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Centers of Research Excellence in Science and Technology (CREST) and HBCU Research Infrastructure for Science and Engineering (RISE) AND Program Evaluation

Ehrlich K, Shephard JD.
GSID: KTPMx4uCGEAJ
JD Shephard, RJ Beck, I Bitharas, K Ehrlich - Optimization, 2003 - spie.org

… increases significantly, due to increase … review approaches for the efficient realization of quantum frequency combs in on-chip waveguide structures and micro-resonators. We will show …

On the consistency of seismically imaged lower mantle slabs.

Scientific reports

Shephard GE, Matthews KJ, Hosseini K, Domeier M.
PMID: 28887461
Sci Rep. 2017 Sep 08;7(1):10976. doi: 10.1038/s41598-017-11039-w.

The geoscience community is increasingly utilizing seismic tomography to interpret mantle heterogeneity and its links to past tectonic and geodynamic processes. To assess the robustness and distribution of positive seismic anomalies, inferred as subducted slabs, we create a set...

A Chemical Probe for the ATAD2 Bromodomain.

Angewandte Chemie (International ed. in English)

Bamborough P, Chung CW, Demont EH, Furze RC, Bannister AJ, Che KH, Diallo H, Douault C, Grandi P, Kouzarides T, Michon AM, Mitchell DJ, Prinjha RK, Rau C, Robson S, Sheppard RJ, Upton R, Watson RJ.
PMID: 27530368
Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6. doi: 10.1002/anie.201603928. Epub 2016 Aug 17.

ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of that target class. Starting from a potent lead, permeability and selectivity were improved through a dual approach: 1) using CF2 as a sulfone...

Deletion of Genes From the Mouse Genome Using Cre/loxP Technology.

Methods in molecular biology (Clifton, N.J.)

Hernandez D, Chandan P, Janmohamed A, Phillips IR, Shephard EA.
PMID: 27699674
Methods Mol Biol. 2006;320:307-319. doi: 10.1385/1-59259-998-2:307.

The steps required to delete genes from the mouse genome are illustrated by showing how a cluster of three flavin-containing monooxygenase (Fmo) genes (Fmo1, Fmo2, and Fmo4) were deleted from mouse chromosome 1. Such large deletions are accomplished using...

Expression of Recombinant Flavin-Containing Monooxygenases in a Baculovirus/Insect Cell System.

Methods in molecular biology (Clifton, N.J.)

Janmohamed A, Thaunsukon P, Shephard EA, Phillips IR.
PMID: 27699678
Methods Mol Biol. 2006;320:39-59. doi: 10.1385/1-59259-998-2:39.

The baculovirus/insect cell heterologous expression system provides an important tool for investigating the catalytic activity of individual drug-metabolizing enzymes toward a particular substrate. In this chapter we describe a baculovirus/insect cell system that we have used for the expression...

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

Computational and structural biotechnology journal

Dona AC, Kyriakides M, Scott F, Shephard EA, Varshavi D, Veselkov K, Everett JR.
PMID: 27087910
Comput Struct Biotechnol J. 2016 Mar 09;14:135-53. doi: 10.1016/j.csbj.2016.02.005. eCollection 2016.

Metabonomics/metabolomics is an important science for the understanding of biological systems and the prediction of their behaviour, through the profiling of metabolites. Two technologies are routinely used in order to analyse metabolite profiles in biological fluids: nuclear magnetic resonance...

Cohort effects: A possible limitation to the interpretation of longitudinal studies.

American journal of human biology : the official journal of the Human Biology Council

Labarre R, Lavallée H, Shephard RJ, Jéquier JC, Rajic M.
PMID: 28548417
Am J Hum Biol. 1993;5(3):305-310. doi: 10.1002/ajhb.1310050309.

The possible limitation that cohort effects could impose upon the interpretation of longitudinal research has been examined, taking data on the standing height and the maximal oxygen intake of 546 primary school students participating in the Trois Rivières mixed-longitudinal...

Synthesis, characterization and crystal structure of a 2-(diethylaminomethyl)indole ligated dimethyl-aluminium complex.

Acta crystallographica. Section E, Crystallographic communications

Shephard LE, Kingsley NB.
PMID: 26594412
Acta Crystallogr E Crystallogr Commun. 2015 Sep 26;71:1222-5. doi: 10.1107/S2056989015017053. eCollection 2015 Oct 01.

The title compound, [Al(CH3)2(C13H17N2)] (systematic name; {2-[(di-ethyl-amino)-meth-yl]indol-1-yl-κ(2) N,N'}di-methyl-aluminium), was prepared by methane elimination from the reaction of 2-(di-ethyl-amino-meth-yl)indole and tri-methyl-aluminium. The complex crystallizes readily from a concentrated toluene solution in high yield. The asymmetric unit contains two crystallographically independent...

Effects of recreational soccer on physical fitness and health indices in sedentary healthy and unhealthy subjects.

Biology of sport

Hammami A, Chamari K, Slimani M, Shephard RJ, Yousfi N, Tabka Z, Bouhlel E.
PMID: 27274105
Biol Sport. 2016 Jun;33(2):127-37. doi: 10.5604/20831862.1198209. Epub 2016 Mar 25.

Recreational soccer (RS) is becoming a popular alternative to the classical continuous exercise mode used for the improvement of cardiovascular and metabolic fitness in untrained people. The objective of this paper was to conduct a detailed systematic review of...

Body Profile of Olympic-Class Sailors.

The Physician and sportsmedicine

Plyley MJ, Davis GM, Shephard RJ.
PMID: 27410218
Phys Sportsmed. 1985 Jun;13(6):152-67. doi: 10.1080/00913847.1985.11708819.

In brief: This study related physiological characteristics of 30 Olympic-class sailors to their class of vessel and their coach's ranking of performance to see if there is an optimal body type. Successful competitors in general have above-average height and...

Motivation: The Key to Fitness Compliance.

The Physician and sportsmedicine

Shephard RJ.
PMID: 27410444
Phys Sportsmed. 1985 Jul;13(7):88-101. doi: 10.1080/00913847.1985.11708835.

In brief: The reasons people say they exercise are to feel better, to have a beautiful body, to socialize, and to be more healthy. People see a lack of free time as the main obstacle to physical activity. However,...

Is High-Density Amorphous Ice Simply a "Derailed" State along the Ice I to Ice IV Pathway?.

The journal of physical chemistry letters

Shephard JJ, Ling S, Sosso GC, Michaelides A, Slater B, Salzmann CG.
PMID: 28323429
J Phys Chem Lett. 2017 Apr 06;8(7):1645-1650. doi: 10.1021/acs.jpclett.7b00492. Epub 2017 Mar 27.

The structural nature of high-density amorphous ice (HDA), which forms through low-temperature pressure-induced amorphization of the "ordinary" ice I, is heavily debated. Clarifying this question is important for understanding not only the complex condensed states of H

Showing 1 to 12 of 253 entries