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Showing 1 to 12 of 196 entries
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Effect of oral azithromycin vs placebo on COVID-19 symptoms in outpatients with SARS-CoV-2 infection: a randomized clinical trial

Latinx/Hispanic ethnicity

Oldenburg CE, Pinsky BA, Ruder K.
GSID: gkpLBSD1X4QJ
CE Oldenburg, BA Pinsky, J Brogdon, C Chen, K Ruder… - Jama, 2021 - jamanetwork.com

… Race and ethnicity were self-reported by participants based on fixed categories with the option to report an “other” race or ethnicity to comply with US Food and Drug Administration …

Improved glycerol utilization by a triacylglycerol-producing Rhodococcus opacus strain for renewable fuels.

Biotechnology for biofuels

Kurosawa K, Radek A, Plassmeier JK, Sinskey AJ.
PMID: 25763105
Biotechnol Biofuels. 2015 Feb 26;8:31. doi: 10.1186/s13068-015-0209-z. eCollection 2015.

BACKGROUND: Glycerol generated during renewable fuel production processes is potentially an attractive substrate for the production of value-added materials by fermentation. An engineered strain MITXM-61 of the oleaginous bacterium Rhodococcus opacus produces large amounts of intracellular triacylglycerols (TAGs) for...

Cell engineering and molecular pharming for biopharmaceuticals.

The open medicinal chemistry journal

Abdullah MA, Rahmah AU, Sinskey AJ, Rha CK.
PMID: 19662143
Open Med Chem J. 2008 May 14;2:49-61. doi: 10.2174/1874104500802010049.

Biopharmaceuticals are often produced by recombinant E. coli or mammalian cell lines. This is usually achieved by the introduction of a gene or cDNA coding for the protein of interest into a well-characterized strain of producer cells. Naturally, each...

Evaluation of hemodynamic parameters as predictors of glaucoma progression.

Journal of ophthalmology

Janulevičiene I, Ehrlich R, Siesky B, Nedzelskienė I, Harris A.
PMID: 21577269
J Ophthalmol. 2011;2011:164320. doi: 10.1155/2011/164320. Epub 2011 Apr 10.

Purpose. To evaluate hemodynamic parameters as possible predictors for glaucoma progression. Methods. An 18-month randomized double-masked cohort study including 30 open-angle glaucoma patients receiving fixed-combination treatment with Dorzolamide/Timolol (DTFC) or Latanoprost/Timolol (LTFC) (n = 15 per group) was performed....

Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients.

Clinical ophthalmology (Auckland, N.Z.)

Moss AM, Harris A, Siesky B, Rusia D, Williamson KM, Shoshani Y.
PMID: 20463789
Clin Ophthalmol. 2010 Apr 26;4:233-41. doi: 10.2147/opth.s6372.

Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be efficacious at reducing intraocular pressure. Many prospective studies have also suggested that carbonic anhydrase inhibitors augment ocular blood flow and vascular regulation independent of...

A streamlined approach to prescription management.

Family practice management

Sinsky TA, Sinsky CA.
PMID: 23317126
Fam Pract Manag. 2012 Nov-Dec;19(6):11-3.

No abstract available.

Comparison of intraocular pressure, blood pressure, ocular perfusion pressure and blood flow fluctuations during dorzolamide versus timolol add-on therapy in prostaglandin analogue treated glaucoma subjects.

Pharmaceuticals (Basel, Switzerland)

Januleviciene I, Siaudvytyte L, Diliene V, Barsauskaite R, Paulaviciute-Baikstiene D, Siesky B, Harris A.
PMID: 24281382
Pharmaceuticals (Basel). 2012 Mar 21;5(3):325-38. doi: 10.3390/ph5030325.

OBJECTIVE: To compare the effects of dorzolamide and timolol add-on therapy in open-angle glaucoma (OAG) patients previously treated with prostaglandin analogue (Pg), by evaluating fluctuations in the intraocular (IOP), blood (BP), ocular perfusion pressures (OPP) and retrobulbar blood flow...

Engineering xylose metabolism in triacylglycerol-producing Rhodococcus opacus for lignocellulosic fuel production.

Biotechnology for biofuels

Kurosawa K, Wewetzer SJ, Sinskey AJ.
PMID: 24041310
Biotechnol Biofuels. 2013 Sep 16;6(1):134. doi: 10.1186/1754-6834-6-134.

BACKGROUND: There has been a great deal of interest in fuel productions from lignocellulosic biomass to minimize the conflict between food and fuel use. The bioconversion of xylose, which is the second most abundant sugar present after glucose in...

Simultaneous wavelength locking of microring modulator array with a single monitoring signal.

Optics express

Dong P, Gatdula R, Kim K, Sinsky JH, Melikyan A, Chen YK, de Valicourt G, Lee J.
PMID: 28789112
Opt Express. 2017 Jul 10;25(14):16040-16046. doi: 10.1364/OE.25.016040.

A microring modulator array coupled to a common bus waveguide can be used to construct low power, compact and flexible wavelength-division-multiplexing (WDM) transmitters. However, due to extremely small working bandwidths of the rings, it is challenging to find the...

Corrigendum to "Experimental evolution and gene knockout studies reveal AcrA-mediated isobutanol tolerance in Ralstonia eutropha" [J Biosci Bioeng 122 (2016) 64-69].

Journal of bioscience and bioengineering

Bernardi AC, Gai CS, Lu J, Sinskey AJ, Brigham CJ.
PMID: 28185833
J Biosci Bioeng. 2017 May;123(5):658. doi: 10.1016/j.jbiosc.2017.01.010. Epub 2017 Feb 06.

No abstract available.

Models to inform neutralizing antibody therapy strategies during pandemics: the case of SARS-CoV-2.

Antibody therapeutics

Guttieres D, Sinskey AJ, Springs SL.
PMID: 33928236
Antib Ther. 2021 Mar 20;4(1):60-71. doi: 10.1093/abt/tbab006. eCollection 2021 Jan.

BACKGROUND: Neutralizing antibodies (nAbs) against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can play an important role in reducing impacts of the COVID-19 pandemic, complementing ongoing public health efforts such as diagnostics and vaccination. Rapidly designing, manufacturing and distributing...

Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies.

Biomaterials

Chen L, Guttieres D, Koenigsberg A, Barone PW, Sinskey AJ, Springs SL.
PMID: 34871881
Biomaterials. 2021 Nov 25;280:121274. doi: 10.1016/j.biomaterials.2021.121274. Epub 2021 Nov 25.

Food systems of the future will need to face an increasingly clear reality - that a protein-rich diet is essential for good health, but traditional meat products will not suffice to ensure safety, sustainability, and equity of food supply...

Showing 1 to 12 of 196 entries