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Showing 1 to 12 of 39 entries
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Signal transduction and the coordination of B lymphocyte development and function I. Transduction of BCR signals from the cell membrane to the nucleus. Introduction.

Current topics in microbiology and immunology

Justement LB, Siminovitch KA.
PMID: 10533308
Curr Top Microbiol Immunol. 2000;245(1):V-X.

No abstract available.

Excision of lambda prophage: effects on host survival.

Virology

Eisen HA, Siminovitch L, Mohide PT.
PMID: 18614110
Virology. 1968 Jan;34(1):97-103. doi: 10.1016/0042-6822(68)90012-3.

Induction with ultraviolet light of K12 lysogens carrying defective prophages leads to death of the host cell. In order to determine whether the killing accompanying induction was due to diffusible phage products, or was a result of prophage excision...

Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].

Clinical immunology (Orlando, Fla.)

Harris VM, Sharma R, Cavett J, Kurien BT, Liu K, Koelsch KA, Rasmussen A, Radfar L, Lewis D, Stone DU, Kaufman CE, Li S, Segal B, Wallace DJ, Weisman MH, Venuturupalli S, Kelly JA, Alarcon-Riquelme ME, Pons-Estel B, Jonsson R, Lu X, Gottenberg JE, Anaya JM, Cunninghame-Graham DS, Huang AJW, Brennan MT, Hughes P, Alevizos I, Miceli-Richard C, Keystone EC, Bykerk VP, Hirschfield G, Xie G, Siminovitch KA, Ng WF, Nordmark G, Bucher SM, Eriksson P, Omdal R, Rhodus NL, Rischmueller M, Rohrer M, Wahren-Herlenius M, Witte T, Mariette X, Lessard CJ, Harley JB, Sivils KL, Scofield RH.
PMID: 29195081
Clin Immunol. 2018 Feb;187:137-138. doi: 10.1016/j.clim.2017.11.012. Epub 2017 Dec 07.

No abstract available.

TIE: A Method to Electroporate Long DNA Templates into Preimplantation Embryos for CRISPR-Cas9 Gene Editing.

The CRISPR journal

Bagheri H, Friedman H, Shao H, Chong Y, Lo CA, Emran F, Kays I, Yang XJ, Cooper E, Chen BE, Siminovitch K, Peterson A.
PMID: 31021258
CRISPR J. 2018 Jun;1:223-229. doi: 10.1089/crispr.2017.0020.

Precise genome editing using CRISPR typically requires delivery of guide RNAs, Cas9 endonuclease, and DNA repair templates. Both microinjection and electroporation effectively deliver these components into mouse zygotes provided the DNA template is an oligonucleotide of only a few...

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.

Gastroenterology

Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA, Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P.
PMID: 33675743
Gastroenterology. 2021 Jun;160(7):2483-2495.e26. doi: 10.1053/j.gastro.2021.02.061. Epub 2021 Mar 04.

BACKGROUND & AIMS: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease.METHODS: We...

Studies on the Chemistry of the Living Bark of the Black Locust Tree in Relation to Frost. VI. Amylase and Phosphorylase Systems of the Bark Tissues.

Plant physiology

Ewart MH, Siminovitch D, Briggs DR.
PMID: 16654580
Plant Physiol. 1953 Oct;28(4):629-44. doi: 10.1104/pp.28.4.629.

No abstract available.

Studies on the Chemistry of the Living Bark of the Black Locust in Relation to Its Frost Hardiness. VII. A Possible Direct Effect of Starch on the Susceptibility of Plants to Freezing Injury.

Plant physiology

Siminovitch D, Briggs DR.
PMID: 16654671
Plant Physiol. 1954 Jul;29(4):331-7. doi: 10.1104/pp.29.4.331.

No abstract available.

Studies on the Chemistry of the Living Bark of the Black Locust in Relation to its Frost Hardiness. VIII. Possible Enzymatic Processes Involved in Starch-Sucrose Interconversions.

Plant physiology

Ewart MH, Siminovitch D, Briggs DR.
PMID: 16654688
Plant Physiol. 1954 Sep;29(5):407-13. doi: 10.1104/pp.29.5.407.

No abstract available.

Protoplasts surviving freezing to -196 C and osmotic dehydration in 5 molar salt solutions prepared from the bark of winter black locust trees.

Plant physiology

Siminovitch D.
PMID: 16660800
Plant Physiol. 1979 Apr;63(4):722-5. doi: 10.1104/pp.63.4.722.

Free protoplasts were prepared from the living bark tissue of the trunk of summer and winter black locust trees by enzymic digestion of thin slices of the tissue for 3 hours in a medium containing 2% Onozuka cellulase, 2%...

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget

Li Y, Xiao X, Bossé Y, Gorlova O, Gorlov I, Han Y, Byun J, Leighl N, Johansen JS, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Wichmann HE, Manz J, Muley T, Risch A, Rosenberger A, Han J, Siminovitch K, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Houlston R, Artigas MS, Grankvist K, Johansson M, Shepherd FA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Liu G, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Bertazzi PA, Pesatori AC, Christiani DC, Caporaso N, Johansson M, McKay JD, Brennan P, Hung RJ, Amos CI.
PMID: 30956756
Oncotarget. 2019 Mar 05;10(19):1760-1774. doi: 10.18632/oncotarget.26678. eCollection 2019 Mar 05.

The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer...

Genome-wide analysis in 756,646 individuals provides first genetic evidence that .

medRxiv : the preprint server for health sciences

Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB, Marcketta A, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Sun D, Baltzell A, Kury FSP, Backman JD, Girshick AR, O'Dushlaine C, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Li AH, Zhang M, Mbatchou J, Watanabe K, Gurski L, McCarthy SE, Kang HM, Dobbyn L, Stahl E, Verma A, Sirugo G, Ritchie MD, Jones M, Balasubramanian S, Siminovitch K, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Locke AE, Marchini J, Overton JD, Carey DJ, Habegger L, Cantor MN, Rand KA, Hong EL, Reid JG, Ball CA, Baras A, Abecasis GR, Ferreira MA.
PMID: 33619501
medRxiv. 2021 Jun 10; doi: 10.1101/2020.12.14.20248176.

SARS-CoV-2 enters host cells by binding angiotensin-converting enzyme 2 (ACE2). Through a genome-wide association study, we show that a rare variant (MAF = 0.3%, odds ratio 0.60,

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.

Gastroenterology

Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA, Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P.
PMID: 33675743
Gastroenterology. 2021 Jun;160(7):2483-2495.e26. doi: 10.1053/j.gastro.2021.02.061. Epub 2021 Mar 04.

BACKGROUND & AIMS: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease.METHODS: We...

Showing 1 to 12 of 39 entries