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Cytotoxic action of carboxyborane heterocyclic amine adducts.

Metal-based drugs

Miller MC, Sood A, Spielvogel BF, Bastow K, Hall IH.
PMID: 18475792
Met Based Drugs. 1997;4(4):229-41. doi: 10.1155/MBD.1997.229.

The heterocyclic carboxyborane amines were found to be potent cytotoxic agents in the murine L1210 lymphoid leukemia and human HeLa suspended carcinoma cells. These agents were observed to inhibit HeLa DNA topoisomerase II activity ~ 200 muM and L1210...

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Miller MC, Sood A, Spielvogel BF, et al. Cytotoxic action of carboxyborane heterocyclic amine adducts. Met Based Drugs. 1997;4(4):229-41doi: 10.1155/MBD.1997.229.
Miller, M. C., Sood, A., Spielvogel, B. F., Bastow, K., & Hall, I. H. (1997). Cytotoxic action of carboxyborane heterocyclic amine adducts. Metal-based drugs, 4(4), 229-41. https://doi.org/10.1155/MBD.1997.229
Miller, M C, et al. "Cytotoxic action of carboxyborane heterocyclic amine adducts." Metal-based drugs vol. 4,4 (1997): 229-41. doi: https://doi.org/10.1155/MBD.1997.229
Miller MC, Sood A, Spielvogel BF, Bastow K, Hall IH. Cytotoxic action of carboxyborane heterocyclic amine adducts. Met Based Drugs. 1997;4(4):229-41. doi: 10.1155/MBD.1997.229. PMID: 18475792; PMCID: PMC2365064.
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Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers.

Metal-based drugs

Elkins AL, Eley JG, Miller Iii MC, Hall IH, Sood A, Spielvogel B.
PMID: 18475758
Met Based Drugs. 1996;3(6):277-86. doi: 10.1155/MBD.1996.277.

Oral delivery of proteins and peptides as therapeutic agents is problematic due to their low bioavailability. This study examined the effect of boronation on the transepithelial transport and metabolism of three glycine-phenylalanine dipeptides in Caco-2 and HCT-8 cell monolayers....

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Elkins AL, Eley JG, Miller Iii MC, et al. Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers. Met Based Drugs. 1996;3(6):277-86doi: 10.1155/MBD.1996.277.
Elkins, A. L., Eley, J. G., Miller Iii, M. C., Hall, I. H., Sood, A., & Spielvogel, B. (1996). Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers. Metal-based drugs, 3(6), 277-86. https://doi.org/10.1155/MBD.1996.277
Elkins, A L, et al. "Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers." Metal-based drugs vol. 3,6 (1996): 277-86. doi: https://doi.org/10.1155/MBD.1996.277
Elkins AL, Eley JG, Miller Iii MC, Hall IH, Sood A, Spielvogel B. Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers. Met Based Drugs. 1996;3(6):277-86. doi: 10.1155/MBD.1996.277. PMID: 18475758; PMCID: PMC2365028.
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The effects of boron derivatives on lipid absorption from the intestine and on bile lipids and bile acids of sprague dawley rats.

Metal-based drugs

Hall IH, Reynolds DJ, Wong OT, Sood A, Spielvogel BF.
PMID: 18472747
Met Based Drugs. 1995;2(2):65-72. doi: 10.1155/MBD.1995.65.

N,N-dimethyl-n-octadecylamine borane 1 at 8 mg/kg/day, tetrakis-u-(trimethylamine boranecarboxylato)-bis(trimethyl-carboxyborane)-dicopper(II) 2 at 2.5 mg/kg/day and trimethylamine-carboxyborane 3 at 8 mg/kg/day were evaluated for their effects on bile lipids, bile acids, small intestinal absorption of cholesterol and cholic acid and liver and...

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Hall IH, Reynolds DJ, Wong OT, et al. The effects of boron derivatives on lipid absorption from the intestine and on bile lipids and bile acids of sprague dawley rats. Met Based Drugs. 1995;2(2):65-72doi: 10.1155/MBD.1995.65.
Hall, I. H., Reynolds, D. J., Wong, O. T., Sood, A., & Spielvogel, B. F. (1995). The effects of boron derivatives on lipid absorption from the intestine and on bile lipids and bile acids of sprague dawley rats. Metal-based drugs, 2(2), 65-72. https://doi.org/10.1155/MBD.1995.65
Hall, I H, et al. "The effects of boron derivatives on lipid absorption from the intestine and on bile lipids and bile acids of sprague dawley rats." Metal-based drugs vol. 2,2 (1995): 65-72. doi: https://doi.org/10.1155/MBD.1995.65
Hall IH, Reynolds DJ, Wong OT, Sood A, Spielvogel BF. The effects of boron derivatives on lipid absorption from the intestine and on bile lipids and bile acids of sprague dawley rats. Met Based Drugs. 1995;2(2):65-72. doi: 10.1155/MBD.1995.65. PMID: 18472747; PMCID: PMC2364959.
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The effects of boron containing peptides on L1210 lymphoid leukemia metabolism.

Amino acids

Hall IH, Hall ES, Miller MC, Sood A, Spielvogel BF.
PMID: 24190609
Amino Acids. 1993 Oct;4(3):287-302. doi: 10.1007/BF00805829.

The purpose of this study was to establish the efficacy and mode of action of peptide boron derivatives as antineoplastic agents and to evaluate their safety in vivo. Boron-containing phenylalanine and tyrosine methyl esters were found to be potent...

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Hall IH, Hall ES, Miller MC, et al. The effects of boron containing peptides on L1210 lymphoid leukemia metabolism. Amino Acids. 1993;4(3):287-302doi: 10.1007/BF00805829.
Hall, I. H., Hall, E. S., Miller, M. C., Sood, A., & Spielvogel, B. F. (1993). The effects of boron containing peptides on L1210 lymphoid leukemia metabolism. Amino acids, 4(3), 287-302. https://doi.org/10.1007/BF00805829
Hall, I H, et al. "The effects of boron containing peptides on L1210 lymphoid leukemia metabolism." Amino acids vol. 4,3 (1993): 287-302. doi: https://doi.org/10.1007/BF00805829
Hall IH, Hall ES, Miller MC, Sood A, Spielvogel BF. The effects of boron containing peptides on L1210 lymphoid leukemia metabolism. Amino Acids. 1993 Oct;4(3):287-302. doi: 10.1007/BF00805829. PMID: 24190609.
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Hemodynamic System Analysis of Intraarterial Microaxial Pumps In Vitro and In Vivo.

Artificial organs

Siess T, Meyns B, Spielvogel K, Reul H, Rau G, Flameng W.
PMID: 28868678
Artif Organs. 1996 May;20(5):650-661. doi: 10.1111/j.1525-1594.1996.tb04497.x.

Because of the lack of a sophisticated pump management system, the performance of the Hemopump in patients cannot be assessed successfully. To clarify the interrelationship between an intravascular nonpulsatile pump and a pulsating ventricle, an in vitro study was...

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Siess T, Meyns B, Spielvogel K, et al. Hemodynamic System Analysis of Intraarterial Microaxial Pumps In Vitro and In Vivo. Artif Organs. 1996;20(5):650-661doi: 10.1111/j.1525-1594.1996.tb04497.x.
Siess, T., Meyns, B., Spielvogel, K., Reul, H., Rau, G., & Flameng, W. (1996). Hemodynamic System Analysis of Intraarterial Microaxial Pumps In Vitro and In Vivo. Artificial organs, 20(5), 650-661. https://doi.org/10.1111/j.1525-1594.1996.tb04497.x
Siess, Thorsten, et al. "Hemodynamic System Analysis of Intraarterial Microaxial Pumps In Vitro and In Vivo." Artificial organs vol. 20,5 (1996): 650-661. doi: https://doi.org/10.1111/j.1525-1594.1996.tb04497.x
Siess T, Meyns B, Spielvogel K, Reul H, Rau G, Flameng W. Hemodynamic System Analysis of Intraarterial Microaxial Pumps In Vitro and In Vivo. Artif Organs. 1996 May;20(5):650-661. doi: 10.1111/j.1525-1594.1996.tb04497.x. PMID: 28868678.
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Does relief of outflow tract obstruction in patients with hypertrophic cardiomyopathy improve long-term survival? Implications for lowering the threshold for surgical myectomy and alcohol septal ablation.

Annals of translational medicine

Naidu SS, Panza JA, Spielvogel D, Malekan R, Goldberg J, Aronow WS.
PMID: 28149847
Ann Transl Med. 2016 Dec;4(24):485. doi: 10.21037/atm.2016.12.47.

No abstract available.

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Naidu SS, Panza JA, Spielvogel D, et al. Does relief of outflow tract obstruction in patients with hypertrophic cardiomyopathy improve long-term survival? Implications for lowering the threshold for surgical myectomy and alcohol septal ablation. Ann Transl Med. 2016;4(24):485doi: 10.21037/atm.2016.12.47.
Naidu, S. S., Panza, J. A., Spielvogel, D., Malekan, R., Goldberg, J., & Aronow, W. S. (2016). Does relief of outflow tract obstruction in patients with hypertrophic cardiomyopathy improve long-term survival? Implications for lowering the threshold for surgical myectomy and alcohol septal ablation. Annals of translational medicine, 4(24), 485. https://doi.org/10.21037/atm.2016.12.47
Naidu, Srihari S, et al. "Does relief of outflow tract obstruction in patients with hypertrophic cardiomyopathy improve long-term survival? Implications for lowering the threshold for surgical myectomy and alcohol septal ablation." Annals of translational medicine vol. 4,24 (2016): 485. doi: https://doi.org/10.21037/atm.2016.12.47
Naidu SS, Panza JA, Spielvogel D, Malekan R, Goldberg J, Aronow WS. Does relief of outflow tract obstruction in patients with hypertrophic cardiomyopathy improve long-term survival? Implications for lowering the threshold for surgical myectomy and alcohol septal ablation. Ann Transl Med. 2016 Dec;4(24):485. doi: 10.21037/atm.2016.12.47. PMID: 28149847; PMCID: PMC5233489.
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The Kobresia pygmaea ecosystem of the Tibetan highlands - Origin, functioning and degradation of the world's largest pastoral alpine ecosystem: Kobresia pastures of Tibet.

The Science of the total environment

Miehe G, Schleuss PM, Seeber E, Babel W, Biermann T, Braendle M, Chen F, Coners H, Foken T, Gerken T, Graf HF, Guggenberger G, Hafner S, Holzapfel M, Ingrisch J, Kuzyakov Y, Lai Z, Lehnert L, Leuschner C, Li X, Liu J, Liu S, Ma Y, Miehe S, Mosbrugger V, Noltie HJ, Schmidt J, Spielvogel S, Unteregelsbacher S, Wang Y, Willinghöfer S, Xu X, Yang Y, Zhang S, Opgenoorth L, Wesche K.
PMID: 30134213
Sci Total Environ. 2019 Jan 15;648:754-771. doi: 10.1016/j.scitotenv.2018.08.164. Epub 2018 Aug 14.

With 450,000 km

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Miehe G, Schleuss PM, Seeber E, et al. The Kobresia pygmaea ecosystem of the Tibetan highlands - Origin, functioning and degradation of the world's largest pastoral alpine ecosystem: Kobresia pastures of Tibet. Sci Total Environ. 2018;648:754-771doi: 10.1016/j.scitotenv.2018.08.164.
Miehe, G., Schleuss, P. M., Seeber, E., Babel, W., Biermann, T., Braendle, M., Chen, F., Coners, H., Foken, T., Gerken, T., Graf, H. F., Guggenberger, G., Hafner, S., Holzapfel, M., Ingrisch, J., Kuzyakov, Y., Lai, Z., Lehnert, L., Leuschner, C., Li, X., Liu, J., Liu, S., Ma, Y., Miehe, S., Mosbrugger, V., Noltie, H. J., Schmidt, J., Spielvogel, S., Unteregelsbacher, S., Wang, Y., Willinghöfer, S., Xu, X., Yang, Y., Zhang, S., Opgenoorth, L., & Wesche, K. (2019). The Kobresia pygmaea ecosystem of the Tibetan highlands - Origin, functioning and degradation of the world's largest pastoral alpine ecosystem: Kobresia pastures of Tibet. The Science of the total environment, 648754-771. https://doi.org/10.1016/j.scitotenv.2018.08.164
Miehe, Georg, et al. "The Kobresia pygmaea ecosystem of the Tibetan highlands - Origin, functioning and degradation of the world's largest pastoral alpine ecosystem: Kobresia pastures of Tibet." The Science of the total environment vol. 648 (2019): 754-771. doi: https://doi.org/10.1016/j.scitotenv.2018.08.164
Miehe G, Schleuss PM, Seeber E, Babel W, Biermann T, Braendle M, Chen F, Coners H, Foken T, Gerken T, Graf HF, Guggenberger G, Hafner S, Holzapfel M, Ingrisch J, Kuzyakov Y, Lai Z, Lehnert L, Leuschner C, Li X, Liu J, Liu S, Ma Y, Miehe S, Mosbrugger V, Noltie HJ, Schmidt J, Spielvogel S, Unteregelsbacher S, Wang Y, Willinghöfer S, Xu X, Yang Y, Zhang S, Opgenoorth L, Wesche K. The Kobresia pygmaea ecosystem of the Tibetan highlands - Origin, functioning and degradation of the world's largest pastoral alpine ecosystem: Kobresia pastures of Tibet. Sci Total Environ. 2019 Jan 15;648:754-771. doi: 10.1016/j.scitotenv.2018.08.164. Epub 2018 Aug 14. PMID: 30134213.
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Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging.

Cancers

Giardina G, Micko A, Bovenkamp D, Krause A, Placzek F, Papp L, Krajnc D, Spielvogel CP, Winklehner M, Höftberger R, Vila G, Andreana M, Leitgeb R, Drexler W, Wolfsberger S, Unterhuber A.
PMID: 34209497
Cancers (Basel). 2021 Jun 29;13(13). doi: 10.3390/cancers13133234.

Pituitary adenomas count among the most common intracranial tumors. During pituitary oncogenesis structural, textural, metabolic and molecular changes occur which can be revealed with our integrated ultrahigh-resolution multimodal imaging approach including optical coherence tomography (OCT), multiphoton microscopy (MPM) and...

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Giardina G, Micko A, Bovenkamp D, et al. Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging. Cancers (Basel). 2021;13(13)doi: 10.3390/cancers13133234.
Giardina, G., Micko, A., Bovenkamp, D., Krause, A., Placzek, F., Papp, L., Krajnc, D., Spielvogel, C. P., Winklehner, M., Höftberger, R., Vila, G., Andreana, M., Leitgeb, R., Drexler, W., Wolfsberger, S., & Unterhuber, A. (2021). Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging. Cancers, 13(13), . https://doi.org/10.3390/cancers13133234
Giardina, Gabriel, et al. "Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging." Cancers vol. 13,13 (2021). doi: https://doi.org/10.3390/cancers13133234
Giardina G, Micko A, Bovenkamp D, Krause A, Placzek F, Papp L, Krajnc D, Spielvogel CP, Winklehner M, Höftberger R, Vila G, Andreana M, Leitgeb R, Drexler W, Wolfsberger S, Unterhuber A. Morpho-Molecular Metabolic Analysis and Classification of Human Pituitary Gland and Adenoma Biopsies Based on Multimodal Optical Imaging. Cancers (Basel). 2021 Jun 29;13(13). doi: 10.3390/cancers13133234. PMID: 34209497; PMCID: PMC8267638.
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Direct Axillary Artery Cannulation Does Not Increase Stroke in Aortic Surgery.

The Annals of thoracic surgery

Ohira S, Lansman SL, Spielvogel D.
PMID: 33711303
Ann Thorac Surg. 2022 Feb;113(2):698. doi: 10.1016/j.athoracsur.2021.02.070. Epub 2021 Mar 10.

No abstract available.

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Ohira S, Lansman SL, Spielvogel D. Direct Axillary Artery Cannulation Does Not Increase Stroke in Aortic Surgery. Ann Thorac Surg. 2021;113(2):698doi: 10.1016/j.athoracsur.2021.02.070.
Ohira, S., Lansman, S. L., & Spielvogel, D. (2022). Direct Axillary Artery Cannulation Does Not Increase Stroke in Aortic Surgery. The Annals of thoracic surgery, 113(2), 698. https://doi.org/10.1016/j.athoracsur.2021.02.070
Ohira, Suguru, et al. "Direct Axillary Artery Cannulation Does Not Increase Stroke in Aortic Surgery." The Annals of thoracic surgery vol. 113,2 (2022): 698. doi: https://doi.org/10.1016/j.athoracsur.2021.02.070
Ohira S, Lansman SL, Spielvogel D. Direct Axillary Artery Cannulation Does Not Increase Stroke in Aortic Surgery. Ann Thorac Surg. 2022 Feb;113(2):698. doi: 10.1016/j.athoracsur.2021.02.070. Epub 2021 Mar 10. PMID: 33711303.
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Insights into the Mechanism of an Allylic Arylation Reaction via Photoredox-Coupled Hydrogen Atom Transfer.

The Journal of organic chemistry

Spielvogel EH, Stevenson BG, Stringer MJ, Hu Y, Fredin LA, Swierk JR.
PMID: 34882427
J Org Chem. 2021 Dec 09; doi: 10.1021/acs.joc.1c02235. Epub 2021 Dec 09.

Despite widespread use as a synthetic method, the precise mechanism and kinetics of photoredox coupled hydrogen atom transfer (HAT) reactions remain poorly understood. This results from a lack of detailed kinetic information as well as the identification of side...

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Spielvogel EH, Stevenson BG, Stringer MJ, et al. Insights into the Mechanism of an Allylic Arylation Reaction via Photoredox-Coupled Hydrogen Atom Transfer. J Org Chem. 2021;doi: 10.1021/acs.joc.1c02235.
Spielvogel, E. H., Stevenson, B. G., Stringer, M. J., Hu, Y., Fredin, L. A., & Swierk, J. R. (2021). Insights into the Mechanism of an Allylic Arylation Reaction via Photoredox-Coupled Hydrogen Atom Transfer. The Journal of organic chemistry, . https://doi.org/10.1021/acs.joc.1c02235
Spielvogel, Ethan H, et al. "Insights into the Mechanism of an Allylic Arylation Reaction via Photoredox-Coupled Hydrogen Atom Transfer." The Journal of organic chemistry vol. (2021). doi: https://doi.org/10.1021/acs.joc.1c02235
Spielvogel EH, Stevenson BG, Stringer MJ, Hu Y, Fredin LA, Swierk JR. Insights into the Mechanism of an Allylic Arylation Reaction via Photoredox-Coupled Hydrogen Atom Transfer. J Org Chem. 2021 Dec 09; doi: 10.1021/acs.joc.1c02235. Epub 2021 Dec 09. PMID: 34882427.
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Applications of Golden Gate cloning to protein production using the baculovirus expression vector system.

Methods in enzymology

Spielvogel E, Neuhold J, Stolt-Bergner P.
PMID: 34742386
Methods Enzymol. 2021;660:155-169. doi: 10.1016/bs.mie.2021.05.017. Epub 2021 Jul 05.

Advances in structural biology techniques over the last decades have made it increasingly possible to determine the structures of multi-protein complexes. Generation of sufficient recombinant material for such studies remains a bottleneck and often requires screening a variety of...

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Spielvogel E, Neuhold J, Stolt-Bergner P. Applications of Golden Gate cloning to protein production using the baculovirus expression vector system. Methods Enzymol. 2021;660:155-169doi: 10.1016/bs.mie.2021.05.017.
Spielvogel, E., Neuhold, J., & Stolt-Bergner, P. (2021). Applications of Golden Gate cloning to protein production using the baculovirus expression vector system. Methods in enzymology, 660155-169. https://doi.org/10.1016/bs.mie.2021.05.017
Spielvogel, Erich, et al. "Applications of Golden Gate cloning to protein production using the baculovirus expression vector system." Methods in enzymology vol. 660 (2021): 155-169. doi: https://doi.org/10.1016/bs.mie.2021.05.017
Spielvogel E, Neuhold J, Stolt-Bergner P. Applications of Golden Gate cloning to protein production using the baculovirus expression vector system. Methods Enzymol. 2021;660:155-169. doi: 10.1016/bs.mie.2021.05.017. Epub 2021 Jul 05. PMID: 34742386.
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Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue.

Frontiers in physiology

Michalski D, Spielvogel E, Puchta J, Reimann W, Barthel H, Nitzsche B, Mages B, Jäger C, Martens H, Horn AKE, Schob S, Härtig W.
PMID: 33192578
Front Physiol. 2020 Oct 26;11:575598. doi: 10.3389/fphys.2020.575598. eCollection 2020.

Ischemic stroke causes cellular alterations in the "neurovascular unit" (NVU) comprising neurons, glia, and the vasculature, and affects the blood-brain barrier (BBB) with adjacent extracellular matrix (ECM). Limited data are available for the zone between the NVU and ECM...

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Michalski D, Spielvogel E, Puchta J, et al. Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue. Front Physiol. 2020;11:575598doi: 10.3389/fphys.2020.575598.
Michalski, D., Spielvogel, E., Puchta, J., Reimann, W., Barthel, H., Nitzsche, B., Mages, B., Jäger, C., Martens, H., Horn, A. K. E., Schob, S., & Härtig, W. (2020). Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue. Frontiers in physiology, 11575598. https://doi.org/10.3389/fphys.2020.575598
Michalski, Dominik, et al. "Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue." Frontiers in physiology vol. 11 (2020): 575598. doi: https://doi.org/10.3389/fphys.2020.575598
Michalski D, Spielvogel E, Puchta J, Reimann W, Barthel H, Nitzsche B, Mages B, Jäger C, Martens H, Horn AKE, Schob S, Härtig W. Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue. Front Physiol. 2020 Oct 26;11:575598. doi: 10.3389/fphys.2020.575598. eCollection 2020. PMID: 33192578; PMCID: PMC7649770.
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