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Showing 1 to 12 of 18 entries
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DISCOVERY OF MOLECULARLY TARGETED THERAPIES.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Regan K, Abrams Z, Sharpnack M, Srivastava A, Huang K, Shah N, Payne PR.
PMID: 26776168
Pac Symp Biocomput. 2016;21:1-8.

No abstract available.

Anomalous Nanoscale Optoacoustic Phonon Mixing in Nematic Mesogens.

The journal of physical chemistry letters

Bolmatov D, Soloviov D, Zav'yalov D, Sharpnack L, Agra-Kooijman DM, Kumar S, Zhang J, Liu M, Katsaras J.
PMID: 29706065
J Phys Chem Lett. 2018 May 17;9(10):2546-2553. doi: 10.1021/acs.jpclett.8b00926. Epub 2018 May 02.

Recent inelastic X-ray scattering (IXS) experiments on mesogens have revealed entirely new capabilities with regards to their nanoscale phonon-assisted heat management. Mesogens such as nematic liquid crystals (LCs) are appealing systems for study because their structure and morphology can...

STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and .

Cancer research

Koenig MJ, Agana BA, Kaufman JM, Sharpnack MF, Wang WZ, Weigel C, Navarro FCP, Amann JM, Cacciato N, Arasada RR, Gerstein MB, Wysocki VH, Oakes C, Carbone DP.
PMID: 34045189
Cancer Res. 2021 Aug 15;81(16):4194-4204. doi: 10.1158/0008-5472.CAN-20-3199. Epub 2021 May 27.

STK11 (liver kinase B1, LKB1) is the fourth most frequently mutated gene in lung adenocarcinoma, with loss of function observed in up to 30% of all cases. Our previous work identified a 16-gene signature for LKB1 loss of function...

Can auxiliary indicators improve COVID-19 forecasting and hotspot prediction?.

Proceedings of the National Academy of Sciences of the United States of America

McDonald DJ, Bien J, Green A, Hu AJ, DeFries N, Hyun S, Oliveira NL, Sharpnack J, Tang J, Tibshirani R, Ventura V, Wasserman L, Tibshirani RJ.
PMID: 34903655
Proc Natl Acad Sci U S A. 2021 Dec 21;118(51). doi: 10.1073/pnas.2111453118.

Short-term forecasts of traditional streams from public health reporting (such as cases, hospitalizations, and deaths) are a key input to public health decision-making during a pandemic. Since early 2020, our research group has worked with data partners to collect,...

3D Micromachined Polyimide Mixing Devices for in Situ X-ray Imaging of Solution-Based Block Copolymer Phase Transitions.

Langmuir : the ACS journal of surfaces and colloids

Vakili M, Merkens S, Gao Y, Gwozdz PV, Vasireddi R, Sharpnack L, Meyer A, Blick RH, Trebbin M.
PMID: 31318572
Langmuir. 2019 Aug 13;35(32):10435-10445. doi: 10.1021/acs.langmuir.9b00728. Epub 2019 Aug 01.

Advances in modern interface- and material sciences often rely on the understanding of a system's structure-function relationship. Designing reproducible experiments that yield in situ time-resolved structural information at fast time scales is therefore of great interest, e.g., for better...

STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and .

Cancer research

Koenig MJ, Agana BA, Kaufman JM, Sharpnack MF, Wang WZ, Weigel C, Navarro FCP, Amann JM, Cacciato N, Arasada RR, Gerstein MB, Wysocki VH, Oakes C, Carbone DP.
PMID: 34045189
Cancer Res. 2021 Aug 15;81(16):4194-4204. doi: 10.1158/0008-5472.CAN-20-3199. Epub 2021 May 27.

STK11 (liver kinase B1, LKB1) is the fourth most frequently mutated gene in lung adenocarcinoma, with loss of function observed in up to 30% of all cases. Our previous work identified a 16-gene signature for LKB1 loss of function...

Can auxiliary indicators improve COVID-19 forecasting and hotspot prediction?.

Proceedings of the National Academy of Sciences of the United States of America

McDonald DJ, Bien J, Green A, Hu AJ, DeFries N, Hyun S, Oliveira NL, Sharpnack J, Tang J, Tibshirani R, Ventura V, Wasserman L, Tibshirani RJ.
PMID: 34903655
Proc Natl Acad Sci U S A. 2021 Dec 21;118(51). doi: 10.1073/pnas.2111453118.

Short-term forecasts of traditional streams from public health reporting (such as cases, hospitalizations, and deaths) are a key input to public health decision-making during a pandemic. Since early 2020, our research group has worked with data partners to collect,...

Detecting Cancer Pathway Crosstalk with Distance Correlation.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Sharpnack MF, Huang K.
PMID: 26306231
AMIA Jt Summits Transl Sci Proc. 2015 Mar 23;2015:41-5. eCollection 2015.

Biological pathway regulation is complex, yet it underlies the functional coordination in a cell. Cancer is a disease that is characterized by unregulated growth, driven by underlying pathway deregulation. This pathway deregulation is both within pathways and between pathways....

Apollonian packing in polydisperse emulsions.

Soft matter

Kwok S, Botet R, Sharpnack L, Cabane B.
PMID: 32100781
Soft Matter. 2020 Mar 11;16(10):2426-2430. doi: 10.1039/c9sm01772k.

We have discovered the existence of polydisperse high internal-phase-ratio emulsions (HIPE) in which the internal-phase droplets, present at 95% volume fraction, remain spherical and organise themselves according to Apollonian packing rules. These polydisperse HIPEs are formed by emulsifying oil...

Time-Resolved Analysis of the Structural Dynamics of Assembling Gold Nanoparticles.

ACS nano

Merkens S, Vakili M, Sánchez-Iglesias A, Litti L, Gao Y, Gwozdz PV, Sharpnack L, Blick RH, Liz-Marzán LM, Grzelczak M, Trebbin M.
PMID: 31095366
ACS Nano. 2019 Jun 25;13(6):6596-6604. doi: 10.1021/acsnano.9b00575. Epub 2019 May 28.

The hydrophobic collapse is a structural transition of grafted polymer chains in a poor solvent. Although such a transition seems an intrinsic event during clustering of polymer-stabilized nanoparticles in the liquid phase, it has not been resolved in real...

Vesicle adhesion in the electrostatic strong-coupling regime studied by time-resolved small-angle X-ray scattering.

Soft matter

Komorowski K, Schaeper J, Sztucki M, Sharpnack L, Brehm G, Köster S, Salditt T.
PMID: 32319505
Soft Matter. 2020 May 06;16(17):4142-4154. doi: 10.1039/d0sm00259c.

We have used time-resolved small-angle X-ray scattering (SAXS) to study the adhesion of lipid vesicles in the electrostatic strong-coupling regime induced by divalent ions. The bilayer structure and the interbilayer distance dw between adhered vesicles was studied for different...

Proteogenomic Analysis of Surgically Resected Lung Adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Sharpnack MF, Ranbaduge N, Srivastava A, Cerciello F, Codreanu SG, Liebler DC, Mascaux C, Miles WO, Morris R, McDermott JE, Sharpnack JL, Amann J, Maher CA, Machiraju R, Wysocki VH, Govindan R, Mallick P, Coombes KR, Huang K, Carbone DP.
PMID: 30017829
J Thorac Oncol. 2018 Oct;13(10):1519-1529. doi: 10.1016/j.jtho.2018.06.025. Epub 2018 Jul 11.

INTRODUCTION: Despite apparently complete surgical resection, approximately half of resected early-stage lung cancer patients relapse and die of their disease. Adjuvant chemotherapy reduces this risk by only 5% to 8%. Thus, there is a need for better identifying who...

Showing 1 to 12 of 18 entries