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Showing 1 to 12 of 27 entries
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Renal Cell Carcinoma Perfusion before and after Radiofrequency Ablation Measured with Dynamic Contrast Enhanced MRI: A Pilot Study.

Diagnostics (Basel, Switzerland)

Wah TM, Sourbron S, Wilson DJ, Magee D, Gregory WM, Selby PJ, Buckley DL.
PMID: 29316711
Diagnostics (Basel). 2018 Jan 08;8(1). doi: 10.3390/diagnostics8010003.

AIM: To investigate if the early treatment effects of radiofrequency ablation (RFA) on renal cell carcinoma (RCC) can be detected with dynamic contrast enhanced (DCE)-MRI and to correlate RCC perfusion with RFA treatment time.MATERIALS AND METHODS: 20 patients undergoing...

Fenfluramine for seizures associated with Sunflower syndrome.

Developmental medicine and child neurology

Geenen KR, Doshi SP, Patel S, Sourbron J, Falk A, Morgan A, Vu U, Bruno PL, Thiele EA.
PMID: 34216017
Dev Med Child Neurol. 2021 Dec;63(12):1427-1432. doi: 10.1111/dmcn.14965. Epub 2021 Jul 03.

AIM: To determine the efficacy of fenfluramine on seizure frequency in patients with Sunflower syndrome. Secondary endpoints were changes in electroencephalogram (EEG) characteristics, cognitive functioning, executive functioning, and quality of life.METHOD: In this open-label study, patients underwent a 4-week...

Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF).

Circulation

Lee MMY, Brooksbank KJM, Wetherall K, Mangion K, Roditi G, Campbell RT, Berry C, Chong V, Coyle L, Docherty KF, Dreisbach JG, Labinjoh C, Lang NN, Lennie V, McConnachie A, Murphy CL, Petrie CJ, Petrie JR, Speirits IA, Sourbron S, Welsh P, Woodward R, Radjenovic A, Mark PB, McMurray JJV, Jhund PS, Petrie MC, Sattar N.
PMID: 33186500
Circulation. 2021 Feb 09;143(6):516-525. doi: 10.1161/CIRCULATIONAHA.120.052186. Epub 2020 Nov 13.

BACKGROUND: Sodium-glucose cotransporter 2 inhibitors reduce the risk of heart failure hospitalization and cardiovascular death in patients with heart failure and reduced ejection fraction (HFrEF). However, their effects on cardiac structure and function in HFrEF are uncertain.METHODS: We designed...

Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis.

European radiology

Yoon JH, Lee JM, Yu MH, Hur BY, Grimm R, Sourbron S, Chandarana H, Son Y, Basak S, Lee KB, Yi NJ, Lee KW, Suh KS.
PMID: 34120229
Eur Radiol. 2022 Jan;32(1):34-45. doi: 10.1007/s00330-021-08087-2. Epub 2021 Jun 12.

OBJECTIVES: To determine if golden-angle radial sparse parallel (GRASP) dynamic contrast-enhanced (DCE)-MRI allows simultaneous evaluation of perfusion and morphology in liver fibrosis.METHODS: Participants who were scheduled for liver biopsy or resection were enrolled (NCT02480972). Images were reconstructed at 12-s...

Epilepsy & behavior reports

Sourbron J, Jansen K, Aerts N, Lagae L.
PMID: 34095804
Epilepsy Behav Rep. 2021 May 07;16:100455. doi: 10.1016/j.ebr.2021.100455. eCollection 2021.

Epilepsy in

Bias and Precision in Magnetic Resonance Imaging-Based Estimates of Renal Blood Flow: Assessment by Triangulation.

Journal of magnetic resonance imaging : JMRI

Alhummiany BA, Shelley D, Saysell M, Olaru MA, Kühn B, Buckley DL, Bailey J, Wroe K, Coupland C, Mansfield MW, Sourbron SP, Sharma K.
PMID: 34397124
J Magn Reson Imaging. 2021 Aug 16; doi: 10.1002/jmri.27888. Epub 2021 Aug 16.

BACKGROUND: Renal blood flow (RBF) can be measured with dynamic contrast enhanced-MRI (DCE-MRI) and arterial spin labeling (ASL). Unfortunately, individual estimates from both methods vary and reference-standard methods are not available. A potential solution is to include a third,...

Validation study of perfusion parameter in hypervascular hepatocellular carcinoma and focal nodular hyperplasia using dynamic susceptibility magnetic resonance imaging with super-paramagnetic iron oxide: comparison with single level dynamic CT arteriography.

Quantitative imaging in medicine and surgery

Saito K, Ledsam J, Sourbron S, Araki Y.
PMID: 32550138
Quant Imaging Med Surg. 2020 Jun;10(6):1298-1306. doi: 10.21037/qims-18-233.

BACKGROUND: Dynamic susceptibility contrast MR imaging (DSC-MRI) offers direct evaluation of neo-vascularity. Ferucarbotran does not accumulate in the interstitial space, instead remaining in the intravascular space during early phase imaging. We investigate tracer kinetic analysis with DSC-MRI with ferucarbotran...

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats.

Molecular pharmaceutics

Scotcher D, Melillo N, Tadimalla S, Darwich AS, Ziemian S, Ogungbenro K, Schütz G, Sourbron S, Galetin A.
PMID: 34283621
Mol Pharm. 2021 Aug 02;18(8):2997-3009. doi: 10.1021/acs.molpharmaceut.1c00206. Epub 2021 Jul 20.

Physiologically based pharmacokinetic (PBPK) models are increasingly used in drug development to simulate changes in both systemic and tissue exposures that arise as a result of changes in enzyme and/or transporter activity. Verification of these model-based simulations of tissue...

Comparison of Correction Techniques for the Spill in Effect in Emission Tomography.

IEEE transactions on radiation and plasma medical sciences

Akerele MI, Karakatsanis NA, Deidda D, Cal-Gonzalez J, Forsythe RO, Dweck MR, Syed M, Newby DE, Aykroyd RG, Sourbron S, Tsoumpas C.
PMID: 33542967
IEEE Trans Radiat Plasma Med Sci. 2020 Jul;4(4):422-432. doi: 10.1109/TRPMS.2020.2980443. Epub 2020 Mar 12.

In positron emission tomography (PET) imaging, accurate clinical assessment is often affected by the partial volume effect (PVE) leading to overestimation (spill-in) or underestimation (spill-out) of activity in various small regions. The spill-in correction, in particular, can be very...

Fenfluramine for seizures associated with Sunflower syndrome.

Developmental medicine and child neurology

Geenen KR, Doshi SP, Patel S, Sourbron J, Falk A, Morgan A, Vu U, Bruno PL, Thiele EA.
PMID: 34216017
Dev Med Child Neurol. 2021 Dec;63(12):1427-1432. doi: 10.1111/dmcn.14965. Epub 2021 Jul 03.

AIM: To determine the efficacy of fenfluramine on seizure frequency in patients with Sunflower syndrome. Secondary endpoints were changes in electroencephalogram (EEG) characteristics, cognitive functioning, executive functioning, and quality of life.METHOD: In this open-label study, patients underwent a 4-week...

Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.

Alzheimer's & dementia (Amsterdam, Netherlands)

Smith EE, Biessels GJ, De Guio F, de Leeuw FE, Duchesne S, Düring M, Frayne R, Ikram MA, Jouvent E, MacIntosh BJ, Thrippleton MJ, Vernooij MW, Adams H, Backes WH, Ballerini L, Black SE, Chen C, Corriveau R, DeCarli C, Greenberg SM, Gurol ME, Ingrisch M, Job D, Lam BYK, Launer LJ, Linn J, McCreary CR, Mok VCT, Pantoni L, Pike GB, Ramirez J, Reijmer YD, Romero JR, Ropele S, Rost NS, Sachdev PS, Scott CJM, Seshadri S, Sharma M, Sourbron S, Steketee RME, Swartz RH, van Oostenbrugge R, van Osch M, van Rooden S, Viswanathan A, Werring D, Dichgans M, Wardlaw JM.
PMID: 30859119
Alzheimers Dement (Amst). 2019 Feb 26;11:191-204. doi: 10.1016/j.dadm.2019.01.002. eCollection 2019 Dec.

INTRODUCTION: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging...

Iterative reconstruction incorporating background correction improves quantification of [.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Akerele MI, Karakatsanis NA, Forsythe RO, Dweck MR, Syed M, Aykroyd RG, Sourbron S, Newby DE, Tsoumpas C.
PMID: 31721093
J Nucl Cardiol. 2021 Oct;28(5):1875-1886. doi: 10.1007/s12350-019-01940-4. Epub 2019 Nov 11.

BACKGROUND: A confounding issue in [METHODS: Seventy-two (72) datasets of patients with AAA were reconstructed with the standard ordered subset expectation maximization (OSEM) algorithm incorporating point spread function (PSF) modelling. The spill in effect in the aneurysm was investigated...

Showing 1 to 12 of 27 entries