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Showing 1 to 12 of 240 entries
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Palladium-Catalyzed Arylation of Carbasugars Enables the Discovery of Potent and Selective SGLT2 Inhibitors.

Angewandte Chemie (International ed. in English)

Ng WL, Lau KM, Lau CB, Shing TK.
PMID: 27699962
Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13818-13821. doi: 10.1002/anie.201608758. Epub 2016 Oct 04.

Selective inhibition of the transporter protein sodium-glucose cotransporter 2 (SGLT2) has emerged as a promising way to control blood glucose level in diabetes patients. Reported herein is a short and convergent synthetic route towards some small-molecule SGLT2 inhibitors by...

Reaction Mechanism of a New Glycosyltrehalose-producing Enzyme Isolated from the Hyperthermophilic Archaeum, Sulfolobus solfataricus KM1.

Bioscience, biotechnology, and biochemistry

Kato M, Miura Y, Kettoku M, Shindo K, Iwamatsu A, Kobayashi K.
PMID: 27281155
Biosci Biotechnol Biochem. 1996 Jan;60(5):921-4. doi: 10.1271/bbb.60.921.

An amylolytic activity, which converts soluble starch to α,α-trehalose (trehalose), was found in the cell homogenate of the hyperthermophilic, acidophilic archaeum Sulfolobus solfataricus KM1. Two enzymes, a glycosyltransferase and an amylase, which are essential for this activity, were purified...

Dynamics of proteins aggregation. II. Dynamic scaling in confined media.

The Journal of chemical physics

Zheng S, Shing KS, Sahimi M.
PMID: 29544316
J Chem Phys. 2018 Mar 14;148(10):104305. doi: 10.1063/1.5008543.

In this paper, the second in a series devoted to molecular modeling of protein aggregation, a mesoscale model of proteins together with extensive discontinuous molecular dynamics simulation is used to study the phenomenon in a confined medium. The medium,...

Abdominal Wall Miscellaneous.

Hernia : the journal of hernias and abdominal wall surgery

Tai F, Li JW, Sun J, Zheng MH, Wink J, Basta M, Fischer J, Kovach S, Tall J, Håkanson BS, Pålstedt J, Thorell A, Huntington C, Cox T, Blair L, Lincourt A, Prasad T, Kercher K, Heniford BT, Augenstein V, Strömberg H, Hellman P, Sandblom G, Gunnarsson U, Hope W, Bringman S, Chudy M, Romanowski C, Jones P, Jacombs A, Roussos E, Read J, Dardano A, Boesel T, Edye M, Ibrahim N, Lyo V, Tufaga M, Shin UK, Primus F, Harris H, Iesalnieks I, Di Cerbo F, Baladov M, Ikhlawi K, Azoury S, Rodriguez-Unda N, Soares K, Hicks C, Baltodano P, Poruk K, Hu L, Cooney C, Cornell P, Burce K, Eckhauser F, Garvey E, Zuhlke T, Jaroszewski D, Egan J, Jamshidi R, Graziano K, McMahon L, Rodriquez-Unda N, Fattori L, Leva A, Coppola S, Gianotti L, Baccay F, Alemayehu H, Singh J, Lo I, Amin A, Harrington A, Benvenuti H, Cho D, George F, Cate S.
PMID: 26518860
Hernia. 2015 Apr;19:S5-S12. doi: 10.1007/BF03355319.

No abstract available.

Separated response function ratios in exclusive, forward π(±) electroproduction.

Physical review letters

Huber GM, Blok HP, Butuceanu C, Gaskell D, Horn T, Mack DJ, Abbott D, Aniol K, Anklin H, Armstrong C, Arrington J, Assamagan K, Avery S, Baker OK, Barrett B, Beise EJ, Bochna C, Boeglin W, Brash EJ, Breuer H, Chang CC, Chant N, Christy ME, Dunne J, Eden T, Ent R, Fenker H, Gibson EF, Gilman R, Gustafsson K, Hinton W, Holt RJ, Jackson H, Jin S, Jones MK, Keppel CE, Kim PH, Kim W, King PM, Klein A, Koltenuk D, Kovaltchouk V, Liang M, Liu J, Lolos GJ, Lung A, Margaziotis DJ, Markowitz P, Matsumura A, McKee D, Meekins D, Mitchell J, Miyoshi T, Mkrtchyan H, Mueller B, Niculescu G, Niculescu I, Okayasu Y, Pentchev L, Perdrisat C, Pitz D, Potterveld D, Punjabi V, Qin LM, Reimer PE, Reinhold J, Roche J, Roos PG, Sarty A, Shin IK, Smith GR, Stepanyan S, Tang LG, Tadevosyan V, Tvaskis V, van der Meer RL, Vansyoc K, Van Westrum D, Vidakovic S, Volmer J, Vulcan W, Warren G, Wood SA, Xu C, Yan C, Zhao WX, Zheng X, Zihlmann B.
PMID: 24856691
Phys Rev Lett. 2014 May 09;112(18):182501. doi: 10.1103/PhysRevLett.112.182501. Epub 2014 May 05.

The study of exclusive π(±) electroproduction on the nucleon, including separation of the various structure functions, is of interest for a number of reasons. The ratio RL=σL(π-)/σL(π+) is sensitive to isoscalar contamination to the dominant isovector pion exchange amplitude,...

Characteristic MRI findings in beta-propeller protein-associated neurodegeneration (BPAN).

Neurology. Clinical practice

Ichinose Y, Miwa M, Onohara A, Obi K, Shindo K, Saitsu H, Matsumoto N, Takiyama Y.
PMID: 24790802
Neurol Clin Pract. 2014 Apr;4(2):175-177. doi: 10.1212/01.CPJ.0000437694.17888.9b.

A 31-year-old woman presented with severe dystonia-parkinsonism. She had nonprogressive psychomotor retardation and cognitive dysfunction from childhood without evidence of dystonia or parkinsonism. At age 30, she then developed severe dystonia and gait disturbance. There was neither dystonia nor...

A Case of Primary MALT Lymphoma of the Breast.

Cancer research and treatment

Jung SW, Kim BS, Park JH, Kim SK, Seo HE, Shin DK, Lee JL, Kim IS, Lee DS, Kim DS.
PMID: 26680796
Cancer Res Treat. 2001 Jun;33(3):269-73. doi: 10.4143/crt.2001.33.3.269.

Primary malignant lymphoma of the breast is rare. The incidence of primary malignant lymphomas of the breast is 0.04% to 0.5% of all malignant tumors of the breast and 0.07% of all non-Hodgkin's lymphomas, and comprises 1.7% of extranodal...

Efficacy of azithromycin in sepsis-associated acute respiratory distress syndrome: a retrospective study and propensity score analysis.

SpringerPlus

Kawamura K, Ichikado K, Takaki M, Sakata Y, Yasuda Y, Shingu N, Tanaka A, Hisanaga J, Eguchi Y, Anan K, Nitawaki T, Suga M.
PMID: 27516931
Springerplus. 2016 Jul 28;5(1):1193. doi: 10.1186/s40064-016-2866-1. eCollection 2016.

PURPOSE: Acute respiratory distress syndrome is a life-threatening form of respiratory failure without an established pharmacological treatment. Recently, macrolides have been found to be beneficial in cases of acute lung injury, but evidence is limited.MATERIALS AND METHODS: This single-centre...

Association of Temporomandibular Joint Signs & Symptoms with Dental Fluorosis & Skeletal Manifestations in Endemic Fluoride Areas of Dungarpur District, Rajasthan, India.

Journal of clinical and diagnostic research : JCDR

Asawa K, Singh A, Bhat N, Tak M, Shinde K, Jain S.
PMID: 26816986
J Clin Diagn Res. 2015 Dec;9(12):ZC18-21. doi: 10.7860/JCDR/2015/15807.6958. Epub 2015 Dec 01.

INTRODUCTION: Endemic fluorosis resulting from high fluoride concentration in groundwater is a major public health problem. India is among the numerous nations, where fluoride sullied groundwater is creating wellbeing issues. Safe drinking water in rural areas of India is...

A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G.

Biology

Shindo K, Li M, Gross PJ, Brown WL, Harjes E, Lu Y, Matsuo H, Harris RS.
PMID: 24832226
Biology (Basel). 2012 Aug 02;1(2):260-76. doi: 10.3390/biology1020260.

APOBEC3G is the best known of several DNA cytosine deaminases that function to inhibit the replication of parasitic genetic elements including the lentivirus HIV. Several high-resolution structures of the APOBEC3G catalytic domain have been generated, but none reveal how...

Complete resolution of myoclonus-like involuntary movements under subarachnoid block after midazolam administration in a patient undergoing cesarean section: a case report.

Korean journal of anesthesiology

Nakamoto T, Hirota K, Iwai T, Shingu K.
PMID: 25844141
Korean J Anesthesiol. 2015 Apr;68(2):193-5. doi: 10.4097/kjae.2015.68.2.193. Epub 2015 Mar 30.

Involuntary movement during and after neuraxial anesthesia, such as spinal and epidural anesthesia, is rarely observed. In this report, we describe a case of myoclonus-like involuntary movement of the upper extremities in a patient undergoing a planned repeat cesarean...

Syntheses of arabinose-derived pyrrolidine catalysts and their applications in intramolecular Diels-Alder reactions.

Organic & biomolecular chemistry

Shing TK, Wu KW, Wu HT, Xiao Q.
PMID: 25503272
Org Biomol Chem. 2015 Feb 14;13(6):1754-62. doi: 10.1039/c4ob02219j.

Six chiral hydroxylated pyrrolidine catalysts were synthesized from commercially available D-arabinose in seven steps. Various aromatic substituents α to the amine can be introduced readily by a Grignard reaction, which enables facile optimization of the catalyst performance. The stereoselectivities...

Showing 1 to 12 of 240 entries