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Showing 1 to 12 of 34 entries
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FDA Engages Collaborators to Address Nonclinical Data Challenges.

Therapeutic innovation & regulatory science

Kropp TJ, Rosario LA, DeHaven S, Houser W, Kramer LA, Nath S, Smyrnios T, Wally JL.
PMID: 30227493
Ther Innov Regul Sci. 2013 Jan;47(1):41-45. doi: 10.1177/0092861512466398.

FDA and PhUSE cohosted a Computational Science Symposium (CSS) in 2012 that brought stakeholders from the pharmaceutical industry and government to work collaboratively to solve common needs and challenges. A nonclinical informatics workgroup was formed, dedicated to improving nonclinical...

Dyspnea and respiratory muscle strength in end-stage liver disease.

World journal of hepatology

Kaltsakas G, Antoniou E, Palamidas AF, Gennimata SA, Paraskeva P, Smyrnis A, Koutsoukou A, Milic-Emili J, Koulouris NG.
PMID: 23646230
World J Hepatol. 2013 Feb 27;5(2):56-63. doi: 10.4254/wjh.v5.i2.56.

AIM: To investigate the prevalence of chronic dyspnea and its relationship to respiratory muscle function in end-stage liver disease.METHODS: Sixty-eight consecutive, ambulatory, Caucasian patients with end-stage liver disease, candidates for liver transplantation, were referred for preoperative respiratory function assessment....

Mirizzi Syndrome: an unexpected problem of cholelithiasis. Our experience with 27 cases.

International seminars in surgical oncology : ISSO

Safioleas M, Stamatakos M, Safioleas P, Smyrnis A, Revenas C, Safioleas C.
PMID: 18495037
Int Semin Surg Oncol. 2008 May 21;5:12. doi: 10.1186/1477-7800-5-12.

PURPOSE: Mirizzi syndrome is a rare complication of long standing cholelithiasis. The purpose of this study is to retrospectively estimate the diagnostic and treatment methods applied in patients with Mirizzi syndrome.MATERIALS AND METHODS: Our experience with 27 cases with...

Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study.

CNS spectrums

Fountoulakis KN, Dragioti E, Theofilidis AT, Wiklund T, Atmatzidis X, Nimatoudis I, Thys E, Wampers M, Hranov L, Hristova T, Aptalidis D, Milev R, Iftene F, Spaniel F, Knytl P, Furstova P, From T, Karlsson H, Walta M, Salokangas RKR, Azorin JM, Bouniard J, Montant J, Juckel G, Haussleiter IS, Douzenis A, Michopoulos I, Ferentinos P, Smyrnis N, Mantonakis L, Nemes Z, Gonda X, Vajda D, Juhasz A, Shrivastava A, Waddington J, Pompili M, Comparelli A, Corigliano V, Rancans E, Navickas A, Hilbig J, Bukelskis L, Stevovic LI, Vodopic S, Esan O, Oladele O, Osunbote C, Rybakowski JK, Wojciak P, Domowicz K, Figueira ML, Linhares L, Crawford J, Panfil AL, Smirnova D, Izmailova O, Lecic-Tosevski D, Temmingh H, Howells F, Bobes J, Garcia-Portilla MP, García-Alvarez L, Erzin G, Karadağ H, De Sousa A, Bendre A, Hoschl C, Bredicean C, Papava I, Vukovic O, Pejuskovic B, Russell V, Athanasiadis L, Konsta A, Stein D, Berk M, Dean O, Tandon R, Kasper S, De Hert M.
PMID: 32290897
CNS Spectr. 2021 Jun;26(3):290-298. doi: 10.1017/S1092852920001091. Epub 2020 Apr 15.

BACKGROUND: The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.METHODS: Twenty-nine centers from 25 countries participated and included...

Adverse Outcomes Prediction for Congenital Heart Surgery: A Machine Learning Approach.

World journal for pediatric & congenital heart surgery

Bertsimas D, Zhuo D, Dunn J, Levine J, Zuccarelli E, Smyrnakis N, Tobota Z, Maruszewski B, Fragata J, Sarris GE.
PMID: 33908836
World J Pediatr Congenit Heart Surg. 2021 Jul;12(4):453-460. doi: 10.1177/21501351211007106. Epub 2021 Apr 28.

OBJECTIVE: Risk assessment tools typically used in congenital heart surgery (CHS) assume that various possible risk factors interact in a linear and additive fashion, an assumption that may not reflect reality. Using artificial intelligence techniques, we sought to develop...

Comorbidity Matters: Social Visual Attention in a Comparative Study of Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder and Their Comorbidity.

Frontiers in psychiatry

Ioannou C, Seernani D, Stefanou ME, Riedel A, Tebartz van Elst L, Smyrnis N, Fleischhaker C, Biscaldi-Schaefer M, Boccignone G, Klein C.
PMID: 33192661
Front Psychiatry. 2020 Sep 30;11:545567. doi: 10.3389/fpsyt.2020.545567. eCollection 2020.

Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) represent two common neurodevelopmental disorders with considerable co-occurrence. Their comorbidity (ASD + ADHD) has been included in the latest diagnostic guidelines (DSM-V, 2013). The present study focuses on social visual attention...

Interleukin-1 Beta in Peripheral Blood Mononuclear Cell Lysates as a Longitudinal Biomarker of Response to Antidepressants: A Pilot Study.

Frontiers in psychiatry

Ferentinos P, Maratou E, Antoniou A, Serretti A, Smyrnis N, Moutsatsou P.
PMID: 35002816
Front Psychiatry. 2021 Dec 24;12:801738. doi: 10.3389/fpsyt.2021.801738. eCollection 2021.

Interleukin-1 beta (IL1β) is primarily produced by monocytes in the periphery and the brain. Yet, IL1β protein levels have to date been investigated in major depressive disorder (MDD) and antidepressant response using either plasma or serum assays although with...

Suicidality and COVID-19: Suicidal ideation, suicidal behaviors and completed suicides amidst the COVID-19 pandemic (Review).

Experimental and therapeutic medicine

Efstathiou V, Stefanou MI, Siafakas N, Makris M, Tsivgoulis G, Zoumpourlis V, Spandidos DA, Smyrnis N, Rizos E.
PMID: 34976149
Exp Ther Med. 2022 Jan;23(1):107. doi: 10.3892/etm.2021.11030. Epub 2021 Dec 02.

Since the outbreak of the coronavirus 2019 (COVID-19) pandemic, there has been widespread concern that social isolation, financial stress, depression, limited or variable access to health care services and other pandemic-related stressors may contribute to an increase in suicidal...

Visual search in neurodevelopmental disorders: evidence towards a continuum of impairment.

European child & adolescent psychiatry

Canu D, Ioannou C, Müller K, Martin B, Fleischhaker C, Biscaldi M, Beauducel A, Smyrnis N, van Elst LT, Klein C.
PMID: 33751240
Eur Child Adolesc Psychiatry. 2021 Mar 22; doi: 10.1007/s00787-021-01756-z. Epub 2021 Mar 22.

Disorders with neurodevelopmental aetiology such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) and Schizophrenia share commonalities at many levels of investigation despite phenotypic differences. Evidence of genetic overlap has led to the concept of a continuum of neurodevelopmental...

Association of antipsychotic use with raised eosinophil count.

Experimental and therapeutic medicine

Tsamakis K, Mueller C, Hortis I, Kallergi M, Tolos I, Alevyzakis E, Siafakas N, Ouranidis A, Tsiptsios D, Kympouropoulos S, Spandidos DA, Smyrnis N, Rizos E.
PMID: 33791022
Exp Ther Med. 2021 May;21(5):513. doi: 10.3892/etm.2021.9944. Epub 2021 Mar 19.

The current study aimed to assess the possibility of an association between first and second generation antipsychotic medication and raised eosinophil count. A total of 22 in-patients at the psychiatric unit of the University General Hospital 'Attikon', a tertiary...

P300 response modulation reflects breaches of non-probabilistic expectations.

Scientific reports

Valakos D, d'Avossa G, Mylonas D, Butler J, Klein C, Smyrnis N.
PMID: 32581245
Sci Rep. 2020 Jun 24;10(1):10254. doi: 10.1038/s41598-020-67275-0.

In oddball paradigms, infrequent stimuli elicit larger P300 event related potentials (ERPs) than frequent ones. One hypothesis is that P300 modulations reflect the degree of "surprise" associated with unexpected stimuli. That is the P300 represents how unlikely the stimulus...

Medical education challenges and innovations during COVID-19 pandemic.

Postgraduate medical journal

Papapanou M, Routsi E, Tsamakis K, Fotis L, Marinos G, Lidoriki I, Karamanou M, Papaioannou TG, Tsiptsios D, Smyrnis N, Rizos E, Schizas D.
PMID: 33782202
Postgrad Med J. 2021 Mar 29; doi: 10.1136/postgradmedj-2021-140032. Epub 2021 Mar 29.

COVID-19 pandemic has undoubtedly disrupted the well-established, traditional structure of medical education. Τhe new limitations of physical presence have accelerated the development of an online learning environment, comprising both of asynchronous and synchronous distance education, and the introduction of...

Showing 1 to 12 of 34 entries