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Showing 1 to 12 of 16 entries
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On the Robustness of Graph-Based Clustering to Random Network Alterations.

Molecular & cellular proteomics : MCP

Stacey RG, Skinnider MA, Foster LJ.
PMID: 33592499
Mol Cell Proteomics. 2020 Nov 24;20:100002. doi: 10.1074/mcp.RA120.002275. Epub 2020 Nov 24.

Biological functions emerge from complex and dynamic networks of protein-protein interactions. Because these protein-protein interaction networks, or interactomes, represent pairwise connections within a hierarchically organized system, it is often useful to identify higher-order associations embedded within them, such as...

An atlas of protein-protein interactions across mouse tissues.

Cell

Skinnider MA, Scott NE, Prudova A, Kerr CH, Stoynov N, Stacey RG, Chan QWT, Rattray D, Gsponer J, Foster LJ.
PMID: 34214469
Cell. 2021 Jul 22;184(15):4073-4089.e17. doi: 10.1016/j.cell.2021.06.003. Epub 2021 Jul 01.

Cellular processes arise from the dynamic organization of proteins in networks of physical interactions. Mapping the interactome has therefore been a central objective of high-throughput biology. However, the dynamics of protein interactions across physiological contexts remain poorly understood. Here,...

On the Robustness of Graph-Based Clustering to Random Network Alterations.

Molecular & cellular proteomics : MCP

Stacey RG, Skinnider MA, Foster LJ.
PMID: 33592499
Mol Cell Proteomics. 2021;20:100002. doi: 10.1074/mcp.RA120.002275. Epub 2020 Nov 24.

Biological functions emerge from complex and dynamic networks of protein-protein interactions. Because these protein-protein interaction networks, or interactomes, represent pairwise connections within a hierarchically organized system, it is often useful to identify higher-order associations embedded within them, such as...

Proteomic Portraits Reveal Evolutionarily Conserved and Divergent Responses to Spinal Cord Injury.

Molecular & cellular proteomics : MCP

Skinnider MA, Rogalski J, Tigchelaar S, Manouchehri N, Prudova A, Jackson AM, Nielsen K, Jeong J, Chaudhary S, Shortt K, Gallagher-Kurtzke Y, So K, Fong A, Gupta R, Okon EB, Rizzuto MA, Dong K, Streijger F, Belanger L, Ritchie L, Tsang A, Christie S, Mac-Thiong JM, Bailey C, Ailon T, Charest-Morin R, Dea N, Wilson JR, Dhall S, Paquette S, Street J, Fisher CG, Dvorak MF, Shannon C, Borchers C, Balshaw R, Foster LJ, Kwon BK.
PMID: 34129941
Mol Cell Proteomics. 2021 Jun 12;20:100096. doi: 10.1016/j.mcpro.2021.100096. Epub 2021 Jun 12.

Despite the emergence of promising therapeutic approaches in preclinical studies, the failure of large-scale clinical trials leaves clinicians without effective treatments for acute spinal cord injury (SCI). These trials are hindered by their reliance on detailed neurological examinations to...

Adrenalitis and anasarca in idiopathic multicentric Castleman's disease.

Lancet (London, England)

Chen LYC, Skinnider BF, Wilson D, Fajgenbaum DC.
PMID: 33965090
Lancet. 2021 May 08;397(10286):1749. doi: 10.1016/S0140-6736(21)00674-7.

No abstract available.

On the Robustness of Graph-Based Clustering to Random Network Alterations.

Molecular & cellular proteomics : MCP

Stacey RG, Skinnider MA, Foster LJ.
PMID: 33592499
Mol Cell Proteomics. 2021;20:100002. doi: 10.1074/mcp.RA120.002275. Epub 2020 Nov 24.

Biological functions emerge from complex and dynamic networks of protein-protein interactions. Because these protein-protein interaction networks, or interactomes, represent pairwise connections within a hierarchically organized system, it is often useful to identify higher-order associations embedded within them, such as...

Post-radiation epithelioid angiosarcoma of the urinary bladder and prostate.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Wang G, Black PC, Skinnider BF, Hayes MM, Jones EC.
PMID: 27790305
Can Urol Assoc J. 2016 May-Jun;10(5):E197-E200. doi: 10.5489/cuaj.3220. Epub 2016 May 12.

Angiosarcoma of the lower urinary tract is exceedingly rare. A minority of cases are associated with local radiotherapy. Epithelioid angiosarcoma is a variant of angiosarcoma composed of large rounded epithelioid endothelial cells that are positive for cytokeratin on immunostaining....

An atlas of protein-protein interactions across mouse tissues.

Cell

Skinnider MA, Scott NE, Prudova A, Kerr CH, Stoynov N, Stacey RG, Chan QWT, Rattray D, Gsponer J, Foster LJ.
PMID: 34214469
Cell. 2021 Jul 22;184(15):4073-4089.e17. doi: 10.1016/j.cell.2021.06.003. Epub 2021 Jul 01.

Cellular processes arise from the dynamic organization of proteins in networks of physical interactions. Mapping the interactome has therefore been a central objective of high-throughput biology. However, the dynamics of protein interactions across physiological contexts remain poorly understood. Here,...

Proteomic Portraits Reveal Evolutionarily Conserved and Divergent Responses to Spinal Cord Injury.

Molecular & cellular proteomics : MCP

Skinnider MA, Rogalski J, Tigchelaar S, Manouchehri N, Prudova A, Jackson AM, Nielsen K, Jeong J, Chaudhary S, Shortt K, Gallagher-Kurtzke Y, So K, Fong A, Gupta R, Okon EB, Rizzuto MA, Dong K, Streijger F, Belanger L, Ritchie L, Tsang A, Christie S, Mac-Thiong JM, Bailey C, Ailon T, Charest-Morin R, Dea N, Wilson JR, Dhall S, Paquette S, Street J, Fisher CG, Dvorak MF, Shannon C, Borchers C, Balshaw R, Foster LJ, Kwon BK.
PMID: 34129941
Mol Cell Proteomics. 2021;20:100096. doi: 10.1016/j.mcpro.2021.100096. Epub 2021 Jun 12.

Despite the emergence of promising therapeutic approaches in preclinical studies, the failure of large-scale clinical trials leaves clinicians without effective treatments for acute spinal cord injury (SCI). These trials are hindered by their reliance on detailed neurological examinations to...

Comparative analysis of chemical similarity methods for modular natural products with a hypothetical structure enumeration algorithm.

Journal of cheminformatics

Skinnider MA, Dejong CA, Franczak BC, McNicholas PD, Magarvey NA.
PMID: 29086195
J Cheminform. 2017 Aug 16;9(1):46. doi: 10.1186/s13321-017-0234-y.

Natural products represent a prominent source of pharmaceutically and industrially important agents. Calculating the chemical similarity of two molecules is a central task in cheminformatics, with applications at multiple stages of the drug discovery pipeline. Quantifying the similarity of...

PrInCE: an R/bioconductor package for protein-protein interaction network inference from co-fractionation mass spectrometry data.

Bioinformatics (Oxford, England)

Skinnider MA, Cai C, Stacey RG, Foster LJ.
PMID: 33471077
Bioinformatics. 2021 Jan 20; doi: 10.1093/bioinformatics/btab022. Epub 2021 Jan 20.

SUMMARY: We present PrInCE, an R/Bioconductor package that employs a machine-learning approach to infer protein-protein interaction networks from co-fractionation mass spectrometry (CF-MS) data. Previously distributed as a collection of Matlab scripts, our ground-up rewrite of this software package in...

Adrenalitis and anasarca in idiopathic multicentric Castleman's disease.

Lancet (London, England)

Chen LYC, Skinnider BF, Wilson D, Fajgenbaum DC.
PMID: 33965090
Lancet. 2021 May 08;397(10286):1749. doi: 10.1016/S0140-6736(21)00674-7.

No abstract available.

Showing 1 to 12 of 16 entries