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Strategies for Integrated Analysis of Genetic, Epigenetic, and Gene Expression Variation in Cancer: Addressing the Challenges.

Frontiers in genetics

Thingholm LB, Andersen L, Makalic E, Southey MC, Thomassen M, Hansen LL.
PMID: 26870081
Front Genet. 2016 Feb 01;7:2. doi: 10.3389/fgene.2016.00002. eCollection 2016.

The development and progression of cancer, a collection of diseases with complex genetic architectures, is facilitated by the interplay of multiple etiological factors. This complexity challenges the traditional single-platform study design and calls for an integrated approach to data...

Gulstonian Lectures on the Nature and Affinities of Tubercle.

British medical journal

Southey R.
PMID: 20744749
Br Med J. 1867 Apr 20;1(329):443-5. doi: 10.1136/bmj.1.329.443.

No abstract available.

Clinical Lecture on Tubercular Meningitis.

British medical journal

Southey R.
PMID: 20748091
Br Med J. 1876 Jan 22;1(786):97-9. doi: 10.1136/bmj.1.786.97.

No abstract available.

PALB2 and breast cancer: ready for clinical translation!.

The application of clinical genetics

Southey MC, Teo ZL, Winship I.
PMID: 23935381
Appl Clin Genet. 2013 Jul 19;6:43-52. doi: 10.2147/TACG.S34116. Print 2013.

For almost two decades, breast cancer clinical genetics has operated in an environment where a heritable cause of breast cancer susceptibility is identified in the vast minority of women seeking advice about their personal and/or family history of breast...

Gulstonian Lectures on the Nature and Affinities of Tubercle.

British medical journal

Southey R.
PMID: 20744734
Br Med J. 1867 Mar 30;1(326):345-8. doi: 10.1136/bmj.1.326.345.

No abstract available.

Lumleian Lectures on Bright's Disease.

British medical journal

Southey R.
PMID: 20749839
Br Med J. 1881 Apr 09;1(1058):541-6. doi: 10.1136/bmj.1.1058.541.

No abstract available.

Exploring Exercise- and Context-Induced Peptide Changes in Mice by Quantitative Mass Spectrometry.

ACS omega

Dowd SE, Mustroph ML, Romanova EV, Southey BR, Pinardo H, Rhodes JS, Sweedler JV.
PMID: 30411050
ACS Omega. 2018 Oct 31;3(10):13817-13827. doi: 10.1021/acsomega.8b01713. Epub 2018 Oct 24.

Recent research suggests that exercise may help facilitate abstinence from cocaine addiction, though the mechanisms are not well understood. In mice, wheel running accelerates the extinction of conditioned place preference (CPP) for cocaine, providing an animal model for evaluating...

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

Nature communications

Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Schmidt MK, Shah M, Luben R, Brown J, Czene K, Darabi H, Eriksson M, Klevebring D, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Lambrechts D, Thienpont B, Neven P, Wildiers H, Broeks A, Van't Veer LJ, Rutgers EJT, Couch FJ, Olson JE, Hallberg E, Vachon C, Chang-Claude J, Rudolph A, Seibold P, Flesch-Janys D, Peto J, Dos-Santos-Silva I, Gibson L, Nevanlinna H, Muranen TA, Aittomäki K, Blomqvist C, Hall P, Li J, Liu J, Humphreys K, Kang D, Choi JY, Park SK, Noh DY, Matsuo K, Ito H, Iwata H, Yatabe Y, Guénel P, Truong T, Menegaux F, Sanchez M, Burwinkel B, Marme F, Schneeweiss A, Sohn C, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Benitez J, Pilar Zamora M, Perez JIA, Menéndez P, Shu XO, Lu W, Gao YT, Cai Q, Cox A, Cross SS, Reed MWR, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Sawyer EJ, Tomlinson I, Kerin MJ, Miller N, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Lindblom A, Margolin S, Teo SH, Yip CH, Lee DSC, Wong TY, Hooning MJ, Martens JWM, Collée JM, van Deurzen CHM, Hopper JL, Southey MC, Tsimiklis H, Kapuscinski MK, Shen CY, Wu PE, Yu JC, Chen ST, Alnæs GG, Borresen-Dale AL, Giles GG, Milne RL, McLean C, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Hartman M, Miao H, Buhari SABS, Teo YY, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Swerdlow A, Ashworth A, Orr N, Schoemaker MJ, García-Closas M, Figueroa J, Chanock SJ, Lissowska J, Simard J, Goldberg MS, Labrèche F, Dumont M, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Brauch H, Brüning T, Koto YD, Radice P, Peterlongo P, Bonanni B, Volorio S, Dörk T, Bogdanova NV, Helbig S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Devilee P, Tollenaar RAEM, Seynaeve C, Van Asperen CJ, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Slager S, Toland AE, Ambrosone CB, Yannoukakos D, Sangrajrang S, Gaborieau V, Brennan P, McKay J, Hamann U, Torres D, Zheng W, Long J, Anton-Culver H, Neuhausen SL, Luccarini C, Baynes C, Ahmed S, Maranian M, Healey CS, González-Neira A, Pita G, Rosario Alonso M, Álvarez N, Herrero D, Tessier DC, Vincent D, Bacot F, de Santiago I, Carroll J, Caldas C, Brown MA, Lupien M, Kristensen VN, Pharoah PDP, Chenevix-Trench G, French JD, Easton DF, Dunning AM.
PMID: 29633761
Nat Commun. 2018 Apr 10;9:16193. doi: 10.1038/ncomms16193.

This corrects the article DOI: 10.1038/ncomms5999.

A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer.

JAMA oncology

Sun L, Brentnall A, Patel S, Buist DSM, Bowles EJA, Evans DGR, Eccles D, Hopper J, Li S, Southey M, Duffy S, Cuzick J, Dos Santos Silva I, Miners A, Sadique Z, Yang L, Legood R, Manchanda R.
PMID: 31580391
JAMA Oncol. 2019 Oct 03; doi: 10.1001/jamaoncol.2019.3323. Epub 2019 Oct 03.

IMPORTANCE: Moving to multigene testing for all women with breast cancer (BC) could identify many more mutation carriers who can benefit from precision prevention. However, the cost-effectiveness of this approach remains unaddressed.OBJECTIVE: To estimate incremental lifetime effects, costs, and...

Interplay Between Amphetamine and Activity Level in Gene Networks of the Mouse Striatum.

Bioinformatics and biology insights

Goncalves TM, Southey BR, Rodriguez-Zas SL.
PMID: 30559594
Bioinform Biol Insights. 2018 Dec 11;12:1177932218815152. doi: 10.1177/1177932218815152. eCollection 2018.

The psychostimulant amphetamine can be prescribed to ameliorate the symptoms of narcolepsy, attention-deficit hyperactivity disorder and to facilitate weight loss. This stimulant can also have negative effects including toxicity and addiction risk. The impact of amphetamine on gene networks...

Prognostic Impact of Total Plasma Cell-free DNA Concentration in Androgen Receptor Pathway Inhibitor-treated Metastatic Castration-resistant Prostate Cancer.

European urology focus

Fettke H, Kwan EM, Bukczynska P, Ng N, Nguyen-Dumont T, Southey MC, Davis ID, Mant A, Parente P, Pezaro C, Hauser C, Azad AA.
PMID: 32739405
Eur Urol Focus. 2021 Nov;7(6):1287-1291. doi: 10.1016/j.euf.2020.07.001. Epub 2020 Jul 29.

Total plasma cell-free DNA (cfDNA) levels were recently shown to be prognostic in two large phase III trials of taxane chemotherapy in metastatic castration-resistant prostate cancer (mCRPC). However, whether cfDNA concentration is predictive of treatment outcomes with androgen receptor...

DNA methylation in childhood dental caries and hypomineralization.

Journal of dentistry

Mj S, N M, Jm C, Dj M, R S, Mc S, Dp B, J L, Nm K, Jl H, Kj S, S L.
PMID: 34875274
J Dent. 2021 Dec 05;117:103913. doi: 10.1016/j.jdent.2021.103913. Epub 2021 Dec 05.

OBJECTIVES: Epigenetic modulation of gene expression may be important in dental conditions, including dental caries and enamel hypomineralisation. The aims of this study were to assess associations between DNA methylation in cord blood leucocytes at birth, and caries experience...

Showing 1 to 12 of 145 entries