries