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Showing 1 to 12 of 81 entries
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Functional outcomes among sexual minority youth emancipating from the child welfare system

Minority STEM

Shpiegel S, Simmel C.
GSID: Sr9KYmDNkbUJ
S Shpiegel, C Simmel - Children and Youth Services Review, 2016 - Elsevier

… and not simply a flurry of training exercises just as youth are about to depart the system. … First, sexual minority youths' involvement with child welfare services may directly stem from …

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells.

Genes & nutrition

Montales MT, Simmen RC, Ferreira ES, Neves VA, Simmen FA.
PMID: 26506839
Genes Nutr. 2015 Nov;10(6):49. doi: 10.1007/s12263-015-0499-6. Epub 2015 Oct 28.

Colorectal cancer (CRC) is a disease whose genesis may include metabolic dysregulation. Cancer stem cells are attractive targets for therapeutic interventions since their aberrant expansion may underlie tumor initiation, progression, and recurrence. To investigate the actions of metabolic regulators...

Assembly and melting of DNA nanotubes from single-sequence tiles.

Journal of physics. Condensed matter : an Institute of Physics journal

Sobey TL, Renner S, Simmel FC.
PMID: 21817257
J Phys Condens Matter. 2009 Jan 21;21(3):034112. doi: 10.1088/0953-8984/21/3/034112. Epub 2008 Dec 17.

DNA melting and renaturation studies are an extremely valuable tool to study the kinetics and thermodynamics of duplex dissociation and reassociation reactions. These are important not only in a biological or biotechnological context, but also for DNA nanotechnology which...

A selective and efficient electrocatalyst for carbon dioxide reduction.

Nature communications

Lu Q, Rosen J, Zhou Y, Hutchings GS, Kimmel YC, Chen JG, Jiao F.
PMID: 24476921
Nat Commun. 2014;5:3242. doi: 10.1038/ncomms4242.

Converting carbon dioxide to useful chemicals in a selective and efficient manner remains a major challenge in renewable and sustainable energy research. Silver is an interesting electrocatalyst owing to its capability of converting carbon dioxide to carbon monoxide selectively...

Atomic layer deposition synthesis of platinum-tungsten carbide core-shell catalysts for the hydrogen evolution reaction.

Chemical communications (Cambridge, England)

Hsu IJ, Kimmel YC, Jiang X, Willis BG, Chen JG.
PMID: 22158836
Chem Commun (Camb). 2012 Jan 25;48(7):1063-5. doi: 10.1039/c1cc15812k. Epub 2011 Dec 08.

Pt was deposited onto tungsten carbide powders using atomic layer deposition to produce core-shell catalysts for the hydrogen evolution reaction (HER). The Pt loading on these catalysts was reduced nearly ten-fold compared to a bulk Pt catalyst while equivalent...

Low intensity ultrasound perturbs cytoskeleton dynamics.

Soft matter

Mizrahi N, Zhou EH, Lenormand G, Krishnan R, Weihs D, Butler JP, Weitz DA, Fredberg JJ, Kimmel E.
PMID: 23646063
Soft Matter. 2012 Feb 28;8(8):2438-2443. doi: 10.1039/C2SM07246G.

Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low intensity ultrasound. These physical changes...

KNGP: A network-based gene prioritization algorithm that incorporates multiple sources of knowledge.

American journal of bioinformatics and computational biology

Kimmel C, Visweswaran S.
PMID: 31245171
Am J Bioinform Comput Biol. 2015;3(1):1-4. doi: 10.7726/ajbcb.2015.1001. Epub 2015 Apr 25.

BACKGROUND: Candidate gene prioritization is the process of identifying and ranking new genes as potential candidates of being associated with a disease or phenotype. Integrating multiple sources of biological knowledge for gene prioritization can improve performance.RESULTS: We developed a...

Correction to: Graph Theoretical Analysis of Brain Network Characteristics in Brain Tumor Patients: A Systematic Review.

Neuropsychology review

Semmel ES, Quadri TR, King TZ.
PMID: 34398436
Neuropsychol Rev. 2021 Aug 16; doi: 10.1007/s11065-021-09520-5. Epub 2021 Aug 16.

No abstract available.

Evaluation of an E. coli Cell Extract Prepared by Lysozyme-Assisted Sonication via Gene Expression, Phage Assembly and Proteomics.

Chembiochem : a European journal of chemical biology

Falgenhauer E, von Schönberg S, Meng C, Mückl A, Vogele K, Emslander Q, Ludwig C, Simmel FC.
PMID: 34240805
Chembiochem. 2021 Sep 14;22(18):2805-2813. doi: 10.1002/cbic.202100257. Epub 2021 Jul 29.

Over the past decades, starting from crude cell extracts, a variety of successful preparation protocols and optimized reaction conditions have been established for the production of cell-free gene expression systems. One of the crucial steps during the preparation of...

Differentiation reveals latent features of aging and an energy barrier in murine myogenesis.

Cell reports

Kimmel JC, Yi N, Roy M, Hendrickson DG, Kelley DR.
PMID: 33910007
Cell Rep. 2021 Apr 27;35(4):109046. doi: 10.1016/j.celrep.2021.109046.

Skeletal muscle experiences a decline in lean mass and regenerative potential with age, in part due to intrinsic changes in progenitor cells. However, it remains unclear how age-related changes in progenitors manifest across a differentiation trajectory. Here, we perform...

Innate immune defenses at the maternal-fetal interface.

Current opinion in immunology

Semmes EC, Coyne CB.
PMID: 34768027
Curr Opin Immunol. 2021 Nov 09;74:60-67. doi: 10.1016/j.coi.2021.10.007. Epub 2021 Nov 09.

The human maternal-fetal interface is an immunologically complex environment that must balance the divergent demands of tolerance towards the developing fetus with anti-pathogen defense. The innate immune responses at the maternal-fetal interface that function in anti-microbial defense have been...

Computational Analysis of Genetic Code Variations Optimized for the Robustness against Point Mutations with Wobble-like Effects.

Life (Basel, Switzerland)

Fimmel E, Gumbel M, Starman M, Strüngmann L.
PMID: 34947869
Life (Basel). 2021 Dec 03;11(12). doi: 10.3390/life11121338.

It is believed that the codon-amino acid assignments of the standard genetic code (SGC) help to minimize the negative effects caused by point mutations. All possible point mutations of the genetic code can be represented as a weighted graph...

Showing 1 to 12 of 81 entries