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The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH).

Hepatology international

Kakazu E, Kondo Y, Ninomiya M, Kimura O, Nagasaki F, Ueno Y, Shimosegawa T.
PMID: 26201790
Hepatol Int. 2013 Jun;7(2):577-85. doi: 10.1007/s12072-012-9395-y. Epub 2012 Aug 14.

BACKGROUND AND AIMS: The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatitis...

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Kakazu E, Kondo Y, Ninomiya M, et al. The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH). Hepatol Int. 2012;7(2):577-85doi: 10.1007/s12072-012-9395-y.
Kakazu, E., Kondo, Y., Ninomiya, M., Kimura, O., Nagasaki, F., Ueno, Y., & Shimosegawa, T. (2013). The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH). Hepatology international, 7(2), 577-85. https://doi.org/10.1007/s12072-012-9395-y
Kakazu, Eiji, et al. "The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH)." Hepatology international vol. 7,2 (2013): 577-85. doi: https://doi.org/10.1007/s12072-012-9395-y
Kakazu E, Kondo Y, Ninomiya M, Kimura O, Nagasaki F, Ueno Y, Shimosegawa T. The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH). Hepatol Int. 2013 Jun;7(2):577-85. doi: 10.1007/s12072-012-9395-y. Epub 2012 Aug 14. PMID: 26201790.
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Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis.

ISRN hepatology

Ninomiya M, Kondo Y, Shimosegawa T.
PMID: 27335818
ISRN Hepatol. 2012 Dec 12;2013:237870. doi: 10.1155/2013/237870. eCollection 2013.

In 1980, Ludwig et al. first reported patients of steatohepatitis who lacked a history of excessive alcohol consumption but showed liver histology resembling alcoholic hepatitis and progression to cirrhosis of the liver accompanied by inflammation and fibrosis. The development...

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Ninomiya M, Kondo Y, Shimosegawa T. Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis. ISRN Hepatol. 2012;2013:237870doi: 10.1155/2013/237870.
Ninomiya, M., Kondo, Y., & Shimosegawa, T. (2013). Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis. ISRN hepatology, 2013237870. https://doi.org/10.1155/2013/237870
Ninomiya, Masashi, et al. "Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis." ISRN hepatology vol. 2013 (2013): 237870. doi: https://doi.org/10.1155/2013/237870
Ninomiya M, Kondo Y, Shimosegawa T. Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis. ISRN Hepatol. 2012 Dec 12;2013:237870. doi: 10.1155/2013/237870. eCollection 2013. PMID: 27335818; PMCID: PMC4890877.
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Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome.

Journal of gastroenterology

Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Watanabe M, Sugano K, Shimosegawa T.
PMID: 26100007
J Gastroenterol. 2015 Jul;50(7):817-8. doi: 10.1007/s00535-015-1074-z. Epub 2015 Jun 23.

No abstract available.

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Fukudo S, Kaneko H, Akiho H, et al. Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome. J Gastroenterol. 2015;50(7):817-8doi: 10.1007/s00535-015-1074-z.
Fukudo, S., Kaneko, H., Akiho, H., Inamori, M., Endo, Y., Okumura, T., Kanazawa, M., Kamiya, T., Sato, K., Chiba, T., Furuta, K., Yamato, S., Arakawa, T., Fujiyama, Y., Azuma, T., Fujimoto, K., Mine, T., Miura, S., Kinoshita, Y., Watanabe, M., Sugano, K., & Shimosegawa, T. (2015). Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome. Journal of gastroenterology, 50(7), 817-8. https://doi.org/10.1007/s00535-015-1074-z
Fukudo, Shin, et al. "Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome." Journal of gastroenterology vol. 50,7 (2015): 817-8. doi: https://doi.org/10.1007/s00535-015-1074-z
Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Watanabe M, Sugano K, Shimosegawa T. Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome. J Gastroenterol. 2015 Jul;50(7):817-8. doi: 10.1007/s00535-015-1074-z. Epub 2015 Jun 23. PMID: 26100007.
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[Molecular pathogenesis of Crohn's disease].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

Kinouchi Y, Takahashi S, Shimosegawa T.
PMID: 20530920
Nihon Shokakibyo Gakkai Zasshi. 2010 Jun;107(6):855-62.

No abstract available.

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Kinouchi Y, Takahashi S, Shimosegawa T. [Molecular pathogenesis of Crohn's disease]. Nihon Shokakibyo Gakkai Zasshi. 2010;107(6):855-62
Kinouchi, Y., Takahashi, S., & Shimosegawa, T. (2010). [Molecular pathogenesis of Crohn's disease]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 107(6), 855-62.
Kinouchi, Yoshitaka, et al. "[Molecular pathogenesis of Crohn's disease]." Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology vol. 107,6 (2010): 855-62.
Kinouchi Y, Takahashi S, Shimosegawa T. [Molecular pathogenesis of Crohn's disease]. Nihon Shokakibyo Gakkai Zasshi. 2010 Jun;107(6):855-62. Japanese. PMID: 20530920.
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Two cases of diffuse duodenitis associated with ulcerative colitis.

Case reports in gastrointestinal medicine

Endo K, Kuroha M, Shiga H, Kakuta Y, Takahashi S, Kinouchi Y, Shimosegawa T.
PMID: 23119193
Case Rep Gastrointest Med. 2012;2012:396521. doi: 10.1155/2012/396521. Epub 2012 Oct 17.

The upper gastrointestinal tract is not generally considered a target organ in ulcerative colitis (UC). However, several cases showing upper gastrointestinal involvement in UC have been reported. In this report, we present 2 rare cases of diffuse duodenitis accompanying...

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Endo K, Kuroha M, Shiga H, et al. Two cases of diffuse duodenitis associated with ulcerative colitis. Case Rep Gastrointest Med. 2012;2012:396521doi: 10.1155/2012/396521.
Endo, K., Kuroha, M., Shiga, H., Kakuta, Y., Takahashi, S., Kinouchi, Y., & Shimosegawa, T. (2012). Two cases of diffuse duodenitis associated with ulcerative colitis. Case reports in gastrointestinal medicine, 2012396521. https://doi.org/10.1155/2012/396521
Endo, Katsuya, et al. "Two cases of diffuse duodenitis associated with ulcerative colitis." Case reports in gastrointestinal medicine vol. 2012 (2012): 396521. doi: https://doi.org/10.1155/2012/396521
Endo K, Kuroha M, Shiga H, Kakuta Y, Takahashi S, Kinouchi Y, Shimosegawa T. Two cases of diffuse duodenitis associated with ulcerative colitis. Case Rep Gastrointest Med. 2012;2012:396521. doi: 10.1155/2012/396521. Epub 2012 Oct 17. PMID: 23119193; PMCID: PMC3483663.
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Cystic lymphangioma of the pancreas with spontaneous rupture: report of a case.

Case reports in gastroenterology

Kawaguchi K, Motoi F, Ohtsuka H, Fukuyama S, Rikiyama T, Katayose Y, Egawa S, Satoh M, Asakura T, Shimosegawa T, Unno M.
PMID: 21712979
Case Rep Gastroenterol. 2011 May;5(2):288-94. doi: 10.1159/000326943. Epub 2011 May 24.

Lymphangioma is a benign and congenital malformation of the lymphatic system. Most lymphangiomas are preferentially located in the head and neck region. The abdominal organs are uncommon sites of origin. Several cases of lymphangioma in abdominal organs were reported,...

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Kawaguchi K, Motoi F, Ohtsuka H, et al. Cystic lymphangioma of the pancreas with spontaneous rupture: report of a case. Case Rep Gastroenterol. 2011;5(2):288-94doi: 10.1159/000326943.
Kawaguchi, K., Motoi, F., Ohtsuka, H., Fukuyama, S., Rikiyama, T., Katayose, Y., Egawa, S., Satoh, M., Asakura, T., Shimosegawa, T., & Unno, M. (2011). Cystic lymphangioma of the pancreas with spontaneous rupture: report of a case. Case reports in gastroenterology, 5(2), 288-94. https://doi.org/10.1159/000326943
Kawaguchi, Kei, et al. "Cystic lymphangioma of the pancreas with spontaneous rupture: report of a case." Case reports in gastroenterology vol. 5,2 (2011): 288-94. doi: https://doi.org/10.1159/000326943
Kawaguchi K, Motoi F, Ohtsuka H, Fukuyama S, Rikiyama T, Katayose Y, Egawa S, Satoh M, Asakura T, Shimosegawa T, Unno M. Cystic lymphangioma of the pancreas with spontaneous rupture: report of a case. Case Rep Gastroenterol. 2011 May;5(2):288-94. doi: 10.1159/000326943. Epub 2011 May 24. PMID: 21712979; PMCID: PMC3124319.
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Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma.

Hepatology research : the official journal of the Japan Society of Hepatology

Kogure T, Kondo Y, Kakazu E, Ninomiya M, Kimura O, Shimosegawa T.
PMID: 23789939
Hepatol Res. 2014 Aug;44(8):907-19. doi: 10.1111/hepr.12188. Epub 2013 Jul 21.

AIM: Epithelial-mesenchymal transition (EMT) is a crucial process during cancer invasion and metastasis, which is accompanied by the suppressed expression of E-cadherin initiated by stimuli such as transforming growth factor (TGF)-β. Recent studies have shown that the epigenetic regulation...

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Kogure T, Kondo Y, Kakazu E, et al. Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Hepatol Res. 2013;44(8):907-19doi: 10.1111/hepr.12188.
Kogure, T., Kondo, Y., Kakazu, E., Ninomiya, M., Kimura, O., & Shimosegawa, T. (2014). Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Hepatology research : the official journal of the Japan Society of Hepatology, 44(8), 907-19. https://doi.org/10.1111/hepr.12188
Kogure, Takayuki, et al. "Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma." Hepatology research : the official journal of the Japan Society of Hepatology vol. 44,8 (2014): 907-19. doi: https://doi.org/10.1111/hepr.12188
Kogure T, Kondo Y, Kakazu E, Ninomiya M, Kimura O, Shimosegawa T. Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Hepatol Res. 2014 Aug;44(8):907-19. doi: 10.1111/hepr.12188. Epub 2013 Jul 21. PMID: 23789939.
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PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma.

PPAR research

Kimura O, Kondo Y, Shimosegawa T.
PMID: 23316217
PPAR Res. 2012;2012:574180. doi: 10.1155/2012/574180. Epub 2012 Dec 16.

Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC). Furthermore, diabetes is known as an independent risk factor...

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Kimura O, Kondo Y, Shimosegawa T. PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. PPAR Res. 2012;2012:574180doi: 10.1155/2012/574180.
Kimura, O., Kondo, Y., & Shimosegawa, T. (2012). PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. PPAR research, 2012574180. https://doi.org/10.1155/2012/574180
Kimura, Osamu, et al. "PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma." PPAR research vol. 2012 (2012): 574180. doi: https://doi.org/10.1155/2012/574180
Kimura O, Kondo Y, Shimosegawa T. PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. PPAR Res. 2012;2012:574180. doi: 10.1155/2012/574180. Epub 2012 Dec 16. PMID: 23316217; PMCID: PMC3533465.
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Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study.

BMJ open

Shiga H, Miyazawa T, Kinouchi Y, Takahashi S, Tominaga G, Takahashi H, Takagi S, Obana N, Kikuchi T, Oomori S, Nomura E, Shiraki M, Sato Y, Takahashi S, Umemura K, Yokoyama H, Endo K, Kakuta Y, Aizawa H, Matsuura M, Kimura T, Kuroha M, Shimosegawa T.
PMID: 23396562
BMJ Open. 2013 Feb 08;3(2). doi: 10.1136/bmjopen-2012-002294. Print 2013.

OBJECTIVE: Stress is thought to be one of the triggers of relapses in patients with inflammatory bowel disease (IBD). We examined the rate of relapse in IBD patients before and after the Great East Japan Earthquake.DESIGN: A retrospective cohort...

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Shiga H, Miyazawa T, Kinouchi Y, et al. Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study. BMJ Open. 2013;3(2)doi: 10.1136/bmjopen-2012-002294.
Shiga, H., Miyazawa, T., Kinouchi, Y., Takahashi, S., Tominaga, G., Takahashi, H., Takagi, S., Obana, N., Kikuchi, T., Oomori, S., Nomura, E., Shiraki, M., Sato, Y., Takahashi, S., Umemura, K., Yokoyama, H., Endo, K., Kakuta, Y., Aizawa, H., Matsuura, M., Kimura, T., Kuroha, M., & Shimosegawa, T. (2013). Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study. BMJ open, 3(2), . https://doi.org/10.1136/bmjopen-2012-002294
Shiga, Hisashi, et al. "Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study." BMJ open vol. 3,2 (2013). doi: https://doi.org/10.1136/bmjopen-2012-002294
Shiga H, Miyazawa T, Kinouchi Y, Takahashi S, Tominaga G, Takahashi H, Takagi S, Obana N, Kikuchi T, Oomori S, Nomura E, Shiraki M, Sato Y, Takahashi S, Umemura K, Yokoyama H, Endo K, Kakuta Y, Aizawa H, Matsuura M, Kimura T, Kuroha M, Shimosegawa T. Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study. BMJ Open. 2013 Feb 08;3(2). doi: 10.1136/bmjopen-2012-002294. Print 2013. PMID: 23396562; PMCID: PMC3586105.
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The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis.

ISRN gastroenterology

Kakazu E, Kondo Y, Shimosegawa T.
PMID: 23326675
ISRN Gastroenterol. 2012;2012:123826. doi: 10.5402/2012/123826. Epub 2012 Dec 26.

In patients with advanced cirrhosis, not only hepatocellular carcinoma but also bacterial infections, such as spontaneous bacterial peritonitis (SBP) or pneumonia, are frequent clinical complications in such immune-compromised patients. These pathologies often progress to renal dysfunction, especially hepatorenal syndrome...

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Kakazu E, Kondo Y, Shimosegawa T. The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis. ISRN Gastroenterol. 2012;2012:123826doi: 10.5402/2012/123826.
Kakazu, E., Kondo, Y., & Shimosegawa, T. (2012). The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis. ISRN gastroenterology, 2012123826. https://doi.org/10.5402/2012/123826
Kakazu, Eiji, et al. "The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis." ISRN gastroenterology vol. 2012 (2012): 123826. doi: https://doi.org/10.5402/2012/123826
Kakazu E, Kondo Y, Shimosegawa T. The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis. ISRN Gastroenterol. 2012;2012:123826. doi: 10.5402/2012/123826. Epub 2012 Dec 26. PMID: 23326675; PMCID: PMC3541637.
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Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A .

Asia Oceania journal of nuclear medicine & biology

Mochida I, Shimosegawa E, Kanai Y, Naka S, Matsunaga K, Isohashi K, Horitsugi G, Watabe T, Kato H, Hatazawa J.
PMID: 28840133
Asia Ocean J Nucl Med Biol. 2017;5(1):3-9. doi: 10.22038/aojnmb.2016.7513.

OBJECTIVES: It is difficult to investigate the whole-body distribution of an orally administered drug by means of positron emission tomography (PET), owing to the short physical half-life of radionuclides, especially when METHODS: We studied 14 healthy volunteers, divided into...

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Mochida I, Shimosegawa E, Kanai Y, et al. Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A . Asia Ocean J Nucl Med Biol. 2017;5(1):3-9doi: 10.22038/aojnmb.2016.7513.
Mochida, I., Shimosegawa, E., Kanai, Y., Naka, S., Matsunaga, K., Isohashi, K., Horitsugi, G., Watabe, T., Kato, H., & Hatazawa, J. (2017). Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A . Asia Oceania journal of nuclear medicine & biology, 5(1), 3-9. https://doi.org/10.22038/aojnmb.2016.7513
Mochida, Ikuko, et al. "Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A ." Asia Oceania journal of nuclear medicine & biology vol. 5,1 (2017): 3-9. doi: https://doi.org/10.22038/aojnmb.2016.7513
Mochida I, Shimosegawa E, Kanai Y, Naka S, Matsunaga K, Isohashi K, Horitsugi G, Watabe T, Kato H, Hatazawa J. Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A . Asia Ocean J Nucl Med Biol. 2017;5(1):3-9. doi: 10.22038/aojnmb.2016.7513. PMID: 28840133; PMCID: PMC5221682.
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Effective and less invasive diagnostic strategy for gastrointestinal GVHD.

Endoscopy international open

Endo K, Fujishima F, Kuroha M, Moroi R, Onodera M, Naito T, Kanazawa Y, Kimura T, Shiga H, Kakuta Y, Kinouchi Y, Shimosegawa T.
PMID: 29507868
Endosc Int Open. 2018 Mar;6(3):E281-E291. doi: 10.1055/s-0043-122226. Epub 2018 Mar 01.

BACKGROUND AND STUDY AIMS:  Rectosigmoidoscopy with biopsy has been regarded to be a useful procedure to diagnose gastrointestinal graft-versus-host disease (GVHD). However, little is known about the specific colonoscopic features of gastrointestinal GVHD. In this study, we focused on...

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Endo K, Fujishima F, Kuroha M, et al. Effective and less invasive diagnostic strategy for gastrointestinal GVHD. Endosc Int Open. 2018;6(3):E281-E291doi: 10.1055/s-0043-122226.
Endo, K., Fujishima, F., Kuroha, M., Moroi, R., Onodera, M., Naito, T., Kanazawa, Y., Kimura, T., Shiga, H., Kakuta, Y., Kinouchi, Y., & Shimosegawa, T. (2018). Effective and less invasive diagnostic strategy for gastrointestinal GVHD. Endoscopy international open, 6(3), E281-E291. https://doi.org/10.1055/s-0043-122226
Endo, Katsuya, et al. "Effective and less invasive diagnostic strategy for gastrointestinal GVHD." Endoscopy international open vol. 6,3 (2018): E281-E291. doi: https://doi.org/10.1055/s-0043-122226
Endo K, Fujishima F, Kuroha M, Moroi R, Onodera M, Naito T, Kanazawa Y, Kimura T, Shiga H, Kakuta Y, Kinouchi Y, Shimosegawa T. Effective and less invasive diagnostic strategy for gastrointestinal GVHD. Endosc Int Open. 2018 Mar;6(3):E281-E291. doi: 10.1055/s-0043-122226. Epub 2018 Mar 01. PMID: 29507868; PMCID: PMC5832465.
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