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Showing 1 to 12 of 237 entries
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Teaching courses in clinical trial research methods.

Journal of clinical pharmacology

Spilker B.
PMID: 1880213
J Clin Pharmacol. 1991 Jun;31(6):496-508. doi: 10.1002/j.1552-4604.1991.tb03727.x.

This article describes nine separate elements that are part of any course: 1) the teachers, 2) the students, 3) expectations and attitudes of the teachers, 4) expectations and attitudes of the students, 5) a strategy of how to achieve...

Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review.

Cancers

Dohmen AJ, Swartz JE, Van Den Brekel MW, Willems SM, Spijker R, Neefjes J, Zuur CL.
PMID: 26343729
Cancers (Basel). 2015 Aug 28;7(3):1716-42. doi: 10.3390/cancers7030858.

Primary human tumor culture models allow for individualized drug sensitivity testing and are therefore a promising technique to achieve personalized treatment for cancer patients. This would especially be of interest for patients with advanced stage head and neck cancer....

Cometary science. Subsurface properties and early activity of comet 67P/Churyumov-Gerasimenko.

Science (New York, N.Y.)

Gulkis S, Allen M, von Allmen P, Beaudin G, Biver N, Bockelée-Morvan D, Choukroun M, Crovisier J, Davidsson BJ, Encrenaz P, Encrenaz T, Frerking M, Hartogh P, Hofstadter M, Ip WH, Janssen M, Jarchow C, Keihm S, Lee S, Lellouch E, Leyrat C, Rezac L, Schloerb FP, Spilker T.
PMID: 25613896
Science. 2015 Jan 23;347(6220):aaa0709. doi: 10.1126/science.aaa0709.

Heat transport and ice sublimation in comets are interrelated processes reflecting properties acquired at the time of formation and during subsequent evolution. The Microwave Instrument on the Rosetta Orbiter (MIRO) acquired maps of the subsurface temperature of comet 67P/Churyumov-Gerasimenko,...

To Be Involved or Not to Be Involved? Using Entertainment-Education in an HIV-Prevention Program for Youngsters.

Health communication

Schouten B, Vlug-Mahabali M, Hermanns S, Spijker E, van Weert J.
PMID: 24299216
Health Commun. 2014 Sep;29(8):762-772. doi: 10.1080/10410236.2013.781938. Epub 2013 Dec 03.

The purpose of this study is to gain insight into factors that are associated with youngsters' involvement with dance4life, a global HIV-prevention program. The Youth Engagement Framework, which includes factors impacting youngsters' involvement on three levels (individual, social, and...

Preschool language development among children of adolescent mothers.

Journal of applied developmental psychology

Oxford M, Spieker S.
PMID: 16619087
J Appl Dev Psychol. 2006;27(2):165-182. doi: 10.1016/j.appdev.2005.12.013.

This longitudinal study examined a comprehensive set of predictors of preschool language performance in a sample of children of adolescent mothers. Six domains of risk (low maternal verbal ability, intergenerational risk, contextual risk, relational risk, home environmental risk, and...

Pharmaceutical tangents: the good, the bad and the ugly.

Drug news & perspectives

Spilker B.
PMID: 15616614
Drug News Perspect. 1998 Apr;11(3):133-8. doi: 10.1358/dnp.1998.11.3.863650.

In this article a "tangent" means a change from the plans or path one has agreed to follow in drug discovery, development, production or marketing. There are positive and negative tangents. It is important for companies to have a...

Quality and quantity of data.

Drug news & perspectives

Spilker B.
PMID: 15616629
Drug News Perspect. 1998 Dec;11(10):605-10. doi: 10.1358/dnp.1998.11.10.863661.

When collecting data, deciding what type and how much to obtain will depend in large measure on how the data will be used and the group(s) that will be given the data, as well as the risk-taking or risk-averse...

Creating standards for basic, medical and market research.

Drug news & perspectives

Spilker B.
PMID: 15616661
Drug News Perspect. 1998 May;11(4):197-203.

Different types of standards that can be created are ideal, realistic, desirable and minimally acceptable. A different approach to viewing types of standards is to view them as existing along a spectrum from very formal to informal. Basic research,...

Developing a pharmaceutical perspective.

Drug news & perspectives

Spilker B.
PMID: 15616668
Drug News Perspect. 1998 Nov;11(9):517-22. doi: 10.1358/dnp.1998.11.9.863688.

A variety of focuses are used in this article to discuss four types of perspectives; these focuses are self, others, drugs/issues and company/industry. There is a hierarchy of concern about the topics one deals with. This hierarchy ranges from...

Applying pharmaceutical lessons: learning lessons from the past.

Drug news & perspectives

Spilker B.
PMID: 15616644
Drug News Perspect. 1998 Jun;11(5):261-4. doi: 10.1358/dnp.1998.11.5.863671.

Systematic evaluation of a project, product or other successes, and failures, is an important method for improving the performance of a company, as well as that of an individual. One should evaluate and determine if lessons learned can be...

Differentiating between current fashions and major innovations.

Drug news & perspectives

Spilker B.
PMID: 15616653
Drug News Perspect. 1998 Mar;11(2):69-72. doi: 10.1358/dnp.1998.11.2.863678.

Every professional discipline has current fashions. Certain ideas or topics are promoted by those who are most closely associated with the idea. These people often have a great deal to gain when ideas are accepted. The traditional approach of...

The impact of biologics on health-related quality of life in patients with inflammatory bowel disease.

Clinical and experimental gastroenterology

Vogelaar L, Spijker AV, van der Woude CJ.
PMID: 21694833
Clin Exp Gastroenterol. 2009;2:101-9. doi: 10.2147/ceg.s4512. Epub 2009 Sep 25.

BACKGROUND: Inflammatory bowel disease (IBD) is characterized by a chronic relapsing inflammation of the gastrointestinal tract. Adult IBD patients suffer from a disabling disease which greatly affects health-related quality of life (HRQoL). A worse HRQoL in these patients may...

Showing 1 to 12 of 237 entries