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Immune Dysfunction in Mendelian Disorders of POLA1 Deficiency.

Journal of clinical immunology

Starokadomskyy P, Escala Perez-Reyes A, Burstein E.
PMID: 33392852
J Clin Immunol. 2021 Feb;41(2):285-293. doi: 10.1007/s10875-020-00953-w. Epub 2021 Jan 03.

POLA1 encodes the catalytic unit of DNA polymerase α, which together with the Primase complex launches the DNA replication process. While complete deficiency of this essential gene is presumed to be lethal, at least two conditions due to partial...

Showing 1 to 1 of 1 entries