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Showing 1 to 12 of 27 entries
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Effect of a low dose of proteasome inhibitor on cell death and gene expression in neonatal rat cardiomyocyte cultures exposed to anoxia-reoxygenation.

Experimental and clinical cardiology

Surova OV, Nagibin VS, Tumanovskaya LV, Dosenko VE, Moibenko AA.
PMID: 19675822
Exp Clin Cardiol. 2009;14(2):e57-61.

BACKGROUND: Recent data suggest that low concentrations of proteasome inhibitors (PIs) are cytoprotective in models of ischemia-reperfusion injury, but the underlying mechanisms of this effect still remain unclear.AIM: To investigate the effect of 100 nM of clasto-lactacystin beta-lactone on...

Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action.

Frontiers in microbiology

Panteleev PV, Bolosov IA, Kalashnikov AÀ, Kokryakov VN, Shamova OV, Emelianova AA, Balandin SV, Ovchinnikova TV.
PMID: 30555455
Front Microbiol. 2018 Nov 30;9:2983. doi: 10.3389/fmicb.2018.02983. eCollection 2018.

Being essential components of innate immune system, animal antimicrobial peptides (AMPs) also known as host-defense peptides came into sharp focus as possible alternatives to conventional antibiotics due to their high efficacy against a broad range of MDR pathogens and...

The phenomenon of multidrug resistance in glioblastomas.

Hematology/oncology and stem cell therapy

Chernov AN, Alaverdian DA, Galimova ES, Renieri A, Frullanti E, Meloni I, Shamova OV.
PMID: 34216549
Hematol Oncol Stem Cell Ther. 2021 Jun 16; doi: 10.1016/j.hemonc.2021.05.006. Epub 2021 Jun 16.

The most common and aggressive brain tumor in the adult population is glioblastoma (GBM). The lifespan of patients does not exceed 22 months. One of the reasons for the low effectiveness of GBM treatment is its radioresistance and chemoresistance....

Comparison of the Antimicrobial and Hemolytic Activities of Various Forms of Silver (Ions, Nanoparticles, Bioconjugates) Stabilized in a Zeolite Matrix.

Langmuir : the ACS journal of surfaces and colloids

Golubeva OY, Ulyanova NY, Vladimirova EV, Shamova OV.
PMID: 34643405
Langmuir. 2021 Oct 26;37(42):12356-12364. doi: 10.1021/acs.langmuir.1c01899. Epub 2021 Oct 13.

A quantitative and qualitative comparison of the antimicrobial and hemolytic activities of silver in various states, in the form of ions, nanoparticles, and bioconjugates with the antimicrobial protein lysozyme stabilized in an inert zeolite matrix, has been carried out....

Targeting ErbB3 Receptor in Cancer with Inhibitory Antibodies from Llama.

Biomedicines

Eliseev IE, Ukrainskaya VM, Yudenko AN, Mikushina AD, Shmakov SV, Afremova AI, Ekimova VM, Vronskaia AA, Knyazev NA, Shamova OV.
PMID: 34572289
Biomedicines. 2021 Aug 28;9(9). doi: 10.3390/biomedicines9091106.

The human ErbB3 receptor confers resistance to the pharmacological inhibition of EGFR and HER2 receptor tyrosine kinases in cancer, which makes it an important therapeutic target. Several anti-ErbB3 monoclonal antibodies that are currently being developed are all classical immunoglobulins....

Interrupted reprogramming of alveolar type II cells induces progenitor-like cells that ameliorate pulmonary fibrosis.

NPJ Regenerative medicine

Guo L, Karoubi G, Duchesneau P, Aoki FG, Shutova MV, Rogers I, Nagy A, Waddell TK.
PMID: 30210809
NPJ Regen Med. 2018 Sep 04;3:14. doi: 10.1038/s41536-018-0052-5. eCollection 2018.

We describe here an interrupted reprogramming strategy to generate "induced progenitor-like (iPL) cells" from alveolar epithelial type II (AEC-II) cells. A carefully defined period of transient expression of reprogramming factors (Oct4, Sox2, Klf4, and c-Myc (OSKM)) is able to...

Myeloperoxidase modulates human platelet aggregation via actin cytoskeleton reorganization and store-operated calcium entry.

Biology open

Gorudko IV, Sokolov AV, Shamova EV, Grudinina NA, Drozd ES, Shishlo LM, Grigorieva DV, Bushuk SB, Bushuk BA, Chizhik SA, Cherenkevich SN, Vasilyev VB, Panasenko OM.
PMID: 24143278
Biol Open. 2013 Jul 26;2(9):916-23. doi: 10.1242/bio.20135314. eCollection 2013.

Myeloperoxidase (MPO) is a heme-containing enzyme released from activated leukocytes into the extracellular space during inflammation. Its main function is the production of hypohalous acids that are potent oxidants. MPO can also modulate cell signaling and inflammatory responses independently...

Carbonic anhydrase activities in pea thylakoids.

Photosynthesis research

Moskvin OV, Shutova TV, Khristin MS, Ignatova LK, Villarejo A, Samuelsson G, Klimov VV, Ivanov BN.
PMID: 16228403
Photosynth Res. 2004;79(1):93-100. doi: 10.1023/B:PRES.0000011925.93313.db.

Pea thylakoids with high carbonic anhydrase (CA) activity (average rates of 5000 micromol H(+) (mg Chl)(-1) h(-1) at pH 7.0) were prepared. Western blot analysis using antibodies raised against the soluble stromal beta-CA from spinach clearly showed that this...

Male pseudohermaphroditism: A case study of 46,XY disorder of sexual development using whole-exome sequencing.

Clinical case reports

Naumova OY, Rychkov SY, Burenkova OV, Solodunova MY, Polyanskaya IV, Arintcina IA, Zhukova MA, Ovchinnikova IV, Zhukova OV, Grigorenko EL.
PMID: 33363845
Clin Case Rep. 2020 Sep 10;8(12):2889-2894. doi: 10.1002/ccr3.3286. eCollection 2020 Dec.

The study shows that whole-exome sequencing is a promising approach to detect novel variants-and gene candidates in DSD, that, as a future direction, may improve the diagnostic gene panels for this heterogeneous disorder.

Tumor-associated macrophages: Role in the pathological process of tumorigenesis and prospective therapeutic use (Review).

Biomedical reports

Zhukova OV, Kovaleva TF, Arkhipova EV, Ryabov SA, Mukhina IV.
PMID: 32934819
Biomed Rep. 2020 Nov;13(5):47. doi: 10.3892/br.2020.1354. Epub 2020 Aug 28.

The aim of the present study was to evaluate the current body of knowledge regarding tumor-associated macrophages (TAMs) and their potential use in antitumor therapy, based on their role in the pathological process of tumorigenesis. For this purpose, a...

Silver Nanoparticles Functionalized With Antimicrobial Polypeptides: Benefits and Possible Pitfalls of a Novel Anti-infective Tool.

Frontiers in microbiology

Zharkova MS, Golubeva OY, Orlov DS, Vladimirova EV, Dmitriev AV, Tossi A, Shamova OV.
PMID: 34975782
Front Microbiol. 2021 Dec 17;12:750556. doi: 10.3389/fmicb.2021.750556. eCollection 2021.

Silver nanoparticles (AgNPs) and antimicrobial peptides or proteins (AMPs/APs) are both considered as promising platforms for the development of novel therapeutic agents effective against the growing number of drug-resistant pathogens. The observed synergy of their antibacterial activity suggested the...

Mature and immature microRNA ratios in cultured rat cardiomyocytes during anoxia-reoxygenation.

Experimental and clinical cardiology

Dosenko VE, Gurianova VL, Surova OV, Stroy DA, Moibenko AA.
PMID: 22826655
Exp Clin Cardiol. 2012;17(2):84-7.

BACKGROUND: The critical role of microRNAs (miRNAs) in the global control of gene expression in the heart has recently been postulated; however, the mechanisms of miRNA regulation in cardiac pathology are not clear.OBJECTIVE: To evaluate the levels of miR-1,...

Showing 1 to 12 of 27 entries