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Showing 1 to 12 of 177 entries
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Mouse Adenovirus Type 1 Early Region 1A Effects on the Blood-Brain Barrier.

mSphere

Tirumuru N, Pretto CD, Castro Jorge LA, Spindler KR.
PMID: 27303733
mSphere. 2016 Apr 20;1(2). doi: 10.1128/mSphere.00079-16. eCollection 2016.

Mouse adenovirus type 1 (MAV-1) infects endothelial cells and disrupts the blood-brain barrier (BBB), causing encephalitis in inbred and outbred mice. Using a virus mutant that does not produce the early region 1A protein E1A, we investigated whether the...

Are Bone Bruise Characteristics and Articular Cartilage Pathology Associated with Inferior Outcomes 2 and 6 Years After Anterior Cruciate Ligament Reconstruction?.

Cartilage

Lattermann C, Jacobs CA, Reinke EK, Scaramuzza EA, Huston LJ, Dunn WR, Spindler KP.
PMID: 28345404
Cartilage. 2017 Apr;8(2):139-145. doi: 10.1177/1947603516653209. Epub 2016 Jul 08.

Objective To determine (1) if bone bruise characteristics seen on magnetic resonance imaging are associated with patient-reported outcomes prior to and following anterior cruciate ligament reconstruction and (2) if the combined presence of bone bruises with articular cartilage pathology...

Perspectives of shaped pulses for EPR spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Spindler PE, Schöps P, Kallies W, Glaser SJ, Prisner TF.
PMID: 28579101
J Magn Reson. 2017 Jul;280:30-45. doi: 10.1016/j.jmr.2017.02.023.

This article describes current uses of shaped pulses, generated by an arbitrary waveform generator, in the field of EPR spectroscopy. We show applications of sech/tanh and WURST pulses to dipolar spectroscopy, including new pulse schemes and procedures, and discuss...

The effects of sulphydryl reagents on morphogenesis in hydroids : I. Metamorphosis and regeneration inHydractinia echinata.

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen

Müller WA, Spindler K-.
PMID: 28304725
Wilhelm Roux Arch Entwickl Mech Org. 1972 Jun;170(2):152-164. doi: 10.1007/BF00577014.

1) The influence of reagents affecting SH or SS groups on morphogenesis has been studied in metamorphosing larvae and in regenerating adult hydranths. The thiol challenges evoke and enhance predominantly the differentiation of basal structures. 2) In larvae undergoing...

Predictors of Hip Pain and Function in Femoroacetabular Impingement: A Prospective Cohort Analysis.

Orthopaedic journal of sports medicine

Westermann RW, Lynch TS, Jones MH, Spindler KP, Messner W, Strnad G, Rosneck J.
PMID: 28944250
Orthop J Sports Med. 2017 Sep 15;5(9):2325967117726521. doi: 10.1177/2325967117726521. eCollection 2017 Sep.

BACKGROUND: Validated patient-reported outcome measures (PROMs) of hip pain and function at the time of arthroscopy could be predictors of the final outcome. Little is known about how patient factors or pathologic intra-articular findings relate to hip pain or...

Single nucleotide polymorphisms in the HIF-1α gene and chemoradiotherapy of locally advanced rectal cancer.

Oncology letters

Havelund BM, Spindler KL, Ploen J, Andersen RF, Jakobsen A.
PMID: 23162650
Oncol Lett. 2012 Nov;4(5):1056-1060. doi: 10.3892/ol.2012.837. Epub 2012 Jul 31.

The aim of this study was to investigate the predictive impact of polymorphisms in the HIF-1α gene on the response to chemoradiotherapy (CRT) in rectal cancer. This study included two cohorts of patients with locally advanced rectal cancer receiving...

Effects of a slatted floor on bacteria and physical parameters in litter in broiler houses.

Veterinary and animal science

Heitmann S, Stracke J, Adler C, Ahmed MFE, Schulz J, Büscher W, Kemper N, Spindler B.
PMID: 32734116
Vet Anim Sci. 2020 Apr 20;9:100115. doi: 10.1016/j.vas.2020.100115. eCollection 2020 Jun.

In this study, a new housing system for broiler was tested. This system consisted of a slatted floor area and a littered area with the aim of improving litter quality. Two experimental broiler houses were provided. In house 1,...

Preferential Identification of Agonistic OX40 Antibodies by Using Cell Lysate to Pan Natively Paired, Humanized Mouse-Derived Yeast Surface Display Libraries.

Antibodies (Basel, Switzerland)

Medina-Cucurella AV, Mizrahi RA, Asensio MA, Edgar RC, Leong J, Leong R, Lim YW, Nelson A, Niedecken AR, Simons JF, Spindler MJ, Stadtmiller K, Wayham N, Adler AS, Johnson DS.
PMID: 31544823
Antibodies (Basel). 2019 Feb 19;8(1). doi: 10.3390/antib8010017.

To discover therapeutically relevant antibody candidates, many groups use mouse immunization followed by hybridoma generation or B cell screening. One modern approach is to screen B cells by generating natively paired single chain variable fragment (scFv) display libraries in...

Enantioselective Total Synthesis and Assignment of the Absolute Configuration of the Furo[3,2- a]carbazole Alkaloid Furoclausine-B.

The Journal of organic chemistry

Spindler B, Kataeva O, Knölker HJ.
PMID: 30484649
J Org Chem. 2018 Dec 21;83(24):15136-15143. doi: 10.1021/acs.joc.8b02426. Epub 2018 Dec 11.

We describe the first enantioselective total synthesis and the assignment of the absolute configuration of the furo[3,2- a]carbazole alkaloid furoclausine-B. As key steps for our approach we used a palladium(II)-catalyzed double C-H-bond activation for the construction of the carbazole...

Bulk micro-defect detection with low-angle illumination.

The Review of scientific instruments

Szarvas T, Molnár G, Nádudvari G, Tóth S, Almásy O, Spindler S, Erdei D, Pothorszky S, Kretschmer R, Bauer S.
PMID: 34243430
Rev Sci Instrum. 2021 Apr 01;92(4):043701. doi: 10.1063/5.0027147.

The detection of oxygen precipitates, voids, and other defects is critical for semiconductor wafer makers. One of the industry standard techniques for detecting these Bulk Micro-Defects (BMDs) is Semilab's Light Scattering Tomograph (LST) system. In this measurement, unpatterned wafers...

Open-label phase 3 study of intravenous golimumab in patients with polyarticular juvenile idiopathic arthritis.

Rheumatology (Oxford, England)

Ruperto N, Brunner HI, Pacheco-Tena C, Louw I, Vega-Cornejo G, Spindler AJ, Kingsbury DJ, Schmeling H, Borzutzky A, Cuttica R, Inman CJ, Malievskiy V, Scott C, Keltsev V, Terreri MT, Viola DO, Xavier RM, Fernandes TAP, Velázquez MDRM, Henrickson M, Clark MB, Bensley KA, Li X, Lo KH, Leu JH, Hsu CH, Hsia EC, Xu Z, Martini A, Lovell DJ.
PMID: 33493312
Rheumatology (Oxford). 2021 Oct 02;60(10):4495-4507. doi: 10.1093/rheumatology/keab021.

OBJECTIVES: To assess efficacy, pharmacokinetics (PK) and safety of intravenous (i.v.) golimumab in patients with polyarticular-course JIA (pc-JIA).METHODS: Children aged 2 to

Suspected Drinking Water Poisoning in a Domestic Kitten with Methemoglobinemia.

Veterinary sciences

Fidanzio F, Corsini A, Spindler KP, Crosara S.
PMID: 34822617
Vet Sci. 2021 Oct 20;8(11). doi: 10.3390/vetsci8110243.

A 4-month-old male indoor cat was referred for dyspnea, mental dullness and weakness, which appeared two days earlier. The cat had been adopted at 3 months of age. Physical exam showed cyanosis, dyspnea and mild hypothermia. The "spot test"...

Showing 1 to 12 of 177 entries