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Showing 1 to 12 of 39 entries
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Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.

Thrombosis journal

Cole JW, Brown DW, Giles WH, Stine OC, O'Connell JR, Mitchell BD, Sorkin JD, Wozniak MA, Stern BJ, Sparks MJ, Dobbins MT, Shoffner LT, Zappala NK, Reinhart LJ, Kittner SJ.
PMID: 18727828
Thromb J. 2008 Aug 26;6:11. doi: 10.1186/1477-9560-6-11.

BACKGROUND: Although cigarette smoking is a well-established risk factor for vascular disease, the genetic mechanisms that link cigarette smoking to an increased incidence of stroke are not well understood. Genetic variations within the genes of the inflammatory pathways are...

Selectivity and noise effects in applications of optical correlation.

Applied optics

Shofner FM, Webb RO.
PMID: 20119270
Appl Opt. 1972 Sep 01;11(9):1991-7. doi: 10.1364/AO.11.001991.

Experimental and theoretical results describing matched filter selectivity for a particular class of signal as obtained, for example, in holographic velocimetry are reviewed. An experiment showing noise rejection is described for filters having both low and high ratios of...

Response to Newman et al.

Genetics in medicine : official journal of the American College of Medical Genetics

Parikh S, Goldstein A, Karaa A, Koenig MK, Anselm I, Brunel-Guitton C, Christodoulou J, Cohen BH, Dimmock D, Enns GM, Falk MJ, Feigenbaum A, Frye RE, Ganesh J, Griesemer D, Haas R, Horvath R, Korson M, Kruer MC, Mancuso M, McCormack S, Josee Raboisson M, Reimschisel T, Salvarinova R, Saneto RP, Scaglia F, Shoffner J, Stacpoole PW, Sue CM, Tarnopolsky M, Van Karnebeek C, Wolfe LA, Zolkipli Cunningham Z, Rahman S, Chinnery PF.
PMID: 29215644
Genet Med. 2017 Dec;19(12). doi: 10.1038/gim.2017.164. Epub 2017 Oct 26.

No abstract available.

Centers for Disease Control and Prevention's Temporary Epidemiology Field Assignee program: Supporting state and local preparedness in the wake of Ebola.

SAGE open medicine

Cáceres VM, Goodell J, Shaffner J, Turner A, Jacobs-Wingo J, Koirala S, Molina M, Leidig R, Celaya M, McGinnis Pilote K, Garrett-Cherry T, Carney J, Johnson K, Daley WR.
PMID: 31205697
SAGE Open Med. 2019 May 16;7:2050312119850726. doi: 10.1177/2050312119850726. eCollection 2019.

OBJECTIVES: The Centers for Disease Control and Prevention launched the Temporary Epidemiology Field Assignee (TEFA) Program to help state and local jurisdictions respond to the risk of Ebola virus importation during the 2014-2016 Ebola Outbreak in West Africa. We...

Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity.

Research square

Zhang W, Chua B, Selva K, Kedzierski L, Ashhurst T, Haycroft E, Shoffner S, Hensen L, Boyd D, James F, Mouhtouris E, Kwong J, Chua K, Drewett G, Copaescu A, Dobson J, Rowntree L, Habel J, Allen L, Koay HF, Neil J, Gartner M, Lee C, Andersson P, Seemann T, Sherry N, Amanat F, Krammer F, Londrigan S, Wakim L, King N, Godfrey D, Mackay L, Thomas P, Nicholson S, Arnold K, Chung A, Holmes N, Smibert O, Trubiano J, Gordon C, Nguyen T, Kedzierska K.
PMID: 34462740
Res Sq. 2021 Aug 26; doi: 10.21203/rs.3.rs-802084/v1.

Although the respiratory tract is the primary site of SARS-CoV-2 infection and the ensuing immunopathology, respiratory immune responses are understudied and urgently needed to understand mechanisms underlying COVID-19 disease pathogenesis. We collected paired longitudinal blood and respiratory tract samples...

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

JAMA neurology

Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, Simmons Z, Pothier L, Kassis SB, La T, Hall M, Evora A, Klements D, Hurtado A, Pereira JD, Koh J, Celnik PA, Chaudhry V, Gable K, Juel VC, Phielipp N, Marei A, Rosenquist P, Meehan S, Oskarsson B, Lewis RA, Kaur D, Kiskinis E, Woolf CJ, Eggan K, Weiss MD, Berry JD, David WS, Davila-Perez P, Camprodon JA, Pascual-Leone A, Kiernan MC, Shefner JM, Atassi N, Cudkowicz ME.
PMID: 33226425
JAMA Neurol. 2021 Feb 01;78(2):186-196. doi: 10.1001/jamaneurol.2020.4300.

IMPORTANCE: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor neuron hyperexcitability using transcranial magnetic stimulation and threshold tracking nerve conduction studies, respectively, although metrics of...

Improving clinical trial outcomes in amyotrophic lateral sclerosis.

Nature reviews. Neurology

Kiernan MC, Vucic S, Talbot K, McDermott CJ, Hardiman O, Shefner JM, Al-Chalabi A, Huynh W, Cudkowicz M, Talman P, Van den Berg LH, Dharmadasa T, Wicks P, Reilly C, Turner MR.
PMID: 33340024
Nat Rev Neurol. 2021 Feb;17(2):104-118. doi: 10.1038/s41582-020-00434-z. Epub 2020 Dec 18.

Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same historically intransigent problem that has existed since the initial description of the disease in the 1860s - a lack of effective therapies. In part, the development...

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities.

Frontiers in physiology

Chang M, Chen B, Shaffner J, Dworkin LD, Gong R.
PMID: 33716796
Front Physiol. 2021 Feb 24;12:651236. doi: 10.3389/fphys.2021.651236. eCollection 2021.

Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important hormonal systems in our body. A plethora of evidence...

Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis.

American journal of otolaryngology

Soffer JM, Nassif SJ, Von Plato M, Chisholm J, O'Leary MA.
PMID: 34171696
Am J Otolaryngol. 2021 Nov-Dec;42(6):103135. doi: 10.1016/j.amjoto.2021.103135. Epub 2021 Jun 19.

OBJECTIVE: Malignant mixed tumors of the salivary gland are a group of neoplasms comprised of carcinoma-ex-pleomorphic adenoma, carcinosarcoma, and metastasizing pleomorphic adenoma. An alternative classification, malignant mixed tumor-not otherwise (MMT-NOS), is a diagnosis of exclusion for neoplasms that do...

Hybrid gel electrophoresis using skin fibroblasts to aid in diagnosing mitochondrial disease.

Neurology. Genetics

Newell C, Khan A, Sinasac D, Shoffner J, Friederich MW, Van Hove JLK, Hume S, Shearer J, Sosova I.
PMID: 31192304
Neurol Genet. 2019 May 01;5(3):e336. doi: 10.1212/NXG.0000000000000336. eCollection 2019 Jun.

OBJECTIVE: We developed a novel, hybrid method combining both blue-native (BN-PAGE) and clear-native (CN-PAGE) polyacrylamide gel electrophoresis, termed BCN-PAGE, to perform in-gel activity stains on the mitochondrial electron transport chain (ETC) complexes in skin fibroblasts.METHODS: Four patients aged 46-65...

Liposuction Gives Complete Reduction of Arm Lymphedema following Breast Cancer Treatment-A 5-year Prospective Study in 105 Patients without Recurrence.

Plastic and reconstructive surgery. Global open

Hoffner M, Ohlin K, Svensson B, Manjer J, Hansson E, Troëng T, Brorson H.
PMID: 30324078
Plast Reconstr Surg Glob Open. 2018 Aug 16;6(8):e1912. doi: 10.1097/GOX.0000000000001912. eCollection 2018 Aug.

BACKGROUND: Arm lymphedema is a well-recognized complication after breast cancer surgery that negatively impacts patients' quality of life, both physiologically and psychologically. Lymph stasis and inflammation result in excess formation of adipose tissue, which makes removal of the deposited...

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

JAMA neurology

Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, Simmons Z, Pothier L, Kassis SB, La T, Hall M, Evora A, Klements D, Hurtado A, Pereira JD, Koh J, Celnik PA, Chaudhry V, Gable K, Juel VC, Phielipp N, Marei A, Rosenquist P, Meehan S, Oskarsson B, Lewis RA, Kaur D, Kiskinis E, Woolf CJ, Eggan K, Weiss MD, Berry JD, David WS, Davila-Perez P, Camprodon JA, Pascual-Leone A, Kiernan MC, Shefner JM, Atassi N, Cudkowicz ME.
PMID: 33226425
JAMA Neurol. 2021 Feb 01;78(2):186-196. doi: 10.1001/jamaneurol.2020.4300.

IMPORTANCE: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor neuron hyperexcitability using transcranial magnetic stimulation and threshold tracking nerve conduction studies, respectively, although metrics of...

Showing 1 to 12 of 39 entries