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Showing 1 to 12 of 19 entries
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A ferroelectric oxide made directly on silicon.

Science (New York, N.Y.)

Warusawithana MP, Cen C, Sleasman CR, Woicik JC, Li Y, Kourkoutis LF, Klug JA, Li H, Ryan P, Wang LP, Bedzyk M, Muller DA, Chen LQ, Levy J, Schlom DG.
PMID: 19372426
Science. 2009 Apr 17;324(5925):367-70. doi: 10.1126/science.1169678.

Metal oxide semiconductor field-effect transistors, formed using silicon dioxide and silicon, have undergone four decades of staggering technological advancement. With fundamental limits to this technology close at hand, alternatives to silicon dioxide are being pursued to enable new functionality...

Molecular Docking-Based Screening for Novel Inhibitors of the Human Immunodeficiency Virus Type 1 Protease that Effectively Reduce the Viral Replication in Human Cells.

Journal of AIDS & clinical research

Mavian C, Coman RM, Zhang X, Pomeroy S, Ostrov DA, Dunn BM, Sleasman JW, Goodenow MM.
PMID: 34950525
J AIDS Clin Res. 2021;12(5). Epub 2021 May 21.

Therapeutic pressure by protease inhibitors (PIs) contributes to accumulation of mutations in the HIV type 1 (HIV-1) protease (PR) leading to development of drug resistance with subsequent therapy failure. Current PIs target the active site of PR in a...

A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles.

ACS medicinal chemistry letters

Beale TM, Allwood DM, Bender A, Bond PJ, Brenton JD, Charnock-Jones DS, Ley SV, Myers RM, Shearman JW, Temple J, Unger J, Watts CA, Xian J.
PMID: 24900453
ACS Med Chem Lett. 2012 Jan 19;3(3):177-81. doi: 10.1021/ml200149g. eCollection 2012 Mar 08.

The combretastatins have been investigated for their antimitotic and antivascular properties, and it is widely postulated that a 3,4,5-trimethoxyaryl A-ring is essential to maintain potent activity. We have synthesized new tetrazole analogues (32-34), demonstrating that 3,5-dihalogenation can consistently increase...

Sub-Wavelength Focusing in Inhomogeneous Media with a Metasurface Near Field Plate.

Sensors (Basel, Switzerland)

Strikwerda AC, Sleasman T, Anderson W, Awadallah R.
PMID: 31635351
Sensors (Basel). 2019 Oct 18;19(20). doi: 10.3390/s19204534.

Overcoming the diffraction limit, which enables focusing much less than the wavelength, requires tailoring the evanescent spectrum of an aperture's field distribution. We model and simulate a corrugated near field plate, which can generate a sub-wavelength focus in inhomogeneous...

The determination of HCN residues on greenhouse tomatoes.

Bulletin of environmental contamination and toxicology

Waldron AC, Robb CJ, Sleesman JP.
PMID: 24185798
Bull Environ Contam Toxicol. 1970 Mar;5(2):95-7. doi: 10.1007/BF01617184.

No abstract available.

Protestant Christian attitudes to ART.

Human reproduction open

Best M, Sleasman M, Hegedus E, Schlub TE.
PMID: 31528709
Hum Reprod Open. 2019 Sep 02;2019(3):hoz018. doi: 10.1093/hropen/hoz018. eCollection 2019.

STUDY QUESTION: How do Christian religious beliefs affect attitudes to ART?SUMMARY ANSWER: Attitudes to ART depend on the religiosity of the respondent, and although the majority of those that had successfully used ART were positive or moderately positive in...

Molecular Docking-Based Screening for Novel Inhibitors of the Human Immunodeficiency Virus Type 1 Protease that Effectively Reduce the Viral Replication in Human Cells.

Journal of AIDS & clinical research

Mavian C, Coman RM, Zhang X, Pomeroy S, Ostrov DA, Dunn BM, Sleasman JW, Goodenow MM.
PMID: 34950525
J AIDS Clin Res. 2021;12(5). Epub 2021 May 21.

Therapeutic pressure by protease inhibitors (PIs) contributes to accumulation of mutations in the HIV type 1 (HIV-1) protease (PR) leading to development of drug resistance with subsequent therapy failure. Current PIs target the active site of PR in a...

Electronically steered metasurface antenna.

Scientific reports

Boyarsky M, Sleasman T, Imani MF, Gollub JN, Smith DR.
PMID: 33633119
Sci Rep. 2021 Feb 25;11(1):4693. doi: 10.1038/s41598-021-83377-9.

Mobile devices, climate science, and autonomous vehicles all require advanced microwave antennas for imaging, radar, and wireless communications. We propose a waveguide-fed metasurface antenna architecture that enables electronic beamsteering from a lightweight circuit board with varactor-tuned elements. Our approach...

IgM Repertoire Biodiversity is Reduced in HIV-1 Infection and Systemic Lupus Erythematosus.

Frontiers in immunology

Yin L, Hou W, Liu L, Cai Y, Wallet MA, Gardner BP, Chang K, Lowe AC, Rodriguez CA, Sriaroon P, Farmerie WG, Sleasman JW, Goodenow MM.
PMID: 24298273
Front Immunol. 2013 Nov 15;4:373. doi: 10.3389/fimmu.2013.00373. eCollection 2013.

BACKGROUND: HIV-1 infection or systemic lupus erythematosus (SLE) disrupt B cell homeostasis, reduce memory B cells, and impair function of IgG and IgM antibodies.OBJECTIVE: To determine how disturbances in B cell populations producing polyclonal antibodies relate to the IgM...

Synthetic aperture radar with dynamic metasurface antennas: a conceptual development.

Journal of the Optical Society of America. A, Optics, image science, and vision

Boyarsky M, Sleasman T, Pulido-Mancera L, Fromenteze T, Pedross-Engel A, Watts CM, Imani MF, Reynolds MS, Smith DR.
PMID: 28463331
J Opt Soc Am A Opt Image Sci Vis. 2017 May 01;34(5):A22-A36. doi: 10.1364/JOSAA.34.000A22.

We investigate the application of dynamic metasurface antennas (DMAs) to synthetic aperture radar (SAR) systems. Metasurface antennas can generate a multitude of tailored electromagnetic waveforms from a physical platform that is low-cost, lightweight, and planar; these characteristics are not...

Single-frequency 3D synthetic aperture imaging with dynamic metasurface antennas.

Applied optics

Boyarsky M, Sleasman T, Pulido-Mancera L, Diebold AV, Imani MF, Smith DR.
PMID: 29791386
Appl Opt. 2018 May 20;57(15):4123-4134. doi: 10.1364/AO.57.004123.

Through aperture synthesis, an electrically small antenna can be used to form a high-resolution imaging system capable of reconstructing three-dimensional (3D) scenes. However, the large spectral bandwidth typically required in synthetic aperture radar systems to resolve objects in range...

Efficient complementary metamaterial element for waveguide-fed metasurface antennas.

Optics express

Yoo I, Imani MF, Sleasman T, Smith DR.
PMID: 27958512
Opt Express. 2016 Dec 12;24(25):28686-28692. doi: 10.1364/OE.24.028686.

We present a metamaterial element designed as an efficient radiator for waveguide-fed metasurface antennas. The metamaterial element is an electrically-small, complimentary electric-LC (cELC) resonator designed to exhibit large radiated power while maintaining low ohmic losses. The shape of the...

Showing 1 to 12 of 19 entries